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PUBLICATIONS:

2018

132: Cheng X, Ferrell JE Jr. Apoptosis propagates through the cytoplasm as trigger waves. Science. 2018 Aug 10;361(6402):607-12. doi:10.1126/science.aah4065

Noted in: Biegler P. For unwanted cells, death comes in waves. Cosmos. 2018. https://cosmosmagazine.com/biology/for-unwanted-cells-death-comes-in-waves.

Noted in: Dormeil L. Here's how Stanford scientists measured the speed of death. Digital Trends. 2018. https://www.digitaltrends.com/cool-tech/stanford-university-measures-speed-of-death/.

Noted in: Hignett K. Death comes as an unrelenting tide of destruction. Newsweek. 2018. https://www.newsweek.com/death-comes-unrelenting-tide-destruction-study-shows-1067775.

Noted in: LePage M. We have measured the speed of death and it's 2 millimetres an hour. New Scientist. 2018. https://www.newscientist.com/article/2176397-we-have-measured-the-speed-of-death-and-its-2-millimetres-an-hour/.

Noted in: Saey TH. Here's how fast cell death can strike. Science News. 2018. https://www.sciencenews.org/article/speed-cell-death-apoptosis.

Noted in: Thirty micrometres a minute: scientists discover the speed of death. The Guardian (US Edition). 2018. https://www.theguardian.com/science/shortcuts/2018/aug/12/thirty-micrometre-minutes-scientists-discover-speed-of-death

131: Chang JB, Ferrell JE Jr. Robustly cycling Xenopus laevis cell-Free extracts in
Teflon chambers. Cold Spring Harb Protoc. 2018 Aug 1;2018(8):pdb.prot097212. doi:
10.1101/pdb.prot097212. PubMed PMID: 29475997.

2017

130: Anderson GA, Gelens L, Baker JC, Ferrell JE Jr. Desynchronizing embryonic cell division waves reveals the robustness of Xenopus laevis development. Cell Rep. 2017, Oct 3;21(1):37-46. doi: 10.1016/j.celrep.2017.09.017. PubMed PMID: 28978482.

129: Lee JJ, Yang SY, Park J, Ferrell JE Jr, Shin DH, Lee KJ. Calcium ion induced structural changes promote dimerization of secratagogin, which is required for its insulin secretory function. Sci Rep. 2017 Published online Aug 1;7:6976 doi:10.1038/s41598-017-07072-4.

128: Kamenz J, Ferrell JE Jr. The temporal ordering of cell-cycle phosphorylation. Mol Cell. 2017 Feb 2;65(3):371-373. doi: 10.1016/j.molcel.2017.01.025. PubMed PMID: 28157499.

2016

127: Ha SH, Ferrell JE Jr. Thresholds and ultrasensitivity from negative cooperativity. Science. 2016 May 20;352(6288):990-3. doi: 10.1126/science.aad5937. Epub 2016 May 12. PubMed PMID: 27174675.

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Noted in: VanHook AM. Papers of note. Sci. Signal. 2016 May 24;9(429):ec125. doi: 10.1126/scisignal.aag1804.

Noted in: Principles of Systems Biology-No. 6. Cell Syst. 2016 Jun 22;2(6):356-9. doi:10.1016/j.cels.2016.06.004. PubMed PMID: 27336964.

126: Ferrell JE Jr. Perfect and near-perfect adaptation in cell signaling. Cell Systems 2016 Feb 24;2:62-7. doi: 10.106/jcels.2016.02.006.

125: Ha SH, Kim SY, Ferrell JE Jr. The prozone effect accounts for the paradoxical
function of the Cdk-binding protein Suc1/Cks. Cell Rep. 2016 Feb 16;14(6):1408-21. doi: 10.1016/j.celrep.2016.01.033. Epub 2016 Feb 4. PubMed PMID: 26854218.

2015

124: Gelens L, Huang KC, Ferrell JE Jr. How does the Xenopus laevis embryonic cell
cycle avoid spatial chaos? Cell Rep. 2015 Aug 4;12(5):892-900. doi:
10.1016/j.celrep.2015.06.070. Epub 2015 Jul 23. PubMed PMID: 26212326; PubMed
Central PMCID: PMC4531097.

2014

123: Ferrell JE Jr, Ha SH. Ultrasensitivity part III: cascades, bistable switches,
and oscillators. Trends Biochem Sci. 2014 Dec;39(12):612-8. doi:
10.1016/j.tibs.2014.10.002. Epub 2014 Nov 10. Review. PubMed PMID: 25456048;
PubMed Central PMCID: PMC4254632.

122: Ferrell JE Jr, Ha SH. Ultrasensitivity part II: multisite phosphorylation,
stoichiometric inhibitors, and positive feedback. Trends Biochem Sci. 2014
Nov;39(11):556-69. doi: 10.1016/j.tibs.2014.09.003. Epub 2014 Oct 23. Review.
PubMed PMID: 25440716; PubMed Central PMCID: PMC4435807.

121: Gelens L, Anderson GA, Ferrell JE Jr. Spatial trigger waves: positive feedback
gets you a long way. Mol Biol Cell. 2014 Nov 5;25(22):3486-93. doi:
10.1091/mbc.E14-08-1306. PubMed PMID: 25368427; PubMed Central PMCID: PMC4230609.

120: Ferrell JE Jr, Ha SH. Ultrasensitivity part I: Michaelian responses and zero-order ultrasensitivity. Trends Biochem Sci. 2014 Oct;39(10):496-503. doi: 10.1016/j.tibs.2014.08.003. Epub 2014 Sep 18. PubMed PMID: 25240485; PubMed Central PMCID: PMC4214216.

