Publications
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* Denotes co-first authorship and † denotes co-corresponding authorship.
374. *Shao, Z.; *Flynn, R. A.; *Crowe, J. L.; *Zhu, Y.; Liang, J.; Jiang, W.; Aryan, F.; Aoude, P.; Bertozzi, C. R.; Estes, V. M.; Lee, B. J.; Bhagat, G.; †Zha, S.; †Calo, E. DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis. Nature, ASAP.
373. Marschallinger, J.; Iram, T.; Zardeneta, M.; Lee, S. E.; Lehallier, B.; Haney, M. S.; Pluvinage, J. V.; Mathur, V.; Hahn, O.; Morgens, D. W.; Kim, J.; Tevini, J.; Felder, T. K.; Wolinski, H.; Bertozzi, C. R.; Bassik, M. C.; Aigner, L.; Wyss-Coray, T. Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain. Nat. Neurosci. 2020, 23(2),194-208.
372. Bule, P.; Chuzel, L.; Blagova, E.; Wu, L.; Gray, M. A.; Henrissat, B.; Rapp, E.; Bertozzi, C. R.; Taron, C. H.; Davies, G. J. Inverting family GH156 sialidases define an unusual catalytic motif for glycosidase action. Nat. Comm. 2019, 10(1),4816.
371. Tsui, C. K.; Barfield, R. M.; Fischer, C. R.; Morgens, D. W.; Li, A.; Smith, B. A. H.; Gray, M. A.; Bertozzi, C. R.; Rabuka, D.; Bassik, M. C. CRISPR-Cas9 screens identify regulators of antibody-drug conjugate toxicity. Nat. Chem. Biol. 2019, 15(10),949-958.
370. Lim, H. C.; Sher, J. W.; Rodriguez-Rivera, F. P.; Fumeaux, C.; Bertozzi, C. R.; Bernhardt, T. G. Identification of new components of the RipC-FtsEX cell separation pathway of Corynebacterineae. PLoS Genet. 2019, 15(8),e1008284.
369. *Ooi, Y. S.; *Majzoub, K.; *Flynn, R. A.; Mata, M. A.; Diep, J.; Li, J. K.; van Buuren, N.; Rumachik, N.; Johnson, A. G.; Puschnik, A. S.; Marceau, C. D.; Mlera, L.; Grabowski, J. M.; Kirkegaard, K.; Bloom, M. E.; Sarnow, P.; Bertozzi, C. R.; Carette, J. E. An RNA-centric dissection of host complexes controlling flavivirus infection. Nat. Microbiol. 2019, 4(12),2369-2382.
368. Choi, J.; Wagner, L. J. S.; Timmermans, S. B. P. E.; Malaker, S. A.; Schumann, B.; Gray, M. A.; Debets, M. F.; Takashima, M.; Gehring, J.; Bertozzi, C. R. Engineering Orthogonal Polypeptide GalNAc-Transferase and UDP-Sugar Pairs. J. Am. Chem. Soc. 2019, 141(34),13442-13453.
367. *Möckl, L.; *Pedram, K.; Roy, A. R.; Krishnan, V.; Gustavsson, A. K.; Dorigo, O.; †Bertozzi, C. R.; †Moerner, W. E. Quantitative Super-Resolution Microscopy of the Mammalian Glycocalyx. Dev. Cell 2019, 50(1),57-72.e6.
366. *Shurer, C. R.; *Kuo, J. C.; *Roberts, L. M.; Gandhi, J. G.; Colville, M. J.; Enoki, T. A.; Pan, H.; Su, J.; Noble, J. M.; Hollander, M. J.; O'Donnell, J. P.; Yin, R.; Pedram, K.; Moeckl, L.; Kourkoutis, L. F.; Moerner, W. E.; Bertozzi, C. R.; Feigenson, G. W.; Reesink, H. L.; Paszek, M. J. Physical Principles of Membrane Shape Regulation by the Glycocalyx. Cell 2019, 177(7),1757-1770.e21.
365. Waldman, A. J.; Bertozzi, C. R. A Sugar Cloak of Invisibility. Biochemistry 2019, 14;58(19), 2385-2386.
364. Pluvinage, J. V.; Haney, M. S.; Smith, B. A. H.; Sun, J.; Iram, T.; Bonanno, L.; Li, L.; Lee, D. P.; Morgens, D. W.; Yang, A. C.; Shuken, S. R.; Gate, D.; Scott, M.; Khatri, P.; Luo, J.; Bertozzi, C. R.; Bassik, M. C.; Wyss-Coray, T. CD22 blockade restores homeostatic microglial phagocytosis in ageing brains. Nature 2019, 568(7751),187-192.
363. *Malaker, S. A.; *Pedram, K.; Ferracane, M. J.; Bensing, B. A.; Krishnan, V.; Pett, C.; Yu, J.; Woods, E.C.; Kramer, J.R.; Westerlind, U.; Dorigo, O.; Bertozzi, C.R. The mucin-selective protease StcE enables molecular and functional analysis of human cancer-associated mucins. PNAS 2019, 116(15),7278-7287.
362. *Appel, M. J.; *Meier, K. K.; Lafrance-Vanasse, J.; Lim, H.; Tsai, C. L.; Hedman, B.; Hodgson, K. O.; †Tainer, J. A.; †Solomon, E. I.; †Bertozzi, C.R. Formylglycine-generating enzyme binds substrate directly at a mononuclear Cu(I) center to initiate O2 activation. PNAS 2019, 116(12), 5370-5375.
361. Zhou, X.; Rodriguez-Rivera, F. P.; Lim, H. C.; Bell, J. C.; Bernhardt, T. G.; Bertozzi, C. R.; Theriot, J. A. Sequential assembly of the septal cell envelope prior to V snapping in Corynebacterium glutamicum. Nat. Chem. Biol. 2019, 15(3),221-231.
360. Baranov, M. V.; Bianchi, F.; Schirmacher, A.; van Aart, M. A. C.; Maassen, S.; Muntjewerff, E. M.; Dingjan, I.; Ter Beest, M.; Verdoes, M.; Keyser, S. G. L.; Bertozzi, C. R.; Diederichsen, U.; van den Bogaart, G. The Phosphoinositide Kinase PIKfyve Promotes Cathepsin-S-Mediated Major Histocompatibility Complex Class II Antigen Presentation. iScience 2018, 11, 160-167.
359. Spiciarich, D. R.; Oh, S. T.; Foley, A.; Hughes, S. B.; Mauro, M. J.; Abdel-Wahab, O.; Press, R. D.; Viner, R.; Thompson, S. L.; Chen, Q.; Azadi, P.; Bertozzi, C. R.; Maxson, J. E. A novel germline variant in CSF3R reduces N-glycosylation and exerts potent oncogenic effects in leukemia. Cancer Res. 2018, 15;78(24), 6762-6770.
358. Walton, E. M.; Cronan, M. R.; Cambier, C. J.; Rossi, A.; Marass, M.; Foglia, M. D.; Brewer, W. J.; Poss, K. D.; Stainier, D. Y. R.; Bertozzi, C. R.; Tobin, D. M. Cyclopropane Modification of Trehalose Dimycolate Drives Granuloma Angiogenesis and Mycobacterial Growth through Vegf Signaling. Cell Host Microbe 2018, 24(4), 514-525.
357. *Barnes, J. M.; *Kaushik, S.; Bainer, R. O.; Sa, J. K.; Woods, E. C.; Kai, F.; Przybyla, L.; Lee, M.; Lee, H. W.; Tung, J. C.; Maller, O.; Barrett, A. S.; Lu, K. V.; Lakins, J. N.; Hansen, K. C.; Obernier, K.; Alvarez-Buylla, A.; Bergers, G.; Phillips, J. J.; Nam, D. H.; Bertozzi, C. R.; Weaver, V. M. A tension-mediated glycocalyx-integrin feedback loop promotes mesenchymal-like glioblastoma. Nat. Cell Biol. 2018, 20(10), 1203-1214.
356. Wan, S. J.; Sullivan, A. B.; Shieh, P.; Metruccio, M. M. E.; Evans, D. J.; Bertozzi, C. R.; Fleiszig, S. M. J. IL-1R and MyD88 Contribute to the Absence of a Bacterial Microbiome on the Healthy Murine Cornea. Front Microbiol. 2018, 29(9), 1117.
355. Yang, A. C.; du Bois, H.; Olsson, N.; Gate, D.; Lehallier, B.; Berdnik, D.; Brewer, K. D.; Bertozzi, C. R.; Elias, J. E.; Wyss-Coray, T. Multiple Click-Selective tRNA Synthetases Expand Mammalian Cell-Specific Proteomics. J. Am. Chem. Soc 2018, 140(23), 7046-7051.
354. Keyser, S. G. L.; Utz, A.; Bertozzi, C. R. Computation-guided rational design of a peptide motif that reacts with cyanobenzothiazoles via internal cysteine-lysine relay. J. Org. Chem. 2018, 20;83(14), 7467-7479.
353. Tomlin, F. M.; Gordon, C. G.; Han, Y.; Wu, T. S.; Sletten, E. M.; Bertozzi, C. R. Site-specific incorporation of quadricyclane into a protein and photocleavage of the quadricyclane ligation adduct. Bioorganic and Med. Chem. 2018, 15;26(19), 5280-5290.
352. *Kamariza, M.; *Shieh, P.; Ealand, C. S.; Peters, J. S.; Chu, B.; Rodriguez-Rivera, F. P.; Babu Sait, M. R.; Treuren, W. V.; Martinson, N.; Kalscheuer, R.; Kana, B. D.; Bertozzi, C. R. Rapid detection of Mycobacterium tuberculosis in sputum with a solvatochromic trehalose probe. Sci. Transl. Med. 2018, 10(430), eaam6310. [Download PDF]
351. Aebersold, R.; Agar, J. N.; Amster, I. J.; Baker, M. S.; Bertozzi, C. R.; et al. How many human proteoforms are there? Nat. Chem. Bio. 2018, 14(3), 206-214.
350. Rodriguez-Rivera, F. P.; Zhou, X.; Theriot, J. A.; Bertozzi, C. R. Acute modulation of mycobacterial cell envelope biogenesis by front-line TB drugs. Angew. Chem. Int. Ed. Engl. 2018, 57(19), 5267-5272.
349. *Zhou, M.; *Delaveris, C. S.; Kramer, J. R.; Kenkel, J. A.; Engleman, E. G.; Bertozzi, C. R. N-carboxyanhydride polymerization of glycopolypeptides that activate antigen presenting cells through Dectin-1 and -2. Angew Chem Int Ed Engl. 2018, 57(12), 3137-3142.
348. *Tsai, C. T.; *Robinson, P. V.; Cortez, F. J.; Elma, M. L. B.; Seftel, D.; Pourmandi, N.; †Pandori, M. W.; †Bertozzi, C. R. Antibody detection by agglutination-PCR (ADAP) enables early diagnosis of HIV infection by oral fluid analysis. Proc Natl Acad Sci U.S.A. 2018, 115(6), 1250-1255.
347. Woo, C.M.; Lund, P.J.; Huang, A. C.; Davis, M. M.; Bertozzi, C. R.; Pitteri, S. Mapping and quantification of over 2,000 O-linked glycopeptides in activated human T cells with isotope-targeted glycoproteomics (IsoTaG). Mol Cell Proteomics. 2018, 17(4), 764-775.
346. Freeman, S. A.; Vega, A.; Riedl, M.; Collins, R. F.; Ostrowski, P. P.; Woods, E. C.; Bertozzi, C. R.; Tammi, M. I.; Lidke, D. S.; Johnson, P.; Mayor, S.; Jaqaman, K.; Grinstein, S. Transmembrane Pickets Connect Cyto- and Pericellular Skeletons Forming Barriers to Receptor Engagement. Cell. 2018, 172, 305-317.
345. Kamariza, M.; Shieh, P.; Bertozzi, C. R. Imaging Mycobacterial Trehalose Glycolipids. Methods Enzymol. 2018, 598, 355-369.
344. Woods, E. C.; Kai, F.; Barnes, J.M.; Pedram, K.; Pickup, M. W.; Hollander, M.J.; Weaver, V. M.; Bertozzi, C. R. A bulky glycocalyx fosters metastasis formation by promoting G1 cell cycle progression. Elife. 2017, 6:e25752.
343. *Tsai, C. T.; *Mukai, K.; Robinson, P. V.; Gray, M. A.; Waschmann, M. B.; Lyu, S. C.; Tsai, M.; Chinthrajah, R. S.; Nadeau, K. C.; †Bertozzi, C. R.; †Galli, S. J. Isotype-Specific Agglutination-PCR (ISAP): a sensitive and multiplex method for measuring allergen-specific IgE. J. Allergy Clin. Immunol. 2018, 141(5), 1901-1904.e15.
342. *Tomlin, F. M.; *Gerling-Driessen, U. I. M.; Liu, Y-C; Flynn, R. A.; Vangala, J. R.; Lentz, C. S.; Clauder-Muenster, S.; Jakob, P.; Mueller, W. F.; Ordoñez-Rueda, D.; Paulsen, M.; Matsui, N.; Foley, D.; Rafalko, A.; Suzuki, T.; Bogyo, M.; Steinmetz, L. M.; Radhakrishnan, S. K.; Bertozzi, C. R. Inhibition of NGLY1 onactivates the transcription factor Nrf1 and potentiates proteasome inhibitor cytotoxicity. ACS Central 2017, 3, 1143-1155.
342. Spiciarich, D. R.; Nolley, R.; Maund, S. L.; Purcell, S. C.; Herschel, J.; Iavarone, A. T.; Peehl, D. M.; Bertozzi, C. R. Bioorthogonal labeling of human prostate cancer tissue slice cultures for glycoproteomics. Angew. Chem. Int. Ed. Engl. 2017, 56, 8992-8997.
341. Hinderlich, S.; Tauber, R.; Bertozzi, C. R.; Hackenberger, C. P. R. Werner Reutter: A visionary pioneer in molecular glycobiology. Chembiochem. 2017, 18, 1141-1145.
