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350. Shin, J.; Kim, M. J.; Kool, E. T.* Fluorogenic Covalent Probes for RNA. J. Am. Chem. Soc. 2025, 147 (48), 44384-44395.
349. Gao, Y.; Kool, E. T.* Convenient syntheses of isotopically labeled pyrimidine 2′-deoxynucleosides and their 5-hydroxy oxidation products. Nucleosides Nucleotides Nucleic Acids 2025, 44 (11), 915-937.
348. Shin, J.; Jaruga, P.; Dizdaroglu, M.; Kool, E. T.* DNA Content and DNA Damage in Raw and Heat-processed Foods. J. Agric. Food Chem. 2025, 73 (45), 29069-29081.
347. Pratihar, S.; Zhong, W.; Feng, S.; Chatterjee, S.; Kool, E. T.* Sequence-Specific Installation of Aryl Groups in RNA via DNA-Catalyst Conjugates. Angew. Chem. Int. Ed. 2025, e202515681.
346. Fang, L.; Zhong, W.; Xiao, L.; Shioi, R.; Lee, A.; Bravo, C. H.; Kool, E. T.* Localized 2′-OH Acylation at Poly(A) Extends RNA Translation. J. Am. Chem. Soc. 2025, 147 (37), 34027-34033.
345. Banerjee, D.; Xiao, L.; Thacker, P. S.; Kundu, J.; Manoharan, M.; Kool, E. T.* C-Nucleosides Stabilize RNA by Reducing Nucleophilicity at 2′-OH. ACS Cent. Sci. 2025, 11 (12), 2400-2409.
344. Mateo-Victoriano, B.; Samaranayake, G. J.; Pokharel, S.; Sahayanathan, G. J.; Jayaraj, C.; Troccoli, C. I.; Watson, D. C.; Mohsen, M. G.; Guo, Y.; Kool, E. T.; Rai, P.* Oncogenic KRAS Addiction States Differentially Influence MTH1 Expression and 8-oxodGTPase Activity in Lung Adenocarcinoma. Redox Biol. 2025, 82, 103610.
343. Thomas, D.; Palczewski, M.; Kuschman, H.; Hoffman, B.; Yang, H.; Glynn, S.; Wilson, D. L.; Kool, E. T.; Montfort, W.; Chang, J.; Petenkaya, A.; Chronis, C.; Cundari, T.; Sappa, S.; Islam, K.; McVicar, D.; Fan, Y.; Chen, Q.; Meerzaman, D.; Sierk, M.* Nitric oxide inhibits ten-eleven translocation DNA demethylases to regulate 5mC and 5hmC across the genome. Nat. Commun. 2025, 16, 1732.
342. Gao, Y.; McPherson, L.; Adimoolam, S.; Suresh, S.; Wilson, D. L.; Das, I.; Park, E. R.; Ng, C. S. C.; Jun, Y. W.; Ford, J. M. Kool, E. T.* Small-molecule activator of SMUG1 enhances repair of pyrimidine lesions in DNA. DNA Repair 2025, 146, 103809.
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339. Shioi, R.; Kool, E. T.* Chemical diversity of reagents that modify RNA 2′-OH in water: a review. Chem. Sci. 2024, 15 (39), 15968-15982.
338. Pandit, B.; Fang, L.; Kool, E. T.; Royzen, M.* Reversible RNA Acylation Using Bio-Orthogonal Chemistry Enables Temporal Control of CRISPR-Cas9 Nuclease Activity. ACS Chem. Biol. 2024, 19 (8), 1719-1724.
337. Gao, S.; Tahara, Y.; Kool, E. T.; Greenberg, M. M.* Promoter dependent RNA polymerase II bypass of the epimerizable DNA lesion, Fapy•dG and 8-Oxo-2′-deoxyguanosine. Nucleic Acids Res. 2024, 52 (13), 7437-7446.
336. Shioi, R.; Chatterjee, S.; Lu, X.; Zhong, W.; Kool, E. T.* Second-Generation Chiral Amino Acid Derivatives Afford High Stereoselectivity and Stability in Aqueous RNA Acylation . J. Org. Chem. 2024, 89 (11), 8055-8063.
335. Chatterjee, S.; Xiao, L.; Zhong, W.; Feng, S.; Kool, E. T.* Selective Arylation of RNA 2′-OH Groups via SNAr Reaction with Trialkylammonium Heterocycles . Angew. Chem. Int. Ed. 2024, 63 (25), e202403496.
334. Guo, J.; Chen, S.; Onishi, Y.; Shi, Q.; Song, Y.; Mei, H.; Chen, L.; Kool, E. T.; Zhu, R.-Y.* RNA Control via Redox-Responsive Acylation . Angew. Chem. Int. Ed. 2024, e202402178.
333. Shioi, R.; Lu, X.; Kool, E. T.* Aqueous Activation of RNA 2′-OH for Conjugation with Amines and Thiols . Bioconjugate Chem. 2024, 35 (1), 43-50.
332. Shioi, R.; Lu, X.; Fang, L.; Kool, E. T.* Efficient Post-synthesis Incorporation and Conjugation of Reactive Ketones in RNA via 2′-Acylation . Chem. Comm. 2024, 60, 232-235.
331. Lu, X.; Fang, L.; Kool, E. T.* 2′-OH as a universal handle for studying intracellular RNAs. Cell Chem. Biol. 2024, 31 (1), 110-124.
330. Fang, L.; Kool, E. T.* Reactivity-based RNA profiling for analyzing transcriptome interactions of small molecules in human cells. STAR Protoc. 2023, 4 (4), 102670.
329. Shioi, R.; Xiao, L.; Chatterjee, S.; Kool, E. T.* Stereoselective RNA Reaction with Chiral 2′-OH Acylating Agents. Chem. Sci. 2023, 14, 13235-13243.
328. Fang, L.; Velema, W. A.; Lee, Y.; Xiao, L.; Mohsen, M. G.; Kietrys, A. M.; Kool, E. T.* Pervasive transcriptome interactions of protein-targeted drugs. Nat. Chem. 2023, 15, 1374-1383.
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326. Jun, Y. W.; Kant, M.; Coskun, E.; Kato, T. A.; Jaruga, P.; Palafox, E.; Dizdaroglu, M.; Kool, E. T.* Possible Genetic Risks from Heat-Damaged DNA in Food. ACS Cent. Sci. 2023, 9 (6), 1170-1179.
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323. Jun, Y. W.; Kool, E. T.* Chemical Tools for the Study of DNA Repair . Acc. Chem. Res. 2022, 55 (23), 3495-3506.
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320. Venzon, M.; Das, R.; Luciano, D. J.; Burnett, J.; Park, H. S.; Devlin, J. C.; Kool, E. T.; Belasco, J. G.; Hubbard, E. J. A.; Cadwell, K.* Microbial byproducts determine reproductive fitness of free-living and parasitic nematodes. Cell Host Microbe 2022, 30 (6), 786-797.
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317. Jash, B.; Kool, E. T.* Conjugation of RNA via 2′-OH acylation: Mechanisms determining nucleotide reactivity. Chem. Commun. 2022, 58 (22), 3693-3696.