119: Tsai TY, Theriot JA, Ferrell JE Jr. Changes in oscillatory dynamics in the cell cycle of early Xenopus laevis embryos. PLoS Biol. 2014 Feb 11;12(2):e1001788. doi: 10.1371/journal.pbio.1001788. eCollection 2014 Feb. PubMed PMID: 24523664; PubMed Central PMCID: PMC3921120.

2013

118: Ferrell JE Jr. Feedback loops and reciprocal regulation: recurring motifs in
the systems biology of the cell cycle. Curr Opin Cell Biol. 2013
Dec;25(6):676-86. doi: 10.1016/j.ceb.2013.07.007. Epub 2013 Aug 5. Review. PubMed
PMID: 23927869; PubMed Central PMCID: PMC3836843.

117: Chang JB, Ferrell JE Jr. Mitotic trigger waves and the spatial coordination of the Xenopus cell cycle. Nature. 2013 Aug 29;500(7464):603-7. doi:10.1038/nature12321. Epub 2013 Jul 17. PubMed PMID: 23863935; PubMed Central PMCID: PMC3758429.

Noted in: Ishihara K, Nguyen PA, Wühr M, Groen AC, Field CM, Mitchison TJ. Organization of early frog embryos by chemical waves emanating from centrosomes. Philos Trans R Soc Lond B Biol Sci. 2014 Sep 5;369(1650). pii: 20130454.

Noted in: Berndt JD, Gough NR. 2013: Signaling breakthroughs of the year. Sci Signal. 2014 Jan 7;7(307):eg1. doi: 10.1126/scisignal.2005013. PubMed PMID: 24399293.

116: Yang Q, Ferrell JE Jr. The Cdk1-APC/C cell cycle oscillator circuit functions as a time-delayed, ultrasensitive switch. Nat Cell Biol. 2013 May;15(5):519-25. doi:10.1038/ncb2737. Epub 2013 Apr 28. PubMed PMID: 23624406; PubMed Central PMCID: PMC3728279.

2012

115: Anderson GA, Liu X, Ferrell JE Jr. Bistability in one equation or fewer. Methods Mol Biol. 2012;880:53-67. doi: 10.1007/978-1-61779-833-7_4. Review. PubMed PMID: 23361981.

114: Santos SD, Wollman R, Meyer T, Ferrell JE Jr. Spatial positive feedback at the onset of mitosis. Cell. 2012 Jun 22;149(7):1500-13. doi:10.1016/j.cell.2012.05.028. PubMed PMID: 22726437; PubMed Central PMCID:PMC3395376.

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113: Ferrell JE Jr. Bistability, bifurcations, and Waddington's epigenetic landscape. Curr Biol. 2012 Jun 5;22(11):R458-66. doi: 10.1016/j.cub.2012.03.045. Review. PubMed PMID: 22677291; PubMed Central PMCID: PMC3372930.

112: Ferrell JE Jr. Dora B. Goldstein 1922-2011. Addiction. 2012 May;107(5):1013-4. doi: 10.1111/j.1360-0443.2011.03746.x. Epub 2012 Feb 11. PubMed PMID: 22324380.

2011

111: Pearlman SM, Serber Z, Ferrell JE Jr. A mechanism for the evolution of phosphorylation sites. Cell. 2011 Nov 11;147(4):934-46. doi:10.1016/j.cell.2011.08.052. PubMed PMID: 22078888; PubMed Central PMCID:PMC3220604.

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110: Ferrell JE Jr. Simple rules for complex processes: new lessons from the budding yeast cell cycle. Mol Cell. 2011 Aug 19;43(4):497-500. doi:10.1016/j.molcel.2011.08.002. PubMed PMID: 21855788; PubMed Central PMCID:PMC3160623.

109: Ferrell JE Jr, Tsai TY, Yang Q. Modeling the cell cycle: why do certain circuits oscillate? Cell. 2011 Mar 18;144(6):874-85. doi:10.1016/j.cell.2011.03.006. PubMed PMID: 21414480.

108: Trunnell NB, Poon AC, Kim SY, Ferrell JE Jr. Ultrasensitivity in the regulation of Cdc25C by Cdk1. Mol Cell. 2011 Feb 4;41(3):263-74. doi:10.1016/j.molcel.2011.01.012. PubMed PMID: 21292159; PubMed Central PMCID:PMC3060667.

Commentary: Goulev Y, Charvin G. Ultrasensitivity and positive feedback to promote sharp mitotic entry. Mol Cell. 2011 Feb 4;41(3):243-4. doi:10.1016/j.molcel.2011.01.016. PubMed PMID: 21292155.

2010

107: Gong D, Ferrell JE Jr. The roles of cyclin A2, B1, and B2 in early and late mitotic events. Mol Biol Cell. 2010 Sep 15;21(18):3149-61. doi:10.1091/mbc.E10-05-0393. Epub 2010 Jul 21. PubMed PMID: 20660152; PubMed Central PMCID: PMC2938381.

2009

106: Wolkenhauer O, Auffray C, Baltrusch S, Blüthgen N, Byrne H, Cascante M, Ciliberto A, Dale T, Drasdo D, Fell D, Ferrell JE Jr, Gallahan D, Gatenby R, Günther U, Harms BD, Herzel H, Junghanss C, Kunz M, van Leeuwen I, Lenormand P, Levi F, Linnebacher M, Lowengrub J, Maini PK, Malik A, Rateitschak K, Sansom O, Schäfer R, Schürrle K, Sers C, Schnell S, Shibata D, Tyson J, Vera J, White M, Zhivotovsky B, Jaster R. Systems biologists seek fuller integration of systems biology approaches in new cancer research programs. Cancer Res. 2010 Jan 1;70(1):12-3. doi: 10.1158/0008-5472.CAN-09-2676. Epub 2009 Dec 22. PubMed PMID: 20028868; PubMed Central PMCID: PMC2802734.

