Humans & VIruses
Program in Human Biology
Professor Robert Siegel
New Findings from 2004 and 2005
Other helpful links:
WHO- Rabies General Information
Leicester Microbiology- Rhabdoviruses
Links from previous Humans & Viruses students:
Catherine's Pathogen Cards
Heather's Pathogen Cards
Central European Encephalitis Virus
Rhabdoviruses are of the Mononegavirales order, which include nonsegmented, single-stranded, negative-sense RNA viruses. The Rhabdoviridae family includes the Lyssavirus , Ephemerovirus , and Vesiculovirus genera. The rabies virus is a member of the lyssavirus genus, and vesicular stomatitis virus belongs to the vesiculovirus genus.
Rhabdoviruses have no polyA tail or 5' cap. The virion has a distinct bullet shape with a helical nucleocapsid and envelope with about 400 large trimeric glycoprotein spikes on the surface. The virion is approximately 75 nm wide and 180 nm long.
Translation, Protein Production
Replication occurs in the cytoplasm, and the genomic length (+) RNA is used as a template. Rhabdoviruses encode 5 proteins: nucleoprotein (N), phosphoprotein (P), matrix protein (M), glycoprotein (G), and polymerase (L).
photo courtesty of: rabies.net
“The Rabies Virus.” http://www.cdc.gov/ncidod/dvrd/rabies/the_virus/virus.htm
Humans & Viruses Class Notes. Robert Siegel. Fall 2005.