Selected publications from Matin Laboratory

Selected Publications

Alexis V. Forterre, Jing-Hung Wang, Alain Delcayre, Kyuri Kim, Carol Green, Mark D. Pegram, Stefanie S. Jeffrey, A. C. Matin. EV-mediated in vitro transcribed mRNA-based gene delivery for targeted treatment of HER2+ breast cancer xenografts in mice by CB1954.Molecular Cancer Therapeutics, Published Online First January 15, 2020; DOI: 10.1158/1535-7163.MCT-19-0928 [PDF]

Michael R. Padgen, Matthew P. Lera, Macarena P. Parra, Antonio J. Ricco, Matthew Chin, Tori N. Chinn, Aaron Cohen, Charlie R. Friedericks, Michael B. Henschke, Timothy V. Snyder, Stevan M. Spremo, Jing-Hung Wang, AC Matin. EcAMSat spaceflight measurements of the role of σs in antibiotic resistance of stationary phase Escherichia coli in microgravity.  Life Sciences in Space Research 24 (2020) 18-24 (Journal highlight) [PDF]

Invited video presentation, LabRoots: Extracellular vesicle-mediated mRNA-based gene-delivery for targeted and safe treatment of HER2-positive breast cancer in mice by prodrugs: A new GDEPT approach. Can be accessed at: (2019)

Fengjiao Lyu, Ming Pan, Sunita Patil, Jing-Hung Wang, A. C Matin, Jason R Andrews, Sindy K.Y. Tang. 2018. Phenotyping antibiotic resistance with single-cell resolution for the detection of heteroresistance. Sensors & Actuators: B. Chemical 270 (2018) 396–404 [PDF]

Wang J-H, Forterre A, Zhao J, Frimannsson D, Delcayre A, Antes T, Efron B, Jeffrey S, Pegram M, Matin A. 2018. Anti-HER2 scFv-directed extracellular vesicle-mediated mRNA-based gene delivery inhibits growth of HER2-positive human breast tumor xenografts by prodrug activation. Molecular Cancer Therapeutics 17 (5), 1133-1142 [PDF]

The above article is Science Translational Medicine EDITORS' CHOICE – CANCER, “An EVolving approach to directed enzyme prodrug therapy for cancer [PDF]

AC Matin, J-H Wang, Mimi Keyhan, Rachna Singh, Michael Benoit, Macarena P. Parra, Michael R. Padgen, Antonio J. Ricco,* Matthew Chin, Charlie R. Friedericks, Tori N. Chinn, Aaron Cohen, Michael B. Henschke, Timothy V. Snyder, Matthew P. Lera, Shannon S. Ross, Christina M. Mayberry, Sungshin Choi, Diana T. Wu, Ming X. Tan, Travis D. Boone, Christopher C. Beasley, and Stevan M. Spremo. Payload hardware and experimental protocol for testing the effect of space microgravity on the resistance to gentamicin of stationary-phase uropathogenic Escherichia coli and its ss-deficient mutant. Life Sciences in Space Research 15: 1-10 (2017) [PDF] (Journal highlight)

Singh R, Matin AC. Cellular response of Escherichia coli to microgravity and microgravity analogue culture. In: Effect of spaceflight and spaceflight analogue culture on human and microbial cells: Novel insights into disease mechanisms. New York: Springer, 2016. p. 259-82. (Available from the publisher.)

Wang JH, Endsley AN, Green C, Matin AC. Utilizing native fluorescence imaging, modeling and simulation to examine pharmacokinetics and therapeutic regimen of a novel anticancer prodrug. BMC Cancer (2016) 16:524 (DOI 10.1 186/s12885-016-2508-6 [PDF]

Matin A.C. , Stress, Bacterial: General and Specific, Reference Module in Biomedical Sciences. Elsevier. 08-Aug-2015 doi: 10.1016/B978-0-12-801238-3.0246 [PDF]

Masamitsu Kanadaa, Michael H. Bachmanna, Jonathan W. Hardy, Daniel Omar Frimannson, Laura Bronsart, Andrew Wang, Matthew D. Sylvester, Tobi L. Schmidt, Roger L. Kaspar, Manish J. Butte, A. C. Matin, and Christopher H. Contag. 2015. Differential fates of biomolecules delivered to target cells via extracellular vesicles. Proc Nat Acad Sci (USA). PNAS Early Edition, [PDF]

Jing-Hung Wang, Rachna Singh, Michael Benoit, Mimi Keyhan, Matthew Sylvester, Michael Hsieh, Anuradha Thathireddy, Yi-Ju Hsieh, A. C. Matin. 2014. Sigma S-Dependent Antioxidant Defense Protects Stationary-Phase Escherichia coli against the Bactericidal Antibiotic Gentamicin. Antimicrobial Agents and Chemotherapy 58 (10): 5964-5975, Manuscript [PDF]; Suppl mat. [PDF]

Haiyu Zhang, Adam L Cohen, Sujatha Krishnakumar, Irene L Wapnir, Selvaraju Veeriah, Glenn Deng, Marc A Coram, Caroline M Piskun, Teri A Longacre, Michael Herrler, Daniel O Frimannsson, Melinda L Telli, Frederick M Dirbas, AC Matin, Shanaz H Dairkee, Banafshe Larijani, Gennadi V Glinsky, Andrea H Bild and Stefanie S Jeffrey. 2014. Patient-derived xenografts of triple-negative breast cancer reproduce molecular features of patient tumors and respond to mTOR inhibition. Breast Cancer Research 2014, 16:R36 ( [PDF].