105: Ferrell JE Jr. Signaling motifs and Weber's law. Mol Cell. 2009 Dec 11;36(5):724-7. doi: 10.1016/j.molcel.2009.11.032. PubMed PMID: 20005833.

104: Hendrickson DG, Hogan DJ, McCullough HL, Myers JW, Herschlag D, Ferrell JE, Brown PO. Concordant regulation of translation and mRNA abundance for hundreds of targets of a human microRNA. PLoS Biol. 2009 Nov;7(11):e1000238. doi: 10.1371/journal.pbio.1000238. Epub 2009 Nov 10. PubMed PMID: 19901979; PubMed Central PMCID: PMC2766070.

103: Ferrell JE Jr, Pomerening JR, Kim SY, Trunnell NB, Xiong W, Huang CY, Machleder EM. Simple, realistic models of complex biological processes: positive feedback and bistability in a cell fate switch and a cell cycle oscillator. FEBS Lett. 2009 Dec 17;583(24):3999-4005. doi: 10.1016/j.febslet.2009.10.068. Epub . Review. PubMed PMID: 19878681.

102: Ferrell JE Jr. Q&A: Cooperativity. J Biol. 2009;8(6):53. doi:10.1186/jbiol157. Epub 2009 Jun 16. PubMed PMID: 19589184; PubMed Central PMCID: PMC2737376.

101: Justman QA, Serber Z, Ferrell JE Jr, El-Samad H, Shokat KM. Tuning the activation threshold of a kinase network by nested feedback loops. Science. 2009 Apr 24;324(5926):509-12. doi: 10.1126/science.1169498. PubMed PMID: 19390045; PubMed Central PMCID: PMC2880456.

Commentary: Skotheim JM. Cell signaling. To divide or not to divide. Science. 2009 Apr 24;324(5926):476-7. doi: 10.1126/science.1173769. PubMed PMID: 19390035

100: Ferrell JE Jr. Q&A: systems biology. J Biol. 2009;8(1):2. doi: 10.1186/jbiol107. Epub 2009 Jan 26. PubMed PMID: 19222866; PubMed Central PMCID: PMC2656213.

99: Aebersold R, Auffray C, Baney E, Barillot E, Brazma A, Brett C, Brunak S, Butte A, Califano A, Celis J, Cufer T, Ferrell J, Galas D, Gallahan D, Gatenby R, Goldbeter A, Hace N, Henney A, Hood L, Iyengar R, Jackson V, Kallioniemi O, Klingmüller U, Kolar P, Kolch W, Kyriakopoulou C, Laplace F, Lehrach H, Marcus F, Matrisian L, Nolan G, Pelkmans L, Potti A, Sander C, Seljak M, Singer D, Sorger P, Stunnenberg H, Superti-Furga G, Uhlen M, Vidal M, Weinstein J, Wigle D, Williams M, Wolkenhauer O, Zhivotovsky B, Zinovyev A, Zupan B. Report on EU-USA workshop: how systems biology can advance cancer research (27 October 2008). Mol Oncol. 2009 Feb;3(1):9-17. doi: 10.1016/j.molonc.2008.11.003. Epub 2008 Dec 9. PubMed PMID: 19383362; PubMed Central PMCID: PMC2930781.

2008

98: Santos SD, Ferrell JE. Systems biology: On the cell cycle and its switches. Nature. 2008 Jul 17;454(7202):288-9. doi: 10.1038/454288a. PubMed PMID: 18633407; PubMed Central PMCID: PMC2727670.

97: Tsai TY, Choi YS, Ma W, Pomerening JR, Tang C, Ferrell JE Jr. Robust, tunable biological oscillations from interlinked positive and negative feedback loops. Science. 2008 Jul 4;321(5885):126-9. doi: 10.1126/science.1156951. PubMed PMID: 18599789; PubMed Central PMCID: PMC2728800.

96: Pomerening JR, Ubersax JA, Ferrell JE Jr. Rapid cycling and precocious termination of G1 phase in cells expressing CDK1AF. Mol Biol Cell. 2008 Aug;19(8):3426-41. doi: 10.1091/mbc.E08-02-0172. Epub 2008 May 14. PubMed PMID:18480403; PubMed Central PMCID: PMC2488275.

95: Hendrickson DG, Hogan DJ, Herschlag D, Ferrell JE, Brown PO. Systematic identification of mRNAs recruited to argonaute 2 by specific microRNAs and corresponding changes in transcript abundance. PLoS One. 2008 May 7;3(5):e2126. doi: 10.1371/journal.pone.0002126. Erratum in: PLoS ONE. 2008;3(11).doi.org/10.1371/annotation/c8902b4c-30fc-42e7-b506-fc756a3cdd4e. PubMed PMID: 18461144; PubMed Central PMCID: PMC2330160.

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94: Ríos-Cardona D, Ricardo-González RR, Chawla A, Ferrell JE Jr. A role for GPRx, a novel GPR3/6/12-related G-protein coupled receptor, in the maintenance of meiotic arrest in Xenopus laevis oocytes. Dev Biol. 2008 May 1;317(1):380-8. doi: 10.1016/j.ydbio.2008.02.047. Epub 2008 Mar 7. PubMed PMID: 18381211; PubMed Central PMCID: PMC2409273.

