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Lo Nuevo y Caliente in Research


Horng-Jyh et al. An association between human papillomavirus 16/18 deoxyribonucleic acid in peripheral blood with p16 protein expression in neoplastic cervical lesions. Cancer Detection and Protection. 2005

There has been previous evidence with the existence of p16 protein in cervical tissue in the existence of an HPV infection. This study wanted to work with that idea and also look at the possibility of finding HPV DNA in the peripheral blood and perhaps use that another marker of cervical lesions. In this study a positive correlation was found with overexpression of p16 and HPV DNA in peripheral blood. Together they might be a very strong marker for HPV-associated cancer development. This is with the help of PCR and RFLP procedures that may be more sensitive and noninvasive markers to better the detection process of cervical lesions especially caused by HPV.

Brenda Y. Hernandez et al. Anal Human Papillomavirus Infection in Women and Its Relationship with Cervical Infection Cancer Epidemiology Biomarkers & Prevention Vol. 14, 2550-2556, November 2005

Very little is known about the relationship of anal HPV infection and cervical infection. There may be very similar progression of between HPV-associated anal infection and cervical infection. In addition, they are both strongly correlated with a statistic of a >3-fold increased risk of anal infection if cervical infection is present. However, there may be some evidence of different genotypes of HPV affecting the anus compared to the cervix especially with the fact of less anal cancer that cervical cancer in general. Also, a women that has infection in both areas probably has multiple HPV strain infection as opposed to a single area infection.

Insinga, Ralph P.; Dasbach, Erik J.; Elbasha, Elamin H. Assessing the Annual Economic Burden of Preventing and Treating Anogenital Human Papillomavirus-Related Disease in the US: Analytic Framework and Review of the Literature. PharmacoEconomics, 2005, Vol. 23 Issue 11, p1107, 16p

Current annual economic burden estimates that are associated to the prevention and treatment of anogenital HPV diseases are somewhat inaccurate and are missing some essential components like direct medical costs of these infections that lead to cancers and the money that is lost because of work absence due to time expenditure for medical care. Current estimates are of $4 billion and would probably be closer to $5 billion +, if direct costs of medical attention and work absence were taken into account. This is huge when compared to human genital herpes 2 with economical burden of $1.9 billion and $2.2 billion for Chlamydia.

Mohammadreza Barghi et al. Correlation between human papillomavirus infection and bladder transitional cell carcinoma BMC Infectious Diseases 2005, 5:102

Despite previous reports, there may actually be a strong case for HPV being the cause in transitional cell carcinoma of the bladder at least in the Iranian population/geographical area. This statement is due to a very high rate of HPV positive in transitional cell carcinoma cases.

C-Y Kan et al. Identification of human papillomavirus DNA gene sequences in human breast cancer. British Journal of Cancer (2005) 93, 946 – 948

Recently HPV 18 DNA was extracted from breast tumors of several Australian women and thus opens the possibility of some kind of role of HPV in breast cancer. The interesting assumption is that these women had self inoculation from their genital area to their breasts. Of course, further investigation is necessary to find what role exactly HPV has in this particular cancer.