Eswaramoorthy S, Poulain S, Hienerwadel R, Nicolas B, Sylvester M, Zhang Y, Berthoeau C, Van D-L, and Matin A.C. 2012. Crystal Structure of ChrR – A Quinone Reductase with the Capacity to Reduce Chromate. PLoS One, April 2012 | Volume 7 | Issue 4 | e36017 [PDF]. Full article with supplementary material is available at:

Benoit, MR, Conant, C, Ionescu-Zanetti, C, Schwartz, M, and Matin, A. New device for high throughput viability screening of flow-bioflims. 2010.  Applied and Environmental Microbiology 76 (13): 4136-4142 [PDF]

Barak, Y., F. Schreiber, S.H. Thorne, C.H. Contag, D. deBeer, and Matin, A . 2010. Role of nitric oxide in Salmonella typhimurium-mediated cancer cell killing. BMC Cancer 10: 146-152 [PDF]

Michael R Benoit, Dirk Mayer, Yoram Barak, Ian Y Chen, Wei Hu,  Zhen Cheng, Shan X Wang, Daniel M Spielman, Sanjiv S Gambhir, A Matin. 2009. Visualizing implanted tumors in mice with MRI using magnetotactic bacteria.Clinical Cancer Research 15 (16): 5170 – 5177. Manuscript [PDF] Suppl mat. [PDF]

Matin, A. 2009. Bacterial stress response: specific and general. Encyclopedia of Microbiology. (Moselio Schaechter, Editor), pp. 485-500 Oxford: Elsevier. [PDF]

Steve H. Thorne, Yoram Barak, Wenchuan Liang, Michael H. Bachmann, Jianghong Rao, Christopher H. Contag and A. Matin. 2009. CNOB/ChrR6, a new prodrug enzyme cancer chemotherapy.- Molecular Cancer Therapeutics 8(2): 333-341, Ms [PDF]; Suppl. figures [PDF]; Suppl. tables [PDF]; Video [PDF]

Barak, Y., Y. Nov., D. Ackerley, and A. Matin. 2008. Enzyme improvement in the absence of structural knowledge - a novel approach. ISME Journal, 2: 171-179 [PDF]. Suppl mat. [PDF]

S.V. Lynch, L. Dixon, M.R. Benoit, E.L. Brodie, M. Keyhan, P. Hu, D.F. Ackerley, G.L. Andersen and A. Matin. 2007. Role of the rapA Gene in Controlling Antibiotic Resistance of Escherichia coli Biofilms. Antimicrobial Agents and Chemotherapy, 51 (10): 3650-3658 [PDF]

Matin, A., and S. Lynch, and M. R. Benoit. 2006. Increased bacterial resistance and virulence in simulated microgravity and its molecular basis. Gravitation and Space Biology 19(2): 31-42 [PDF]

Lynch, S.V., K. Mukundakrishnan, M. R. Benoit, P. Ayyaswami, and A. Matin. 2006. Escherichia coli biofilms formed under low shear simulated microgravity in a ground-based system. Applied & Environmental Microbiology 72 (12): 7701-7710 [PDF]

Barak, Y., D. F. Ackerley, C. J. Dodge, B. Lal, A. Cheng, A. J. Francis, and A. Matin. 2006. Analysis of novel soluble Cr(VI) and U(VI) reductases and generation of improved enzymes using directed evolution. Applied and Environmental Microbiology  72 (11): 7074-7082 [PDF]

Ackerley, D.F., Y. Barak, S.V. Lynch, J. Curtin, and A. Matin. 2006. Effect of chromate stress on Escherichia coli K12. Journal of Bacteriology 188 (9): 3371-3381. [PDF]

Barak, Y , Stephen H. Thorne, David F. Ackerley, Susan V. Lynch, Christopher H. Contag, and A. Matin. 2006. New enzyme for reductive cancer chemotherapy (YieF) and its improvement by directed evolution. Molecular Cancer Therapeutics 5(1): 97-103. [PDF]

Matin A., and S. V. Lynch. 2005. Investigating the Threat of Bacteria Grown in Space. ASM News 71(5): 235-240 [PDF]