93: Ferrell JE Jr. Feedback regulation of opposing enzymes generates robust, all-or-none bistable responses. Curr Biol. 2008 Mar 25;18(6):R244-5. doi: 10.1016/j.cub.2008.02.035. PubMed PMID: 18364225; PubMed Central PMCID: PMC2832910.

2007

92: Poon AC, Ferrell JE Jr. Systems biology. A clock with a flip switch. Science. 2007 Nov 2;318(5851):757-8. PubMed PMID: 17975056.

91: Ubersax JA, Ferrell JE Jr. Mechanisms of specificity in protein phosphorylation. Nat Rev Mol Cell Biol. 2007 Jul;8(7):530-41. Review. Erratum in: Nat Rev Mol Cell Biol. 2007 Aug;8(8):665. PubMed PMID: 17585314.

90: Serber Z, Selenko P, Hänsel R, Reckel S, Löhr F, Ferrell JE Jr, Wagner G, Dötsch V. Investigating macromolecules inside cultured and injected cells by in-cell NMR spectroscopy. Nat Protoc. 2006;1(6):2701-9. PubMed PMID: 17406526.

89: Kim SY, Ferrell JE Jr. Substrate competition as a source of ultrasensitivity in the inactivation of Wee1. Cell. 2007 Mar 23;128(6):1133-45. PubMed PMID: 17382882.

88: Hansen DV, Pomerening JR, Summers MK, Miller JJ, Ferrell JE Jr, Jackson PK. Emi2 at the crossroads: where CSF meets MPF. Cell Cycle. 2007 Mar 15;6(6):732-8. Epub 2007 Mar 14. PubMed PMID: 17361104.

87: Serber Z, Ferrell JE Jr. Tuning bulk electrostatics to regulate protein function. Cell. 2007 Feb 9;128(3):441-4. PubMed PMID: 17289565.

86: Gong D, Pomerening JR, Myers JW, Gustavsson C, Jones JT, Hahn AT, Meyer T, Ferrell JE Jr. Cyclin A2 regulates nuclear-envelope breakdown and the nuclear accumulation of cyclin B1. Curr Biol. 2007 Jan 9;17(1):85-91. PubMed PMID: 17208191; PubMed Central PMCID: PMC1830184.

85. Ferrell JE Jr. A clear view of the cell cycle. Curr Biol. 2007 Apr;17(7):R231-R232. Book review.

84. Ferrell JE. Journal club. Nature. 2007 Oct 31;450(7166):5-5 doi:10.1038/450005a

2006

83: Yue J, Ferrell JE Jr. Mechanistic studies of the mitotic activation of Mos. Mol Cell Biol. 2006 Jul;26(14):5300-9. PubMed PMID: 16809767; PubMed Central PMCID: PMC1592720.

82: Ubersax JA, Ferrell JE Jr. A noisy 'Start' to the cell cycle. Mol Syst Biol. 2006;2:2006.0014. Epub 2006 Mar 21. PubMed PMID: 16738559; PubMed Central PMCID: PMC1681488.

81: Yue J, Xiong W, Ferrell JE. B-Raf and C-Raf are required for Ras-stimulated p42 MAP kinase activation in Xenopus egg extracts. Oncogene. 2006 Jun 1;25(23):3307-15. Epub 2006 Jan 23. PubMed PMID: 16434971.

80: Myers JW, Chi JT, Gong D, Schaner ME, Brown PO, Ferrell JE. Minimizing off-target effects by using diced siRNAs for RNA interference. J RNAi Gene Silencing. 2006 Jul 17;2(2):181-94. PubMed PMID: 19771225; PubMed Central PMCID: PMC2737221.

2005

79: Kim SY, Song EJ, Lee KJ, Ferrell JE Jr. Multisite M-phase phosphorylation of Xenopus Wee1A. Mol Cell Biol. 2005 Dec;25(23):10580-90. PubMed PMID: 16287869; PubMed Central PMCID: PMC1291245.

78: Brandman O, Ferrell JE Jr, Li R, Meyer T. Interlinked fast and slow positive feedback loops drive reliable cell decisions. Science. 2005 Oct 21;310(5747):496-8. PubMed PMID: 16239477; PubMed Central PMCID: PMC3175767.

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Commentary: Bornholdt S. Systems biology. Less is more in modeling large genetic networks. Science. 2005 Oct 21;310(5747):449-51. PubMed PMID: 16239464.

Commentary: Adler EM, Gough NR, Ray LB. 2005: signaling breakthroughs of the year. Sci STKE. 2006 Jan 3;2006(316):eg1. PubMed PMID: 16391177.

77: Pomerening JR, Kim SY, Ferrell JE Jr. Systems-level dissection of the cell-cycle oscillator: bypassing positive feedback produces damped oscillations. Cell. 2005 Aug 26;122(4):565-78. PubMed PMID: 16122424.

Commentary: Cross FR, Siggia ED. Shake it, don't break it: positive feedback and the evolution of oscillator design. Dev Cell. 2005 Sep;9(3):309-10. Review. PubMed PMID: 16139219.

Commentary: Adler EM, Gough NR, Ray LB. 2005: signaling breakthroughs of the year. Sci STKE. 2006 Jan 3;2006(316):eg1. PubMed PMID: 16391177.

