Tom Dean, Google Research,
[PUBS]:
Introduction to Scalable Neuroscience: Part 1 [SLIDES]
Thomas Dean, Biafra Ahanonu, Mainak Chowdhury, Anjali Datta, Andre Esteva, Daniel Eth, Nobie Redmon, Oleg Rumyantsev, Ysis Tarter. On the technology prospects and investment opportunities for scalable neuroscience. CoRR, arXiv:1307.7302, 2013. [HTML] [PDF]
Thomas Dean. Expansion Circuity. Brain Tissue as a Computational Substrate. Technical Report. 2015. [PDF]
Thomas Dean. Inferring mesoscale models of neural computation. CoRR, arXiv:1710.05183, 2017. [PDF]
Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction: [VIDEO] SOURCE: L. Weinhard, G. di Bartolomei, G. Bolasco, P. Machado, N.L. Schieber U. Neniskyte, M. Exiga, A. Vadisiute, A. Raggioli, A. Schertel, Y. Schwab, and C.T. Gross. Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction. Nature Communications Volume 9, Issue 1, 1228, 2018.
Time-lapse imaging of GFP-labeled microglia demonstrates that the fine termini of microglial processes are highly dynamic in the intact mouse cortex. Upon local brain injury, microglial processes rapidly and autonomously converge on the site of injury without cell body movement, establishing a potential barrier between the healthy and injured tissue: [VIDEO]. SOURCE: J. Tønnesen, V.V.G.K. Inavalli, and U.V. Nägeri. Super-resolution imaging of the extracellular space in living brain tissue. Cell Volume 172, Issue 5, 1108–1121, 2018.
Two-photon microscopy time-lapse images of individual microglia cells exhibiting their extraordinary motility: [VIDEO]. SOURCE: A. Nimmerjahn, F. Kirchhoff, and F. Helmchen. Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science Volume 308, 1314-1317, 2005.
Microglia imaged in the living brain with thin-skulled, two-photon microscopy: [VIDEO]. SOURCE: C.N. Parkhurst, G. Yang, I. Ninan, J.N. Savas, J.R. Yates, J.J. Lafaille, B.L. Hempstead, D.R. Littman, and W.B. Gan. Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor. Cell Volume 155, Issue 7, 1596-609, 2013
The time-averaged fluorescence intensity analysis in a rat hippocampal neuron during an action potential: [VIDEO] SOURCE: J. M. Kralj, A. D. Douglass, D. R. Hochbaum, D. Maclaurin, and A. E. Cohen. Optical recording of action potentials in mammalian neurons using a microbial rhodopsin. Nature Methods Volume 9, Issue 1, 90-95, 2011.