340. Andres, L. M.; Blong, I. W.; Evans, A.C.; Rumachik, N. G.; Yamaguchi, T.; Pham, N. D.; Thompson, P.; Kohler, J. J.; Bertozzi, C. R. Chemical modulation of protein O-GlcNAcylation via OGT inhibition promotes human neural cell differentiation ACS Chem. Biol. 2017, 18, 2030-2039.
339. Woo, C. M.; Felix, A.; Byrd, W. E.; Zuegel, D. K.; Ishihara, M.; Azadi, P.; Iavarone, A. T.; Pitteri, S. J.; Bertozzi, C. R. Development of IsoTaG, a chemical glycoproteomics technique for profiling intact N- and O-glycopeptides from whole cell proteomes. J. Proteome Res. 2017, 16 1706–1718.
338. Jolly, A. L.; Agarwal, P.; Metruccio, M. M.; Spiciarich, D. R.; Evans, D. J.; Bertozzi, C. R.; Fleiszig, S. M. Corneal surface glycosylation is modulated by IL-1R and Pseudomonas aeruginosa challenge but is insufficient for inhibiting bacterial binding. FASEB J. 2017, 31, 2393-2404.
337. Ganesan, L.; Shieh, P.; Bertozzi, C. R.; Levental, I.Click-chemistry based high throughput screening platform for modulators of Ras palmitoylation. Sci Rep. 2017, 7, 41147.
336. Rodriguez-Rivera, F. P.; Zhou, X,; Theriot, J. A. ; Bertozzi, C, R.Visualization of mycobacterial membrane dynamics in live cells. J. Am. Chem. Soc. 2017, 139, 3488-3495.
335. Schump, M. D.; Fox, D. M.; Bertozzi, C. R.; Riley, L. W. Subcellular partitioning and intra-macrophage selectivity of antimicrobial compounds against Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 2017, 61, e01639-16.
334. Woo, C. M.; Felix, A.; Zhang, L.; Elias, J. E.; Bertozzi, C. R. Isotope-targeted glycoproteomics (IsoTaG) analysis of sialylated N- and O-glycopeptides on an Orbitrap Fusion Tribrid using azido and alkynyl sugars. Anal. Bioanal. Chem. 2017, 409, 579-588.
333. Palaniappan, K. K.; Bertozzi, C. R. Chemical glycoproteomics. Chem. Rev. 2016, 116, 14277-14306.
332. Sogi, K. M.; Holsclaw, C. M.; Fragiadakis, G. K.; Nomura, D. K.; Leary, J. A.; Bertozzi, C. R. Biosynthesis and regulation of sulfomenaquinone, a metabolite associated with virulence in Mycobacterium tuberculosis. ACS Infect. Dis. 2016, 2, 800-806.
331. Zhu, X.; Shieh, P.; Su, M.; Bertozzi, C. R.; Zhang, W. A fluorogenic screening platform enables directed evolution of an alkyne biosynthetic tool. Chem. Commun. (Camb). 2016, 52, 11239-11242.
330. *Xiao, H.; *Woods, E. C.; Vukojicic, P.; Bertozzi, C. R. Precision glycocalyx editing as a strategy for cancer immunotherapy. Proc. Natl. Acad. Sci. U.S.A. 2016, 113, 10304-10309.
329. *Bhat, R.; *Belardi, B.; Mori, H.; Kuo, P.; Tam, A.; Hines, W. C.; Le, Q. T.; †Bertozzi, C. R.; †Bissell, M. J. Nuclear repartitioning of galectin-1 by an extracellular glycan switch regulates mammary morphogenesis. Proc. Natl. Acad. Sci. U.S.A. 2016, 113, E4820-E4827.
328. *Robinson, P. V.; *Tsai, C. T.; de Groot, A. E.; McKechnie, J. L.; Bertozzi, C. R. Glyco-seek: Ultrasensitive detection of protein-specific glycosylation by proximity ligation polymerase chain reaction. J. Am. Chem. Soc. 2016, 138,, 10722-10725.
327. *Hudak, J. E.; *Belardi, B.; Appel, M. J.; Solania, A.; Robinson, P. V.; Bertozzi, C. R. Piperidine-based glycodendrons as protein N-glycan prosthetics. Bioorg. Med. Chem. 2016, S0968-0896, 30383-30292.
326. Ngo, J. T.; Adams, S. R.; Deerinck, T. J.; Boassa, D.; Rodriguez-Rivera, F.; Palida, S. F.; Bertozzi, C. R.; Ellisman, M. H.; Tsien, R. Y. Click-EM for imaging metabolically tagged nonprotein biomolecules. Nat. Chem. Bio. 2016, 12, 459–465.
325. Sheta, R.; Woo, C. M.; Roux-Dalvai, F.; Fournier, F.; Bourassa, S.; Droit, A.; Bertozzi, C. R.; Bachvarov, D. A metabolic labeling approach for glycoproteomic analysis reveals altered glycoprotein expression upon GALNT3 knockdown in ovarian cancer cells. J. Prot. 2016, 145, 91-102.
324. Lantos, A. B.; Carlevaro, G.; Araoz, B.; Ruiz Diaz, P.; Camara, Mde. L.; Buscaglia, C. A.; Bossi, M.; Yu, H.; Chen, X.; Bertozzi, C. R.; †Mucci, J.; †Campetella, O. Sialic acid glycobiology unveils Trypanosoma cruzi trypomastigote membrane physiology. PLoS Pathog. 2016, 12, e1005559.
323. Woo, C. M.; Bertozzi, C R. Isotope targeted glycoproteomics (IsoTaG) to characterize intact, metabolically labeled glycopeptides from complex proteomes. Curr. Protoc. Chem. Biol. 2016, 8, 59-82.
322. Tsai, C.; Robinson, P. V.; Spencer, C. A.; Bertozzi, C. R. Ultrasensitive antibody detection by agglutination-PCR (ADAP). ACS Cent. Sci. 2016, 2, 139-147.
321. Freeman, S. A.; Goyette, J.; Furuya, W.; Woods, E. C.; Bertozzi, C. R.; Bergmeier, W.; Hinz, B.; van der Merwe, P. A.; Das, R.; Grinstein, S. Integrins form an expanding diffusional barrier that coordinates phagocytosis. Cell 2016, 164, 128-140.
320. Woods, E. C.; Yee, N. A.; Shen, J.; Bertozzi, C. R. Glycocalyx engineering with a recycling glycopolymer that increases cell survival in vivo. Angew. Chem. Int. Ed. Engl. 2015, 54, 15782-15788.
319. Kim, J.; Bertozzi, C. R. A bioorthogonal reaction of N-oxide and boron reagents. Angew. Chem. Int. Ed. Engl. 2015, Available online.
318. Varki, A.; Cummings, R. D.; Aebi, M.; Packer, N. H.; Seeberger, P. H.; Esko, J. D.; Stanley, P.; Hart, G.; Darvill, A.; Kinoshita, T.; Prestegard, J. J.; Schnaar, R. L.; Freeze, H. H.; Marth, J. D.; Bertozzi, C. R.; Etzler, M. E.; Frank, M. Vliegenthart, J. F.; Lütteke, T.; Perez, S.; Bolton, E.; Rudd, P.; Paulson, J.; Kanehisa, M.; Toukach, P.; Aoki-Kinoshita, K. F.; Dell, A.; Narimatsu, H.; York, W.; Taniguchi, N.; Kornfeld, S. Symbol nomenclature for graphical representations of glycans. Glycobiology 2015, 25, 1323-1324.
317. Kramer, J. R.; Onoa, B.; Bustamante, C.; Bertozzi, C. R. Chemically tunable mucin chimeras assembled on living cells. Proc. Natl. Acad. Sci. U. S. A. 2015, 112, 12574-12579.
316. Robinson, P. V.; de Almeida-Escobedo, G.; de Groot, A. E.; McKechnie, J. L.; Bertozzi, C. R. Live-cell labeling of specific protein glycoforms by proximity-enhanced bioorthogonal ligation. J. Am. Chem. Soc. 2015, 137, 10452-10455.
315. Belardi, B.; Bertozzi, C. R. Chemical lectinology: tools for probing the ligands and dynamics of mammalian lectins in vivo. Chem Biol. 2015, 15, 259-268.
314. *Agarwal, P.; *Beahm B. J.; Shieh, P.; Bertozzi, C. R. Systemic fluorescence imaging of zebrafish glycans with bioorthogonal chemistry. Angew. Chem. Int. Ed. Engl. 2015. 54, 11504-11510.
313. Tapia, H.; Young, L.; Fox, D.; Bertozzi, C. R.; Koshland, D. Increasing intracellular trehalose is sufficient to confer desiccation tolerance to Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. U. S. A. 2015, 16, 6122-6127.
312. Shieh, P.; Dien, V. T.; Beahm, B. J.; Castellano, J. M.; Wyss-Coray, T.; Bertozzi, C. R. CalFluors: A universal motif for fluorogenic azide probes across the visible spectrum. J. Am. Chem. Soc. 2015, 22, 7145-7151.
311. Woo, C. M.; Iavarone, A. T.; Spiciarich, D. R.; Palaniappan, K. K.; Bertozzi, C. R. Isotope-targeted glycoproteomics (IsoTaG): a mass-independent platform for intact N- and O-glycopeptide discovery and analysis. Nat. Methods. 2015, 6, 561-567.
310. Siegrist, M. S.; Aditham, A.; Espaillat, A.; Cameron, T. A.; Whiteside, S.; Cava, F.; Portnoy, D. A.; Bertozzi, C. R. Host actin polymerization tunes the cell division cycle of an intracellular pathogen. Cell Rep. 2015, 4, 499-507.
309. Kuhn, J.; Götting, C.; Beahm. B. J.; Bertozzi, C. R.; Faust, I.; Kuzaj, P.; Knabbe. C.; Hendig, D. Xylosyltransferase II is the predominant isoenzyme which is responsible for the steady-state level of xylosyltransferase activity in human serum. Biochem. Biophys. Res. Commun. 2015, 3, 469-74.
308. Siegrist, M. S.; Swarts, B. M.; Fox, D. M.; Lim, S. A.; Bertozzi, C. R. Illumination of growth, division and secretion by metabolic labeling of the bacterial cell surface. FEMS Microbiol. Rev. 2015, 39,184-202.
307. Appel, M. J.; Bertozzi, C. R. Formylglycine, a post-translationally generated residue with unique catalytic capabilities and biotechnology applications. ACS Chem. Biol. 2015, 10, 72-84.
306. Agarwal, P.; Bertozzi, C. R. Site-specific antibody-drug conjugates: the nexus of bioorthogonal chemistry, protein engineering, and drug development. Bioconjug. Chem. 2014. 16, 176-192.
305. Touchette, M. H.; Holsclaw, C. M.; Previti, M. L.; Solomon, V. C.; Leary, J. A.; Bertozzi, C. R.; Seeliger, J. C. The rv1184c locus encodes Chp2, an acyltransferase in Mycobacterium tuberculosis polyacyltrehalose lipid biosynthesis. J Bacteriol. 2014.1m 201-10.
304. Shieh, P.; Bertozzi, C. R. Design strategies for bioorthogonal smart probes. Org. Biomol. Chem. 2014, 12, 9307-9320.
303. Meniche, X.; Otten, R.; Siegrist, M. S.; Baer, C. E.; Murphy, K. C.; Bertozzi, C. R.; Sassetti, C. M. Subpolar addition of new cell wall is directed by DivIVA in mycobacteria. Proc. Natl. Acad. Sci. U. S. A. 2014, 111, E3243–E3251.
302. Paszek, M. J.; DuFort, C. C.; Rossier, O.; Bainer, R.; Mouw, J. K.; Godula, K.; Hudak, J. E.; Lakins, J. N.; Wijekoon, A. C.; Cassereau, L.; Rubashkin, M. G.; Magbanua, M. J.; Thorn, K. S.; Davidson, M. W.; Rugo, H. S.; Park, J. W.; Hammer, D. A.; Giannone, G.; Bertozzi, C. R.; Weaver, V. M. The cancer glycocalyx mechanically primes integrin-mediated growth and survival. Nature 2014, 511, 319-325.
301. Smith, E. L.; Bertozzi, C. R.; Beatty, K. E. An Expanded Set of Fluorogenic Sulfatase Activity Probes. Chembiochem. 2014, 15, 1101-1105.
300. Shieh, P.; Siegrist, M. S.; Cullen, A. J.; Bertozzi, C. R. Imaging bacterial peptidoglycan with near-infrared fluorogenic azide probes. Proc. Natl. Acad. Sci. U. S. A. 2014, 111, 5456-5461.
299. Beahm, B. J.; Bertozzi, C. R. "Imaging Cell-Surface Glycans in Animals with Bioorthogonal Chemistry." Glycoscience: Biology and Medicine. Ed. Endo, T.; Seeberger, P. H.; Hart, G. W.; Wong, C-H.; Taniguchi, T. Japan: Springer, 2014.1-11.
298. Smith, E. L.; Giddens, J. P.; Iavarone, A. T.; Godula, K.; Wang, L. X.; Bertozzi, C. R. Chemoenzymatic Fc Glycosylation via Engineered Aldehyde Tags. Bioconjug. Chem. 2014, 25,788-795.
297. Sletten, E. M.; de Almeida, G.; Bertozzi, C. R. A Homologation Approach to the Synthesis of Difluorinated Cycloalkynes. Org. Lett. 2014, 16, 1634-1637.
296. Beahm, B. J.; Dehnert, K. W.; Derr, N. L.; Kuhn, J.; Eberhart, J. K.; Spillmann, D,; Amacher, S. L.; Bertozzi, C. R. A Visualizable Chain-Terminating Inhibitor of Glycosaminoglycan Biosynthesis in Developing Zebrafish. Angew. Chem. Int. Ed. Engl. 2014, 53, 3347-3352.