76: Liou J, Kim ML, Heo WD, Jones JT, Myers JW, Ferrell JE Jr, Meyer T. STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx. Curr Biol. 2005 Jul 12;15(13):1235-41. PubMed PMID: 16005298; PubMed Central PMCID: PMC3186072.

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Commentary: Adler EM, Gough NR, Ray LB. 2005: signaling breakthroughs of the year. Sci STKE. 2006 Jan 3;2006(316):eg1. PubMed PMID: 16391177.

75: Myers JW, Ferrell JE. Silencing gene expression with Dicer-generated siRNA pools. Methods Mol Biol. 2005;309:93-196. PubMed PMID: 15990400.

74: Myers JW, Ferrell JE Jr. Dicer in RNAi: its roles in vivo and utility in vitro.  In RNA Interference:  From Basic Science to Drug Development. 2005. Edited by K. Appasani, Cambridge University Press, Cambridge UK, pp. 29-54.

73: Green SL, Westendorf JM, Jaffe H, Pant HC, Cork LC, Ostrander EA, Vignaux F, Ferrell JE Jr. Allelic variants of the canine heavy neurofilament (NFH) subunit and extensive phosphorylation in dogs with motor neuron disease. J Comp Pathol. 2005 Jan;132(1):33-50. PubMed PMID: 15629478.

72: Cheng A, Xiong W, Ferrell JE Jr, Solomon MJ. Identification and comparative analysis of multiple mammalian Speedy/Ringo proteins. Cell Cycle. 2005 Jan;4(1):155-65. Epub 2005 Jan 5. PubMed PMID: 15611625.

2004

71: Yue J, Ferrell JE Jr. Mos mediates the mitotic activation of p42 MAPK in Xenopus egg extracts. Curr Biol. 2004 Sep 7;14(17):1581-6. PubMed PMID: 15341746.

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70: Gong D, Ferrell JE Jr. Picking a winner: new mechanistic insights into the design of effective siRNAs. Trends Biotechnol. 2004 Sep;22(9):451-4. PubMed PMID: 15331225.

69: Jones JT, Myers JW, Ferrell JE, Meyer T. Probing the precision of the mitotic clock with a live-cell fluorescent biosensor. Nat Biotechnol. 2004 Mar;22(3):306-12. Epub 2004 Feb 8. PubMed PMID: 14990952.

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68: Angeli D, Ferrell JE Jr, Sontag ED. Detection of multistability, bifurcations, and hysteresis in a large class of biological positive-feedback systems. Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):1822-7. Epub 2004 Feb 6. PubMed PMID: 14766974; PubMed Central PMCID: PMC357011.

2003

67: Xiong W, Ferrell JE Jr. A positive-feedback-based bistable 'memory module' that governs a cell fate decision. Nature. 2003 Nov 27;426(6965):460-5. Corrigendum in: Nature. 2007 Aug 30;448(7157):1076. PubMed PMID: 14647386.

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Commentary: Sible JC. Cell biology: thanks for the memory. Nature. 2003 Nov 27;426(6965):392-3. PubMed PMID: 14647363.

Commentary: LeBrasseur N. Eggs never forget. J Cell Biol. 2003 Dec 15;163(6):1187.

Commentary: Maturing from memory. Sci STKE. 2003 Dec 2;2003(211):tw462.

66: Fink CC, Bayer KU, Myers JW, Ferrell JE Jr, Schulman H, Meyer T. Selective regulation of neurite extension and synapse formation by the beta but not the alpha isoform of CaMKII. Neuron. 2003 Jul 17;39(2):283-97. PubMed PMID: 12873385.

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65: Pomerening JR, Sontag ED, Ferrell JE Jr. Building a cell cycle oscillator: hysteresis and bistability in the activation of Cdc2. Nat Cell Biol. 2003 Apr;5(4):346-51. PubMed PMID: 12629549.

Commentary: Solomon MJ. Hysteresis meets the cell cycle. Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):771-2. Epub 2003 Jan 27. Review. PubMed PMID: 12552095; PubMed Central PMCID: PMC298675.

64: Ferrell JE Jr, Cimprich KA. Enforced proximity in the function of a famous scaffold. Mol Cell. 2003 Feb;11(2):289-91. Review. PubMed PMID: 12620218.

63: Bagowski CP, Besser J, Frey CR, Ferrell JE Jr. The JNK cascade as a biochemical switch in mammalian cells: ultrasensitive and all-or-none responses. Curr Biol. 2003 Feb 18;13(4):315-20. PubMed PMID: 12593797.

62: Myers JW, Jones JT, Meyer T, Ferrell JE Jr. Recombinant Dicer efficiently converts large dsRNAs into siRNAs suitable for gene silencing. Nat Biotechnol. 2003 Mar;21(3):324-8. Epub 2003 Feb 18. PubMed PMID: 12592410.

2002

61: Gilman AG, Simon MI, Bourne HR, Harris BA, Long R, Ross EM, Stull JT, Taussig R, Bourne HR, Arkin AP, Cobb MH, Cyster JG, Devreotes PN, Ferrell JE, Fruman D, Gold M, Weiss A, Stull JT, Berridge MJ, Cantley LC, Catterall WA, Coughlin SR, Olson EN, Smith TF, Brugge JS, Botstein D, Dixon JE, Hunter T, Lefkowitz RJ, Pawson AJ, Sternberg PW, Varmus H, Subramaniam S, Sinkovits RS, Li J, Mock D, Ning Y, Saunders B, Sternweis PC, Hilgemann D, Scheuermann RH, DeCamp D, Hsueh R, Lin KM, Ni Y, Seaman WE, Simpson PC, O'Connell TD, Roach T, Simon MI, Choi S, Eversole-Cire P, Fraser I, Mumby MC, Zhao Y, Brekken D, Shu H, Meyer T, Chandy G, Heo WD, Liou J, O'Rourke N, Verghese M, Mumby SM, Han H, Brown HA, Forrester JS, Ivanova P, Milne SB, Casey PJ, Harden TK, Arkin AP, Doyle J, Gray ML, Meyer T, Michnick S, Schmidt MA, Toner M, Tsien RY, Natarajan M, Ranganathan R, Sambrano GR; Participating investigators and scientists of the Alliance for Cellular Signaling. Overview of the Alliance for Cellular Signaling. Nature. 2002 Dec 12;420(6916):703-6. PubMed PMID: 12478301.

