Lab Members

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MBL Neurobiology Course

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Madison Web Index

Poppin' them puppies with a trode since 1989 *

Our laboratory is located in the Department of Molecular and Cellular Physiology, Beckman Center for Molecular and Genetic Medicine at the Stanford University School of Medicine. The School of Medicine is located on the main campus of Stanford University in Palo Alto, CA, in the San Francisco Bay Area.

Phone: 650-725-7563

FAX: 650-618-2779

Email - Business: madison "at" stanford "dot" edu   Personal: DVMadison "at" gmail "dot" com

Mailing Address: Beckman Center Rm B003, Stanford University School of Medicine, Stanford, CA 94305-5345  USA

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Daniel Madison, Ph.D. , Principal Investigator (madison@stanford.edu

Fearless Leader (which one???)
Our laboratory uses electrophysiological techniques to study the mechanisms of synaptic transmission
and plasticity in the mammalian hippocampus. One of the main focuses in the lab is in the study of
synaptic long-term potentiation (LTP). LTP is the persistent increase in synaptic strength that occurs
after a period of heavy activity in a synaptic connection. It is the most widely studied and compelling
model for mechanisms underlying memory formation in the mammalian central nervous system. Most
recently, we have been involved in studies of LTP that occurs between individual pairs of neurons.

The other major focus of the lab is the study of the modulation and short term plasticity of inhibitory
synaptic transmission in the hippocampus by different neurotransmitter systems. Projects under this
focus include studies on the modulatory properties of norepinephrine, acetylcholine and opiates on
hippocampal inhibitory circuitry and transmitter release.

Studies in the lab are carried out using a full range of electrophysiological techniques including
extracellular field potential recording, intracellular recording,whole cell and single channel recording in
hippocampal slices and cultured neurons.

Science Animations

Continuum Model of Synaptic Plasticity

State-Model of Synaptic Plasticity

Introduction to the Preparation

 Teaching stuff (powerpoints, etc.):

Introduction to the Hippocampus

The origin of the membrane potential

The ionic basis of the action potential

Action Potential Conduction and Basis of synaptic transmission

Introduction to sensory transduction


Fun Stuff........


Chia Lab

The Madison Lab Project

The Madison Lab and the Search for the Holy Grail on the Madison Lab Renovation

Wassup from the Madison Lab?

Matt as Heather

Pretty Fly........

The Legend of Ricky Jack

Autumn Invitation


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This page is now archived.  It will no longer be updated.  For the current version of the Madison Lab Web Page, please go to http://www.stanford.edu/~madison/madlab

Last update:11/04/11




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