Gene expression profiling of low-grade endometrial stromal sarcoma indicates fusion protein-mediated activation of the Wnt signaling pathway.

TitleGene expression profiling of low-grade endometrial stromal sarcoma indicates fusion protein-mediated activation of the Wnt signaling pathway.
Publication TypeJournal Article
Year of Publication2018
AuthorsPrzybyl J, Kidzinski L, Hastie T, Debiec-Rychter M, Nusse R, van de Rijn M
JournalGynecologic oncology
Volume149
Issue2
Pagination388-393
Date Published2018 May
ISSN0090-8258
AbstractLow-grade endometrial stromal sarcomas (LGESS) harbor chromosomal translocations that affect proteins associated with chromatin remodeling Polycomb Repressive Complex 2 (PRC2), including SUZ12, PHF1 and EPC1. Roughly half of LGESS also demonstrate nuclear accumulation of β-catenin, which is a hallmark of Wnt signaling activation. However, the targets affected by the fusion proteins and the role of Wnt signaling in the pathogenesis of these tumors remain largely unknown.
URLhttps://linkinghub.elsevier.com/retrieve/pii/S0090-8258(18)30177-X
DOI10.1016/j.ygyno.2018.03.007
Short TitleGynecol Oncol