60: Ferrell JE Jr. Self-perpetuating states in signal transduction: positive feedback, double-negative feedback and bistability. Curr Opin Cell Biol. 2002 Apr;14(2):140-8. Review. PubMed PMID: 11891111.

59: Sohaskey ML, Ferrell JE Jr. Activation of p42 mitogen-activated protein kinase (MAPK), but not c-Jun NH(2)-terminal kinase, induces phosphorylation and stabilization of MAPK phosphatase XCL100 in Xenopus oocytes. Mol Biol Cell. 2002  Feb;13(2):454-68. PubMed PMID: 11854404; PubMed Central PMCID: PMC65641.

2001

58: Deshaies RJ, Ferrell JE Jr. Multisite phosphorylation and the countdown to S  phase. Cell. 2001 Dec 28;107(7):819-22. Review. PubMed PMID: 11779457.

57: Ferrell JE, Xiong W. Bistability in cell signaling: How to make continuous processes discontinuous, and reversible processes irreversible. Chaos. 2001 Mar;11(1):227-236. PubMed PMID: 12779456.

56: Ferrell JE Jr. Six steps to destruction. Nature. 2001 Nov 29;414(6863):498-9. PubMed PMID: 11734834.

55: Bagowski CP, Ferrell JE Jr. Bistability in the JNK cascade. Curr Biol. 2001 Aug 7;11(15):1176-82. PubMed PMID: 11516948.

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54: Bagowski CP, Myers JW, Ferrell JE Jr. The classical progesterone receptor associates with p42 MAPK and is involved in phosphatidylinositol 3-kinase signaling in Xenopus oocytes. J Biol Chem. 2001 Oct 5;276(40):37708-14. Epub 2001 Jul 30. PubMed PMID: 11479298.

53: Bagowski CP, Xiong W, Ferrell JE Jr. c-Jun N-terminal kinase activation in Xenopus laevis eggs and embryos. A possible non-genomic role for the JNK signaling pathway. J Biol Chem. 2001 Jan 12;276(2):1459-65. PubMed PMID: 11029471.

52: Ferrell JE Jr. Cell cycle. In: McGraw-Hill Encyclopedia of Science and Technology. 2001. Ninth edition.

51: Ferrell JE Jr. Regulatory cascades: function and properties. In: Encyclopedia of Life Sciences. 2001. Macmillan Publishing Ltd.

2000

50: Ferrell JE Jr. What do scaffold proteins really do? Sci STKE. 2000 Oct 3;2000(52):pe1. Review. PubMed PMID: 11752612.

49: Green SL, Lifland BD, Bouley DM, Brown BA, Wallace RJ Jr, Ferrell JE Jr. Disease attributed to Mycobacterium chelonae in South African clawed frogs (Xenopus laevis). Comp Med. 2000 Dec;50(6):675-9. PubMed PMID: 11200577.

48: Kim SY, Ferrell JE Jr, Chae SK, Lee KJ. Inhibition of progesterone-induced Xenopus oocyte maturation by Nm23. Cell Growth Differ. 2000 Sep;11(9):485-90. PubMed PMID: 11007453.

47: Bhatt RR, Ferrell JE Jr. Cloning and characterization of Xenopus Rsk2, the predominant p90 Rsk isozyme in oocytes and eggs. J Biol Chem. 2000 Oct 20;275(42):32983-90. PubMed PMID: 10934212.

46: Walter SA, Guadagno SN, Ferrell JE Jr. Activation of Wee1 by p42 MAPK in vitro and in cycling xenopus egg extracts. Mol Biol Cell. 2000 Mar;11(3):887-96.  PubMed PMID: 10712507; PubMed Central PMCID: PMC14818.

1999

45: Sohaskey ML, Ferrell JE Jr. Distinct, constitutively active MAPK phosphatases function in Xenopus oocytes: implications for p42 MAPK regulation In vivo. Mol Biol Cell. 1999 Nov;10(11):3729-43. PubMed PMID: 10564268; PubMed Central PMCID:  PMC25672.

44: Bhatt RR, Ferrell JE Jr. The protein kinase p90 rsk as an essential mediator  of cytostatic factor activity. Science. 1999 Nov 12;286(5443):1362-5. PubMed PMID: 10558991.

43: Ferrell JE Jr. Building a cellular switch: more lessons from a good egg. Bioessays. 1999 Oct;21(10):866-70. Review. PubMed PMID: 10497337.

42: Ferrell JE Jr. Xenopus oocyte maturation: new lessons from a good egg. Bioessays. 1999 Oct;21(10):833-42. Review. PubMed PMID: 10497333.

41: Green SL, Bouley DM, Tolwani RJ, Waggie KS, Lifland BD, Otto GM, Ferrell JE Jr. Identification and management of an outbreak of Flavobacterium meningosepticum infection in a colony of South African clawed frogs (Xenopus laevis). J Am Vet Med Assoc. 1999 Jun 15;214(12):1833-8, 1792-3. PubMed PMID: 10382028.

