Carja O, MacIsaac JL, Mah SM, Henn BM, Kobor MS, Feldman MW and Fraser HB. (2017) Worldwide patterns of human epigenetic variation. Nature Ecology & Evolution, 1 (10): 1577-1583.

Kita R, Venkataram S, Zhou Y and Fraser HB. (2017) High-resolution mapping of cis-regulatory variation in budding yeast. PNAS, 114 (50): E10736-E10744.

Artieri CG, Naor A, Turgeman-Grott I, Zhou Y, York R, Gophna U and Fraser HB. (2017) Cis-regulatory evolution in prokaryotes revealed by interspecific archaeal hybrids. Scientific Reports, 7 (1): 3986.

Kita R and Fraser HB. (2016) Local Adaptation of Sun-Exposure-Dependent Gene Expression Regulation in Human Skin. PLoS Genetics, 12 (10): e1006382.

Sharon E, Sibener LV, Battle A, Fraser HB, Garcia KC and Pritchard JK. (2016) Genetic variation in MHC proteins is associated with T cell receptor expression biases. Nature Genetics, 48 (9): 995-1002.

Tehranchi AK, Myrthil M, Martin T, Hie BL, Golan D and Fraser HB. (2016) Pooled ChIP-Seq Links Variation in Transcription Factor Binding to Complex Disease Risk. Cell, 165 (3): 730-41.

Naranjo S, Smith JD, Artieri CG, Zhang M, Zhou Y, Palmer ME and Fraser HB. (2015) Dissecting the Genetic Basis of a Complex cis-Regulatory Adaptation. PLoS Genetics, 11 (12): e1005751.

Agoglia RM and Fraser HB. (2015) Disentangling Sources of Selection on Exonic Transcriptional Enhancers. Molecular Biology and Evolution, 33 (2): 585-90.

Kaplow IM, MacIsaac JL, Mah SM, McEwen LM, Kobor MS and Fraser HB. (2015) A pooling-based approach to mapping genetic variants associated with DNA methylation. Genome Research, 25 (6): 907-17.

McCoy RC, Demko Z, Ryan A, Banjevic M, Hill M, Sigurjonsson S, Rabinowitz M, Fraser HB and Petrov DA. (2015) Common variants spanning PLK4 are associated with mitotic-origin aneuploidy in human embryos. Science, 348 (6231): 235-8.

Babak T, DeVeale B, Tsang EK, Zhou Y, Li X, Smith KS, Kukurba KR, Zhang R, Li JB, van der Kooy D, Montgomery SB and Fraser HB. (2015) Genetic conflict reflected in tissue-specific maps of genomic imprinting in human and mouse. Nature Genetics, 47 (5): 544-9.

Jiang R, Jones MJ, Chen E, Neumann SM, Fraser HB, Miller GE and Kobor MS. (2015) Discordance of DNA methylation variance between two accessible human tissues. Scientific Reports, 5 8257.

Artieri CG and Fraser HB. (2014) Accounting for biases in riboprofiling data indicates a major role for proline in stalling translation. Genome Research, 24 (12): 2011-21.

Artieri CG and Fraser HB. (2014) Transcript length mediates developmental timing of gene expression across Drosophila. Molecular Biology and Evolution, 31 (11): 2879-89.

Artieri CG and Fraser HB. (2013) Evolution at two levels of gene expression in yeast. Genome Research, 24 (3): 411-21.

Fraser HB. (2013) Cell-cycle regulated transcription associates with DNA replication timing in yeast and human. Genome Biology, 14 (10): R111.

Chang J, Zhou Y, Hu X, Lam L, Henry C, Green EM, Kita R, Kobor MS and Fraser HB. (2013) The molecular mechanism of a cis-regulatory adaptation in yeast. PLoS Genetics, 9 (9): e1003813.

Smith JD, McManus KF and Fraser HB. (2013) A novel test for selection on cis-regulatory elements reveals positive and negative selection acting on mammalian transcriptional enhancers. Molecular Biology and Evolution, 30 (11): 2509-18.

Irimia M, Maeso I, Roy SW and Fraser HB. (2013) Ancient cis-regulatory constraints and the evolution of genome architecture. Trends in Genetics : TIG, 29 (9): 521-8.

