Spyridon (Spyros) Bakas, PhD
Assistant Professor in the Department of Pathology,
Laboratory Medicine, and of Radiology
Center for Biomedical Image Computing and Analytics (CBICA)
Perelman School of Medicine
University of Pennsylvania
Title: Imaging Analytics for Neuro-Oncology:
Towards Computational Diagnostics
Abstract: Central nervous system (CNS) tumors come with vastly heterogeneous histologic, molecular, and radiographic landscapes, rendering their precise characterization challenging. The rapidly growing fields of biophysical modeling and radiomics have shown promise in better characterizing the molecular, spatial, and temporal heterogeneity of tumors. Integrative analysis of CNS tumors, including clinically acquired multi-parametric magnetic resonance imaging (mpMRI), assists in identifying macroscopic quantifiable tumor patterns of invasion and proliferation, potentially leading to improved (a) detection/segmentation of tumor subregions and (b) computer-aided diagnostic/prognostic/predictive modeling. This talk will touch upon example studies on this space, as well as an overview of the largest to-date real-world federated learning study to detect brain tumor boundaries.