Lynch S. V. and A. Matin. 2005. Travails of microgravity:man and microbes in space. Biologist 52(2): 80-87 [PDF]

Gonzalez C.F., D.F. Ackerley, S.V. Lynch, and A. Matin. 2005. ChrR, A soluble quinone reductase of Pseudomonas Putida that defends against H2O2. The Journal of Biological Chemistry. 280(24): 22590-22595. [PDF]

Ackerley, D.F., C.F. Gonzalez, C.H. Park, R. Blake II, M. Keyhan, and A. Matin. 2004. Mechanism of chromate reduction by the Escherichia coli protein, NfsA, and the role of different chromate reductases in minimizing oxidative stress during chromate reduction. Environmental Microbiology 6 (8): 851-860 [PDF]

Ackerley, D.F., C.F. Gonzalez, C.H. Park, R. Blake II, M. Keyhan, and A. Matin. 2004. Chromate reducing properties of soluble flavoproteins from Pseudomonas putida and Escherichia coli. Applied & Environmental Microbiology 70: 873-882 [PDF]

Keyhan, M. , D. F. Ackerley, and A. Matin. 2004. Targets of improvement in bacterial chromate bioremediation. In: M. Pellei and A. Porta (Eds.), Remediation of Contaminated Sediments -- 2003. Proceedings of the Second International Conference on Remediation of Contaminated Sediments (Venice, Italy; 30 Sep-3 Oct 2003). ISBN 1-57477-143-4, published by Battelle Press, Columbus, OH. [PDF]

Lynch, S., E.L. Bradie, and A. Matin. 2004. Role and regulation of sigmaS in low shear simulated microgravity-conferred general resistance in Escherichia coli. Journal of Bacteriology 186 (24): 8207-8212 [PDF]

Gonzalez, C.F., D. F. Ackerley, C. H. Park, M. Keyhan, and A. Matin. 2003. A soluble flavoprotein contributes to chromate reduction and tolerance by Pseudomonas putida. Acta Biotechnol. 23: 233-239 [PDF]

Stone, G., P. Wood, L. Dixon, M. Keyhan and A. Matin. 2002. Tetracycline rapidly reaches all the constituent cells of uropathogenic Escherichia coli biofilms. Antimicrobial Agents and Chemotherapy 46: 2458-2461. [PDF]

Matin, A. 2002. Ion transport in acidophiles. In Theme 6.73 Extremophiles, In Encycloppedia of Life Support Systems (EOLSS), Eolss Publishers, Oxford, U.K. [] pp.1-21 [PDF]

Park, C-H., M. Keyhan, B. Wielinga, S. Fendorf, and A. Matin. 2000. Purification to homogeneity and charcterization of a novel Pseudomonas putida chromate reductase. Applied & Environmental Microbiology 66 (5): 1788-1795. [PDF]

Xiong, A., A. Gottman, C. Park, M. Baetens, S. Pandza, and A. Matin. 2000. The EmrR protein represses the Escherichia coli emrRAB multidrug resistance operon by directly binding to its promoter region. Antimicrobial Agents and Chemotherapy. [PDF]

Pandza. S., M. Baetens, C-H. Park, T. Au, M. Keyhan, and A. Matin. 2000. The putative G-protein FLHF has a role in polar flagellar placement and general stress response induction in Pseudomonas putida. Molecular Microbiology 36: 414-423 [PDF]

Matin, A., M. Baetens, S. Pandza, C.H. Park, and S. Waggoner. 1999. Survival strategies in the stationary phase. In Microbial Ecology of Infectious Disease (E. Rosenberg, editor), American Society for Microbiology: Washington D.C., pp. 30-48

Saier, M. H., I.T. Paulsen, and A. Matin. 1997. A Bacterial Model System for Understanding Multidrug Resistance. Microbial Drug Resistance, 3:289-295. [PDF]

Matin, A., C.D. Little, C.D. Fraley, and M. Keyhan. 1995. Use of starvation promoters to limit growth and selectively express trichloroethylene and phenol transformation activity in recombinant Escherichia coli. Applied and Environmental Microbiology, 61:3323-3328. [PDF]


Reducing chromium and/or uranium involves contacting them with a Escherichia coli nitroreductase polypeptide having amino acid alteration relative to wild-type enzyme, and produces enhanced enzyme kinetics for reduction of toxic metals
Patent Number(s): US2007254355-A1

Cultivating magnetotactic bacterium, useful e.g. for enhancing contrast of magnetic resonance image, comprises obtaining isolated strain of magnetotactic bacteria, and cultivating the bacteria in growth medium comprising iron salt

Patent Number(s): US2010135912-A1

Nitroreductase enzymes
Patent Number(s): US 07687474

S17-343A_STAN-1442WO_2019-04-05_Publication.Therapeutic agents specifically delivered by exosomes for cancer treatment. US S17-343_STAN-1442PRV2-application, Serial No. 62/697,758