316. Baskar, R.; Chen, A. F.; Favaro, P.; Reynolds, W.; Mueller, F.; Borges, L.; Jiang, S.; Park, H. S.; Kool, E. T.; Greenleaf, W. J.;* Bendall, S. C.* Integrating transcription-factor abundance with chromatin accessibility in human erythroid lineage commitment. Cell Rep. Methods 2022, 2 (3), 100188.
315. Jun, Y. W.; Albarran, E.; Wilson, D. L.; Ding, J.; Kool, E. T.* Fluorescence Imaging of Mitochondrial DNA Base Excision Repair Reveals Dynamics of Oxidative Stress Responses. Angew. Chem. Int. Ed. 2022, 61 (6), e202111829.
314. Kant, M.; Tahara, Y.; Jaruga, P.; Coskun, E.; Lloyd, R. S.; Kool, E. T.*, Dizdaroglu, M.* Inhibition by Tetrahydroquinoline Sulfonamide Derivatives of the Activity of Human 8-Oxoguanine DNA Glycosylase (OGG1) for Several Products of Oxidatively induced DNA Base Lesions. ACS Chem. Biol. 2021, 16 (1), 45-51.
313. Xiao, L.; Jun, Y. W.; Kool, E. T.* DNA Tiling Enables Precise Acylation-Based Labeling and Control of mRNA. Angew. Chem. Int. Ed. 2021, 60 (51), 26798-26805.
312. Kuljanin, M.; Mitchell, D. C.; Schweppe, D. K.; Gikandi, A. S.; Nusinow, D. P.; Bulloch, N. J.; Vinogradova, E. V.; Wilson, D. L.; Kool, E. T.; Mancias, J. D.; Cravatt, B. F.; Gygi, S. P.* Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat. Biotechnol. 2021, 39 (5), 630-641.
311. Zhang, L.; Misiara, L.; Samaranayake, G. J.; Sharma, N.; Nguyen, D. M.; Tahara, Y. K.; Kool, E. T.; Rai, P.* OGG1 co-inhibition antagonizes the tumor-inhibitory effects of targeting MTH1. Redox. Biol. 2021, 40, 101848.
310. Park, H. S.; Jash, B.; Xiao, L.; Jun, Y. W.; Kool, E. T.* Control of RNA with quinone methide reversible acylating reagents. Org. Biomol. Chem. 2021, 19 (38), 8367-8376.
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307. Xiao, L.; Habibian, M.; Kool, E. T.* Site-Selective RNA Functionalization via DNA-Induced Structure. J. Am. Chem. Soc. 2020, 142 (38), 16357-16363.
306. Zhu, R. Y.; Majumdar, C.; Khuu, C.; De, R. o. s. a.; Opresko, P. L.; David, S. S.; Kool, E. T.* Designer Fluorescent Adenines Enable Real-Time Monitoring of MUTYH Activity. ACS Cent. Sci. 2020, 6 (10), 1735-1742.
305. Velema, W. A.; Park, H. S.; Kadina, A.; Orbai, L.; Kool, E. T.* Trapping Transient RNA Complexes by Chemically Reversible Acylation.. Angew Chem Int Ed Engl 2020, 59 (49), 22017-22022.
304. Jun, Y. W.; Wilson, D. L.; Kietrys, A. M.; Lotsof, E. R.; Conlon, S. G.; David, S. S.; Kool, E. T.* An Excimer Clamp for Measuring Damaged-Base Excision by the DNA Repair Enzyme NTH1. Angew. Chem. Int. Ed. 2020, 59 (19), 7450-7455.
303. Samaranayake, G. J.; Troccoli, C. I.; Zhang, L.; Huynh, M.; Jayaraj, C. J.; Ji, D.; McPherson, L.; Onishi, Y.; Nguyen, D. M.; Robbins, D. J.; Karbaschi, M.; Cooke, M. S.; Barrientos, A.; Kool, E. T.; Rai, P.* The Existence of MTH1-independent 8-oxodGTPase Activity in Cancer Cells as a Compensatory Mechanism against On-target Effects of MTH1 Inhibitors. Mol. Cancer Ther. 2020, 19 (2), 432-446.
302. Habibian, M.; McKinlay, C.; Blake, T. R.; Kietrys, A. M.; Waymouth, R. M.; Wender, P. A.; Kool, E. T.* Reversible RNA acylation for control of CRISPR-Cas9 gene editing. Chem. Sci. 2020, 11 (4), 1011-1016.
301. Wilson, D. L.; Kool, E. T.* Ultrafast Oxime Formation Enables Efficient Fluorescence Light-up Measurement of DNA Base Excision. J. Am. Chem. Soc. 2019, 141 (49), 19379-19388.
300. Jun, Y. W.; Hebenbrock, M.; Kool, E. T.* A fluorescent hydrazone exchange probe of pyridoxal phosphate for the assessment of vitamin B6 status.. Chem. Commun. 2019, 56 (2), 317-320.
299. Velema, W. A.; Kool, E. T.,* The chemistry and applications of RNA 2′-OH acylation. Nat. Rev. Chem., 2019, 4, 22-37.
298. McPherson, L. A.; Troccoli, C. I.; Ji, D.; Bowles, A. E.; Gardiner, M. L.; Mohsen, M. G.; Nagathihalli, N. S.; Nguyen, D. M.; Robbins, D. J.; Merchant, N. B.; Kool, E. T.; Rai, P.; Ford, J. M.* Increased MTH1-specific 8-oxodGTPase activity is a hallmark of cancer in colon, lung and pancreatic tissue.. DNA Repair 2019, 83, 102644.
297. Tahara, Y. K.; Kietrys, A. M.; Hebenbrock, M.; Lee, Y.; Wilson, D. L.; Kool, E. T.* Dual Inhibitors of 8-Oxoguanine Surveillance by OGG1 and NUDT1. ACS Chem. Biol. 2019, 14 (12), 2606-2615.
296. Mohsen, M. G.; Ji, D.; Kool, E. T.* Polymerase synthesis of four-base DNA from two stable dimeric nucleotides. Nucleic Acids Res. 2019, 47 (18), 9495-9501.
295. Habibian, M.; Velema, W. A.; Kietrys, A. M.; Onishi, Y.; Kool, E. T.* Polyacetate and Polycarbonate RNA: Acylating Reagents and Properties. Org. Lett. 2019, 21 (14), 5413-5416.
294. Park, H. S.; Kietrys, A. M.; Kool, E. T.* Simple alkanoyl acylating agents for reversible RNA functionalization and control. Chem. Commun. 2019, 55 (35), 5135-5138.
293. Sun, L.; Fazal, F. M.; Li, P.; Broughton, J. P.; Lee, B.; Tang, L.; Huang, W.; Kool, E. T.; Chang, H. Y.; Zhang, Q. C.* RNA structure maps across mammalian cellular compartments. Nat. Struct. Mol. Biol. 2019, 26 (35), 322-330.
292. Nagel, Z. D.; Beharry, A. A.; Mazzucato, P.; Kitange, G. J.; Sarkaria, J. N.; Kool, E. T.; Samson, L. D.* Fluorescent reporter assays provide direct, accurate, quantitative measurements of MGMT status in human cells. PLoS One 2019, 14 (2), e0208341.
