Optophysiology: interferometric imaging of neural signals and cell metabolism

Quantitative phase imaging enables characterization of cellular motion with sub-nanometer precision, without any exogenous markers. This opens the door to optophysiology - an optical alternative to traditional electrophysiology: non-invasive optical detection of neural signals, as well as other metabolic changes in cells and tissues.

We are working on two approaches to quantitative phase imaging: full-field interferometry in transmission, and phase-resolved optical coherence tomography in reflection.

We study the mechanisms of electro-optical coupling and develop biological applications of this technology, including mapping the neural activity in cells and tissues, detecting metabolic changes in photoreceptors during light exposure, optical thermometry, and others.