Phone: 650 852 3220
Fax: 650 849 1983
Office: 3801 Miranda Ave, 154-W
Office: Bldg 4, Rm. B230
Office: Palo Alto, CA 94304
Dr. Tony Wyss-Coray
Over-expression of TGF-β1 has been demonstrated by Dr. Wyss-Coray to reduce Aβ deposition in brain parenchyma of APP transgenic mice. I am currently working on a drug-screening project searching for small-molecule compounds that mimic the beneficial effect of TGF-β1.
Research Scientist/Lab Manager
I was trained as a cell biologist during my Ph.D. studies in Vienna, Austria at the Institute of Molecular Pathology (IMP) in the lab of Juergen Knoblich. In 2003, I moved to Stanford working in the lab of Liqun Luo as a postdoctoral fellow on developmental neurobiology, particularly interested in the assembly and maintenance of neural circuits. I joined the Wyss-Coray lab in January 2011. I am using proteomics approaches to discover novel signaling pathways associated with aging and neurodegenerative diseases.
Benoit has obtained his master in biostatics from Paul Sabatier University (Toulouse France) and his Ph.D. in Neuroscience from Blaise Pascal University (Clermont Ferrand, France). His main interest lies in the development of new biostatistical approaches to better understand complex biological processes.
During his doctoral studies, he used BOLD fMRI and MEMRI to understand deep brain processing of complex stimulus. After completing his doctoral degree, Benoit started his postdoc at Roche Ltd (Basel Switzerland) in collaboration with the Wyss-Coray lab at Stanford University. He studied normal and abnormal aging to identify biomarkers that could be used for the early detection of diseases and/or targeted to develop new treatments.
Having a strong interest in aging, neurodegeneration, and learning and memory, I joined the Wyss-Coray lab in hopes of using novel experimental approaches to uncover mechanistic aspects of how the systemic environment influences the aging brain.
I was able to develop a system to label proteins specifically in the liver using bioorthogonal labeling, then detect these labeled proteins in plasma, as well as in the brain after these proteins cross the blood-brain barrier. I am now labeling proteins in the brain to determine what proteins secreted by neurons can be found in the bloodstream. This work may lead to a pool of protein targets that can be used as blood biomarkers for neurodegenrative diseases.
I received my graduate degree in Integrative Biology of Disease from the University of Southern California in 2015. For my thesis, I studied the role of T cells in pediatric brain cancer and also explored the role of microglial TLR receptor signaling in Alzheimer’s disease. For this work, I received an NIH/NINDS F31 fellowship. I joined the Wyss-Coray lab in 2015 to explore the role adaptive immunity in Alzheimer’s disease in collaboration with the Stanford Alzheimer’s Disease Research Center. I am a recipient of a Glenn/AFAR Postdoctoral Fellowship in the Biology of Aging, an NIH/NIA F32, Alzheimer’s Association Young Investigator Award and a Junior Faculty Award from the AD/PD Congress. Outside of the lab, I enjoy hiking, camping and playing basketball.
“Prior to joining the Wyss-Coray lab, I completed my PhD degree in Neuroscience at the University of Miami. For my thesis project, I worked on a prophylactic approach to cerebral ischemia known as preconditioning by focusing on the metabolic adaptations it induces in the brain. For my postdoctoral project, I am interested in understanding how alterations in the cerebrovasculature observed during aging and neurodegeneration contribute to disease pathology.
Song Eun Lee
Tristan Qingyun Li
During my Ph.D. at the University of Salzburg, Austria, I studied muscle stem cells in adult zebrafish. For my post doc, having always been intrigued by the brain, I changed my research focus to neural stem cells and joined the Aigner lab (PMU Salzburg). Here I became interested in the identification of mechanisms that contribute to reduced neurogenesis and to neuroinflammation in aging. I could identify leukotrienes as key mediators for brain aging and showed that its pharmacological inhibition ameliorated neuroinflammation and improved cognition in aged rats.
I joined the Wyss-Coray lab in August 2015 to further explore the role of microglia in brain aging. Specifically, I aim to understand the role of microglial lipid accumulations in structural and functional brain aging. Also, I started to work on the killifish as a new model to study microglia and brain aging.
Patricia Moran Losada
My goal is to keep people as healthy as possible for as long as possible. To accomplish this, I study the biology of aging, as aging is the root cause of the majority of deaths and disease worldwide. I hope to develop therapies to treat these root causes and prevent diseases like cancer, heart disease, Alzheimer's, stroke, and diabetes. My main areas of focus have been cellular senescence, how young circulating factors rejuvenate aged tissues, and characterizing organism-wide aging with RNA-seq and scRNA-seq.
MD PhD Student
I am an MD-PhD student in the MSTP program. Prior to joining the Wyss-Coray lab, I worked in Irv Weissman’s lab investigating the pathogenesis of and immunotherapies for myelodysplastic syndrome. I am interested in the role of microglia and peripheral myeloid cells in aging.
MD PhD Student
Ryan grew up in Lexington, NC and earned his BS in Chemical Engineering at North Carolina State University. He is currently PhD candidate in the Stanford department of Chemical Engineering and is coadvised by James Swartz. His research focuses on developing therapeutics to target age and disease-associated neuroinflammation.
Steven earned his BS in Chemistry at UC Berkeley under Richmond Sarpong doing research in synthetic organic chemistry. Steven then came to Stanford, earning an MS in Chemistry in the Burns lab studying the synthesis and biophysics of structurally unusual lipids. Finally, he joined the Wyss-Coray lab as a BioX SIGF Fellow to complete a PhD in Chemistry. He studies changes in the cerebrospinal fluid proteome that occur with aging, rejuvenation, and Alzheimer’s disease using state-of-the-art mass spectrometry techniques.
Andrew is a bioengineering PhD student developing chemical and genetic tools to study blood-brain barrier function with age.
Olivia graduated from Swarthmore college in 2018 with a degree in honors neuroscience. In the Wyss-Coray lab, she is working to understand the role of the adaptive immune system in Alzheimer’s disease. Olivia hopes to pursue a dual MD/MPH degree in order to expand her career in research to understanding and reducing global health disparities.
Originally from Singapore, I am a sophomore at Stanford University majoring in Chemical Engineering and Biology. I started college with an interest in neurodegenerative disease, but that grew to include the general biology of brain aging. I am particularly interested in changes in microglia and cerebrospinal fluid with age and disease.
Research Data Analyst