Karl Deisseroth



November 18, 1971; Boston, Massachusetts


P.O. Box 17970  
Stanford CA 94309


(650) 723-8222 Pager# 22032
(650) 728-5126


A.B.      Harvard      1992     (Biochemical Sciences, summa cum laude)  
Ph.D.     Stanford     1998     (Neuroscience)
M.D.     Stanford      2000

Imaging Structure and Function in the Nervous System  
Cold Spring Harbor  1995

Methods in Computational Neuroscience  
Woods Hole             1997

Mouse Behavioral Analysis
Cold Spring Harbor   2003

Psychiatry Residency

Stanford Hospital and Clinics




A novel source of neural stem cells

Filed 2001; US Patent and Trademark Office through Stanford University


Awards and  Honors:

National Merit Scholarship (Harvard) 1988  
Harvard College Scholarship (Harvard) 1989  
John Harvard Scholarship: Academic Achievement of the Highest Distinction (Harvard) 1990, 1991, 1992  
Highest Honors (Department of Biochemistry and Molecular Biology, Harvard) 1992  
Summa cum laude (Harvard) 1992  
Phi Beta Kappa (Harvard) 1992

Medical Scientist Training Program (Stanford) 1992-2000  
1st Yanofsky Graduate Research Award (Stanford) 1997

National Institute of Mental Health Outstanding Resident 2002

West Coast College of Biological Psychiatry Resident Award 2003

Professional Experience:    
Teaching fellow, Harvard University, physical chemistry and quantum mechanics 1991-1992

Stanford Hospital MD internship 2000-2001

California MD license 2001


Psychiatry residency, Stanford University Medical Center 2001- 2004


Certified physician provider of ECT (Stanford Hospital 2003)

Active Clinical Research Protocols:



Protocol Director:

Exploring cerebrospinal fluid as a source of neural stem cells.

Stanford University, 2001-present



Protocol Director:

Exploring cerebrospinal fluid as a source of neural stem cells after electroconvulsive therapy.

Stanford University, 2002-present


Zwelling L.A., Mayes J., Deisseroth K., Hinds M., Grant G., Pathak S., Ledley F., Vyas R., and
Hittelman W. (1990). A restriction fragment length polymorphism for human topoisomerase II:
possible relationship to drug-resistance. Cancer Communications 2, 357-361.  

Hinds M., Deisseroth K., Mayes J., Altschuler E., Jansen R., Ledley F., and Zwelling L.A.
(1991). Identification of a point mutation in the topoisomerase II gene from a human leukemia
cell line containing an amsacrine-resistant form of topoisomerase II. Cancer Research 51, 4729-

Zwelling L.A., Mayes J., Hinds M., Chan D., Altschuler E., Carroll B., Parker E., Deisseroth K.,
Radcliffe A., Seligman M., Li L., and Farquhar D. (1991). Cross-resistance of an amsacrine-
resistant human leukemia line to topoisomerase II reactive DNA intercalating agents. Evidence
for two topoisomerase II directed drug actions. Biochemistry 30, 4048-4055.  
Deisseroth K., Bito H., Schulman H., and Tsien R.W. (1995). A molecular mechanism for
metaplasticity. Current Biology 5, 1334-1338.

Deisseroth K., Bito H., and Tsien R.W. (1996). Signalling from synapse to nucleus: postsynaptic
CREB phosphorylation during multiple forms of hippocampal synaptic plasticity. Neuron 16,

Bito H.*, Deisseroth K.*, and Tsien R.W. (1996). CREB phosphorylation and
dephosphorylation: a Ca2+- and stimulus duration- dependent switch for hippocampal gene
expression. Cell 87, 1203-1214. *Co-first authors

Bito H., Deisseroth K., and Tsien R.W. (1997). Ca2+-dependent regulation in neuronal gene
expression. Current Opinion in Neurobiology 7, 419-429.

Deisseroth K., Heist E.K., and Tsien R.W. (1998). Translocation of calmodulin to the nucleus
supports CREB phosphorylation in hippocampal neurons. Nature 392, 198-202.  

Zühlke R., Pitt G.S., Deisseroth K., Tsien R.W., and Reuter H. (1999). Calmodulin supports
both inactivation and facilitation of L-type calcium channels. Nature 399, 159-162.  

Graef I.A., Mermelstein P.G., Stankunas K., Neilson J.R., Deisseroth K. , Tsien R.W., and
Crabtree, G. (1999). Interplay of L-type calcium channels and GSK-3 in regulating the
localization and activity of NF-ATc4 in hippocampal neurons. Nature 401, 703-708.  

Mermelstein P.G., Bito H., Deisseroth K., and Tsien R.W. (2000). Critical dependence of cAMP
response element-binding protein phosphorylation on L-type calcium channels supports a
selective response to EPSPs in preference to action potentials. Journal of Neuroscience 20, 266-

Wu G.-Y., Deisseroth K., and Tsien R.W. (2001). Activity-dependent CREB phosphorylation:
convergence of a fast, sensitive calmodulin kinase pathway and a slow, less sensitive mitogen-
activated protein kinase pathway. Proceedings of the National Academy of Sciences 98, 2808-

Wu G.-Y., Deisseroth K., and Tsien R.W. (2001). Spaced stimuli stabilize MAPK pathway
activation and its effects on dendritic morphology. Nature Neuroscience 4, 151-158.   

Mermelstein P.G., Deisseroth K., Dasgupta N., Isaksen A., and Tsien R.W. (2001). Calmodulin
priming: nuclear translocation of a calmodulin complex and the memory of prior neuronal
activity. Proceedings of the National Academy of Sciences 98, 15342-15347.

Deisseroth K. and Tsien R.W. (2002). Dynamic multiphosphorylation passwords for activity-
dependent gene expression. Neuron 34, 179-182.

Deisseroth K., Mermelstein P.G., Xia H. and Tsien R.W. (2003). Signaling from synapse to nucleus:

the logic behind the mechanisms. Current Opinion in Neurobiology, in press.