ORIGINAL TEXT: -------------- PARAGRAPH 1: ------------ In bioinformatics, Basic Local Alignment Search Tool, or BLAST, is an algorithm for comparing primary biological sequence information, such as the amino-acid sequences of different proteins or the nucleotides of DNA sequences. A BLAST search enables a researcher to compare a query sequence with a library or database of sequences, and identify library sequences that resemble the query sequence above a certain threshold. For example, following the discovery of a previously unknown gene in the mouse, a scientist will typically perform a BLAST search of the human genome to see if humans carry a similar gene; BLAST will identify sequences in the human genome that resemble the mouse gene based on similarity of sequence. PARAGRAPH 2: ------------ BLAST - the Basic Local Alignment Search Tool (http://www.ncbi.nlm.nih.gov/BLAST/) searches for sequences (nucleotide or protein) in a given database that are similar to a given sequence. It was developed by Altschul and coworkers at the National Center for Biotechnology Information. Further information about BLAST can be reached from the server page listed above. The two BLAST programs listed below are the ones used in the game. * Standard nucleotide-nucleotide BLAST [blastn] - The blastn program is used to compare an input nucleotide sequence to the entries in a nucleotide sequence database. * Standard protein-protein BLAST [blastp] - The blastp program is used to * compare an input amino acid sequence to the entries in an amino acid * database. Paragraph 3: ------------ In bioinformatics, Basic Local Alignment Search Tool, or BLAST, is an algorithm for comparing primary biological sequence information, such as the amino-acid sequences of different proteins or the nucleotides of DNA sequences. It was developed by Altschul and coworkers at the National Center for Biotechnology Information. Further information about BLAST can be reached from the server page listed above. To see an illustrative example, following the discovery of a previously unknown gene in the mouse, a scientist will typically perform a BLAST search of the human genome to see if humans carry a similar gene; BLAST will identify sequences in the human genome that resemble the mouse gene based on similarity of sequence. PARAGRAPH 4: ------------ Recent times have been good to Marvel comics, and the long-anticipated arrival of Spider-Man represents the latest step up the ladder. Long the underdog in the motion picture arena, Marvel has at last been able to catch up to rival DC comics by placing a trio of its superheroes into multiplexes - Blade, the X-Men, and Spider-Man. DC may have struck first with Superman and Batman, but, these days, the comics-to-cinema summit belongs to Stan Lee's corporation. The second X-Men movie is on its way, as are Daredevil, The Hulk, and, a little farther into the future, The Fantastic Four. LIST OF WORDS: -------------- PARAGRAPH 1: ------------ Bioinformatics Basic Local Alignment Search Tool BLAST algorithm comparing primary biological sequence information such amino acid sequences different proteins nucleotides sequences BLAST search enables researcher compare query sequence with library database sequences identify library sequences that resemble query sequence above certain threshold example following discovery previously unknown gene mouse scientist will typically perform BLAST search human genome humans carry similar gene BLAST will identify sequences human genome that resemble mouse gene based similarity sequence PARAGRAPH 2: ------------ BLAST Basic Local Alignment Search Tool http ncbi BLAST searches sequences nucleotide protein given database that similar given sequence developed Altschul coworkers National Center Biotechnology Information Further information about BLAST reached from server page listed above BLAST programs listed below ones used game Standard nucleotide nucleotide BLAST blastn blastn program used compare input nucleotide sequence entries nucleotide sequence database Standard protein protein BLAST blastp blastp program used compare input amino acid sequence entries amino acid database PARAGRAPH 3: ------------ bioinformatics Basic Local Alignment Search Tool BLAST algorithm comparing primary biological sequence information such amino acid sequences different proteins nucleotides sequences developed Altschul coworkers National Center Biotechnology Information Further information about BLAST reached from server page listed above illustrative example following discovery previously unknown gene mouse scientist will typically perform BLAST search human genome humans carry similar gene BLAST will identify sequences human genome that resemble mouse gene based similarity sequence Paragraph 4: ------------ Recent times have been good Marvel comics long anticipated arrival Spider represents latest step ladder Long underdog motion picture arena Marvel last been able catch rival comics placing trio superheroes into multiplexes Blade Spider have struck first with Superman Batman these days comics cinema summit belongs Stan corporation second movie Daredevil Hulk little farther into future Fantastic Four