Microfabrication and Nanotechnology can be used to fabricate both active and passive sensing devices that are ultasensitive, densely packed, cheap and either for single use or for long term repeated use.  We have been utlizing some of these sensing modalities inconjunction with bio-inspired concepts to detect biomolecules as shown below. The targeted biomedical need areas for these sensors include the detection of infectious agents and diseases, in particular cancer, in clinically relevant samples.