Repetitive Intravenous Dosing

In repetitive dosing, the plasma concentration at the end of the first dosing interval is given by:

(1)     C_P1^T = C_P1^Oexp(-k_elT)

Immediately after the second dose is injected, the plasma [ ] will be,

(2)     C_P2^O = C_P1^T + C_P1^O = C_P1^Oexp(-k_elT) + C_P1^O   and so on.

We then need to define a certain parameter R, which is the fraction of the initial plasma concentration that remains at the end of any dosing interval.  R is given as

(3)     R = exp(-k_elT) = 10^{-(k_elT /2.30)}

Equations (1) and (2) are simplified into

C_P1^T = C_P1^OR

for the plasma concentration at the end of the first dosing interval, and

C_P2^O = C_P1^OR + C_P1^O

for the plasma concentration at the beginning and end of the nth dosing interval.

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B.9b-1