295. Siegrist, M. S.; Bertozzi, C. R. Mycobacterial lipid logic. Cell Host Microbe. 2014, 15, 1-2.
294. *Hudak, J. E.; *Canham, S. M.; Bertozzi, C. R. Glycocalyx engineering reveals a Siglec-based mechanism for NK cell immunoevasion. Nature Chem. Biol. 2014, 10, 69-75.
293. Hatzios, S. K.; Baer, C. E.; Rustad, T. R.; Siegrist, M. S.; Pang, J. M.; Ortega, C.; Alber, T.; Grundner, C.; Sherman, D. R.; Bertozzi, C. R. Osmosensory signaling in Mycobacterium tuberculosis mediated by a eukaryotic-like Ser/Thr protein kinase. Proc. Natl. Acad. Sci. U. S. A. 2013, 110, E5069-E5077.
292. Hudak, J. E.; Bertozzi, C. R. Glycotherapy: New Advances Inspire a Reemergence of Glycans in Medicine. Chem. Biol. 2013, 21, 16-37.
291. Belardi, B.; de la Zerda, A.; Spiciarich, D. R.; Maund, S. L; Peehl, D. M.; Bertozzi, C. R. Imaging the glycosylation state of cell surface glycoproteins by two-photon fluorescence lifetime imaging microscopy. Angew. Chem. Int. Ed. Engl. 2013, 52, 14045-14049.
290. Bertozzi, C. R.; Wu, P. In vivo chemistry. Curr. Opin. Chem, Biol. 2013, 17, 717-718.
289. Palaniappan, K. K.; Hangauer, M. J.; Smith, T. J.; Smart, B. P.; Pitcher, A. A.; Cheng, E. H.; Bertozzi, C. R.; Boyce, M. A Chemical Glycoproteomics Platform Reveals O-GlcNAcylation of Mitochondrial Voltage-Dependent Anion Channel 2. Cell Rep. 2013, 5, 546-52.
288. Mauris, J.; Mantelli, F.; Woodward, A. M.; Cao, Z.; Bertozzi, C. R.; Panjwani, N.; Godula, K.; Argüeso, P. Modulation of Ocular Surface Glycocalyx Barrier Function by a Galectin-3 N-terminal Deletion Mutant and Membrane-Anchored Synthetic Glycopolymers. PLoS One 2013, 8, e72304.
287. Beatty, K. E.; Williams, M.; Carlson, B. L.; Swarts, B. M.; Warren, R. M.; van Helden, P. D.; Bertozzi, C. R. Sulfatase-activated fluorophores for rapid discrimination of mycobacterial species and strains. Proc. Natl. Acad. Sci. U. S. A. 2013, 110, 12911-12916.
286. Sogi, K. M.; Gartner, Z. J.; Breidenbach, M. A.; Appel, M. J.; Schelle, M. W.; Bertozzi, C. R. Mycobacterium tuberculosis Rv3406 Is a Type II Alkyl Sulfatase Capable of Sulfate Scavenging. PLoS One 2013, 6, e65080.
285. Almeida, G. D.; Townsend, L. C.; Bertozzi, C. R. Synthesis and Reactivity of Dibenzoselenacycloheptynes. Org. Lett. 2013. Available ahead of print.
284. Shin, S. H.; Comolli, L, R.; Tscheliessnig, R.; Wang, C.; Nam, K. T.; Hexemer, A.; Siegerist, C. E.; De Yoreo, J. J.; Bertozzi, C. R. Self-Assembly of “S-Bilayers”, a Step Toward Expanding the Dimensionality of S-Layer Assemblies. A. C. S. Nano. 2013, 7, 4946-4953.
283. Comolli, L. R.; Siegerist, C. E.; Shin, S. H.; Bertozzi, C.; Regan, W.; Zettl, A.; De Yoreo, J. Conformational transitions at an S-layer growing boundary resolved by cryo-TEM. Angew. Chem. Int. Ed. Engl. 2013, 52, 4829-4832.
282. Van de Bittner, G. C.; Bertozzi, C. R.; Chang C. J. Strategy for dual-analyte luciferin imaging: in vivo bioluminescence detection of hydrogen peroxide and caspase activity in a murine model of acute inflammation. J. Am. Chem. Soc. 2013, 135, 1783-1795.
281. Siegrist, M. S.; Whiteside, S.; Jewett, J. C.; Aditham, A.; Cava, F.; Bertozzi, C. R. D-Amino Acid Chemical Reporters Reveal Peptidoglycan Dynamics of an Intracellular Pathogen. ACS Chem. Biol. 2013. 8, 500-505.
280. Agarwal, P.; van der Weijden, J.; Sletten, E. M.; Rabuka, D.; Bertozzi, C. R. A Pictet-Spengler ligation for protein chemical modification. Proc. Natl. Acad. Sci. U. S. A. 2013, 110, 46-51.
279. *Shieh, P.; *Hangauer, M. J.; Bertozzi, C. R. Fluorogenic Azidofluoresceins for Biological Imaging. J. Am. Chem. Soc. 2012, 134, 17428-17431.
278. Swarts, B. M.; Holsclaw, C. M.; Jewett, J. C.; Alber, M.; Fox, D. M.; Siegrist, M. S.; Leary, J. A.; Kalscheuer, R.; Bertozzi, C. R. Probing the Mycobacterial Trehalome with Bioorthogonal Chemistry. J. Am. Chem. Soc. 2012, 134, 16123-16126.
277. Godula, K.; Bertozzi, C. R. Density Variant Glycan Microarray for Evaluating Cross-Linking of Mucin-like Glycoconjugates by Lectins. J. Am. Chem. Soc. 2012, 134, 15732-15742.
276. Henkin, A. H.; Cohen, A. S.; Dubikovskaya, E. A.; Park, H. M.; Nikitin, G. F.; Auzias, M. G.; Kazantzis, M.; Bertozzi, C. R.; Stahl, A. Real time non-invasive imaging of fatty acid uptake in vivo. A. C. S. Chem. Bio. 2012, 7 1884-1891.
275. *Shin, S. H.; *Chung S.; Sanii, B.; Comolli, L. R.; †Bertozzi, C. R.; †De Yoreo, J. J. Direct observation of kinetic traps associated with structural transformations leading to multiple pathways of S-layer assembly. Proc. Natl. Acad. Sci. U.S.A. 2012, 109, 12968-12973.
274. Chang, P. V.; Bertozzi, C. R. Imaging beyond the proteome. Chem. Commun. (Camb). 2012. 48, 8864-8879.
273. Rabuka, D.; Rush, J. S.; deHart, G. W.; Wu, P.; Bertozzi, C. R.; Site-specific chemical protein conjugation using genetically encoded aldehyde tags. Nat. Protoc. 2012, 5, 1052-1067.
272. Gordon, C. G.; Mackey, J. L.; Jewett, J. C.; Sletten, E. M.; †Houk, K. N.; †Bertozzi, C. R.; Reactivity of Biarylazacyclooctynones in Copper-Free Click Chemistry. J. Am. Chem. Soc. 2012, 134, 9199-9208.
271. Belardi, B.; O'Donoghue, G. P.; Smith, A. W.; Groves, J. T.; Bertozzi, C. R. Investigating Cell Surface Galectin-Mediated Cross-linking on Glycoengineered Cells. J. Am. Chem. Soc. 2012, 134, 9549-9552.
270. Onoe, H.; Hsiao, S. C.; Douglas, E. S.; Gartner, Z. J.; Bertozzi, C. R.; Francis, M. B.; Mathies, R. A. Cellular Microfabrication: Observing Intercellular Interactions Using Lithographically-Defined DNA Capture Sequences. Langmuir 2012, 28, 8120-8126.
269. Yu, S. H.; Boyce, M.; Wands, A. M.; Bond, M. R.; Bertozzi, C. R.; Kohler, J. J. Metabolic labeling enables selective photocrosslinking of O-GlcNAc-modified proteins to their binding partners. Proc. Natl. Acad. Sci. U.S.A. 2012, 109, 4834-4839.
268. Hudak, J. E.; Barfield, R. M.; de Hart, G.W.; Grob, P.; Nogales, E.; Bertozzi, C.R.; Rabuka, D. Synthesis of Heterobifunctional Protein Fusions Using Copper-Free Click Chemistry and the Aldehyde Tag.. Angew Chem Int Ed Engl. 2012, 51, 4161-4165.
267. *Griffin, J. E.; *Pandey, A. K.; Gilmore, S. A.; Mizrahi, V.; McKinney, J. D.; Bertozzi, C. R.; Sassetti C.M. Cholesterol Catabolism by Mycobacterium tuberculosis Requires Transcriptional and Metabolic Adaptations. Chem Biol. 2012, 19, 218-227.
266. Gilmore, S. A.; Schelle, M. W.; Holsclaw, C. M.; Leigh, C. D.; Jain, M.; Cox, J. S.; Leary, J. A.; Bertozzi, C. R. Sulfolipid-1 Biosynthesis Restricts Mycobacterium tuberculosis Growth in Human Macrophages. ACS Chem Biol. 2012, 7, 863-870.
265. de Almeida, G.; Sletten, E. M.; Nakamura, H.; Palaniappan, K. K.; Bertozzi, C. R. Thiacycloalkynes for Copper-Free Click Chemistry. Angew Chem Int Ed Engl. 2012, 51, 2443-2447.
264. Seeliger, J. C.; Topp, S.; Sogi, K. M.; Previti, M. L.; Gallivan, J. P.; Bertozzi, C. R. A riboswitch-based inducible gene expression system for mycobacteria.. PLoS One. 2012, 7, e29266.
263. Dehnert, K. W.; Baskin, J. M.; Laughlin, S. T.; Beahm, B. J.; Naidu, N. N.; Amacher, S. L.; Bertozzi, C. R. Imaging the Sialome during Zebrafish Development with Copper-Free Click Chemistry. Chembiochem. 2012, 13, 353-357.
262. *Breidenbach, M. A.; *Palaniappan, K. K.; Pitcher, A. A.; Bertozzi, C. R. Mapping yeast N-glycosites with isotopically recoded glycans. Mol Cell Proteomics. 2012, 11, M111.015339.
261. Yao, J. Z.; Uttamapinant, C.; Poloukhtine, A. A.; Baskin, J. M.; Codelli, J. A.; Sletten, E. M.; Bertozzi, C. R.; Popik, V. V.; Ting, A. Y. Fluorophore targeting to cellular proteins via enzyme-mediated azide ligation and strain-promoted cycloaddition. J Am Chem Soc. 2012, 134, 3720-3728.
260. *An, H. J.; *Gip, P.; Kim, J.; Wu, S.; Park, K. W.; McVaugh, C. T.; †Schaffer, D. V.; †Bertozzi, C. R.; †Lebirlla, C. B. Extensive Determination of Glycan Heterogeneity Reveals an Unusual Abundance of High-Mannose Glycans in Enriched Plasma Membranes of Human Embryonic Stem Cells Mol Cell Proteomics. 2012, 11, M111.010660.
259. Seeliger, J. C.; Holsclaw, C. M.; Schelle, M. W.; Botyanszki, Z.; Gilmore, S. A.; Tully, S. E.; Niederweis, M.; Cravatt, B. F.; Leary, J. A.; Bertozzi, C. R. Elucidation and Chemical Modulation of Sulfolipid-1 Biosynthesis in Mycobacterium tuberculosis. J Biol Chem. 2012, 287, 7990-8000.
258. Jewett, J. C.; Bertozzi, C. R. Synthesis of a Fluorogenic Cyclooctyne Activated by Cu-Free Click Chemistry. Org Lett. 2011, 13, 5937-5939.
257. Bertozzi, C. R. A decade of bioorthogonal chemistry. Acc. Chem. Res 2011, 44, 651-653.
256. Sletten, E. M.; Bertozzi, C. R. A bioorthogonal quadricyclane ligation. J. Am. Chem. Soc. 2011, 133, 17570-17573.
255. Hudak, J. E.; Yu H. H.; Bertozzi, C. R. Protein Glycoengineering Enabled by the Versatile Synthesis of Aminooxy Glycans and the Genetically Encoded Aldehyde Tag. J. Am. Chem. Soc. 2011, 40, 16127-35.
254. Sletten, E. M.; Bertozzi, C. R. From Mechanism to Mouse: A Tale of Two Bioorthogonal Reactions. Acc Chem Res. 2011, 44, 666-676.
253. Boyce, M.; Bertozzi, C. R. Bringing chemistry to life. Nat Methods. 2011, 8, 638-642.
252. Hatzios, S. K.; Bertozzi, C. R. The Regulation of Sulfur Metabolism in Mycobacterium tuberculosis. PLoS Pathog. 2011, 7,e1002036.
251. Hatzios, S. K.; Schelle, M. W.; Newton, G. L.; Sogi, K. M.; Holsclaw, C. M.; Fahey, R. C.; Bertozzi, C. R. The Mycobacterium tuberculosis CysQ phosphatase modulates the biosynthesis of sulfated glycolipids and bacterial growth. Bioorg Med Chem Lett. 2011, 21, 4945-4950.
250. Hubbard, S. C.; Boyce M.; McVaugh, C. T.; Peehl, D. M.; Bertozzi, C. R. Cell surface glycoproteomic analysis of prostate cancer-derived PC-3 cells. Bioorg Med Chem Lett. 2011, 21, 4945-4950.
249. *Palaniappan, K. K.; *Pitcher, A. A.; *Smart, B. P.; Spiciarich, D. R.; Iavarone, A. T.; Bertozzi, C. R. Isotopic signature transfer and mass pattern prediction (IsoStamp): An enabling technique for chemically-directed proteomics. ACS Chem. Biol. 2011, 6, 829-836.
248. Dehnert, K. W.; Beahm, B. J.; Huynh, T. T.; Baskin, J. M.; Laughlin, S. T.; Wang, W.; Wu, P.; Amacher, S. L.; Bertozzi, C. R. Metabolic labeling of fucosylated glycans in developing zebrafish. ACS Chem. Biol. 2011, 6, 547-552.
