Wnt proteins form a family of highly conserved secreted signaling molecules that regulate cell-to-cell interactions during development and adult tissue homeostasis. Wnt signaling is often implicated in stem cell control, as a self-renewal signal. Mutations in Wnt genes or Wnt pathway components lead to specific developmental defects, while various human diseases, including cancer, are caused by abnormal Wnt signaling. Insights into the mechanisms of Wnt action have emerged from several systems: genetics in Drosophila and Caenorhabditis elegans; biochemistry in cell culture and ectopic gene expression in Xenopus embryos. As currently understood, Wnt proteins bind to receptors of the Frizzled and LRP families on the cell surface. Through several cytoplasmic relay components, the signal is transduced to ß-catenin, which enters the nucleus and forms a complex with TCF to activate transcription of Wnt target genes.
This website serves as a resource for members of the Wnt community, providing information on progress in the field, maps on signaling pathways, and methods. The page on reagents lists many resources generously made available to and by the Wnt community.
Wnt signaling is discussed in many reviews, listed here.
Wnt meetings are announced here. In 2017, there will be a Wnt Gordon conference, August 6 - 11, 2017 at the Stoweflake Conference Center, Stowe, VT.
Wnt signaling components
Wnt proteins and genes
Wnt Target genes
Diagrams of Wnt signaling events
Wnt signaling (overview)
The destruction complex (new, 2016)
Have a question about Wnt? Consult the Wnt community on LinkedIn®!