Optophysiology: interferometric imaging of neural signals and cell metabolism

Quantitative phase imaging enables characterization of cellular motion with sub-nanometer precision, without any exogenous markers. This opens the door to optophysiology - an optical alternative to traditional electrophysiology: non-invasive optical detection of neural signals, as well as other metabolic changes in cells and tissues.

We are working on two approaches to quantitative phase imaging: full-field interferometry in transmission, and phase-resolved optical coherence tomography in reflection.

We are studying the mechanisms of electro-optical coupling and developing biological applications of this technology, including mapping the neural activity in cultured cells and in the retina, detecting metabolic changes in photoreceptors during light exposure, optical thermometry of cells and tissues, and others.