291. Mohsen, M. G.; Ji, D.; Kool, E. T.* Polymerase-amplified release of ATP (POLARA) for detecting single nucleotide variants in RNA and DNA. Chem. Sci.. 2019, 10 (11), 3264-3270.
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289. Velema, W. A.; Kool, E. T.* Water-Soluble Leaving Group Enables Hydrophobic Functionalization of RNA. Org. Lett. 2018, 20 (20), 6587-6590.
288. Wilson, D. L.; Beharry, A. A.; Srivastava, A.; O’Connor, T. R.; Kool, E. T.* Fluorescence Probes of ALKBH2 Measure DNA Alkylation Repair and Drug Resistance Responses. Angew. Chem. Int. Ed. 2018, 57, 12896-12900.
287. Saiki, J. P.; Cao, H.; Van Wassenhove, L. D.; Viswanathan, V.; Bloomstein, J.; Nambiar, D. K.; Mattingly, A. J.; Jiang, D.; Chen, C.-H.; Stevens, M. C.; Simmons, A. L.; Park, H. S.; von Eyben, R.; Kool, E. T.; Sirjani, D.; Knox, S. M.; Le, Q. T.;* Mochly-Rosen, D.* Aldehyde dehydrogenase 3A1 activation prevents radiation-induced xerostomia by protecting salivary stem cells from toxic aldehydes. Proc. Natl. Acad. Sci. U.S.A.. 2018, 115 (24), 6279-6284.
286. Larsen, D.; Kietrys, A. M.; Clark, S. A.; Park, H. S.; Ekebergh, A.; Kool, E. T.* Exceptionally rapid oxime and hydrazone formation promoted by catalytic amine buffers with low toxicity. Chem. Sci. 2018, 9 (23), 5252-5259.
285. Ji, D.; Kietrys, A. M.; Lee, Y.; Kool, E. T.* ATP-Linked Chimeric Nucleotide as a Specific Luminescence Reporter of Deoxyuridine Triphosphatase. Bioconjug. Chem. 2018, 29 (5), 1614-1621.
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282. Kadina, A.; Kietrys, A. M.; Kool, E. T.* RNA Cloaking by Reversible Acylation. Angew. Chem. Int. Ed. 2018, 57, 3059-3063.
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279. Ji, D.; Stepchenkova, E. I.; Cui, J.; Menezes, M. R.; Pavlov, Y. I.; Kool, E. T.* Measuring deaminated nucleotide surveillance enzyme ITPA activity with an ATP-releasing nucleotide chimera. Nucleic Acids Res. 2017, 45 (20), 11515-11524.
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272. Lee, B.; Flynn, R. A.; Kadina, A.; Guo, J. K.; Kool, E. T.; Chang, H. Y.* Comparison of SHAPE reagents for mapping RNA structures inside living cells. RNA 2017, 23 (2), 169-174.
271. Clark, S. A.; Singh, V.; Vega, M. e. n. d. o. z. a.; Margolin, W.; Kool, E. T.* Light-Up “Channel Dyes” for Haloalkane-Based Protein Labeling in Vitro and in Bacterial Cells. Bioconjug. Chem. 2016, 27 (12), 2839-2843.
270. Mohsen, M. G.; Kool, E. T.* The Discovery of Rolling Circle Amplification and Rolling Circle Transcription. Acc. Chem. Res. 2016, 49 (11), 2540-2550.
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266. Kölmel, D. K.; Barandun, L. J.; Kool, E. T.* Efficient synthesis of fluorescent alkynyl C-nucleosides via Sonogashira coupling for the preparation of DNA-based polyfluorophores. Org. Biomol. Chem. 2016, 14 (27), 6407-12.
265. Hwang, C. S.; Xu, L.; Wang, W.; Ulrich, S.; Zhang, L.; Chong, J.; Shin, J. H.; Huang, X.; Kool, E. T.; McKenna, C. E.; Wang, D.* Functional interplay between NTP leaving group and base pair recognition during RNA polymerase II nucleotide incorporation revealed by methylene substitution. Nucleic Acids Res. 2016, 44 (8), 3820-8.
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263. Beharry, A. A.; Nagel, Z. D.; Samson, L. D.; Kool, E. T.* Fluorogenic Real-Time Reporters of DNA Repair by MGMT, a Clinical Predictor of Antitumor Drug Response. PLoS One 2016, 11 (4), e0152684.
262. Beharry, A. A.; Lacoste, S.; O’Connor, T. R.; Kool, E. T.* Fluorescence Monitoring of the Oxidative Repair of DNA Alkylation Damage by ALKBH3, a Prostate Cancer Marker. J. Am. Chem. Soc. 2016, 138 (11), 3647-50.
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245. Winnacker, M.; Kool, E. T.* Artificial genetic sets composed of size-expanded base pairs. Angew. Chem. Int. Ed. 2013, 52 (48), 12498-508.
244. Kool, E. T.; Park, D. H.; Crisalli, P.* Fast hydrazone reactants: electronic and acid/base effects strongly influence rate at biological pH. J. Am. Chem. Soc. 2013, 135 (47), 17663-6.
243. Jiang, W.; Wang, S.; Yuen, L. H.; Kwon, H.; Ono, T.; Kool, E. T.* DNA-polyfluorophore Chemosensors for Environmental Remediation: Vapor-phase Identification of Petroleum Products in Contaminated Soil. Chem. Sci. 2013, 4 (8), 3184-3190.
242. Xu, L.; Butler, K. V.; Chong, J.; Wengel, J.; Kool, E. T.; Wang, D.* Dissecting the chemical interactions and substrate structural signatures governing RNA polymerase II trigger loop closure by synthetic nucleic acid analogues. Nucleic Acids Res. 2014, 42 (9), 5863-70.
241. Ono, T.; Edwards, S. K.; Wang, S.; Jiang, W.; Kool, E. T.* Monitoring eukaryotic and bacterial UDG repair activity with DNA-multifluorophore sensors. Nucleic Acids Res. 2013, 41 (12), e127.
240. Singh, V.; Wang, S.; Kool, E. T.* Genetically Encoded Multispectral Labeling of Proteins with Polyfluorophores on a DNA Backbone. J. Am. Chem. Soc. 2013, 16, 6184-6191.
239. Attwater, J.; Tagami, J.; Kimoto, M; Butler, K.; Kool, E. T.; Wengel, J.; Herdewijn, P.; Hirao, I.; Holliger, P.* Chemical fidelity of an RNA polymerase ribozyme. Chem. Sci. 2013, 4, 2804-2814.
238. Crisalli, P.; Kool, E. T.* The Importance of ortho Proton Donors in Catalysis of Hydrazone Formation. Org. Lett. 2013, 15, 1646-1649.
237. Jung, J. W.; Edwards, S. K.; Kool, E. T.* Selective fluorogenic chemosensors for distinct classes of nucleases. ChemBioChem 2013, 14 (4), 440-4.