247. Boyce, M.; Carrico, I. S.; Ganguli, A. S.; Yu, S.-H.; Hangauer, M. J.; Hubbard, S. C.; Kohler, J. J.; Bertozzi, C. R. Metabolic cross-talk allows labeling of O-linked ß-N-acetylglucosamine-modified proteins via the N-acetylgalactosamine salvage pathway. Proc. Natl. Acad. Sci. U.S.A. 2011, 108, 3141-3146.
246. Shui, W.; Petzold, C. J.; Redding, A.; Liu, J.; Pitcher, A.; Sheu, L.; Hsieh, T.; Keasling, J. D.; Bertozzi, C. R. Organelle membrane proteomics reveals differential influence of mycobacterial lipoglycans on macrophage phagosome maturation and autophagosome accumulation. J. Proteome Res. 2011, 10, 339-348.
245. Binda, O.; Boyce, M.; Rush, J. S.; Palaniappan, K. K.; Bertozzi, C. R.; Gozani, O. A chemical method for labeling lysine methyltransferase substrates. ChemBioChem 2011, 12, 330-334.
244. Jasti, R.; Bertozzi, C. R. Progress and challenges for the bottom-up synthesis of carbon nanotubes with discrete chirality. Chem. Phys. Lett. 2010, 494, 1-7.
243. Van de Bittner, G. C.; Dubikovskaya, E. A.; Bertozzi, C. R.; Chang, C. J. In vivo imaging of hydrogen peroxide production in a murine tumor model with a chemoselective bioluminescent reporter. Proc. Natl. Acad. Sci. U.S.A. 2010, 107, 21316-21321.
242. Topp, S.; Reynoso, C. M.; Seeliger, J. C.; Goldlust, I. S.; Desai, S. K.; Murat, D.; Shen, A.; Puri, A. W.; Komeili, A.; Bertozzi, C. R.; Scott, J. R.; Gallivan, J. P. Synthetic riboswitches that induce gene expression in diverse bacterial species. Appl. Environ. Microbiol. 2010, 76, 7881-7884.
241. Rush, J. S.; Beatty, K. E.; Bertozzi, C. R. Bioluminescent probes of sulfatase activity. ChemBioChem 2010, 15, 2096-2099.
240. Beatty, K. E.; Fisk, J. D.; Smart, B. P.; Lu, Y. Y.; Szychowski, J.; Hangauer, M. J.; Baskin, J. M.; Bertozzi, C. R.; Tirrell, D. A. Live-cell imaging of cellular proteins by a strain-promoted azide-alkyne cycloaddition. ChemBioChem 2010, 15, 2092-2095.
239. Chung, S.; Shin, S.-H.; Bertozzi, C. R.; De Yoreo, J. J. Self-catalyzed growth of S layers via an amorphous-to-crystalline transition limited by folding kinetics. Proc. Natl. Acad. Sci. U.S.A. 2010, 107, 16536-16541.
238. Sletten, E. M.; Nakamura, H.; Jewett, J. C.; Bertozzi, C. R. Difluorobenzocyclooctyne: synthesis, reactivity, and stabilization by beta-cyclodextrin. J. Am. Chem. Soc. 2010, 132, 11799-11805.
237. Godula, K.; Bertozzi, C. R. Synthesis of glycopolymers for microarray applications via ligation of reducing sugars to a poly(acryloyl hydrazide) scaffold. J. Am. Chem. Soc. 2010, 132, 9963-9965.
236. Chang, P. V.; Dube, D. H.; Sletten, E. M.; Bertozzi, C. R. A strategy for the selective imaging of glycans using caged metabolic precursors. J. Am. Chem. Soc. 2010, 132, 9516-9518.
235. Baskin, J. M.; Bertozzi, C. R. Copper-free click chemistry: bioorthogonal reagents for tagging azides. Aldrichimica Acta 2010, 43, 15-23.
234. Cohen, A. S.; Dubikovskaya, E. A.; Rush, J. S.; Bertozzi, C. R. Real-time bioluminescence imaging of glycans on living cells. J. Am. Chem. Soc. 2010, 132, 8563-8565.
233. *Baskin, J. M.; *Dehnert, K. W.; *Laughlin, S. T.; Amacher, S. L.; Bertozzi, C. R. Visualizing enveloping layer glycans during zebrafish early embryogenesis. Proc. Natl. Acad. Sci. U.S.A. 2010, 107, 10360-10365.
232. Muia, R. P.; Yu, H.; Prescher, J. A.; Hellman, U.; Chen, X.; Bertozzi, C. R.; Campetella, O. Identification of glycoproteins targeted by Trypanosoma cruzi trans-sialidase, a virulence factor that disturbs lymphocyte glycosylation. Glycobiology 2010, 20, 833-842.
231. Jewett, J. C.; Bertozzi, C. R. Cu-free click cycloaddition reactions in chemical biology. Chem. Soc. Rev. 2010, 39, 1272-1279.
230. Jewett, J. C.; Sletten, E. M.; Bertozzi, C. R. Cu-free click chemistry with readily synthesized biarylazacyclooctynones. J. Am. Chem. Soc. 2010, 132, 3688-3690.
229. Breidenbach, M. A.; Gallagher, J. E. G.; King, D. S.; Smart, B. P.; Wu, P.; Bertozzi, C. R. Targeted metabolic labeling of yeast N-glycans with unnatural sugars. Proc. Natl. Acad. Sci. U.S.A. 2010, 107, 3988-3993.
228. *Chang, P. V.; *Prescher, J. A.; Sletten, E. M.; Baskin, J. M.; Miller, I. A.; Agard, N. J.; Lo, A.; Bertozzi, C. R. Copper-free click chemistry in living animals. Proc. Natl. Acad. Sci. U.S.A. 2010, 107, 1821-1826.
227. *Yap, M. C.; *Kostiuk, M. A.; Martin, D. D.; Perinpanayagam, M. A.; Hak, P. C.; Siddam, A.; Majjigapu, J. R.; Rajaiah, G.; Keller, B. O.; Prescher, J. A.; Wu, P.; Bertozzi, C. R.; Falck, J. R.; Berthiaume, L. G. Rapid and selective detection of fatty acylated proteins using omega-alkynyl-fatty acids and click chemistry. J. Lipid Res. 2010, 51, 1566-1580.
226. Laughlin, S. T.; Bertozzi, C. R. In Vivo Imaging of Caenorhabditis elegans Glycans. ACS Chem. Biol. 2009, 4, 1068-1072.
225. Varki, A.; Cummings, R. D.; Esko, J. D.; Freeze, H. H.; Stanley, P.; Marth, J. D.; Bertozzi, C. R.; Hart, G. W.; Etzler, M. E. Symbol nomenclature for glycan representation. Proteomics 2009, 9, 5398-5399.
224. Sletten, E. M.; Bertozzi, C. R. Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality. Angew. Chem., Int. Ed. 2009, 48, 6974-6998.
223. Godula, K.; Umbel, M. L.; Rabuka, D.; Botyanszki, Z.; Bertozzi, C. R.; Parthasarathy, R. Control of the Molecular Orientation of Membrane-Anchored Biomimetic Glycopolymers. J. Am. Chem. Soc. 2009, 131, 10263-10268.
222. Drake, P. M.; Stock, C. M.; Nathan, J. K.; Gip, P.; Golden, K. P.; Weinhold, B.; Gerardy-Schahn, R.; Bertozzi, C. R. Polysialic acid governs T-cell development by regulating progenitor access to the thymus. Proc. Natl. Acad. Sci. U.S.A. 2009, 106, 11995-12000.
221. Douglas, E. S.; Hsiao, S. C.; Onoe, H.; Bertozzi, C. R.; Francis, M. B.; Mathies, R. A. DNA-barcode directed capture and electrochemical metabolic analysis of single mammalian cells on a microelectrode array. Lab Chip 2009, 9, 2010-2015.
220. Hsiao, S.C.; Shum, B.J.; Onoe, H.; Douglas, E.S.; Gartner, Z.J.; Mathies, R.A.; Bertozzi, C.R.; Francis, M.B. Direct cell surface modification with DNA for the capture of primary cells and the investigation of myotube formation on defined patterns. Langmuir 2009, 25, 6985-6991.
219. Godula, K.; Rabuka, D.; Nam, K.T.; Bertozzi, C.R. Synthesis and Microcontact Printing of Dual End-Functionalized Mucin-Like Glycopolymers for Microarray Applications. Angew. Chem., Int. Ed. 2009, 48, 4973-4976.
218. Song, J.; Xu, J.; Filion, T.; Saiz, E.; Tomsia, A. P.; Lian, J. B.; Stein, G. S.; Ayers, D. C.; Bertozzi, C. R. Elastomeric high-mineral content hydrogel-hydroxyapatite composites for orthopedic applications. J. Biomed. Mater. Res. 2009, 89, 1098-1107.
217. Perrine, C. L.; Ganguli, A.; Wu, P.; Bertozzi, C. R.; Fritz, T. A.; Raman, J.; Tabak, L. A.; Gerken, T. A. The glycopeptdie preferring polypeptide-GalNAc transferase-10 (ppGalNAc T10), involved in mucin type-O-glycosylation, has a unique GalNAc-O-Ser/Thr binding site in its catalytic domain not found in ppGalNAc T1 or T2. J. Biol. Chem. 2009, 284, 20387-20397.
216. Nessen, M. A.; Kramer, G.; Back, J.; Baskin, J. M.; Smeenk, L. E.; Van Maarseveen, J.; de Koning, L. J.; de Jong, L.; Bertozzi, C.; Hiemstra, H.; de Koster, C. G. Selective Enrichment of Azide-Containing Peptides from Complex Mixtures. J. Proteome Res. 2009, 8, 3702-3711.
215. Chang, P. V.; Chen, X.; Smyrniotis, C.; Xenakis, A.; Hu, T.; Bertozzi, C. R.; Wu, P. Metabolic Labeling of Sialic Acids in Living Animals with Alkynyl Sugars. Angew. Chem., Int. Ed. 2009, 48, 4030-4033. [Download PDF]
214. Agard, N. J.; Bertozzi, C. R. Chemical Approaches to Perturb, Profile, and Perceive Glycans. Acc. Chem. Res. 2009, 42, 788-797.
213. Hur, G. H.; Meier, J. L.; Baskin, J.; Codelli, J. A.; Bertozzi, C. R.; Marahiel, M. A.; Burkart, M. D. Crosslinking Studies of Protein-Protein Interactions in Nonribosomal Peptide Biosynthesis. Chem. Biol. 2009, 16, 372-381.
212. Harland, C. W.; Botyanszki, Z.; Rabuka, D.; Bertozzi, C. R.; Parthasarathy, R. Synthetic Trehalose Glycolipids Confer Dessication Resistance to Supported Lipid Monolayers. Langmuir 2009, 25, 5193-5198.
211. Barb, A. W.; Leavy, T. M.; Robins, L. I.; Guan, Z.; Six, D. A.; Zhou, P.; Bertozzi, C. R.; Raetz, C. R. Uridine-Based Inhibitors as New Leads for Antibiotics Targeting Escherichia coli LpxC. Biochemistry 2009, 48, 3068-3077.
210. Gartner, Z. J.; Bertozzi, C. R. Programmed assembly of 3-dimensional microtissues with defined cellular connectivity. Proc. Natl. Acad. Sci. U.S.A. 2009, 106, 4606-4610.
209. Hatzios, S. K.; Schelle, M. W.; Holsclaw, C. M.; Behrens, C. R.; Botyanszki, Z.; Lin, F. L.; Carlson, B. L.; Kumar, P.; Leary, J. A.; Bertozzi, C. R. PapA3 is an acyltransferase required for Polyacyltrehalose biosynthesis in Mycobacterium tuberculosis. J. Biol. Chem. 2009, 284, 12745-12751.
208. Wu, P.; Shui, W.; Carlson, B. L.; Hu, N.; Rabuka, D.; Lee, J.; Bertozzi, C. R. Site-specific chemical modification of recombinant proteins produced in mammalian cells by using the genetically encoded aldehyde tag. Proc. Natl. Acad. Sci. U.S.A. 2009, 106, 3000-3005.
207. Chen, X.; Wu, P.; Rousseas, M.; Okawa, D.; Gartner, Z.; Zettl, A.; Bertozzi, C. R. Boron Nitride Nanotubes Are Noncytotoxic and Can Be Functionalized for Interaction with Proteins and Cells. J. Am. Chem. Soc. 2009, 131, 890-891.
206. Laughlin, S. T.; Bertozzi, C. R. Imaging the Glycome. Proc. Natl. Acad. Sci. U.S.A. 2009, 106, 12-17.
205. Wu, P.; Chen, X.; Hu, N.; Tam, U. C.; Blixt, O.; Zettl, A.; Bertozzi, C. R. Biocompatible carbon nanotubes generated by functionalization with glycodendrimers. Angew. Chem., Int. Ed. 2008, 47, 5022-5025. [Download PDF]
204. Toriello, N. M.; Douglas, E. S.; Thaitrong, N.; Hsiao, S. C.; Francis, M. B.; Bertozzi, C. R.; Mathies, R. A. Integrated Microfluidic Bioprocessor for Single-Cell Gene Expression Analysis. Proc. Natl. Acad. Sci. U.S.A. 2008, 105, 20173-20178.
203. Shui, W.; Gilmore, S. A.; Sheu, L.; Liu, J.; †Keasling, J. D.; †Bertozzi, C. R. Quantitative Proteomic Profiling of Host-Pathogen Interactions: The Macrophage Response to Mycobacterium tuberculosis Lipids. J. Prot. Res. 2008, 8, 282-289.
202. Jasti, R.; Bhattacharjee, J.; Neaton, J. B.; Bertozzi, C. R. Synthesis, Characterization, and Theory of [9]-, [12]-, and [18]Cycloparaphenylene: Carbon Nanohoop Structures. J. Am. Chem. Soc. 2008, 130, 17646-17647.
