Reviews on Wnt signaling

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Liu C, He X.Destruction of a destructor: a new avenue for cancer therapeutics targeting the Wnt pathway.J Mol Cell Biol. 2010 Apr;2(2):70-3. Epub 2009 Dec 11.
McNeill H, Woodgett JR.When pathways collide: collaboration and connivance among signalling proteins in development.Nat Rev Mol Cell Biol. 2010 May 12.
Inestrosa NC, Arenas E. Emerging roles of Wnts in the adult nervous system. Nat Rev Neurosci. 2010 Feb;11(2):77-86. Epub 2009 Dec 16.
Fradkin LG, Dura JM, Noordermeer JN. Ryks: new partners for Wnts in the developing and regenerating nervous system. Trends Neurosci. 2010 Feb;33(2):84-92. Epub 2009 Dec 11.
Port F, Basler K.Wnt trafficking: New insights into Wnt maturation, secretion and spreading.
Traffic. 2010 May 3.
Petersen, CP and Reddien, PW (2009) Wnt Signaling and the Polarity of the Primary Body Axis. Cell 139, 1056-1068
van Amerongen R, Nusse R.Towards an integrated view of Wnt signaling in development. Development. 2009 Oct;136(19):3205-14. Korkut C, Budnik V. WNTs tune up the neuromuscular junction. Nat Rev Neurosci. 2009 Sep;10(9):627-34.
van Amerongen R, Mikels A, Nusse R. Alternative wnt signaling is initiated by distinct receptors. Sci Signal. 2008 Sep 2;1(35):re9.
Verheyen EM, Gottardi CJ. Regulation of Wnt/beta-catenin signaling by protein kinases. Dev Dyn. 2009 Jul 21.
Nusse, R. Wnt signaling and stem cell control
Cell Research (2008) 18:523-527.
MacDonald BT, Tamai K, He X. Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev Cell. 2009 Jul;17(1):9-26.
Fuerer C, Nusse R, Ten Berge D. Wnt signalling in development and disease. EMBO Rep. 2008 Feb;9(2):134-8. Phillips BT, Kimble J. A new look at TCF and beta-catenin through the lens of a divergent C. elegans Wnt pathway. Dev Cell. 2009 Jul;17(1):27-34.
Nusse, R. Converging on ß-Catenin in Wilms Tumor. Science 316, 988 (2007) Lorenowicz MJ, Korswagen HC. Sailing with the Wnt: Charting the Wnt processing and secretion route. Exp Cell Res. 2009 Jun 24.
Mikels, AJ. and Nusse, R. Wnts as ligands:processing, secretion and reception. Oncogene 25, 7461-7468 (2006) Angers S, Moon RT.Proximal events in Wnt signal transduction.Nat Rev Mol Cell Biol. 2009 Jul;10(7):468-77.
Gordon MD, Nusse R. Wnt signaling: multiple pathways, multiple receptors, and multiple transcription factors.
J Biol Chem. 2006 Aug 11;281(32):22429-33.
Mosimann C, Hausmann G, Basler K. Beta-catenin hits chromatin: regulation of Wnt target gene activation.Nat Rev Mol Cell Biol. 2009 Apr;10(4):276-86
Ching, W. and Nusse, R. (2006) A Dedicated Wnt Secretion Factor. Cell 125, p432 Josefa Steinhauera and Jessica E Treisman,Lipid-modified morphogens: functions of fats Current Opinion in Genetics & Development
Nusse R.Cell biology: relays at the membrane.
Nature. 2005 Dec 8;438(7069):747-9.
Schlessinger K, Hall A, Tolwinski N. Wnt signaling pathways meet Rho GTPases. Genes Dev. 2009 Feb 1;23(3):265-77.
Johnson ML, Harnish K, Nusse R, Van Hul W
LRP5 and Wnt signaling: a union made for bone.
J Bone Miner Res. 2004 Nov;19(11):1749-57
Cadigan, KM. Wnt-beta-catenin signaling.Curr Biol. 2008 18 :R943-7.
Nusse, R. Wnt signaling in disease and in development Cell Research, 15(1):28-32, Jan 2005 | Wnt Signaling · Volume 1 and 2, Methods Mol Biol. Vincan, E. (Ed.), Vol. 468, 2009, Springer ISBN 978-1-58829-912-3, has a series of chapters on Wnt signaling.