236. Crisalli, P.; Kool, E. T.* Water-soluble organocatalysts for hydrazone and oxime formation. J. Org. Chem. 2013, 78 (3), 1184-9.
235. Spitale, R. C.; Crisalli, P.; Flynn, R. A.; Torre, E. A.; Kool, E. T.*; Chang, H. Y.* RNA SHAPE Analysis in Living Cells. Nat. Chem. Biol. 2013, 9, 18-20.
234. Crisalli, P.; Hernández, A. R.; Kool, E. T.* Fluorescence quenchers for hydrazone and oxime orthogonal bioconjugation. Bioconjug. Chem. 2012, 23 (9), 1969-80.
233. Lee, S. H.; Wang, S.; Kool, E. T.* Templated chemistry for monitoring damage and repair directly in duplex DNA. Chem. Commun. 2012, 48 (65), 8069-71.
232.Kwon, H.; Samain, F.; Kool, E. T.* Fluorescent DNAs Printed on Paper: Sensing Food Spoilage and Ripening in the Vapor Phase. Chem. Sci. 2012, 3, 2542-2549.
231. Wang, S.; Guo, J.; Ono, T.; Kool, E. T.* DNA polyfluorophores for real-time multicolor tracking of dynamic biological systems. Angew. Chem. Int. Ed. 2012, 51 (29), 7176-80.
230. Hernández, A. R.; Peterson, L. W.; Kool, E. T.* Steric restrictions of RISC in RNA interference identified with size-expanded RNA nucleobases. ACS Chem. Biol. 2012, 7 (8), 1454-61.
229. Kellinger, M. W.; Ulrich, S.; Chong, J.; Kool, E. T.;* Wang, D.* Dissecting Chemical Interactions governing RNA Polymerase II Transcriptional Fidelity. J. Am. Chem. Soc. 2012, 134, 8231-8240.
228. Teo, Y. N.; Kool, E. T.* DNA-multichromophore systems. Chem. Rev. 2012, 112 (7), 4221-45.
227. Khakshoor, O.; Wheeler, S. E.; Houk, K. N.; Kool, E. T.* Measurement and theory of hydrogen bonding contribution to isosteric DNA base pairs. J. Am. Chem. Soc. 2012, 134 (6), 3154-63.
226. Harcourt, E. M.; Kool, E. T.* Amplified microRNA detection by templated chemistry. Nucleic Acids Res. 2012, 40 (9), e65.
225. Ono, T.; Wang, S.; Koo, C.-K.; Engstrom, L.; David, S. S.; Kool, E. T.; Direct Fluorescence Monitoring of DNA Base Excision Repair. Angew. Chem. Int. Ed. 2012, 51, 1689-1692.
224. McKibbin, P. L.; Kobori, A.; Taniguchi, Y.; Kool, E. T.; David, S. S.* Surprising repair activities of nonpolar analogs of 8-oxoG expose features of recognition and catalysis by base excision repair glycosylases. J. Am. Chem. Soc. 2012, 134 (3), 1653-61.
223. Ulrich, S.; Kool, E. T.* Importance of steric effects on the efficiency and fidelity of transcription by T7 RNA polymerase. Biochemistry 2011, 50 (47), 10343-9.
222. Crisalli, P.; Kool, E. T.* Multi-path quenchers: efficient quenching of common fluorophores. Bioconjug. Chem. 2011, 22 (11), 2345-54.
221. Krueger, A. T.; Peterson, L. W.; Chelliserry, J.; Kleinbaum, D. J.; Kool, E. T.* Encoding phenotype in bacteria with an alternative genetic set. J. Am. Chem. Soc. 2011, 133 (45), 18447-51.
220. Koo, C. K.; Wang, S.; Gaur, R. L.; Samain, F.; Banaei, N.; Kool, E. T.* Fluorescent DNA chemosensors: identification of bacterial species by their volatile metabolites. Chem. Commun. 2011, 47 (41), 11435-7.
219. Franzini, R. M.; Kool, E. T.* Improved templated fluorogenic probes enhance the analysis of closely related pathogenic bacteria by microscopy and flow cytometry. Bioconjug. Chem. 2011, 22 (9), 1869-77.
218. Koo, C.-K.; Samain, F.; Dai, N.; Kool, E. T.* DNA polyfluorophores as highly diverse chemosensors of toxic gases. Chem. Sci. 2011, 2, 1910-1917.
217. Khakshoor, O.; Kool, E. T.* Chemistry of nucleic acids: impacts in multiple fields. Chem. Commun. 2011, 47 (25), 7018-24.
216. Dai, N.; Guo, J.; Teo, Y. N.; Kool, E. T.; Protease Probes Built from DNA: Multispectral Fluorescent DNA–Peptide Conjugates as Caspase Chemosensor. Angew. Chem. Int. Ed. 2011, 50, 5105-5109.
215. Guo, J.; Wang, S.; Dai, N.; Teo, Y. N.; Kool, E. T.* Multispectral labeling of antibodies with polyfluorophores on a DNA backbone and application in cellular imaging. Proc. Natl. Acad. Sci. U. S. A. 2011, 108 (9), 3493-8.
214. Dai, N.; Kool, E. T.* Fluorescent DNA-based enzyme sensors. Chem. Soc. Rev. 2011, 40 (12), 5756-70.
213. Tan, S. S.; Kim, S. J.; Kool, E. T.* Differentiating between fluorescence-quenching metal ions with polyfluorophore sensors built on a DNA backbone. J. Am. Chem. Soc. 2011, 133 (8), 2664-71.
212. Franzini, R. M.; Kool, E. T.* Two successive reactions on a DNA template: a strategy for improving background fluorescence and specificity in nucleic acid detection. Chemistry 2011, 17 (7), 2168-75.
211. Hernández, A. R.; Kool, E. T.* The components of xRNA: synthesis and fluorescence of a full genetic set of size-expanded ribonucleosides. Org. Lett. 2011, 13 (4), 676-9.
210. Samain, F.; Dai, N.; Kool, E. T.* Differentiating a diverse range of volatile organic compounds with polyfluorophore sensors built on a DNA scaffold. Chemistry 2011, 17 (1), 174-83.
209. Jarchow-Choy, S. K.; Krueger, A. T.; Liu, H.; Gao, J.; Kool, E. T.* Fluorescent xDNA nucleotides as efficient substrates for a template-independent polymerase. Nucleic Acids Res. 2011, 39 (4), 1586-94.
208. Kleinbaum, D. J.; Kool, E. T.* Sandwich probes: two simultaneous reactions for templated nucleic acid detection. Chem. Commun. 2010, 46 (43), 8154-6.
207. Tan, S. S.; Teo, Y. N.; Kool, E. T.* Selective sensor for silver ions built from polyfluorophores on a DNA backbone. Org. Lett. 2010, 12 (21), 4820-3.
206. Li, H.; Franzini, R. M.; Bruner, C.; Kool, E. T.* Templated chemistry for sequence-specific fluorogenic detection of duplex DNA. ChemBioChem 2010, 11 (15), 2132-7.
205. Samain, F.; Ghosh, S.; Teo, Y. N.; Kool, E. T.* Polyfluorophores on a DNA backbone: sensors of small molecules in the vapor phase. Angew. Chem. Int. Ed. 2010, 49 (39), 7025-9.
