Reviews on Wnt Signaling

 R. Nusse and Hans Clevers (2017). Wnt/ß-catenin signaling, Disease and Emerging Therapeutic Modailties. Cell 169, p 985. doi: 10.1016/j.cell.2017.05.016 (PDF)

Kyle M. Loh, Renee van Amerongen,  and Roel Nusse.  Generating Cellular Diversity and Spatial Form: Wnt Signaling and the Evolution of Multicellular Animals.  Developmental Cell 38, p 643,  2016 (PDF)

PF Langton, S Kakugawa, JP Vincent - Making, Exporting, and Modulating Wnts. Trends in Cell Biology, 2016 Jun 17. pii: S0962-8924(16)30054-X. doi: 10.1016/j.tcb.2016.05.011.

Wang et al, 2016. Curr. Topics Dev Bio. Frizzled Receptors in Development and Diseases 

Nile AH, Hannoush RN Fatty acylation of Wnt proteins. Nat Chem Biol. 2016 Jan 19;12(2):60-69

Clevers H, Loh KM, Nusse R. An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control. Science. 2014 Oct 3;346(6205):1248012 (PDF)

Kahn, M. 2014 Can we safely target the Wnt pathway? Nat Rev Drug Discovery Jul;13(7):513-32. doi: 10.1038/nrd4233. 

Kneissel M, Baron R. WNT signaling in bone homeostasis and disease: from human mutations to treatments. Nat Med. ; 2013 Feb 6;19(2):179–92

Anastas, JN and Moon, RT WNT signalling pathways as therapeutic targets in cancer.Nature Rev Cancer 13 2013:11-26

Green, J., Nusse, R., and van Amerongen, R. (2014). The role of Ryk and Ror receptor tyrosine kinases in Wnt signal transduction. Cold Spring Harbor perspectives in biology 6.

Niehrs, C. The complex world of WNT receptor signalling. Nat Rev Mol Cell Biol. 2012 Dec;13(12):767-79. doi: 10.1038nrm3470.

EMBO Journal (2012) published a special focus issue on Wnt signaling, on the occasion of the 30th anniversary of the field. It contains six reviews of various areas of Wnt signaling. 

Cold Spring Harbor Perspectives in Biology (2012)  has published a series of reviews on Wnt signaling and  a book on the field.

Nusse, R. & Varmus, H. Three decades of Wnts: a personal perspective on how a scientific field developed. The EMBO journal, doi:10.1038/emboj.2012.146 (2012).

Clevers, H. & Nusse, R. Wnt/Beta-Catenin Signaling and Disease. Cell 149, 1192-1205, doi:10.1016/j.cell.2012.05.012 (2012).

Port F, Basler K.Wnt trafficking: New insights into Wnt maturation, secretion and spreading. Traffic. 2010 May 3

De Robertis EM  Wnt signaling in axial patterning and regeneration: lessons from planaria. Sci Signal. 2010 Jun 22;3(127)

Dodge ME, Lum L Annu Rev Pharmacol Toxicol. 2010 Jan 18. Drugging the Cancer Stem Cell Compartment: Lessons Learned from the Hedgehog and Wnt Signal Transduction Pathways.

Petersen, CP and Reddien, PW (2009) Wnt Signaling and the Polarity of the Primary Body Axis. Cell 139, 1056-1068

MacDonald BT, Tamai K, He X. Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev Cell. 2009 Jul;17(1):9-26

van Amerongen R, Nusse R.Towards an integrated view of Wnt signaling in development. Development. 2009 Oct;136(19):3205-14.

Verheyen EM, Gottardi CJ. Regulation of Wnt/beta-catenin signaling by protein kinases. Dev Dyn. 2009 Jul 21

Cadigan KM, Peifer M.Cold Spring Harb Perspect Biol. 2009 Aug;1  Wnt signaling from development to disease: insights from model systems.

Angers S, Moon RT.Proximal events in Wnt signal transduction.Nat Rev Mol Cell Biol. 2009 Jul;10(7):468-77.

Klaus A, Birchmeier W. Wnt signalling and its impact on development and cancer.
Nat Rev Cancer. 2008 May;8(5):387-98.

van Amerongen R, Mikels A, Nusse R. Alternative wnt signaling is initiated by distinct receptors. Sci Signal. 2008 Sep 2;1(35):re9.

Clevers, H Wnt/beta-Catenin Signaling in Development and Disease. Cell 2006, 469 (2006)

Wnt signalling in stem cells and cancer. Reya T, Clevers H. Nature. 2005 Apr 14;434(7035):843-50.

Logan CY, Nusse R  The Wnt Signaling Pathway in Development and Disease. Annu Rev Cell Dev Biol. 2004 Jul 2

W. J. Nelson and R. Nusse. Convergence of Wnt, beta Catenin, and Cadherin Pathways
Science 303 (2004) p1483

R. Nusse, Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface.
Development. 2003 Nov;130(22):5297-305. PDF file