201. Drake, P. M.; Nathan, J. K.; Stock, C. M.; Chang, P. V.; Muench, M. O.; Nakata, D.; Reader, J. R.; Gip, P.; Golden, K. P.; Weinhold, B.; Gerardy-Schahn, R.; Troy, F. A. 2nd, Bertozzi, C. R. Polysialic acid, a glycan with highly restricted expression, is found on human and murine leukocytes and modulates immune responses. J. Immunol. 2008, 181, 6850-6858.
200. Shui, W.; Sheu, L.; Liu, J.; Smart, B.; Petzold, C. J.; Hsieh, T. Y.; Pitcher, A.; Keasling, J. D.; Bertozzi, C. R. Membrane proteomics of phagosomes suggests a connection to autophagy. Proc. Natl. Acad. Sci. U.S.A. 2008, 105, 16952-16957.
199. Holsclaw, C. M.; Sogi, K. M.; Gilmore, S. A.; Schelle, M. W.; Leavell, M. D.; Bertozzi, C. R.; Leary, J. A. Structural Characterization of a Novel Sulfated Menaquinone produced by stf3 from Mycobacterium tuberculosis. ACS Chem. Biol. 2008, 3, 619-624.
198. Hsiao, S. C.; Crow, A. K.; Lam, W. A.; Bertozzi, C. R.; Fletcher, D. A.; Francis, M. B. DNA-Coated AFM Cantilevers for the Investigation of Cell Adhesion and the Patterning of Live Cells. Angew. Chem., Int. Ed. 2008, 120, 8601-8605.
197. Czlapinski, J. L.; Schelle, M. W.; Miller, L. W.; Laughlin, S. T.; Kohler, J. J.; Cornish, V. W.; Bertozzi, C. R. Conditional Glycosylation in Eukaryotic Cells Using a Biocompatible Chemical Inducer of Dimerization. J. Am. Chem. Soc. 2008, 130, 13186-13187.
196. Rush, J. S.; Bertozzi, C. R. New Aldehyde Tag Sequences Identified by Screening Formylglycine Generating Enzymes in Vitro and in Vivo. J. Am. Chem. Soc. 2008, 130, 12240-12241.
195. Codelli, J. A.; Baskin, J. M.; Agard, N. J.; Bertozzi, C. R. Second-Generation Difluorinated Cyclooctynes for Copper-Free Click Chemistry. J. Am. Chem. Soc. 2008, 130, 11486-11493.
194. Johnson, J. A.; Baskin, J. M.; Bertozzi, C. R.; Koberstein, J. T.; Turro, N. J. Copper-free click chemistry for the in situ crosslinking of photodegradable star polymers. Chem. Commun. 2008, 3064-3066.
193. Paulick, M. G.; Bertozzi, C. R. The Glycosylphosphatidylinositol Anchor: A Complex Membrane-Anchoring Structure for Proteins. Biochemistry 2008, 47, 6991-7000.
192. Sletten, E. M.; Bertozzi, C. R. A Hydrophilic Azacyclooctyne for Cu-Free Click Chemistry. Org. Lett. 2008, 10, 3097-3099.
191. Hatzios, S. K.; Iavarone, A. T.; Bertozzi, C. R. Rv2131c from Mycobacterium tuberculosis Is a CysQ 3'-Phosphoadenosine-5'-phosphatase. Biochemistry 2008, 47, 5823-5831.
190. *Laughlin, S. T.; *Baskin, J. M.; Amacher, S. L.; Bertozzi, C. R. In vivo imaging of membrane-associated glycans in developing zebrafish. Science 2008, 320, 664-667.
189. Rabuka, D.; Forstner, M. B.; Groves, J. T.; Bertozzi, C. R. Noncovalent Cell Surface Engineering: Incorporation of Bioactive Synthetic Glycopolymers into Cellular Membranes. J. Am. Chem. Soc. 2008, 130, 5947-5953.
188. Harland, C. W.; Rabuka, D.; Bertozzi, C. R.; Parthasarathy, R. The Mycobacterium tuberculosis Virulence Factor Trehalose Dimycolate Imparts Desiccation Resistance to Model Mycobacterial Membranes. Biophys. J. 2008, 94, 4718-4724.
187. Carlson, B. L.; Ballister, E. R.; Skordalakes, E.; King, D. S.; Breidenbach, M. A.; Gilmore, S. A.; Berger, J. M.; Bertozzi, C. R. Function and structure of a prokaryotic formylglycine-generating enzyme. J. Biol. Chem. 2008, 283, 20117-20125.
186. Hangauer, M. J.; Bertozzi, C. R. A FRET-based fluorogenic phosphine for live-cell imaging with the Staudinger ligation. Angew. Chem., Int. Ed. 2008, 47, 2394-2397.
185. Leigh, C. D.; Bertozzi, C. R. Synthetic Studies toward Mycobacterium tuberculosis Sulfolipid-I. J. Org. Chem. 2008, 73, 1008-1017.
184. Martin, D. D.; Vilas, G. L.; Prescher, J. A.; Rajaiah, G.; Falck, J. R.; Bertozzi, C. R.; Berthiaume, L. G. Rapid detection, discovery, and identification of post-translationally myristoylated proteins during apoptosis using a bio-orthogonal azidomyristate analog. FASEB J. 2008, 22, 797-806.
183. *Kostiuk, M. A.; *Corvi, M. M.; Keller, B. O.; Plummer, G.; Prescher, J. A.; Hangauer, M. J.; Bertozzi, C. R.; Rajaiah, G.; Falck, J. R.; Berthiaume, L. G. Identification of palmitoylated mitochondrial proteins using a bio-orthogonal azido-palmitate analogue. FASEB J. 2008, 22, 721-732.
182. Bertozzi, C. R.; Schelle, M. W. Sulfated Metabolites from Mycobacterium tuberculosis: Sulfolipid-1 and Beyond. In The Mycobacterial Cell Envelope, D. Mamadou & J.-M. Reyrat, Editors. ASM Press (Washington, DC), 2008.
181. Baskin, J. M.; Bertozzi, C. R. Bioorthogonal Click Chemistry: Covalent Labeling in Living Systems. QSAR Comb. Sci. 2007, 26, 1211-1219.
180. Paulick, M. G.; Forstner, M. B.; Groves, J. T.; Bertozzi, C. R. A chemical approach to unraveling the biological function of the glycosylphosphatidylinositol anchor. Proc. Natl. Acad. Sci. U.S.A. 2007, 104, 20332-20337.
179. Fernandez-Suarez, M.; Baruah, H.; Martinez-Hernandez, L.; Xie, K. T.; Baskin, J. M.; Bertozzi, C. R.; Ting, A. Y. Redirecting lipoic acid ligase for cell surface protein labeling with small-molecule probes. Nat. Biotechnol. 2007, 25, 1483-1487.
178. Douglas, E. S.; Chandra, R. A.; Bertozzi, C. R.; Mathies, R. A.; Francis, M. B. Self-assembled cellular microarrays patterned using DNA barcodes. Lab Chip 2007, 7, 1442-1448.
177. Parthasarathy, R.; Rabuka, D.; Bertozzi, C. R.; Groves, J. T. Molecular orientation of membrane-anchored mucin glycoprotein mimics. J. Phys. Chem. B. 2007, 111, 12133-12135.
176. Baskin, J. M.; Prescher, J. A.; Laughlin, S. T.; Agard, N. J.; Chang, P. V.; Miller, I. A.; Lo, A.; Codelli, J. A.; Bertozzi, C. R. Copper-free click chemistry for dynamic in vivo imaging. Proc. Natl. Acad. Sci. U.S.A. 2007, 104, 16793-16797.
175. Paulick, M. G.; Wise, A. R.; Forstner, M. B.; Groves, J. T.; Bertozzi, C. R. Synthetic analogues of glycosylphosphatidylinositol-anchored proteins and their behavior in supported lipid bilayers. J. Am. Chem. Soc. 2007, 129, 11543-11550.
174. Laughlin, S. T.; Bertozzi, C. R. Metabolic labeling of glycans with azido sugars and subsequent glycan-profiling and visualization via Staudinger ligation. Nat. Protoc. 2007, 2, 2930-2944.
173. Lin, F. L.; van Halbeek, H.; Bertozzi, C. R. Synthesis of Mono- and Dideoxygenated a,a-Trehalose Analogs. Carbohydr. Res. 2007, 342, 2014-2030.
172. Chang. P. V.; Prescher, J. A.; Hangauer, M. J.; Bertozzi, C. R. Imaging Cell Surface Glycans with Bioorthogonal Chemical Reporters. J. Am. Chem. Soc. 2007, 129, 8400-8401.
171. *Kumar, P.; *Schelle, M. W.; Jain, M.; Lin, F. L.; Petzold, C. J.; Leavell, M. D.; Leary, J. A.; Cox, J. S.; Bertozzi, C. R. PapA1 and PapA2 are Acyltransferases Essential for the Biosynthesis of the Mycobacterium tuberculosis Virulence Factor Sulfolipid-1. Proc. Natl. Acad. Sci. U.S.A. 2007, 104, 11221-11226.
170. Leavy, T. L.; Bertozzi, C. R. A High-Throughput Assay for O-GlcNAc Transferase Detects Primary Sequence Preferences in Peptide Substrates. Bioorg. Med. Chem. Lett. 2007, 7, 3851-3854.
169. Rabuka, D.; Parthasarathy, R.; Lee, G. S.; Chen, X.; Groves, J. T.; Bertozzi, C. R. Hierarchical Assembly of Model Cell Surfaces: Synthesis of Mucin Mimetic Polymers and Their Display on Supported Bilayers. J. Am. Chem. Soc. 2007, 129, 5462-5471.
168. *Carrico, I. S.; *Carlson, B. L.; Bertozzi, C. R. Introducing Genetically Encoded Aldehydes into Proteins. Nature Chem. Biol. 2007, 3, 321-322.
167. Jain, M; Petzold, C.J.; Schelle, M.W.; Leavell, M.D.; Mougous, J.D.; Bertozzi, C.R.; Leary, J.A.; Cox, J.S. Lipidomics Reveals Control of Mycobacterium tuberculosis Virulence Lipids via Metabolic Coupling. Proc. Natl. Acad. Sci. U.S.A. 2007, 104, 5133-5138.
166. Chen, X.; Kis, A.; Zettl, Z.; Bertozzi, C. R. A Cell Nanoinjector Based on Carbon Nanotubes. Proc. Natl. Acad. Sci. U.S.A. 2007, 104, 8218-8222.
165. Senaratne, R. H.; Mougous, J. D.; Reader, J. R.; Williams, S. J.; Zhang, T.; Bertozzi, C. R.; Riley, L. W. Vaccine Efficacy of Attenuated but Persistent Mycobacterium tuberculosis cysH Mutant. J. Med. Microbiol. 2007, 56, 454-458.
164. Gao, H.; Leary, J.; Carroll, K. S.; Bertozzi, C. R.; Chen, H. Noncovalent Complexes of APS Reductase from M. tuberculosis: Delineating a Mechanistic Model Using ESI-FTICR MS. J. Am. Soc. Mass Spectrom. 2007, 18, 167-178.
163. Laughlin, S. T.; Agard, N. J.; Baskin, J. M.; Carrico, I. S.; Chang, P. V.; Ganguli, A. S.; Hangauer, M. J.; Lo, A.; Prescher, J. A.; Bertozzi, C. R. Metabolic Labeling of Glycans with Azido Sugars for Visualization and Glycoproteomics. Methods Enzymol. 2006, 415, 230-250.
162. Czlapinski, J. L.; Bertozzi, C. R. Synthetic Glycobiology: Exploits in the Golgi Compartment. Curr. Opin. Chem. Biol. 2006, 10, 645-51.
161. Agard, N. J.; Baskin, J. M.; Prescher, J. A.; Lo, A.; Bertozzi, C. R. A Comparative Study of Bioorthogonal Reactions with Azides. ACS Chem. Biol. 2006, 1, 644-8.
160. *Kehoe, J. W.; *Velappan, N.; Walbolt, M.; Rasmussen, J.; King, D.; Lou, J.; Knopp, K.; Pavlik, P.; Marks, J.; †Bertozzi, C. R.; †Bradbury, A. R. M. Using Phage Display to Select Antibodies Recognizing Post-translational Modifications Independently of Sequence Context. Mol. Cell. Proteomics 2006, 5, 2350-63.
159. Chartron, J.; Carroll, K. S.; Shiau, C.; Gao, H.; Leary, J. A.; Bertozzi, C. R.; Stout, C. D. Substrate Recognition, Protein Dynamics, and Iron-Sulfur Cluster in Pseudomonas aeruginosa Adenosine 5’-Phosphosulfate Reductase. J. Mol. Biol. 2006 364, 152-69.
158. Rabuka, D.; Hubbard, S. C.; Laughlin, S. T.; Argade, S. P.; Bertozzi, C. R. A Chemical Reporter Strategy to Probe Glycoprotein Fucosylation. J. Am. Chem. Soc. 2006, 128, 12078-9.
157. Schelle, M. W.; Bertozzi, C. R. Sulfate Metabolism in Mycobacteria. ChemBioChem 2006, 7, 1516-24.
156. Prescher, J. A.; Bertozzi, C. R. Chemical Technologies for Probing Glycans. Cell 2006, 126, 851-854.
155. Stowell, C. L.; Barvian, K. K.; Young, P. C.; Bigsby, R. M.; Verdugo, D. E.; Bertozzi, C. R.; Widlanski, T. S. A Role for Sulfation-Desulfation in the Uptake of Bisphenol A Into Breast Tumor Cells. Chem. Biol. 2006, 13, 891-897.
154. Link, A. J.; Vink, M. K.; Agard, N. J.; Prescher, J. A.; Bertozzi, C. R.; Tirrell, D. A. Discovery of Aminoacyl-tRNA Synthetase Activity Through Cell Surface Display of Noncanonical Amino Acids. Proc. Natl. Acad. Sci. U.S.A. 2006, 103, 10180-5.
153. Chen, X.; Tam, U. C.; Czlapinski, J. L.; Lee, G. S.; Rabuka, D.; Zettl, A.; Bertozzi, C. R. Interfacing Carbon Nanotubes with Living Cells. J. Am. Chem. Soc. 2006, 128, 6292-3.