Logan CY, Nusse R   The Wnt Signaling Pathway in Development and Disease.  Annu Rev Cell Dev Biol. 2004 Jul 2; Green, J. et al. (2008) Ror receptor tyrosine kinases: orphans no more. Trends Cell Biol. 536-44. Epub 2008 Oct 9
W. J. Nelson and R. Nusse. Convergence of Wnt, beta Catenin, and Cadherin Pathways
Science 303 (2004) p1483
Grigoryan T, Wend P, Klaus A, Birchmeier W.Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of {beta}-catenin in mice. Genes Dev. 2008 Sep 1;22(17):2308-41.
R. Nusse, Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface.
Development. 2003 Nov;130(22):5297-305. PDF file
Huang H, He X. Wnt/beta-catenin signaling: new (and old) players and new insights. Curr Opin Cell Biol. 2008 Apr;20(2):119-25
Povelones M, Nusse R. Wnt signalling sees spots.
Nat Cell Biol. 2002 Nov;4(11):E249-50. PDF fiile
Klaus A, Birchmeier W. Wnt signalling and its impact on development and cancer.
Nat Rev Cancer. 2008 May;8(5):387-98.
Nusse R.
Developmental biology Making head or tail of Dickkopf.
Nature. 2001 May 17;411(6835):255-6. PDF file
Hayward P, Kalmar T, Martinez Arias A.Wnt/Notch signalling and information processing during development. Development. 2008 Feb;135(3):411-24.
Wodarz and Nusse, MECHANISMS OF WNT SIGNALING IN DEVELOPMENT Annu. Rev. Cell Dev. Biol. 1998, Vol. 14: 59-88 (PDF file)
Cohen ED, Tian Y, Morrisey EE. Wnt signaling: an essential regulator of cardiovascular differentiation, morphogenesis and progenitor self-renewal.
Development. 2008 Mar;135(5):789-98.
Nusse, R. Wnt targets. Repression and Activation
Trends Genet 1999;15:1-3 (PDF file)
Barker N, Clevers H. Mining the Wnt pathway for cancer therapeutics. Nat Rev Drug Discov. 2006 Dec;5(12):997-1014
Wnt signaling: a common theme in animal development
Ken M. Cadigan and Roel Nusse
Genes & Dev. 1997 11: 3286-3305
PDF file
Hausmann G, Bänziger C, Basler K.
Helping Wingless take flight: how WNT proteins are secreted. Nat Rev Mol Cell Biol. 2007 Apr;8(4):331-6
Willert, K. and Nusse, R.
b-catenin: a key mediator of Wnt signaling
Current Opinion in Genetics & Development 1998, 8:95-102. (PDF file)
Renee van Amerongen and Anton Berns Knockout mouse models to study Wnt signal transduction TRENDS in Genetics Vol.22 No.12, 2006 PDF
Report on the Wnt meeting 1998
Norbert Perrimon and Roel Nusse
BBA Rev Cancer. 1377: R45, 1998
Perez-Moreno M, Fuchs E. Catenins: keeping cells from getting their signals crossed. Dev Cell. 2006 Nov;11(5):601-12.
Signaling by wingless in Drosophila
John Klingensmith* and Roel Nusse
Dev Biol 166(2), 396-414 (1994)
Oncogene Vol 25, Dec 2006 has a series of many reviews on Wnt signaling
Meeting Review: The Wnt meeting 1996
Kenneth M. Cadigan and Roel Nusse
Biochim Biophys Acta 1332(1), R1-R5 (1997)
Coudreuse D, Korswagen HC. The making of Wnt: new insights into Wnt maturation, sorting and secretion.
Development. 2006 Nov 30
A versatile transcriptional effector for wingless signaling PDF
Roel Nusse
Cell 89(3), 321-323 (1997)
Korswagen HC. Regulation of the Wnt/beta-catenin pathway by redox signaling.
Dev Cell. 2006, 10:687-8.
Nusse and Varmus, 1992  
Wnt genes.
Cell 69(7), 1073-1087 (1992)
Clevers, H Wnt/beta-Catenin Signaling in Development and Disease. Cell 2006, 469 (2006)
Bovolenta, P Frizzled/RYK mediated signalling in axon guidance. Development 133, 4399, 2006
He X Axelrod JD. A WNTer wonderland in Snowbird.Development. 2006 Jul;133(14):2597-603.

