Adeno-associated virus (1-8)

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Adenovirus was one of the first viruses discovered, yet in the 1960's, electron microscopy showed that adenovirus samples often contained a second, smaller particle. This was classified as a second virus, adeno-associated virus, in 1965.

Adeno-associated virus (AAV) is a dependovirus that is a satellite virus on adenovirus and also certain herpes viruses. It is also a orphan virus - it is not known to cause any disease in humans.

Because of its relatively simple genome and its status as an non-pathogenic, AAV has been of interest as a vector for gene therapy. AAV can also stably integrate into the human 19th chromosome.

Current trials include gene therapies for cystic fibrosis, AIDS, muscular dystrophy, hemophilia, Parkinson's, and Alzheimer's.



Clinical trials

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Examples of governemnt adeno-associated virus clinical trials:

HIV Vaccine

Parkinson's Disease