Lam LL, Emberly E, Fraser HB, Neumann SM, Chen E, Miller GE and Kobor MS. (2013) Reply to Suderman et al.: Importance of accounting for blood cell composition in epigenetic studies. PNAS, 110 (14): E1247.

Fraser HB. (2013) Gene expression drives local adaptation in humans. Genome Research, 23 (7): 1089-96.

Ariza-Cosano A, Visel A, Pennacchio LA, Fraser HB, Gómez-Skarmeta JL, Irimia M and Bessa J. (2012) Differences in enhancer activity in mouse and zebrafish reporter assays are often associated with changes in gene expression. BMC Genomics, 13 713.

Lam LL, Emberly E, Fraser HB, Neumann SM, Chen E, Miller GE and Kobor MS. (2012) Factors underlying variable DNA methylation in a human community cohort. PNAS, 109 Suppl 2 17253-60.

Irimia M, Tena JJ, Alexis MS, Fernandez-Miñan A, Maeso I, Bogdanovic O, de la Calle-Mustienes E, Roy SW, Gómez-Skarmeta JL and Fraser HB. (2012) Extensive conservation of ancient microsynteny across metazoans due to cis-regulatory constraints. Genome Research, 22 (12): 2356-67.

Fraser HB, Levy S, Chavan A, Shah HB, Perez JC, Zhou Y, Siegal ML and Sinha H. (2012) Polygenic cis-regulatory adaptation in the evolution of yeast pathogenicity. Genome Research, 22 (10): 1930-9.

Fraser HB, Lam LL, Neumann SM and Kobor MS. (2012) Population-specificity of human DNA methylation. Genome Biology, 13 (2): R8.

Lamb JR, Zhang C, Xie T, Wang K, Zhang B, Hao K, Chudin E, Fraser HB, Millstein J, Ferguson M, Suver C, Ivanovska I, Scott M, Philippar U, Bansal D, Zhang Z, Burchard J, Smith R, Greenawalt D, Cleary M, Derry J, Loboda A, Watters J, Poon RT, Fan ST, Yeung C, Lee NP, Guinney J, Molony C, Emilsson V, Buser-Doepner C, Zhu J, Friend S, Mao M, Shaw PM, Dai H, Luk JM and Schadt EE. (2011) Predictive genes in adjacent normal tissue are preferentially altered by sCNV during tumorigenesis in liver cancer and may rate limiting. PloS One, 6 (7): e20090.

Fraser HB. (2011) Genome-wide approaches to the study of adaptive gene expression evolution: systematic studies of evolutionary adaptations involving gene expression will allow many fundamental questions in evolutionary biology to be addressed. BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology, 33 (6): 469-77.

Fraser HB, Babak T, Tsang J, Zhou Y, Zhang B, Mehrabian M and Schadt EE. (2011) Systematic detection of polygenic cis-regulatory evolution. PLoS Genetics, 7 (3): e1002023.

Babak T, Garrett-Engele P, Armour CD, Raymond CK, Keller MP, Chen R, Rohl CA, Johnson JM, Attie AD, Fraser HB and Schadt EE. (2010) Genetic validation of whole-transcriptome sequencing for mapping expression affected by cis-regulatory variation. BMC Genomics, 11 473.

Fraser HB, Moses AM and Schadt EE. (2010) Evidence for widespread adaptive evolution of gene expression in budding yeast. PNAS, 107 (7): 2977-82.

Fraser HB and Schadt EE. (2010) The quantitative genetics of phenotypic robustness. PloS One, 5 (1): e8635.

Yassour M, Kaplan T, Fraser HB, Levin JZ, Pfiffner J, Adiconis X, Schroth G, Luo S, Khrebtukova I, Gnirke A, Nusbaum C, Thompson DA, Friedman N and Regev A. (2009) Ab initio construction of a eukaryotic transcriptome by massively parallel mRNA sequencing. PNAS, 106 (9): 3264-9.

Fraser HB and Xie X. (2009) Common polymorphic transcript variation in human disease. Genome Research, 19 (4): 567-75.

