Gene expression profiling of low-grade endometrial stromal sarcoma indicates fusion protein-mediated activation of the Wnt signaling pathway.
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Title | Gene expression profiling of low-grade endometrial stromal sarcoma indicates fusion protein-mediated activation of the Wnt signaling pathway. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Przybyl J, Kidzinski L, Hastie T, Debiec-Rychter M, Nusse R, van de Rijn M |
Journal | Gynecologic oncology |
Volume | 149 |
Issue | 2 |
Pagination | 388-393 |
Date Published | 2018 May |
ISSN | 0090-8258 |
Abstract | Low-grade endometrial stromal sarcomas (LGESS) harbor chromosomal translocations that affect proteins associated with chromatin remodeling Polycomb Repressive Complex 2 (PRC2), including SUZ12, PHF1 and EPC1. Roughly half of LGESS also demonstrate nuclear accumulation of β-catenin, which is a hallmark of Wnt signaling activation. However, the targets affected by the fusion proteins and the role of Wnt signaling in the pathogenesis of these tumors remain largely unknown. |
URL | https://linkinghub.elsevier.com/retrieve/pii/S0090-8258(18)30177-X |
DOI | 10.1016/j.ygyno.2018.03.007 |
Short Title | Gynecol Oncol |