Multiple-Dosing Regimens (Repetitive Dosing)
Graph 1:
Cmax and Cmin are defined as:
where the maximum and minimum plasma concentrations of a repetitive intravenous dosing regimen can be determined if the dosing interval (T), the overall elimination rate constant(kel), and the initial plasma concentration
are known. R is the fraction of the initial plasma concentration that remains at the end of any dosing interval.
(for the derivation of Cmin & Cmax for IV dosing)
B.9a-2