152. *Dube, D. H.; *Prescher, J. A.; Quang, C. N.; Bertozzi, C. R. Probing Mucin-type O-linked Glycosylation in Living Animals. Proc. Natl. Acad. Sci. U.S.A. 2006, 103, 4819-24.
151. Juan Perez-Vilar, Raean Mabolo, Cheryl T. McVaugh, Carolyn R. Bertozzi, and Richard C. Boucher. Mucin Granule Intraluminal Organization in Living Mucous/Goblet Cells. Roles of Protein Post-translational Modifications and Secretion. J. Biol. Chem. 2006, 281, 4844-55.
150. Senaratne, R. H.; DeSilva, D.; Williams, S. J.; Mougous, J. D.; Zhang, T.; Chan, S.; Sidders, B.; Chan, J.; Bertozzi, C. R.; W. Riley, L. W. 5’-Adenosinephosphosulphate Reductase (CysH) Protects Mycobacterium tuberculosis Against Free Radicals During Chronic Infection Phase in Mice. Mol. Microbiol. 2006, 59, 1744-53.
149. Mougous, J. D.; Senaratne, R. H.; Petzold, C. J.; Jain, M.; Lee, D. H.; Schelle, M. W.; Leavell, M. D.; Cox, J. S.; Leary, J. A.; Riley, L. W.; Bertozzi, C. R. A Sulfated Metabolite Produced by stf3 Negatively Regulates the Virulence of Mycobacterium tuberculosis. Proc. Natl. Acad. Sci. U.S.A. 2006, 103, 4258-63.
148. Rush, J. S.; Bertozzi, C. R. An a-formylglycine building block for Fmoc-based solid phase peptide synthesis. Org. Lett. 2006, 8, 131-134.
147. Mougous, J. D.; Lee, D. H.; Hubbard, S. C.; Schelle, M. W.; Vocadlo, D. J.; Berger, J. M.; Bertozzi, C. R. Molecular Basis for G protein Control of ATP Sulfurylase in Bacteria. Molecular Cell 2006, 21, 109-122.
146. Chandra, R. A.; Douglas, E. S.; Mathies, R. A.; Bertozzi, C. R.; Francis, M. B. Programmable Cell Adhesion Encoded by DNA Hybridization. Angew. Chem., Int. Ed. 2006, 45, 896-901.
145. *Carroll, K. S.; *Gao, H.; Chen, H.; Leary, J. A.; Bertozzi, C. R. Investigation of the Iron-Sulfur Cluster in Mycobacterium tuberculosis APS Reductase: Implications for Substrate Binding and Catalysis. Biochemistry 2005, 44, 14647-14657.
144. Tomsia, A. P.; Saiz, E.; Song, J.; Bertozzi, C. R. Biomimetic Bonelike Composites and Novel Bioactive Glass Coatings. Adv. Eng. Mater. 2005, 7, 999-1004.
143. Hang, H. C.; Bertozzi, C. R. The Chemistry and Biology of Mucin-Type O-Linked Glycosylation. Bioorg. Med. Chem. 2005, 13, 5021-5034.
142. Carroll, K. S.; Gao, H.; Chen, H.; Stout, C. D.; Leary, J. A.; Bertozzi, C. R. A Conserved Mechanism for Sulfonucleotide Reduction. PloS Biology 2005, 3 (8), e250.
141. Grogan, M. J.; Kaizuka, Y.; Conrad, R. M.; Groves, J. T.; Bertozzi, C. R. Synthesis of Lipidated Green Fluorescent Protein and its Incorporation in Supported Lipid Bilayers. J. Am. Chem. Soc., 2005, 127, 14383-14387.
140. Prescher, J. A.; Bertozzi, C. R. Chemistry in Living Systems. Nature Chem. Biol. 2005, 1, 13-21.
139. Dube, D. H.; Bertozzi, C. R. Glycans in Cancer and Inflammation – Potential for Therapeutics and Diagnostics. Nature Rev. Drug Disc. 2005, 4, 477-88.
138. Saad, O. M.; Ebel, H.; Uchimura, K.; Rosen, S. D.; Bertozzi, C. R.; Leary, J. A. Compositional Profiling of Heparin/Heparan Sulfate Using Mass Spectrometry: Assay for Specificity of a Novel Extracellular Human Endosulfatase. Glycobiology 2005, 15, 818-826.
137. Pi, N.; Hoang, M. B.; Gao, H.; Mougous, J. D.; Bertozzi, C. R.; Leary, J. A. Kinetic Measurements and Mechanism Determination of Stf0 Sulfotransferase Using Mass Spectrometry. Anal. Biochem. 2005, 341, 94-104.
136. Song, J.; Malathong, V.; Bertozzi, C. R. Mineralization of Synthetic Polymer Scaffolds: A Bottom-up Approach for the Development of Artificial Bone. J. Am. Chem. Soc. 2005, 127, 3366-3372.
135. Lin, F., Hoyt, H. M.; van Halbeek, H.; Bergman, R. G.; Bertozzi, C. R. Mechanistic Investigation of the Staudinger Ligation. J. Am. Chem. Soc. 2005, 127, 2686-2695.
134. Pratt, M. R.; Bertozzi, C. R. Synthetic Glycopeptides and Glycoproteins as Tools for Biology and as Therapeutic Agents. Chem. Soc. Rev. 2005, 34, 58-68.
133. Samuel, J.; Bertozzi, C. R. Chemical Tools for the Study of Polysialic Acid. Trends in Glycoscience 2004, 91, 305-318.
132. Vocadlo, D. J.; Bertozzi, C. R. A Strategy for Functional Proteomic Analysis of Glycosidase Activity from Cell Lysates. Angew. Chem., Int. Ed. 2004, 43, 5338-5342.
131. Tian, E.; Ten Hagen, K. G.; Shum, L.; Hang, H. C.; Imbert, Y.; Young, W. W., Jr.; Bertozzi, C. R.; Tabak, L. A. An Inhibitor of O-Glycosylation Induces Apoptosis in NIH3T3 Cells and Developing Mouse Embryonic Mandibular Tissues. J. Biol. Chem. 2004, 279, 50382-50390.
130. Agard, N. J.; Prescher, J. A.; Bertozzi, C. R. A Strain-Promoted [3+2] Azide-Alkyne Cycloaddition for Covalent Modification of Biomolecules in Living Systems. J. Am. Chem. Soc. 2004, 126, 15046-15047.
129. Song, J.; Bertozzi, C. R. Functional Polymers for Bone Tissue Engineering Applications, In Handbook of Nanostructured Materials and Their Applications in Nanobiotechnology, H. S. Nalwa, Editor. American Scientific Publishers, 2005. Vol 1, pp 1-22.
128. Chen, X.; Lee, G. S.; Zettl, A.; Bertozzi, C. R. Biomimetic Engineering of Carbon Nanotubes By Using Cell Surface Mimics. Angew. Chem., Int. Ed. 2004, 43, 6112-6116.
127. Luchansky, S. J.; Argade, S.; Hayes, B. K.; Bertozzi, C. R. Metabolic Functionalization of Recombinant Glycoproteins. Biochemistry 2004, 43, 12358-12366.
126. *Prescher, J. A.; *Dube, D. H.; Bertozzi, C. R. Chemical Remodelling of Cell Surfaces in Living Animals. Nature 2004, 430, 873-877.
125. Luchansky, S. J.; Bertozzi, C. R. Azido Sialic Acids can Modulate Cell Surface Interactions. ChemBioChem 2004, 5, 1706-1709.
124. Kohler, J. J.; Czlapinski, J. L.; Laughlin, S. T.; Schelle, M. W.; de Graffenried, C. L.; Bertozzi, C. R. Directing Flux in Glycan Biosynthetic Pathways with a Small Molecule Switch. ChemBioChem 2004, 5, 1455-1458.
123. de Graffenried, C. L.; Laughlin, S. T.; Kohler, J. J.; Bertozzi, C. R. A Small-Molecule Switch for Golgi Sulfotransferases. Proc. Natl. Acad. Sci. U.S.A. 2004, 101, 16715-16720.
122. de Graffenried, C. L.; Bertozzi, C. R. The Stem Region of the Sulfotransferase GlcNAc6ST-1 is a Determinant of Substrate Specificity. J. Biol. Chem. 2004, 279, 40035-40043.
121. Song, J.; Chen, J.; Klapperich, C. M.; Eng, V.; Bertozzi, C. R. Functional Glass Slides for In Vitro Evaluation of Interactions Between Osteosarcoma TE85 Cells and Mineral-Binding Ligands. J. Mat. Chem. 2004, 14, 2643-2648.
120. de Graffenried, C. L.; Bertozzi, C. R. The Roles of Enzyme Localisation and Complex Formation in Glycan Assembly within the Golgi Apparatus. Curr. Opin. Cell Biol. 2004, 16, 356-363.
119. Song, J.; Cisar, J. S.; Bertozzi, C. R. Functional Self-Assembling Bolaamphiphilic Polydiacetylenes as Colorimetric Sensor Scaffolds. J. Am. Chem. Soc. 2004, 126, 8459-8465.
118. Mougous, J. D.; Petzold, C. J.; Senaratne, R. H.; Lee, D. H.; Akey, D. L.; Lin, F. L.; Munchel, S. E.; Pratt, M. R.; Riley, L. W.; Leary, J. A.; Berger, J. M.; Bertozzi, C. R. Identification, Function and Structure of the Mycobacterial Sulfotransferase that Initiates Sulfolipid-1 Biosynthesis. Nature Struct. Mol. Biol. 2004, 11, 721-729.
117. Woodruff, P. J.; Carlson, B. L.; Siridechadilok, B.; Pratt, M. R.; Mougous, J. D.; Senaratne, R.; Riley, L. W.; Williams, S. J.; Bertozzi, C. R. Trehalose is Required for Growth of Mycobacterium smegmatis. J. Biol. Chem. 2004, 279, 28835-28843.
116. Pratt, M. R.; Bertozzi, C. R. Syntheses of 6-Sulfo Sialyl Lewis X Glycans Corresponding to the L-Selectin Ligand “Sulfoadhesin”. Org. Lett. 2004, 6, 345-2348.
115. Pratt, M. R.; Hang, H. C.; Ten Hagen, K. G.; Rarick, J.; Gerken, T. A.; Tabak, L. A.; Bertozzi, C. R. Deconvoluting the Functions of Polypeptide N-a-Acetylgalactosaminyltransferase (ppGalNAcT) Family Members by Glycopeptide Substrate Profiling. Chem. Biol. 2004, 11, 1009-1016.
114. Klapperich, C. M.; Bertozzi, C. R. Global Gene Expression Patterns of Cells Attached to a Tissue Engineering Scaffold. Biomaterials 2004, 25, 5631-5641.
113. Macmillan, D.; Bertozzi, C. R. Modular Assembly of Glycoproteins: Toward the Synthesis of GlyCAM-1 by Using Expressed Protein Ligation. Angew. Chem., Int. Ed. 2004, 43, 1355-1359.
112. Hang, H. C.; Yu, C.; Ten Hagen, K. G.; Tian, E.; Winans, K. A.; Tabak, L. A.; Bertozzi, C. R. Small Molecule Inhibitors of Mucin-type O-Linked Glycosylation from a Uridine-based Library. Chem. Biol. 2004, 11, 337-345.
111. Grossman, H. L.; Myers, W. R.; Vreeland, V. J.; Bruehl, R.; Alper, M. D.; Bertozzi, C. R.; Clarke, J. Detection of Bacteria in Suspension by Using a Superconducting Quantum Interference Device. Proc. Natl. Acad. Sci. U.S.A. 2004, 101, 129-134.
110. *Luchansky, S. J.; *Goon, S.; Bertozzi, C. R. Expanding the Diversity of Unnatural Cell Surface Sialic Acids. ChemBioChem 2004, 5, 371-374.
109. Hang, H. C.; Yu, C.; Pratt, M. R.; Bertozzi, C. R. Probing Glycosyltransferase Activities with the Staudinger Ligation. J. Am. Chem. Soc. 2004, 126, 6-7.
108. Hang, H. C.; Yu, C.; Kato, D. L.; Bertozzi, C. R. A Metabolic Labeling Approach Towards Proteomic Analysis of Mucin-type O-Linked Glycosylation. Proc. Natl. Acad. Sci. U.S.A. 2003, 100, 14846-14851.
107. Kohler, J. J.; Bertozzi, C. R. Regulating Cell Surface Glycosylation by Small Molecule Control of Enzyme Localization. Chem. Biol. 2003, 10, 1303-1311.
106. Verdugo, D. E.; Pedersen, L. C.; Bertozzi, C. R. Small Molecule Inhibitors of the Sulfotransferases, in Carbohydrate-Based Drug Discovery, Wong, C.-H., Ed. Wiley-VCH, 2003. pp 781-797.
105. Dube, D. H.; Bertozzi, C. R. Metabolic Oligosaccharide Engineering as a Tool for Glycobiology. Curr. Opin. Chem. Biol. 2003, 7, 616-625.
104. Wojczyk, B. S.; Stwora-Wojczyk, M. M.; Hagen, F. K.; Striepen, B.; Hang, H. C.; Bertozzi, C. R.; Roos, D. S.; Spitalnik, S. L. cDNA Cloning and Expression of UDP-N-acetyl-D-galactosamine:Polypeptide N-Acetylgalactosaminyltransferase T1 from Toxoplasma gondii. Mol. Biochem. Parasitol., 2003, 131, 93-107.
103. Pratt, M. R.; Leigh, C. D.; Bertozzi, C. R. Formation of 1,1-a,a-Glycosidic Bonds by Intramolecular Aglycone Delivery. A Convergent Synthesis of Trehalose. Org. Lett. 2003, 5, 3185-3188.
102. de Graffenried, C. L.; Bertozzi, C. R. Golgi Localization of Carbohydrate Sulfotransferases is a Determinant of L-Selectin Ligand Biosynthesis. J. Biol. Chem. 2003, 278, 40282-40295.
