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Wnt in Human Genetic DiseasesWnt in MouseWnt in FlyWnt in ZebrafishWnt in Cancer

Wnt proteins form a family of highly conserved secreted signaling molecules that regulate cell-to-cell interactions during embryogenesis. Insights into the mechanisms of Wnt action have emerged from several systems: genetics in Drosophila and Caenorhabditis elegans; biochemistry in cell culture and ectopic gene expression in Xenopus embryos. Mutations in Wnt genes or Wnt pathway components lead to specific developmental defects, while various human diseases, including cancer, are caused by abnormal Wnt signaling. As currently understood, Wnt proteins bind to receptors of the Frizzled and LRP families on the cell surface. Through several cytoplasmic relay components, the signal is transduced to beta-catenin, which enters the nucleus and forms a complex with TCF to activate transcription of Wnt target genes (see diagrams of the Wnt pathway). 

This website serves as a resource for members of the Wnt community, providing information on progress in the field, maps on signaling pathways, and methods. The page on reagents lists many resources generously made available to and by the Wnt community.

Wnt signaling is discussed in many reviews, listed here and in a recent book

Wnt meetings are announced here, with meetings planned for 2014 and 2016.

Wnt Signaling monograph by CSHL



Wnt 

Frizzled, SFRP

Dishevelled




 

TCF

Other receptors/LRP

APC




β-catenin

Axin

Other genes




Wnt Target genes

Diseases/Other systems

Methods, Reagents




 

 


Wnt signaling Pathway DiagramProtein InteractionsWnt in CancerTwo-state ModelWnt-Hedgehog ComparisonMultiple Wnt ReceptorsWnt signaling pathway componentsProtein InteractionsWnt in CancerWnt signaling Two-state modelMultiple Wnt receptors

Wnt Signaling DiagramProtein InteractionsWnt in CancerTwo-state modelWnt-Hedgehog ComparisonMultiple Wnt Receptors