Fraser HB and Plotkin JB. (2007) Using protein complexes to predict phenotypic effects of gene mutation. Genome Biology, 8 (11): R252.

Bertin N, Simonis N, Dupuy D, Cusick ME, Han JD, Fraser HB, Roth FP and Vidal M. (2007) Confirmation of organized modularity in the yeast interactome. PLoS Biology, 5 (6): e153.

Plotkin JB and Fraser HB. (2007) Assessing the determinants of evolutionary rates in the presence of noise. Molecular Biology and Evolution, 24 (5): 1113-21.

Plotkin JB, Dushoff J, Desai MM and Fraser HB. (2006) Codon usage and selection on proteins. Journal of Molecular Evolution, 63 (5): 635-53.

Fraser HB. (2006) Coevolution, modularity and human disease. Current Opinion in Genetics & Development, 16 (6): 637-44.

Plotkin JB, Dushoff J, Desai MM and Fraser HB. (2006) Estimating selection pressures from limited comparative data. Molecular Biology and Evolution, 23 (8): 1457-9.

Fraser HB, Khaitovich P, Plotkin JB, Pääbo S and Eisen MB. (2005) Aging and gene expression in the primate brain. PLoS Biology, 3 (9): e274.

Lynch PJ, Fraser HB, Sevastopoulos E, Rine J and Rusche LN. (2005) Sum1p, the origin recognition complex, and the spreading of a promoter-specific repressor in Saccharomyces cerevisiae. Molecular and Cellular Biology, 25 (14): 5920-32.

Wall DP, Hirsh AE, Fraser HB, Kumm J, Giaever G, Eisen MB and Feldman MW. (2005) Functional genomic analysis of the rates of protein evolution. PNAS, 102 (15): 5483-8.

Fraser HB. (2005) Modularity and evolutionary constraint on proteins. Nature Genetics, 37 (4): 351-2.

Wall DP, Fraser HB and Hirsh AE. (2003) Detecting putative orthologs. Bioinformatics, 19 (13): 1710-1.

Gasch AP, Moses AM, Chiang DY, Fraser HB, Berardini M and Eisen MB. (2004) Conservation and evolution of cis-regulatory systems in ascomycete fungi. PLoS Biology, 2 (12): e398.

Hirsh AE, Fraser HB and Wall DP. (2004) Adjusting for selection on synonymous sites in estimates of evolutionary distance. Molecular Biology and Evolution, 22 (1): 174-7.

Fraser HB, Hirsh AE, Wall DP and Eisen MB. (2004) Coevolution of gene expression among interacting proteins. PNAS, 101 (24): 9033-8.

Fraser HB and Hirsh AE. (2004) Evolutionary rate depends on number of protein-protein interactions independently of gene expression level. BMC Evolutionary Biology, 4 13.

Fraser HB, Hirsh AE, Giaever G, Kumm J and Eisen MB. (2004) Noise minimization in eukaryotic gene expression. PLoS Biology, 2 (6): e137.

Plotkin JB, Dushoff J and Fraser HB. (2004) Detecting selection using a single genome sequence of M. tuberculosis and P. falciparum. Nature, 428 (6986): 942-5.

Fraser HB, Wall DP and Hirsh AE. (2003) A simple dependence between protein evolution rate and the number of protein-protein interactions. BMC Evolutionary Biology, 3 11.

Fraser HB, Hirsh AE, Steinmetz LM, Scharfe C and Feldman MW. (2002) Evolutionary rate in the protein interaction network. Science, 296 (5568): 750-2.

Weitz JS and Fraser HB. (2001) Explaining mortality rate plateaus. PNAS, 98 (26): 15383-6.

Snapper SB, Takeshima F, Antón I, Liu CH, Thomas SM, Nguyen D, Dudley D, Fraser H, Purich D, Lopez-Ilasaca M, Klein C, Davidson L, Bronson R, Mulligan RC, Southwick F, Geha R, Goldberg MB, Rosen FS, Hartwig JH and Alt FW. (2001) N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility. Nature Cell Biology, 3 (10): 897-904.

Hirsh AE and Fraser HB. (2001) Protein dispensability and rate of evolution. Nature, 411 (6841): 1046-9.

Cover Images

MBE Cover Genome Research Cover