The Michaelis-Menten equation is shown below depicting the relationship between the rate of elimination of the drug and its concentration.

---

If the plasma's concentration is expessed in µg/ml and time in hours, the units are:

V_max    (µg/ml)/h

K_m          µg/ml

---

V_max = maximum velocity of the enzyme process; the velocity may approach V_max but will never reach it.

K_m = Michaelis-Menten constant, equal to the concentration at which the rate of the process equals half of the maximum rate.

dS/dt = elimination rate of the substrate

dP/dt = rate of product formation

S = substrate

---

C.3a-2