101. Song, J.; Saiz, E.; Bertozzi, C. R. Preparation of pHEMA-CP Composites with High Interfacial Adhesion via Template-Driven Mineralization. J. Eur. Ceramic Soc. 2003, 23, 2905-2919.
100. Vocadlo, D. J.; Hang, H. C.; Kim, E. J.; Hanover, J. A.; Bertozzi, C. R. A Chemical Approach for Identifying O-GlcNAc Modified Proteins in Cells. Proc. Natl. Acad. Sci. U.S.A. 2003, 100, 9116-9121.
99. Converse, S. E.; Mougous, J. M.; Leavell, M. D.; Leary, J. A.; Bertozzi, C. R.; Cox, J. S. MmpL8 is Required for Sulfolipid Biosynthesis and M. tuberculosis Virulence. Proc. Natl. Acad. Sci. U.S.A. 2003, 100, 6121-6126.
98. Pratt, M. R.; Bertozzi, C. R. Chemoselective Ligation Applied to the Synthesis of a Biantennary N-Linked Glycoform of CD52. J. Am. Chem. Soc. 2003, 125, 6149-6159.
97. Goon, S.; Schilling, B.; Tullius, M. V.; †Gibson, B. W.; †Bertozzi, C. R. Metabolic Incorporation of Unnatural Sialic Acids into Haemophilus ducreyi Lipooligosaccharides. Proc. Natl. Acad. Sci. U.S.A. 2003, 100, 3089-3094.
96. Lemieux, G. A.; de Graffenried, C. L.; Bertozzi, C. R. A Fluorogenic Dye Activated by the Staudinger Ligation. J. Am. Chem. Soc. 2003, 128, 4708-4709.
95. Luchansky, S. J.; Yarema, K. J.; Bertozzi, C. R. GlcNAc 2-Epimerase Can Serve a Catabolic Role in Sialic Acid Metabolism. J. Biol. Chem. 2003, 278, 8035-8042.
94. Song, J.; Saiz, E.; Bertozzi, C. R. A New Approach to Mineralization of Biocompatible Hydrogel Scaffolds: An Efficient Process Toward 3-Dimensional Bonelike Composites. J. Am. Chem. Soc. 2003, 125, 1236-1243.
93. Marcaurelle, L. A.; Pratt, M. R.; Bertozzi, C. R. Synthesis of Thioether-Linked analogs of the 2,3-Sialyl-TF and MECA-79 Antigens: Mucin-Type Glycopeptides Associated with Cancer and Inflammation. ChemBioChem. 2003, No. 2-3, 224-228.
92. Luchansky, S. J.; Hang, H. C.; Saxon, E.; Grunwell, J. R.; Yu, C.; Dube, D. H.; Bertozzi, C. R. Constructing Azide-Labeled Cell Surfaces Using Polysaccharide Biosynthetic Pathways. Meth. Enzymol. 2003, 362, 249-272.
91. Scherman, M. S.; Winans, K. A.; Stern, R. J.; Jones, V.; Bertozzi, C. R.; McNeil, M. R. Drug Targeting Mycobacterium tuberculosis Cell Wall Synthesis: Development of a Microtiter Plate-Based Screen for UDP-galactopyranose Mutase and Identification of an Inhibitor from a Uridine-Based Library. Antimicrobial Agents and Chemotherapy 2003, 47, 378-382.
90. Armstrong, J. I.; Verdugo, D. E.; Bertozzi, C. R. Synthesis of a Bisubstrate Analog Targeting Estrogen Sulfotransferase. J. Org. Chem. 2003, 68, 170-173.
89. *Mougous, J. D.; *Leavell, M. D.; Senaratne, R. H.; Leigh, C. D.; Williams, S. J.; Riley, L. W.; †Leary, J. A.; †Bertozzi, C. R. Discovery of Sulfated Metabolites in Mycobacteria With a Genetic and Mass Spectrometric Approach. Proc. Natl. Acad. Sci. U.S.A. 2002, 99, 17037-17042.
88. Saxon, E.; Luchansky, S. J.; Hang, H. C.; Yu, C.; Lee, S. C.; Bertozzi, C. R. Investigating Cellular Metabolism of Synthetic Azidosugars Using the Staudinger Ligation. J. Am. Chem. Soc. 2002, 124, 14893-14902.
87. Grunwell, J. R.; Rath, V. L.; Rasmussen, J.; Cabrilo, Z.; Bertozzi, C. R. Characterization and Mutagenesis of Gal/GlcNAc-6-O-sulfotransferases. Biochemistry 2002, 41, 15590-15600.
86. Grunwell, J. R.; Bertozzi, C. R. Carbohydrate Sulfotransferases of the GalNAc/Gal/GlcNAc6ST Family. Biochemistry 2002, 41, 13117-13126.
85. *Parak, W. J.; *Gerion, D.; Zanchet, D.; Woerz, A. S.; Pellegrino, R.; Micheel, C.; Williams, S. C.; Seitz, M.; Bruehl, R. E.; Bryant, Z.; Bustamante, C.; Bertozzi, C. R.; Alivisatos, A. P. Conjugation of DNA to Silanized Colloidal Semiconductor Nanocrystalline Quantum Dots. Chem. Mater. 2002, 14, 2113-2119.
84. Pi, N.; Armstrong, J. I.; Bertozzi, C. R.; Leary, J. A. Kinetic Analysis of NodST Sulfotransferase Using an Electrospray Ionization Mass Spectrometry Assay. Biochemistry 2002, 41, 13283-13288.
83. Mougous, J. D.; Green, R. E.; Williams, S. J.; Brenner, S. E.; Bertozzi, C. R. Sulfotransferases and Sulfatases in Mycobacteria. Chem. Biol. 2002, 9, 767-776.
82. Williams, S. J.; Senaratne, R. H.; Mougous, J. D.; Riley, L. W.; Bertozzi, C. R. 5’-Adenosinephosphosulfate Lies at a Metabolic Branchpoint in Mycobacteria. J. Biol. Chem. 2002, 277, 32606-32615.
81. Verdugo, D. E.; Bertozzi, C. R. A 96-Well Dot-Blot Assay for Carbohydrate Sulfotransferases. Anal. Biochem. 2002, 307, 330-336.
80. Grogan, M. J.; Pratt, M. R.; Marcaurelle, L. A.; Bertozzi, C. R. Homogeneous Glycopeptides and Glycoproteins for Biological Investigation. Annu. Rev. Biochem. 2002, 71, 593-634.
79. Conrad, R. M.; Grogan, M. J.; Bertozzi, C. R. Stereoselective Synthesis of myo-Inositol via Ring-Closing Metathesis: A Building Block for Glycosylphosphatidylinositol (GPI) Anchor Synthesis. Org. Lett. 2002, 4, 1359-1361.
78. Charter, N; Mahal, L. K.; Koshland, D. E., Jr.; Bertozzi, C. R. Differential Effects of Unnatural Sialic Acids on the Polysialylation of NCAM and Neuronal Behavior. J. Biol. Chem. 2002, 277, 9255-9261.
77. Winans, K. A.; Bertozzi, C. R. An Inhibitor of the Human UDP-GlcNAc 4-Epimerase Identified from a Uridine-Based Library: A Strategy to Inhibit O-Linked Glycosylation. Chem. Biol. 2002, 9, 113-129.
76. *Kiick, K. L.; *Saxon, E.; †Tirrell, D. A.; †Bertozzi, C. R. Incorporation of Azides into Recombinant Proteins for Chemoselective Modification by the Staudinger Ligation. Proc. Natl. Acad. Sci. U.S.A. 2002, 99, 19-24.
75. Cook, B. N.; Bertozzi, C. R. Chemical Approaches to the Investigation of Cellular Systems. Bioorg. Med. Chem. 2002, 10, 829-840.
74. Marcaurelle, L. A.; Bertozzi, C. R. Recent Advances in the Chemical Synthesis of Mucin-Type Glycoproteins. Glycobiology 2002, 12, R69-R77.
73. Kehoe, J. W.; Maly, D. J.; Verdugo, D. E.; Armstrong, J. I.; Cook, B. N.; Ouyang, Y.-B.; Moore, K. L.; Ellman, J. E.; Bertozzi, C. R. Tyrosylprotein Sulfotransferase Inhibitors Generated by Combinatorial Target-Guided Ligand Assembly. Bioorg. Med. Chem. Lett. 2002, 12, 329-332.
72. Nauman, D. A.; Bertozzi, C. R. Determination of Kinetic Parameters for Chemoselective Reaction with Cell-Surface Ketones: A Mathematical Model for Small-Molecule Drug Delivery. Biochim. Biophys. Acta. 2001, 1568, 147-154.
71. Sampson, N. S.; Mrksich, M.; Bertozzi, C. R. Surface Molecular Recognition. Proc. Natl. Acad. Sci. U.S.A 2001, 98, 12870-12871.
70. Marcaurelle, L. A.; Shin, Y.; Goon, S.; Bertozzi, C. R. Synthesis of Oxime-linked Mucin Mimics Containing the Tumor-related TN and Sialyl TN Antigens. Org. Lett. 2001, 3, 3691-3694.
69. Mahal, L. K.; Charter, N. W.; Angata, K.; Fukuda, M.; Koshland, D. E., Jr.; Bertozzi, C. R. A Small Molecule Modulator of Poly-a2,8-Sialic Acid Expression on Cultured Neurons and Tumor Cells. Science 2001, 294, 380-382.
68. Jacobs, C. L.; Goon, S.; Yarema, K. J.; Hinderlich, S.; Hang, H. C.; Chai, D. H.; Bertozzi, C. R. Substrate Specificity of the Sialic Acid Biosynthetic Pathway. Biochemistry 2001, 40, 12864-12874.
67. Saxon, E.; Bertozzi, C. R. Chemical and Biological Strategies for Engineering Cell Surface Glycosylation. Ann. Rev. Cell Dev. Biol. 2001, 17, 1-23.
66. Schilling, B.; Goon, S.; Samuels, N. M.; Gaucher, S. P.; Leary, J. A.; Bertozzi, C. R.; Gibson, B. W. Biosynthesis of Sialylated Lipooligosaccharides in Haemophilus ducreyi is Dependent on Exogenous Sialic Acid and not Mannosamine. Biochemistry 2001, 40, 12666-12677.
65. Bruehl, R. E.; Dasgupta, F.; Katsumoto, T. R.; Tan, J. H.; Bertozzi, C. R.; Spevak, W.; Ahn, D. J.; Rosen, S. D.; Nagy, J. O. Polymerized Liposome Assemblies: Bifunctional Macromolecular Selectin Inhibitors Mimicking Physiological Selectin Ligands. Biochemistry 2001, 40, 5964-5974.
64. Armstrong, J. I.; Ge, X.; Verdugo, D. E.; Winans, K. A.; Leary, J. A.; Bertozzi, C. R. A Library Approach to the Generation of Bisubstrate Analog Sulfotransferase Inhibitors. Org. Lett. 2001, 3, 2657-2660.
63. Verdugo, D. E.; Cancilla, M. T.; Ge, X.; Gray, N. S.; Chang, Y.-T.; Schultz, P. G.; Negishi, M.; Leary, J. A.; Bertozzi, C. R. Discovery of Estrogen Sulfotransferase Inhibitors from a Purine Library Screen. J. Med. Chem., 2001, 44, 2683-2686.
62. Hang, H. C.; Bertozzi, C. R. Chemoselective Approaches to Glycoprotein Engineering. Accounts Chem. Res. 2001, 34, 727-736.
61. Groves, J. T.; Mahal, L. K.; Bertozzi, C. R. Control of Cell Adhesion and Growth with Micropatterned Supported Lipid Membranes. Langmuir 2001, 17, 5129-5133.
60. Yarema, K. J.; Goon, S.; Bertozzi, C. R. Metabolic Selection of Glycosylation Defects in Human Cells. Nature Biotechnol. 2001, 19, 553-558.
59. Yarema, K. J.; Bertozzi, C. R. Characterizing Glycosylation Pathways. Genome Biology 2001, 2, 0004.1-0004.10.
58. Lemieux, G. A.; Bertozzi, C. R. Modulating Cell Surface Immunoreactivity by Metabolic Induction of Unnatural Carbohydrate Antigens. Chem. Biol. 2001, 8, 265-275.
57. Bertozzi, C. R.; Kiessling, L. L. Chemical Glycobiology. Science 2001, 291, 2357-2364.
56. Marcaurelle, L. A.; Bertozzi, C. R. Chemoselective Elaboration of O-Linked Glycopeptide Mimetics by Alkylation of 3-ThioGalNAc. J. Am. Chem. Soc. 2001, 123, 1587-1595.
55. Marcaurelle, L. A.; Mizoue, L. S.; Wilken, J.; Oldham, L.; Kent, S. B. H.; Handel, T. M.; Bertozzi, C. R. Chemical Synthesis of Lymphotactin, a Glycosylated Chemokine with a C-terminal Mucin-like Domain. Chem. Eur. J. 2001, 7, 1129-1132.
54. Hang, H. C., Bertozzi, C. R. Ketone Isosteres of 2-N-Acetamidosugars as Substrates for Metabolic Cell Surface Engineering. J. Am. Chem. Soc. 2001, 123, 1242-1243.
53. Bowman, K. G.; Cook, B. N.; de Graffenried, C. L.; Bertozzi, C. R. Biosynthesis of L-selectin Ligands: Sulfation of Sialyl Lewis x-Related Oligosaccharides by a Family of GlcNAc-6-Sulfotransferases. Biochemistry 2001, 40, 5382-5391.
52. Bruehl, R. E.; Bertozzi, C. R.; Rosen, S. D. Minimal sulfated carbohydrates for recognition by L-selectin and the MECA-79 antibody. J. Biol. Chem. 2000, 275, 32642-32648.
51. Bhakta, S.; Bartes, A.; Bowman, K. G.; Kao, W.-M.; Polsky, I.; Lee, J. K.; Cook, B. N.; Bruehl, R.; Rosen, S. D.; Bertozzi, C. R.; Hemmerich, S. Sulfation of N-Acetylglucosamine by Chondroitin 6-Sulfotransferase 2 (GST5). J. Biol. Chem. 2000, 275, 40226-40234.