204. Killelea, T.; Ghosh, S.; Tan, S. S.; Heslop, P.; Firbank, S. J.; Kool, E. T.; Connolly, B. A.* Probing the interaction of archaeal DNA polymerases with deaminated bases using X-ray crystallography and non-hydrogen bonding isosteric base analogues. Biochemistry 2010, 49 (27), 5772-81.
203. Kleinbaum, D. J.; Miller, G. P.; Kool, E. T.* Double displacement: An improved bioorthogonal reaction strategy for templated nucleic acid detection. Bioconjug. Chem. 2010, 21 (6), 1115-20.
202. Lu, H.; Krueger, A. T.; Gao, J.; Liu, H.; Kool, E. T.* Toward a designed genetic system with biochemical function: polymerase synthesis of single and multiple size-expanded DNA base pairs. Org. Biomol. Chem. 2010, 8, 2704-2710.
201. Dai, N.; Teo, Y. N.; Kool, E. T.* DNA-polyfluorophore excimers as sensitive reporters for esterases and lipases. Chem. Commun. 2010, 46 (8), 1221-3.
200. Teo, Y. N.; Kool, E. T.* Polyfluorophore excimers and exciplexes as FRET donors in DNA. Bioconjug. Chem. 2009, 20 (12), 2371-80.
199. Lu, H.; Lynch, S. R.; Lee, A. H.; Kool, E. T.* Structure and replication of yDNA: a novel genetic set widened by benzo-homologation. ChemBioChem 2009, 10 (15), 2530-8.
198. Teo, Y. N.; Wilson, J. N.; Kool, E. T.* Polyfluorophore labels on DNA: dramatic sequence dependence of quenching. Chemistry 2009, 15 (43), 11551-8.
197. Loakes, D.; Gallego, J.; Pinheiro, V. B.; Kool, E. T.; Holliger, P.* Evolving a polymerase for hydrophobic base analogues. J. Am. Chem. Soc. 2009, 131 (41), 14827-37.
196. Franzini, R. M.; Kool, E. T.* Efficient nucleic acid detection by templated reductive quencher release. J. Am. Chem. Soc. 2009, 131 (44), 16021-3.
195. Delaney, J. C.; Gao, J.; Liu, H.; Shrivastav, N.; Essigmann, J. M.; Kool, E. T.* Efficient replication bypass of size-expanded DNA base pairs in bacterial cells. Angew. Chem. Int. Ed. 2009, 48 (25), 4524-7.
194. Krueger, A. T.; Kool, E. T.* Redesigning the architecture of the base pair: toward biochemical and biological function of new genetic sets. Chem. Biol. 2009, 16 (3), 242-8.
193. Jarchow-Choy, S. K.; Sjuvarsson, E.; Sintim, H. O.; Eriksson, S.; Kool, E. T.* Nonpolar nucleoside mimics as active substrates for human thymidine kinases. J. Am. Chem. Soc. 2009, 131 (15), 5488-94.
192. Teo, Y. N.; Wilson, J. N.; Kool, E. T.* Polyfluorophores on a DNA backbone: a multicolor set of labels excited at one wavelength. J. Am. Chem. Soc. 2009, 131 (11), 3923-33.
191. Terrazas, M.; Kool, E. T.* RNA major groove modifications improve siRNA stability and biological activity. Nucleic Acids Res. 2009, 37 (2), 346-53.
190. Krueger, A. T.; Lu, H.; Hojland, T.; Liu, H.; Gao, J.; Kool, E. T.* Toward the Replication of xDNA, a Size-expanded Unnatural Genetic System. Nucleic Acids Symp. Ser. 2008, 52, 455-456.
189. Teo, Y. N.; Kool, E. T.* Studies of oligodeoxyfluorosides (ODFs) as FRET probes for DNA hybridization. Nucleic. Acids. Symp. Ser. 2008, (52), 233-4.
188. Franzini, R. M.; Kool, E. T.* 7-Azidomethoxy-coumarins as profluorophores for templated nucleic acid detection. ChemBioChem 2008, 9 (18), 2981-8.
187. Chelliserrykattil, J.; Lu, H.; Lee, A. H.; Kool, E. T.* Polymerase amplification, cloning, and gene expression of benzo-homologous “yDNA” base pairs. ChemBioChem 2008, 9 (18), 2976-80.
186. Somoza, A.; Silverman, A. P.; Miller, R. M.; Chelliserrykattil, J.; Kool, E. T.* Steric effects in RNA interference: probing the influence of nucleobase size and shape. Chemistry 2008, 14 (26), 7978-87.
185. Pomerantz, A. K.; Moerner, W. E.; Kool, E. T.* Visualization of long human telomere mimics by single-molecule fluorescence imaging. J. Phys. Chem. B 2008, 112 (42), 13184-7.
184. Silverman, A. P.; Abe, H.; Kool, E. T.* Quenched autoligation probes. Methods Mol. Biol. 2008, 429, 161-170.
183. Livingston, A. L.; O’Shea, V. L.; Kim, T.; Kool, E. T.; David, S. S.* Unnatural Substrates Reveal the Importance of 8-oxoguanine for in vivo Mismatch Repair by MutY. Nat. Chem. Bio. 2008, 4, 51-58.
182. Franzini, R. M.; Kool, E. T.* Organometallic activation of a fluorogen for templated nucleic acid detection. Org. Lett. 2008, 10 (14), 2935-8.
181. Lee, H. R.; Helquist, S. A.; Kool, E. T.; Johnson, K. A.* Base pair hydrogen bonds are essential for proofreading selectivity by the human mitochondrial DNA polymerase. J. Biol. Chem. 2008, 283 (21), 14411-6.
180. Lee, H. R.; Helquist, S. A.; Kool, E. T.; Johnson, K. A.* Importance of hydrogen bonding for efficiency and specificity of the human mitochondrial DNA polymerase. J. Biol. Chem. 2008, 283 (21), 14402-10.
179. Silverman, A. P.; Garforth, S. J.; Prasad, V. R.; Kool, E. T.* Probing the active site steric flexibility of HIV-1 reverse transcriptase: different constraints for DNA- versus RNA-templated synthesis. Biochemistry 2008, 47 (16), 4800-7.
178. Krueger, A. T.; Kool, E. T.* Fluorescence of size-expanded DNA bases: reporting on DNA sequence and structure with an unnatural genetic set. J. Am. Chem. Soc. 2008, 130 (12), 3989-99.
177. Wilson, J. N.; Cho, Y.; Tan, S. S.; Cuppoletti, A.; Kool, E. T.* Quenching of fluorescent nucleobases by neigboring DNA: The “Insulator” concept. ChemBioChem 2008, 2, 279-285.
176. Miller, G. P.; Silverman, A. P.; Kool, E. T.* New, stronger nucleophiles for nucleic acid-templated chemistry: Synthesis and application in fluorescence detection of cellular RNA. Bioorg. Med. Chem. 2008, 16 (1), 56-64.
