The package TreeLD is a free software tool for mapping complex trait loci. TreeLD performs a multipoint LD-analysis by inferring the ancestry of a genomic region and analyzing this ancestry for signals of disease mutations. The generated likelihoods can be used to test for the presence of a disease locus and to fine-map its location, providing a point estimate and a credible region. Furthermore, the package provides a novel way of visualizing the association signal in a sample. TreeLD is designed for high-density SNP haplotypes and can be applied to case-control data, TDT trio data and quantitative trait data.
The package has a user friendly point and click interface, allowing an in-depth exploration of the data.
The methods in this program are detailed in Zollner and Pritchard (2005).
For Windows 95/98/NT/2000/XP : [Windows].
Click here for installation instructions.