40: Huang CY, Chang CP, Huang CL, Ferrell JE Jr. M phase phosphorylation of cytoplasmic dynein intermediate chain and p150(Glued). J Biol Chem. 1999 May 14;274(20):14262-9. PubMed PMID: 10318847.

1998

39: Ferrell JE Jr. How regulated protein translocation can produce switch-like responses. Trends Biochem Sci. 1998 Dec;23(12):461-5. Review. PubMed PMID: 9868363.

38: Guadagno TM, Ferrell JE Jr. Requirement for MAPK activation for normal mitotic progression in Xenopus egg extracts. Science. 1998 Nov 13;282(5392):1312-5. PubMed PMID: 9812894.

37: Ferrell JE Jr, Machleder EM. The biochemical basis of an all-or-none cell fate switch in Xenopus oocytes. Science. 1998 May 8;280(5365):895-8. PubMed PMID: 9572732.

Commentary: Koshland DE Jr. The era of pathway quantification. Science. 1998 May 8;280(5365):852-3. PubMed PMID: 9599157.

36: Ferrell JE Jr, Martin GS. Assessing activities of blotted protein kinases.  In:  Protein Phosphorylation. 1998. Ed. by Hunter T, Sefton BM, Academic Press, San Diego, pp. 177-82.  [This is a re-publication of Ref. 23]

1997

35: Walter SA, Guadagno TM, Ferrell JE Jr. Induction of a G2-phase arrest in Xenopus egg extracts by activation of p42 mitogen-activated protein kinase. Mol Biol Cell. 1997 Nov;8(11):2157-69. PubMed PMID: 9362060; PubMed Central PMCID: PMC25699.

34: Ferrell JE Jr. How responses get more switch-like as you move down a protein  kinase cascade. Trends Biochem Sci. 1997 Aug;22(8):288-9. PubMed PMID: 9270299.

33: Ferrell JE Jr, Bhatt RR. Mechanistic studies of the dual phosphorylation of mitogen-activated protein kinase. J Biol Chem. 1997 Jul 25;272(30):19008-16. PubMed PMID: 9228083.

32: Wang XM, Zhai Y, Ferrell JE Jr. A role for mitogen-activated protein kinase in the spindle assembly checkpoint in XTC cells. J Cell Biol. 1997 Apr 21;137(2):433-43. PubMed PMID: 9128253; PubMed Central PMCID: PMC2139774.

31: Ferrell JE Jr. Cell cycle. In: McGraw-Hill Encyclopedia of Science and Technology, Eighth edition. 1997 3:378-80.

1996

30: Ferrell JE Jr. Tripping the switch fantastic: how a protein kinase cascade can convert graded inputs into switch-like outputs. Trends Biochem Sci. 1996 Dec;21(12):460-6. Review. PubMed PMID: 9009826.

29: Huang CY, Ferrell JE Jr. Ultrasensitivity in the mitogen-activated protein kinase cascade. Proc Natl Acad Sci U S A. 1996 Sep 17;93(19):10078-83. PubMed PMID: 8816754; PubMed Central PMCID: PMC38339.

28: Huang CY, Ferrell JE Jr. Dependence of Mos-induced Cdc2 activation on MAP kinase function in a cell-free system. EMBO J. 1996 May 1;15(9):2169-73. PubMed PMID: 8641282; PubMed Central PMCID: PMC450139.

27: Ferrell JE Jr. MAP kinases in mitogenesis and development. Curr Top Dev Biol. 1996;33:1-60. Review. PubMed PMID: 9138904.

1994

26: Hsiao KM, Chou SY, Shih SJ, Ferrell JE Jr. Evidence that inactive p42 mitogen-activated protein kinase and inactive Rsk exist as a heterodimer in vivo. Proc Natl Acad Sci U S A. 1994 Jun 7;91(12):5480-4. PubMed PMID: 8202512; PubMed  Central PMCID: PMC44019.

1992

25: Chou SY, Baichwal V, Ferrell JE Jr. Inhibition of c-Jun DNA binding by mitogen-activated protein kinase. Mol Biol Cell. 1992 Oct;3(10):1117-30. PubMed PMID: 1421569; PubMed Central PMCID: PMC275676.

1991

24: Ferrell JE Jr, Wu M, Gerhart JC, Martin GS. Cell cycle tyrosine phosphorylation of p34cdc2 and a microtubule-associated protein kinase homolog in Xenopus oocytes and eggs. Mol Cell Biol. 1991 Apr;11(4):1965-71. PubMed PMID: 2005892; PubMed Central PMCID: PMC359881.

23: Ferrell JE Jr, Martin GS. Assessing activities of blotted protein kinases. Methods Enzymol. 1991;200:430-5. PubMed PMID: 1956329.

1990

22: Ferrell JE Jr, Noble JA, Martin GS, Jacques YV, Bainton DF. Intracellular localization of pp60c-src in human platelets. Oncogene. 1990 Jul;5(7):1033-6. PubMed PMID: 1695725.

21: Ferrell JE Jr, Martin GS. Identification of a 42-kilodalton phosphotyrosyl protein as a serine(threonine) protein kinase by renaturation. Mol Cell Biol. 1990 Jun;10(6):3020-6. PubMed PMID: 1692963; PubMed Central PMCID: PMC360666.

1989

20: Ferrell JE Jr, Martin GS. Thrombin stimulates the activities of multiple previously unidentified protein kinases in platelets. J Biol Chem. 1989 Dec 5;264(34):20723-9. PubMed PMID: 2555369.

