Wyss-Coray Lab

Can we slow or reverse brain aging and prevent dementia?

The Wyss-Coray research team studies brain aging and neurodegeneration with a focus on age-related cognitive decline and Alzheimer’s disease. The lab is following up on earlier discoveries which showed circulatory blood factors can modulate brain structure and function and factors from young organisms can rejuvenate old brains. Current studies focus on the molecular basis of this systemic communication with the brain by employing a combination of genetic, cell biology, and proteomics approaches in model organisms and humans. The lab is working closely with the Knight Initiative for Brain Resilience and is affiliated with the Wu Tsai Neurosciences Institute, The Department of Neurology and Neurological Sciences, the Sarafan ChEM-H Institute, and the NIH-funded Stanford Alzheimer’s Disease Research Center.

The lab's work has been recently highlighted in:
NewScientist The Wall Street Journal Eric Topol's Substack NOMIS Insights Science The New York Times .

Resources

Atlas of the aging mouse brain reveals white matter as vulnerable foci

Single-cell Atlas of Parabiosis

Human BBB Atlas

Aging Plasma Proteome

Tabula Muris Senis

Tabula Muris

Can we slow or reverse brain aging and prevent dementia?

Resources

Recent publications