Willert K. and Jones KA. Wnt signaling: is the party in the nucleus? Genes Dev. 2006 Jun 1;20(11):1394-404.
Croce JC, McClay DR. (2006) The canonical Wnt pathway in embryonic axis polarity. Semin Cell Dev Biol. 2006 Apr 25
Masckauchan TN, Kitajewski J. (2006) Wnt/Frizzled signaling in the vasculature: new angiogenic factors in sight. Physiology (Bethesda). 2006 Jun;21:181-8.
Stadeli R, Hoffmans R, Basler K. (2006) Transcription under the control of nuclear Arm/beta-catenin. Curr Biol. 2006 May 23;16(10):R378-85.
Lee PN, Pang K, Matus DQ, Martindale MQ. (2006) A WNT of things to come: Evolution of Wnt signaling and polarity in cnidarians. Semin Cell Dev Biol. 2006 May 7;
Cadigan KM, Liu YI. Wnt signaling: complexity at the surface.
J Cell Sci. 2006:395-402.
Price MA. CKI, there's more than one: casein kinase I family members in Wnt and Hedgehog signaling.
Genes Dev. 2006 :399-410.
Hartmann C. A Wnt canon orchestrating osteoblastogenesis.
Trends Cell Biol. 2006 151-8. Epub 2006 Feb 7.
Brembeck FH, Rosario M, Birchmeier W.Balancing cell adhesion and Wnt signaling, the key role of beta-catenin.
Curr Opin Genet Dev. 2005 Dec 22;
Wnt pathway activation: new relations and locations.
Bejsovec A. Cell. 2005 Jan 14;120(1):11-4
Wnt signaling in the intestinal epithelium: from endoderm to cancer. Gregorieff A, Clevers H. Genes Dev. 2005 Apr 15;19(8):877-90.
Wnt signalling in stem cells and cancer. Reya T, Clevers H. Nature. 2005 Apr 14;434(7035):843-50.
WNT signalling and haematopoiesis: a WNT-WNT situation. Staal FJ, Clevers HC. Nat Rev Immunol. 2005 Jan;5(1):21-30.
Cell biology. Wnt signaling glows with RNAi.
Fearon ER, Cadigan KM. Science. 2005 May 6;308(5723):801-3.
He X. Wnt signaling went derailed again: a new track via the LIN-18 receptor?
Cell. 2004 Sep 17;118(6):668-70. Review.
WNT and beta-catenin signalling: diseases and therapies. Moon RT, Kohn AD, De Ferrari GV, Kaykas A. Nat Rev Genet. 2004 Sep;5(9):691-701.
Beachy PA, Karhadkar SS, Berman DM. Tissue repair and stem cell renewal in carcinogenesis.   Nature. 2004 Nov 18;432(7015):324-331.
Wnt proteins in mammary development and cancer. Brennan KR, Brown AM.J Mammary Gland Biol Neoplasia. 2004 Apr;9(2):119-31.
Nathke IS   The Adenomatous Polyposis Coli Protein: The Achilles Heel of the Gut Epithelium.
  Annu Rev Cell Dev Biol. 2004 Jun 15;.
Sancho E, Batlle E, Clevers H  Signaling Pathways in Intestinal Development and Cancer.
  Annu Rev Cell Dev Biol. 2004 Jul 2;
He X, Semenov M, Tamai K, Zeng X.
LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: arrows point the way. Development. 2004 Apr;131(8):1663-77
Seto, ES and Bellen, H. The ins and outs of Wingless signaling.
Trends Cell Biol. 2004 Jan;14(1).:45-53
The Frizzled family: receptors for multiple signal transduction pathways
Hui-Chuan Huang and Peter S Klein Genome Biology 2004, 5:23
Imondi R, Thomas JB.Neuroscience. The ups and downs of Wnt signaling. Science. 2003 Dec 12;302:1903-4.
Hatsell S, Rowlands T, Hiremath M, Cowin P.Beta-catenin and Tcfs in mammary development and cancer.
J Mammary Gland Biol Neoplasia. 2003 Apr;8:145-58.
A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling. Veeman MT, Axelrod JD, Moon RT. Dev Cell. 2003 Sep;5(3):367-77
Frizzled signalling and cell polarisation in Drosophila and vertebrates. Strutt D. Development. 2003 Oct;130(19):4501-13.
Veeman MT, Axelrod JD, Moon RT.
You Wnt some, you lose some: oncogenes in the Wnt signaling pathway. van Es JH, Barker N, Clevers H. Curr Opin Genet Dev. 2003
A Wnt-Wnt situation.
Xi He, Dev Cell. 2003 Jun;4(6):791-7.
Wnt signaling--20 years and counting. Cadigan, K
Trends Genet. 2002 Jul;18(7):340-2.
Alonso L, Fuchs E. Stem cells in the skin: waste not, Wnt not.Genes Dev. 2003 May 15;17(10):1189-200.
Salinas PC.Synaptogenesis: wnt and tgf-Beta take centre stage.
Curr Biol. 2003 Jan 21;13(2):R60-2.
Goodwin AM, D'Amore PA. Angiogenesis. 2002;5(1-2):1-9.
Clevers, H. Inflating cell numbers by wnt. Mol Cell 2002 Dec;10(6):1260-1
Wu J, Saint-Jeannet JP, Klein PS.Wnt-frizzled signaling in neural crest formation. Trends Neurosci. 2003 Jan;26(1):40-45.
Mlodzik M. Planar cell polarization: do the same mechanisms regulate Drosophila tissue polarity and vertebrate gastrulation?
Trends Genet. 2002 Nov;18(11):564-71.
LaBonne C.Vertebrate development: wnt signals at the crest.
Curr Biol. 2002 Oct 29;12(21):R743-4.
Dominguez, MI, Green, J. Missing links in GSK3 regulation.
Dev Biol. 2001 Jul 15;235(2):303-13.
Church VL, Francis-West P Wnt signalling during limb development Int J Dev Biol. 2002;46(7):927-36.
Yamaguchi TP.

