The TWC- Lab is located at the Hospital of Veterans Affairs in Palo Alto. Click here to get directions.
12-10-15 Tony featured on TED's Year in Ideas
10-06-15 Tony receives a NIH Director's Pioneer Award
09-10-15 Liz receives a K99 award
Liz received an NIH Pathway to Independence Award (K99) from the NINDS. Congratulations Liz!
08-04-15 Tony and Saul are featured in The Guardian
Tony and Saul talk in depth about the past and future of rejuvenation in a recent article in The Guardian. The article can be read here.
06-16-15 Tony speaks at TEDGlobalLondon
Tony talks at TEDGlobalLondon. View the presentation here.
Welcome to the Wyss-Coray Laboratory! Our laboratory studies immune and injury responses in aging and neurodegeneration. A growing body of information in recent years has documented the interchangeability of key proteins between the immune and central nervous systems (CNS). One prominent example, and a focus of our lab, is TGF-β1 which is a key regulator of immune functions but is also necessary for neuronal protection and survival and may have a role in Alzheimer’s disease. Another group of proteins we are interested in constitutes the complement system, which is critical in the removal of pathogens and dying cells not only in the periphery, but likely in the CNS as well. In a less biased approach, we use proteomics to study cellular communication on a larger scale in plasma and relate it to aging and degenerative changes in the CNS.In much of our studies we seek to understand neurodegeneration and neurological disease in the context of immune responses. One exciting hypothesis is that altered or failing immune responses might underlie or at least contribute to age-related degenerative diseases of the nervous system. We use mouse genetics, behavior, cell culture, and proteomic approaches to try to test this hypothesis.
TWC-Lab April 2015