175. Wilson, J. N.; Gao, J.; Kool, E. T.;* Oligodeoxyfluorosides: Strong Sequence Dependence of Fluorescence Emission. Tetrahedron 2007, 63, 3427-3433.
174. Krueger, A. T.; Kool, E. T.* Model systems for understanding DNA base pairing. Curr. Opin. Chem. Biol. 2007, 11 (6), 588-94.
173. Wilson, J. N.; Teo, Y. N.; Kool, E. T.* Efficient quenching of oligomeric fluorophores on a DNA backbone. J. Am. Chem. Soc. 2007, 129 (50), 15426-7.
172. Silverman, A. P.; Jiang, Q.; Goodman, M. F.;* Kool, E. T.* Steric and Electrostatic Effects in DNA Synthesis by the SOS-Induced Polymerase II and IV of Escherichia Coli. Biochemistry 2007, 46, 13874-13881.
171. Silverman, A. P.; Kool, E. T.* RNA probes of steric effects in active sites: high flexibility of HIV-1 reverse transcriptase. J. Am. Chem. Soc. 2007, 129 (35), 10626-7.
170. Taniguchi, Y.; Kool, E. T.; Synthesis and properties of low-polarity mimics of 8-oxopurines. Nucleic Acids Symp. Ser. 2007, 51, 217-218.
169. Taniguchi, Y.; Kool, E. T.* Nonpolar isosteres of damaged DNA bases: effective mimicry of mutagenic properties of 8-oxopurines. J. Am. Chem. Soc. 2007, 129 (28), 8836-44.
168. Kool, E. T.; Waters, M. L.* The model student: what chemical model systems can teach us about biology. Nat. Chem. Biol. 2007, 3 (2), 70-3.
167. Garforth, S. J.; Kim, T. W.; Parniak, M. A.; Kool, E. T.;* Prasad, V. R.* Site-Directed Mutagenesis in the Fingers Subdomain of HIV-1 Reverse Transcriptase Reveals a Specific Role for the b3-b4 Hairpin Loop in dNTP Selection. J. Mol. Bio. 2007, 365, 38-49.
166. Silverman, A. P.; Kool, E. T.* Oligonucleotide Probes for RNA-Targeted Fluorescence In Situ Hybridization. Adv. Clin. Chem. 2007, 43, 79-115.
165. Krueger, A. T.; Lu, H.; Lee, A. H.; Kool, E. T.* Synthesis and properties of size-expanded DNAs: toward designed, functional genetic systems. Acc. Chem. Res. 2007, 40 (2), 141-50.
164. Wilson, J. N.; Kool, E. T.* Fluorescent DNA base replacements: Reporters and sensors for biological systems. Org. Biomol. Chem. 2006, 4 (23), 4265-74.
163. Kool, E. T.; Lu, H.; Kim, S. J.; Tan, S.; Wilson, J. N.; Gao, J.; Liu, H.* New designs for DNA bases: expanded DNAs and oligofluorosides. Nucleic. Acids. Symp. Ser. 2006, (50), 15-6.
162. Silverman, A. P.; Baron, E. J.; Kool, E. T.* RNA-templated chemistry in cells: discrimination of Escherichia, Shigella and Salmonella bacterial strains with a new two-color FRET strategy. ChemBioChem 2006, 7 (12), 1890-4.
161. Yakovleva, L.; Lai, J.; Kool, E. T.; Shuman, S.* Nonpolar nucleobase analogs illuminate requirements for site-specific DNA cleavage by vaccinia topoisomerase. J. Biol. Chem. 2006, 281 (47), 35914-21.
160. Sintim, H. O.; Kool, E. T.* The Difluorotoluene Debate–A Decade Later. Chem. Comm. 2006, 35, 3665-3675.
159. Silverman, A. P.; Kool, E. T.* Detecting RNA and DNA with templated chemical reactions. Chem. Rev. 2006, 106 (9), 3775-89.
158. Lynch, S. R.; Lu, H.; Gao, J.; Kool, E. T.* Toward a Designed, Functioning Genetic System with Expanded-Size Base Pairs: Solution Structure of the Eight-Base xDNA Double Helix. J. Am Chem. Soc. 2006, 128, 14704-14711.
157. Somoza, A.; Chelliserrykattil, J.; Kool, E. T.* The roles of hydrogen bonding and sterics in RNA interference. Angew. Chem. Int. Ed. 2006, 45 (30), 4994-7.
156. Lee, A. H.; Kool, E. T.* Exploring the limits of DNA size: naphtho-homologated DNA bases and pairs. J. Am. Chem. Soc. 2006, 128 (28), 9219-30.
155. Kim, S. J.; Kool, E. T.* Sensing metal ions with DNA building blocks: fluorescent pyridobenzimidazole nucleosides. J. Am. Chem. Soc. 2006, 128 (18), 6164-71.
154. Hariharan, C.; Bloom, L. B.; Helquist, S. A.; Kool, E. T.; Reha-Krantz, L. J.* Dynamics of Nucleotide Incorporation: Snapshots Revealed by 2-Aminopurine Fluorescence Studies. Biochemistry 2006, 45, 2836-2844.
153. Sintim, H. O.; Kool, E. T.* Remarkable sensitivity to DNA base shape in the DNA polymerase active site. Angew. Chem. Int. Ed. 2006, 45 (12), 1974-9.
152. Mizukami, S.; Kim, T. W.; Helquist, S. A.; Kool, E. T.* Varying DNA Base Pair Size in Sub-Angstrom Increments: Evidence for a Loose, Not Large, Active Site in Low-fidelity Dpo4 Polymerase. Biochemistry 2006, 45, 2772-2778.
151. Cho, Y.; Kool, E. T.* Enzymatic synthesis of fluorescent oligomers assembled on a DNA backbone. ChemBioChem 2006, 7 (4), 669-72.
150. Sintim, H. O.; Kool, E. T.* Enhanced base pairing and replication efficiency of thiothymidines, expanded-size variants of thymidine. J. Am. Chem. Soc. 2006, 128 (2), 396-7.
149. Abe, H.; Kool, E. T.* Flow cytometric detection of specific RNAs in native human cells with quenched autoligating FRET probes. Proc. Natl. Acad. Sci. U. S. A. 2006, 103 (2), 263-8.
148. Kim, T. W.; Brieba, L. G.; Ellenberger, T.; Kool, E. T.* Functional evidence for a small and rigid active site in a high-fidelity DNA polymerase: Probing T7 DNA Pol with variable-sized base pairs. J. Biol. Chem. 2006, 281, 2289-2295.
147. Potapova, O.; Chan, C.; DeLucia, A. M.; Helquist, S. A.; Kool, E. T.; Grindley, N. D.; Joyce, C. M.* DNA polymerase catalysis in the absence of Watson-Crick hydrogen bonds: analysis by single-turnover kinetics. Biochemistry 2006, 45 (3), 890-8.
146. Wolfle, W. T.; Washington, M. T.; Kool, E. T.; Spratt, T. E.; Helquist, S. A.; Prakash, L.; Prakash, S.* Evidence for a Watson-Crick hydrogen bonding requirement in DNA synthesis by human DNA polymerase kappa. Mol. Cell. Biol. 2005, 25 (16), 7137-43.