19: Ferrell JE Jr, Martin GS. Tyrosine-specific protein phosphorylation is regulated by glycoprotein IIb-IIIa in platelets. Proc Natl Acad Sci U S A. 1989 Apr;86(7):2234-8. PubMed PMID: 2928328; PubMed Central PMCID: PMC286886.

1988

18: Ferrell JE Jr, Martin GS. Platelet tyrosine-specific protein phosphorylation is regulated by thrombin. Mol Cell Biol. 1988 Sep;8(9):3603-10. PubMed PMID: 2464741; PubMed Central PMCID: PMC365415.

17: Ferrell JE Jr, Mitchell KT, Huestis WH. Membrane bilayer balance and platelet shape: morphological and biochemical responses to amphipathic compounds. Biochim  Biophys Acta. 1988 Apr 7;939(2):223-37. PubMed PMID: 3355815.

1986

16: Mitchell KT, Ferrell JE Jr, Huestis WH. Separation of phosphoinositides and other phospholipids by two-dimensional thin-layer chromatography. Anal Biochem. 1986 Nov 1;158(2):447-53. PubMed PMID: 3028208.

15: Truong HT, Ferrell JE Jr, Huestis WH. Sulfhydryl reducing agents and shape regulation in human erythrocytes. Blood. 1986 Jan;67(1):214-21. PubMed PMID: 3000479.

1985

14: Ferrell JE Jr, Lee KJ, Huestis WH. Lipid transfer between phosphatidylcholine vesicles and human erythrocytes: exponential decrease in rate with increasing acyl chain length. Biochemistry. 1985 Jun 4;24(12):2857-64. PubMed PMID: 4016076.

13: Ferrell JE Jr, Lee KJ, Huestis WH. Membrane bilayer balance and erythrocyte shape: a quantitative assessment. Biochemistry. 1985 Jun 4;24(12):2849-57. PubMed PMID: 2990533.

1984

12: Ferrell JE Jr, Huestis WH. Phosphoinositide metabolism and the morphology of  human erythrocytes. J Cell Biol. 1984 Jun;98(6):1992-8. PubMed PMID: 6327723; PubMed Central PMCID: PMC2113039.

11: Loew GH, Poulsen M, Kirkjian E, Ferrell J, Sudhindra BS, Rebagliati M. Computer-assisted mechanistic structure-activity studies: application to diverse classes of chemical carcinogens. Environ Health Perspect. 1985 Sep;61:69-96. Review. PubMed PMID: 3905382; PubMed Central PMCID: PMC1568757.

1983

10: Ferrell JE Jr, Newton AC, Huestis WH. Analysis of chloride flux. Biochem. 1983 Dec 20;22(26):6116-7. Appendix to Newton AC, Cook SL, Huestis WH. Transfer of band 3, the erythrocyte anion transporter, between phospholipid vesicles and cells. Biochemistry. 1983 Dec 20;22(26):6110-7. PubMed PMID: 6661430.

9: Loew GH, Ferrell JE Jr, Poulsen M. Mechanistic structure-activity studies using quantum chemical methods:  application to polycyclic aromatic hydrocarbons. In: Structure-Activity Correlation as a Predictive Tool in Toxicology. 1983. Edited by L. Golberg. Hemisphere, Washington DC, 111-38.

1982

8: Ferrell JE Jr, Huestis WH. Calcium does not mediate the shape change that follows ATP depletion in human erythrocytes. Biochim Biophys Acta. 1982 May 7;687(2):321-8. PubMed PMID: 6807344.

1981

7: Huestis WH, Nelson MJ, Ferrell JE Jr. Calmodulin-dependent spectrin kinase activity in human erythrocytes. Prog Clin Biol Res. 1981;56:137-55. PubMed PMID:  6120520.

1980

6: Loew G, Poulsen M, Ferrell J, Chaet D. Quantum chemical studies of methylbenz[a]anthracenes: metabolism and correlations with carcinogenicity. Chem Biol Interact. 1980 Sep;31(3):319-40. PubMed PMID: 7408039.

5: Loew GH, Pudzianowski AT, Czerwinski A, Ferrell JE Jr. Mechanistic studies of addition of nucleophiles to arene oxides and diol epoxides: candidate ultimate carcinogens.  Int J Quantum Chem Quant Biol Symp. 1980 7:223-244.

1979

4: Nelson MJ, Ferrell JE Jr, Huestis WH. Adrenergic stimulation of membrane protein phosphorylation in human erythrocytes. Biochim Biophys Acta. 1979 Nov 16;558(1):136-40. PubMed PMID: 91385.

3: Ferrell JE Jr, Chang Sing PD, Loew G, King R, Mansour JM, Mansour TE. Structure/activity studies of flavonoids as inhibitors of cyclic AMP phosphodiesterase and relationship to quantum chemical indices. Mol Pharmacol. 1979 Sep;16(2):556-68. PubMed PMID: 229402.

2: Loew GH, Sudhindra BS, Ferrell JE Jr. Quantum chemical studies of polycyclic aromatic hydrocarbons and their metabolites: correlations to carcinogenicity. Chem Biol Interact. 1979 Jun;26(1):75-89. PubMed PMID: 466745.

1: Ferrell JE Jr, Loew GH. Mechanistic studies of arene oxide and diol epoxide rearrangement and hydrolysis reactions. J Am Chem Soc. 1979 Mar 1;101(6):1379-88. doi: 10.1021/ja00500a005.