Heads or tails: Wnts and anterior-posterior patterning.
Curr Biol. 2001 Sep 4;11(17):R713-24.

van de Wetering M, de Lau W, Clevers H

WNT signaling and lymphocyte development

Weston CR, Davis RJ.Signal transduction: signaling specificity- a complex affair.
Science. 2001 Jun 29;292(5526):2439-40
Polakis P. More than one way to skin a catenin.
Cell. 2001 Jun 1;105(5):563-6.
Taipale J, Beachy PA.
The Hedgehog and Wnt signalling pathways in cancer.
Nature. 2001 May 17;411(6835):349-54.
Brown AM.
Wnt signaling in breast cancer: have we come full circle?
Breast Cancer Res. 2001;3(6):351-5.
Lau Wd, Clevers H
LEF1 turns over a new leaf.
Nat Genet. 2001 May;28(1):3-4.

Bienz M, Clevers H.

Linking colorectal cancer to Wnt signaling.
Cell. 2000 Oct 13;103(2):311-20.

Cossu G, Borello U
Wnt signaling and the activation of myogenesis in mammals.
EMBO J. 1999 Dec 15;18(24):6867-72. Review.


Polakis P

Wnt signaling and cancer.
Genes Dev. 2000 Aug 1;14(15):1837-51.

  1. Smalley MJ, Dale TC
    Wnt signalling in mammalian development and cancer.
    Cancer Metastasis Rev. 1999;18(2):215-30
Peifer M, Polakis P.
Wnt signaling in oncogenesis and embryogenesis--a look outside the nucleus.
Science. 2000 Mar 3;287(5458):1606-9.
Miller et al,
Mechanism and function of signal transduction by the Wnt/beta-catenin
and Wnt/Ca2+ pathways.
Oncogene. 1999 Dec 20;18(55):7860-72
Moon RT, 1997     
WNTs modulate cell fate and behavior during vertebrate development.
Trends Genet 13(4), 157-162
Peifer M, 1997
Beta-catenin as oncogene: the smoking gun
Science 275(5307), 1752-1753 (1997)