145. Silverman, A. P.; Kool, E. T.* Quenched autoligation probes allow discrimination of live bacterial species by single nucleotide differences in rRNA. Nucleic Acids Res. 2005, 33 (15), 4978-86.
144. Kim, T. W.; Delaney, J. C.; Essigmann, J. M.;* Kool, E. T.* Probing the Active Site Tightness of DNA Polymerase in Sub-Angstrom Increments. Proc. Natl. Acad. Sci. U. S. A. 2005, 102, 15803-15808.
143. Hartig, J. S.; Kool, E. T.* Efficient Isothermal Expansion of Human Telomeric and Minisatellite Repeats by Thermococcus litoralis DNA Polymerase. Nucleic Acids Res. 2005, 33, 4922-4927.
142. Hartig, J. S.; Fernandez-Lopez, S.; Kool, E. T.* Guanine-rich DNA nanocircles for the synthesis and characterization of long cytosine-rich telomeric DNAs. ChemBioChem 2005, 6 (8), 1458-62.
141. Devaraj, N. K.; Miller, G. P.; Ebina, W.; Kakaradov, B.; Collman, J. P.; Kool, E. T.; Chidsey, C. E.* Chemoselective covalent coupling of oligonucleotide probes to self-assembled monolayers. J. Am. Chem. Soc. 2005, 127 (24), 8600-1.
140. Cuppoletti, A.; Cho, Y.; Park, J. S.; Strässler, C.; Kool, E. T.* Oligomeric fluorescent labels for DNA. Bioconjug. Chem. 2005, 16 (3), 528-34.
139. Lai, J. S.; Kool, E. T.* Fluorous Base-pairing Effects in a DNA Polymerase Active Site. Chemistry 2005, 11, 2966-2971.
138. Gao, J.; Liu, H.; Kool, E. T.* Assembly of the complete eight-base artificial genetic helix, xDNA, and its interaction with the natural genetic system. Angew. Chem. Int. Ed. 2005, 44 (20), 3118-22.
137. Yoshina-Ishii, C.; Miller, G. P.; Kraft, M. L.; Kool, E. T.; Boxer, S. G.* General method for modification of liposomes for encoded assembly on supported bilayers. J. Am. Chem. Soc. 2005, 127 (5), 1356-7.
136. Silverman, A. P.; Kool, E. T.* Quenched probes for highly specific detection of cellular RNAs. Trends Biotechnol. 2005, 23 (5), 225-30.
135. Lee, A. H.; Kool, E. T.* A new four-base genetic helix, yDNA, composed of widened benzopyrimidine-purine pairs. J. Am. Chem. Soc. 2005, 127 (10), 3332-8.
134. Kim, T. W.; Kool, E. T.* A series of nonpolar thymidine analogues of increasing size: DNA base pairing and stacking properties. J. Org. Chem. 2005, 70 (6), 2048-53.
133. Lee, A. H. F.; Kool, E. T.* Novel Benzopyrimidines in a New Geometry for Widened Base Pairs. J. Org. Chem. 2005, 70, 132-140.
132. Liu, H.; Gao, J.; Kool, E. T.* Size-expanded analogues of dG and dC: synthesis and pairing properties in DNA. J. Org. Chem. 2005, 70 (2), 639-47.
131. Abe, H.; Kool, E. T.* Universal linkers for signal amplification in auto-ligating probes. Nucleic. Acids. Symp. Ser. 2005, (49), 37-8.
130. Liu, H.; Gao, J.; Kool, E. T.* Helix-forming properties of size-expanded DNA, an alternative four-base genetic form. J. Am. Chem. Soc. 2005, 127 (5), 1396-402.
129. Hartig, J. S.; Kool, E. T.* Small circular DNAs for synthesis of the human telomere repeat: varied sizes, structures and telomere-encoding activities. Nucleic Acids Res. 2004, 32 (19), e152.
128. Kim, T. W.; Kool, E. T.* A Set of Nonpolar Thymidine Nucleoside Analogues With Gradually Increasing Size. Org. Lett. 2004, 6, 3949-3952.
127. Gao, J.; Watanabe, S.; Kool, E. T.* Modified DNA analogues that sense light exposure with color changes. J. Am. Chem. Soc. 2004, 126 (40), 12748-9.
126. Gao, J.; Liu, H.; Kool, E. T.* Expanded-size bases in naturally sized DNA: evaluation of steric effects in Watson-Crick pairing. J. Am. Chem. Soc. 2004, 126 (38), 11826-31.
125. Abe, H.; Kool, E. T.* Destabilizing universal linkers for signal amplification in self-ligating probes for RNA. J. Am. Chem. Soc. 2004, 126 (43), 13980-6.
124. Lu, H.; He, K.; Kool, E. T.* yDNA: A New Geometry for Size-expanded Base Pairs, Angew. Chem. Int. Ed. 2004, 43, 5834-5836.
123. Liu, H.; Lynch, S. R.; Kool, E. T.* Solution structure of xDNA: a paired genetic helix with increased diameter. J. Am. Chem. Soc. 2004, 126 (22), 6900-5.
122. Miller, G. P.; Kool, E. T.* Versatile 5′-functionalization of oligonucleotides on solid support: amines, azides, thiols, and thioethers via phosphorus chemistry. J. Org. Chem. 2004, 69 (7), 2404-10.
121. Lai, J.; Qu, J.; Kool, E. T.* Selective Pairing of Polyfluorinated DNA Bases. J. Am. Chem. Soc. 2004, 126, 3040-3041.
120. Niimi, A.; Limsirichaikul, S.; Yoshida, S.; Iwai, S.; Masutani, C.; Hanaoka, F.; Kool, E. T.; Nishiyama, Y.; Suzuki, M.* Palm mutants in DNA polymerases alpha and eta alter DNA replication fidelity and translesion activity. Mol. Cell. Biol. 2004, 24 (7), 2734-46.
119. Maki, A. S.; Kim, T. W.; Kool, E. T.* Direct Comparison of A-strand and T-strand Minor Groove Interactions in DNA Curvature at A Tracts. Biochemistry 2004, 43, 1102-1110.
118. Liu, H.; Gao, J.; Saito, D.; Maynard, L.; Kool, E. T.*Toward a New Genetic System with Expanded Dimensions: Size-expanded Analogs of Deoxyadenosine and Thymidine. J. Am. Chem. Soc. 2004, 126, 1102-1109.
117. Smietana, M.; Johnson, R. B.; Wang, Q. M.; Kool, E. T.* Solid-phase synthesis and screening of macrocyclic nucleotide-hybrid compounds targeted to hepatitis C NS5B. Chemistry 2004, 10 (1), 173-81.
116. Sando, S.; Abe, H.; Kool, E. T.* Quenched auto-ligating DNAs: multicolor identification of nucleic acids at single nucleotide resolution. J. Am. Chem. Soc. 2004, 126 (4), 1081-7.
115. Francis, A. W.; Helquist, S. A.; Kool, E. T.; David, S. S.* Probing the requirements for recognition and catalysis in Fpg and MutY with nonpolar adenine isosteres. J. Am. Chem. Soc. 2003, 125 (52), 16235-42.
