GCMS example 2

Dose % Response LOG Dose % Response

2 10 0.30103 10

4 20 0.60205999 20

5 25 0.69897 25

8 40 0.90308999 40

10 50 1 50

20 70 1.30103 70

30 85 1.47712125 85

50 90 1.69897 90

Now one can linearize this plot in order to obtain the dose at which 50% response occurs. This is done by doing a linear regression on the LOG dose vs. (Response-Median).

LOG Dose % Response % Response Median (% Response-Median)

0.30103 10 45 -35

0.60205999 20 -25

0.69897 25 -20

0.90308999 40 -5

1 50 5

1.30103 70 25

1.47712125 85 40

1.69897 90 45

9:1

Dose	% Response	LOG Dose	% Response
2	10	0.30103	10
4	20	0.60205999	20
5	25	0.69897	25
8	40	0.90308999	40
10	50	1	50
20	70	1.30103	70
30	85	1.47712125	85
50	90	1.69897	90

LOG Dose	% Response	% Response Median	(% Response-Median)
0.30103	10	45	-35
0.60205999	20		-25
0.69897	25		-20
0.90308999	40		-5
1	50		5
1.30103	70		25
1.47712125	85		40
1.69897	90		45