Humans & VIruses

Program in Human Biology

Professor Robert Siegel


created by Catherine Hammons and Heather Narciso

November 2005


New Findings from 2004 and 2005

Viral Profiles:

Rabies Virus

Vesicular Stomatitis Virus

Drug Profile:

Rabies Immune Globulin

Other helpful links:

CDC-About Rabies

WHO- Rabies General Information

ICTV- Rhabdoviridae

Leicester Microbiology- Rhabdoviruses

Links from previous Humans & Viruses students:





Catherine's Pathogen Cards

Coxsackie A 1-21, A24 Viruses

Ebola Reston Virus

Hepatitis E Virus

Heather's Pathogen Cards

Central European Encephalitis Virus

Monkeypox Virus

Murray Valley Encephalitis Virus



Rhabdoviruses are of the Mononegavirales order, which include nonsegmented, single-stranded, negative-sense RNA viruses. The Rhabdoviridae family includes the Lyssavirus , Ephemerovirus , and Vesiculovirus genera. The rabies virus is a member of the lyssavirus genus, and vesicular stomatitis virus belongs to the vesiculovirus genus.


Rhabdoviruses have no polyA tail or 5' cap. The virion has a distinct bullet shape with a helical nucleocapsid and envelope with about 400 large trimeric glycoprotein spikes on the surface. The virion is approximately 75 nm wide and 180 nm long.

Translation, Protein Production

Replication occurs in the cytoplasm, and the genomic length (+) RNA is used as a template. Rhabdoviruses encode 5 proteins: nucleoprotein (N), phosphoprotein (P), matrix protein (M), glycoprotein (G), and polymerase (L).

photo courtesty of:



“The Rabies Virus.”

Humans & Viruses Class Notes. Robert Siegel. Fall 2005.