50. Macmillan, D.; Bertozzi, C. R. New Directions in Glycoprotein Engineering. Tetrahedron 2000, 56, 9515-9525.
49. Cook, B. N.; Bhakta, S.; Biegel, T.; Bowman, K. G.; Armstrong, J. I.; Hemmerich, S.; Bertozzi, C. R. Differential Carbohydrate Recognition of Two GlcNAc-6-Sulfotransferases with Possible Roles in L-Selectin Ligand Biosynthesis. J. Am. Chem. Soc. 2000, 122, 8612-8622.
48. Armstrong, J. I.; Bertozzi, C. R. Sulfotransferases as Targets for Therapeutic Intervention. Curr. Opin. Drug Disc. Dev. 2000, 3, 502-515.
47. *Charter, N. W.; *Mahal, L. K.; Koshland, D. E., Jr.; Bertozzi, C. R. Biosynthetic Incorporation of Unnatural Sialic Acids into Polysialic Acid on Neural Cells. Glycobiology, 2000, 10, 1-8.
46. Jacobs, C. J.; Yarema, K. J.; Mahal, L. K.; Nauman, D. A.; Charters, N.; Bertozzi, C. R. Metabolic Labeling of Glycoproteins with Chemical Tags through Unnatural Sialic Acid Biosynthesis. Meth. Enzymol. 2000, 327, 260-275.
45. Saxon, E.; Armstrong, J. I.; Bertozzi, C. R. A "Traceless" Staudinger Ligation for the Chemoselective Synthesis of Amide Bonds. Org. Lett. 2000, 2, 2141-2143.
44. Saxon, E.; Bertozzi, C. R. Cell Surface Engineering by a Modified Staudinger Reaction. Science 2000, 287, 2007-2010.
43. Armstrong, J. I.; Portley, A. R.; Chang, Y.-T.; Nierengarten, D. M.; Cook, B. N.; Bowman, K. G.; Bishop, A.; Gray, N. S.; Shokat, K. M.; Schultz, P. G.; Bertozzi, C. R. Discovery of Carbohydrate Sulfotransferase Inhibitors from a Kinase-Directed Library. Angew. Chem., Int. Ed. 2000, 39, 1303-1306.
42. Kehoe, J. W.; Bertozzi, C. R. Tyrosine Sulfation: A Modulator of Extracellular Protein-Protein Interactions. Chem. Biol. 2000, 7, R57-R61.
41. Shin, Y.; Winans, K. A.; Backes, B. J.; Kent, S. B. H.; Ellman, J. A.; Bertozzi, C. R. Fmoc-Based Synthesis of Peptide-aThioesters: Application to the Total Chemical Synthesis of a Glycoprotein by Native Chemical Ligation. J. Am. Chem. Soc. 1999, 121, 11684-11689.
40. Mahal, L. K.; Yarema, K. J.; Lemieux, G. A.; Bertozzi, C. R. Chemical Approaches to Glycobiology: Engineering Cell Surface Sialic Acids for Tumor Targeting, in Sialobiology and Other Novel Forms of Glycosylation, Inoue, Y.; Lee, Y. C.; Troy, F. A., III, eds. Gakushin Publishing Company: Osaka, 1999, pp. 237-280.
39. Winans, K. A.; King, D. A.; Rao, V.; Bertozzi, C. R. A Chemically Synthesized Version of the Insect Antibacterial Glycopeptide, Diptericin, Disrupts Bacterial Membrane Integrity. Biochemistry 1999, 38, 11700-11710.
38. Lee, J. H.; Baker, T. J.; Mahal, L. K.; Zabner, J.; Bertozzi, C. R.; Wiemer, D. F.; Welsh, M. J. Engineering Novel Cell Surface Receptors for Virus-Mediated Gene Transfer. J. Biol. Chem. 1999, 274, 21878-21884.
37. Lemieux, G. A.; Yarema, K. J.; Jacobs, C. L.; Bertozzi, C. R. Exploiting Differences in Sialoside Expression for Selective Targeting of MRI Contrast Reagents. J. Am. Chem. Soc. 1999, 121, 4278-4279.
36. Marcaurelle, L. A.; Bertozzi, C. R. New Directions in the Synthesis of Glycopeptide Mimetics. Chem. Eur. J. 1999, 5, 1384-1390.
35. Chen, Q.; Zhang, D.; Somorjai, G.; Bertozzi, C. R. Probing the Surface Structural Rearrangement of Hydrogels by Sum-Frequency Generation Spectroscopy. J. Am. Chem. Soc. 1999, 121, 446-447.
34. Bowman, K. G.; Bertozzi, C. R. Carbohydrate Sulfotransferases: Mediators of Extracellular Communication. Chem. Biol. 1999, 6, R9-R22.
33. Winans, K. A.; Bertozzi, C. R. Inner Space Exploration: The Chemical Biologist's Guide to the Cell. Chem. Biol. 1998, 5, R313-R315.
32. Yarema, K. J.; Mahal, L. K.; Bruehl, R.; Rodriguez, E. C.; Bertozzi, C. R. Metabolic Delivery of Ketone Groups to Sialic Acid Residues. Application to Cell Surface Glycoform Engineering. J. Biol. Chem. 1998, 273, 31168-31179.
31. Marcaurelle, L. A.; Rodriguez, E. C.; Bertozzi, C. R. Synthesis of an Oxime-Linked Neoglycopeptide with Glycosylation-Dependent Activity Similar to its Native Counterpart. Tetrahedron Lett. 1998, 39, 8417-8420.
30. Rodriguez, E. C.; Marcaurelle, L. A.; Bertozzi, C. R. Aminooxy, Hydrazide and Thiosemicarbazide-Functionalized Saccharides: Versatile Reagents for Glycoconjugate Synthesis. J. Org. Chem. 1998, 63, 7134-7135.
29. Marcaurelle, L. A.; Bertozzi, C. R. Direct Incorporation of Unprotected Ketone Groups into Peptides During Solid-Phase Synthesis: Application to the One-Step Synthesis of Peptides with Two Different Biophysical Probes for FRET. Tetrahedron Lett. 1998, 39, 7279-7282.
28. Bowman, K. G.; Hemmerich, S.; Bhakta, S.; Singer, M. S.; Rosen, S. D.; Bertozzi, C. R. Identification of an N-Acetylglucosamine-6-O-Sulfotransferase Activity Restricted to Lymphoid Tissue: An Enzyme with a Possible Role in Lymphocyte Homing. Chem. Biol. 1998, 5, 447-460.
27. Lemieux, G. A. ; Bertozzi, C. R. Chemoselective Ligation Reactions with Proteins, Oligosaccharides and Cells. Trends Biotech. 1998, 16, 506-513.
26. Yarema, K. J.; Bertozzi, C. R. Chemical Approaches to Glycobiology and Emerging Carbohydrate-Based Therapeutic Agents. Curr. Opin. Chem. Biol. 1998, 2, 49-61.
25. Rodriguez, E. C.; Winans, K. A.; King, D. S.; Bertozzi, C. R. A Strategy for the Chemoselective Synthesis of O-Linked Glycopeptides with Native Sugar-Peptide Linkages. J. Am. Chem. Soc. 1997, 119, 9905-9906.
24. Mahal, L. K.; Bertozzi, C. R. Engineered Cell Surfaces: Fertile Ground for Molecular Landscaping. Chem. Biol. 1997, 4, 415-422.
23. Mahal, L. K.; Yarema, K. J.; Bertozzi, C. R. Engineering Chemical Reactivity on Cell Surfaces Through Oligosaccharide Biosynthesis. Science 1997, 276, 1125-1128.
22. Bertozzi, C. R.; Singer, M. S.; Rosen, S. D. An ELISA for Selectin Inhibitors Based on Binding to a Physiological Ligand. J. Immunol. Meth. 1997, 203, 157-165.
21. Sanders, W. J.; Katsumoto, T. R.; Bertozzi, C. R.; Rosen, S. D.; Kiessling, L. L. L-Selectin-Carbohydrate Interactions: An Investigation into the Relevant Modifications of the Lewis x Trisaccharide. Biochemistry 1996, 35, 14862-14867.
20. Roe, B. A.; Boojamra, D. G.; Griggs, J.; Bertozzi, C. R. Synthesis of beta-C-Glycosides of N-acetylglucosamine via Keck Allylation Directed by Neighboring Phthalimide Groups. J. Org. Chem. 1996, 61, 6442-6445.
19. Manning, D. D.; Bertozzi, C. R.; Rosen, S. D.; Kiessling, L. L. Tin Mediated Phosphorylation: Synthesis and Selectin Binding of a Phospho Lewis a Analog. Tetrahedron Lett. 1996, 37, 1953-1956.
18. Rosen, S. D.; Bertozzi, C. R. Leukocyte Adhesion: Two Selectins Converge on Sulphate. Current Biol. 1996, 6, 261-264.
17. Kobertz, W. R.; Bertozzi, C. R.; Bednarski, M. D. C-Glycosyl Aldehydes: Synthons for C-linked Disaccharides. J. Org. Chem. 1996, 61, 1894-1897.
16. Bertozzi, C. R.; Bednarski, M. D. "Synthesis of C-Glycosides: Stable Mimics of O-Glycosidic Linkages" in Modern Methods in Carbohydrate Synthesis, Khan, S. H.; O'Neill, R. A., eds. Harwood Academic Publishers GmbH: Amsterdam, 1996, pp 316-351.
15. Bertozzi, C. R. Cracking the Carbohydrate Code for Selectin Recognition. Chem. Biol. 1995, 2, 703-708.
14. Bertozzi, C. R.; Fukuda, S.; Rosen, S. D. Sulfated Disaccharide Inhibitors of L-Selectin: Deriving Structural Leads from a Physiological Selectin Ligand. Biochemistry 1995, 34, 14271-14278.
13. Manning, D. D.; Bertozzi, C. R.; Pohl, N. L.; Rosen, S. D.; Kiessling, L. L. Selectin-Saccharide Interactions: Revealing Structure-Activity Relationships with Total Synthesis. J. Org. Chem. 1995, 60, 6254-6255.
12. Rosen, S. D.; Bertozzi, C. R. The Selectins and Their Ligands. Curr. Opin. Cell Biol. 1994, 6, 663-673.
11. Hemmerich, S.; Bertozzi, C. R.; Leffler, H.; Rosen, S. D. Identification of the Sulfated Monosaccharides of GlyCAM-1, an Endothelial-Derived Ligand for L-Selectin. Biochemistry 1994, 33, 4820-4829.
10. Grabowski, J. J.; Bertozzi, C. R.; Jacobsen, J. R.; Jain, A.; Marzluff, E. M.; Suh, A. Y. Fluorescence Probes in Biochemistry: An Examination of the Non-Fluorescent Behavior of Dansylamide by Photoacoustic Calorimetry. Analytical Biochem. 1992, 207, 214-226.
9. Bertozzi, C. R.; Cook, D. G.; Kobertz, W. R.; Gonzalez-Scarano, F.; Bednarski, M. D. Carbon-Linked Galactosphingolipid Analogs Bind Specifically to HIV-1 gp120. J. Am. Chem. Soc. 1992, 114, 10639-10641.
8. Bertozzi, C. R.; Hoeprich, P. D., Jr.; Bednarski, M. D. Synthesis of Carbon-Linked Glycopeptides as Stable Glycopeptide Models. J. Org. Chem. 1992, 57, 6092-6094.
7. Bertozzi, C. R.; Bednarski, M. D. The Synthesis of 2-Azido C-Glycosyl Sugars. Tetrahedron Lett. 1992, 33, 3109-3112.
6. Bertozzi, C. R.; Bednarski, M. D. A Receptor-Mediated Immune Response Using Synthetic Glycoconjugates. J. Am. Chem. Soc. 1992, 114, 5543-5546.
5. Bertozzi, C. R.; Bednarski, M. D. Antibody Targeting to Bacterial Cells Using Receptor-Specific Ligands. J. Am. Chem. Soc. 1992, 114, 2242-2245.
4. Kobertz, W. R.; Bertozzi, C. R.; Bednarski, M. D. An Efficient Method for the Synthesis of alpha- and beta-C-Glycosyl Aldehydes. Tetrahedron Lett. 1992, 33, 737-740.
3. Bertozzi, C. R.; Bednarski, M. D. C-Glycosyl Compounds Bind to Receptors on the Surface of Escherichia coli and can Target Proteins to the Organism. Carbohydrate Res. 1992, 223, 243-253.
2. Bertozzi, C. R.; Bednarski, M. D. The Synthesis of Heterobifunctional Linkers for the Conjugation of Ligands to Molecular Probes. J. Org. Chem. 1991, 56, 4326-4329.
1. Chidsey, C. E. D.; Bertozzi, C. R.; Putvinski, T. M.; Mujsce, A. M. Coadsorption of Ferrocene-Terminated and Unsubstituted Alkanethiols on Gold: Electroactive Self-Assembled Monolayers. J. Am. Chem. Soc. 1990, 112, 4301-4306.
Books & Chapters
Wang, P. G.; Bertozzi, C. R., Eds. Glycochemistry. Principles, Synthesis and Applications. Marcel Dekker, Inc.: New York, 2001.
Varki, A.; Cummings, R. D.; Esko, J. D.; Freeze, H. H.; Stanley, P.; Bertozzi, C. R.; Hart, G. W.; Etzler, M. E., Eds. Essentials of Glycobiology, Second Edition. Cold Spring Harbor Laboratory Press: Cold Spring Harbor, NY, 2009.
Beahm, B. J.; Bertozzi, C. R. "Imaging Cell-Surface Glycans in Animals with Bioorthogonal Chemistry." Glycoscience: Biology and Medicine. Ed. Endo, T.; Seeberger, P. H.; Hart, G. W.; Wong, C-H.; Taniguchi, T. Japan: Springer, 2014.1-11.
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