114. Maki, A.; Brownewell, F. E.; Liu, D.; Kool, E. T.* DNA curvature at A tracts containing a nonpolar thymine mimic. Nucleic Acids Res. 2003, 31, 1059-1066.
113. Kool, E. T.; Miller, G. P.* 5′-Iodination of solid-phase-linked oligodeoxyribonucleotides. Curr. Protoc. Nucleic Acid Chem. 2003, Chapter 4, Unit 4.19.
112. Liu, H.; Gao, J.; Lynch, S. R.; Saito, Y. D.; Maynard, L.; Kool, E. T.* A four-base paired genetic helix with expanded size. Science 2003, 302 (5646), 868-71.
111. Lai, J. S.; Qu, J.; Kool, E. T.* Fluorinated DNA bases as probes of electrostatic effects in DNA base stacking. Angew. Chem. Int. Ed. 2003, 42 (48), 5973-7.
110. Sun, L.; Zhang, K.; Zhou, L.; Hohler, P.; Kool, E. T.; Yuan, F.; Wang, Z.; Taylor, J. S.* Yeast pol eta holds a cis-syn thymine dimer loosely in the active site during elongation opposite the 3′-T of the dimer, but tightly opposite the 5′-T. Biochemistry 2003, 42 (31), 9431-7.
109. Rausch, J. W.; Qu, J.; Yi-Brunozzi, H. Y.; Kool, E. T.; Le Grice, S. F. J.* Hydrolysis of RNA/DNA hybrids containing nonpolar pyrimidine isosteres defines regions essential for HIV type 1 polypurine tract selection. Proc. Natl. Acad. Sci. U. S. A. 2003, 100, 11279-11284.
108. Begley, T. J.; Haas, B. J.; Morales, J. C.; Kool, E. T.; Cunningham, R. P.* Kinetics and Binding of the Thymine DNA Mismatch Glycosylase, Mig-Mth with Mismatch-Containing DNA Substrates. DNA Repair 2003, 2, 107-120.
107. Delaney, J. C.; Henderson, P. T.; Helquist, S. A.; Morales, J. C.; Essigmann, J. M.; Kool, E. T.* High-fidelity in vivo replication of DNA base shape mimics without Watson-Crick hydrogen bonds. Proc. Natl. Acad. Sci. U. S. A. 2003, 100 (8), 4469-73.
106. Washington, M. T.; Helquist, S. A.; Kool, E. T.; Prakash, L.; Prakash, S.* Requirement of Watson-Crick hydrogen bonding for DNA synthesis by yeast DNA polymerase eta. Mol. Cell. Biol. 2003, 23 (14), 5107-12.
105. Morales-Rojas, H.; Kool, E. T.* A porphyrin C-nucleoside incorporated into DNA. Org. Lett. 2002, 4 (25), 4377-80.
104. Smirnov, S.; Matray, T. J.; Kool, E. T.; de, l. o. s.* Integrity of duplex structures without hydrogen bonding: DNA with pyrene paired at abasic sites. Nucleic Acids Res. 2002, 30 (24), 5561-9.
103. Lindstrom, U. M.; Chandrasekaran, R. A.; Orbai, L.; Helquist, S. A.; Miller, G. P.; Oroudjev, E.; Hansma, H. G.; Kool, E. T.* Artificial human telomeres from DNA nanocircle templates. Proc. Natl. Acad. Sci. U. S. A. 2002, 99 (25), 15953-8.
102. Miller, G. P.; Kool, E. T.* A simple method for electrophilic functionalization of DNA. Org. Lett. 2002, 4 (21), 3599-601.
101. Lindström, U. M.; Kool, E. T.* An orthogonal oligonucleotide protecting group strategy that enables assembly of repetitive or highly structured DNAs. Nucleic Acids Res. 2002, 30 (19), e101.
100. Gao, J.; Strässler, C.; Tahmassebi, D.; Kool, E. T.* Libraries of composite polyfluors built from fluorescent deoxyribosides. J. Am. Chem. Soc. 2002, 124 (39), 11590-1.
99. Smietana, M.; Kool, E. T.* Efficient and simple solid-phase synthesis of short cyclic oligodeoxynucleotides bearing a phosphorothioate linkage. Angew. Chem. Int. Ed. 2002, 41 (19), 3704-7; 3523.
98. Sando, S.; Kool, E. T.* Imaging of RNA in bacteria with self-ligating quenched probes. J. Am. Chem. Soc. 2002, 124 (33), 9686-7.
97. O’Neill, B. M.; Ratto, J. E.; Good, K. L.; Tahmassebi, D. C.; Helquist, S. A.; Morales, J. C.; Kool, E. T.* A highly effective nonpolar isostere of deoxyguanosine: synthesis, structure, stacking, and base pairing. J. Org. Chem. 2002, 67 (17), 5869-75.
96. Kool, E. T.* Replacing the nucleobases in DNA with designer molecules. Acc. Chem. Res. 2002, 35 (11), 936-43.
95. Kool, E. T.* Active site tightness and substrate fit in DNA replication. Annu. Rev. Biochem. 2002, 71 (), 191-219.
94. Sando, S.; Kool, E. T.* Quencher as leaving group: efficient detection of DNA-joining reactions. J. Am. Chem. Soc. 2002, 124 (10), 2096-7.
93. Drotschmann, K.; Hall, M. C.; Shcherbakova, P. V.; Wang, H.; Erie, D. A.; Brownewell, F. R.; Kool, E. T.; Kunkel, T. A.* DNA binding properties of the yeast Msh2-Msh6 and Mlh1-Pms1 heterodimers. Biol. Chem. 2002, 383 (6), 969-75.
92. Ohmichi, T.; Maki, A.; Kool, E. T.* Efficient bacterial transcription of DNA nanocircle vectors with optimized single-stranded promoters. Proc. Natl. Acad. Sci. U. S. A. 2002, 99 (1), 54-9.
91. Drotschmann, K.; Yang, W.; Brownewell, F. E.; Kool, E. T.; Kunkel, T. A.* Asymmetric recognition of DNA local distortion. Structure-based functional studies of eukaryotic Msh2-Msh6. J. Biol. Chem. 2001, 276 (49), 46225-9.
90. Schofield, M. J.; Brownewell, F. E.; Nayak, S.; Du, C.; Kool, E. T.; Hsieh, P.* The Phe-X-Glu DNA binding motif of MutS. The role of hydrogen bonding in mismatch recognition. J. Biol. Chem. 2001, 276 (49), 45505-8.
89. Diegelman, A. M.; Kool, E. T.* Chemical and enzymatic methods for preparing circular single-stranded DNAs. Curr. Protoc. Nucleic Acid Chem. 2001, Chapter 5, Unit 5.2.
88. Dzantiev, L.; Alekseyev, Y. O.; Morales, J. C.; Kool, E. T.; Romano, L. J.* Significance of nucleobase shape complementarity and hydrogen bonding in the formation and stability of the closed polymerase-DNA complex. Biochemistry 2001, 40 (10), 3215-21.
87. Xu, Y.; Karalkar, N. B.; Kool, E. T.* Nonenzymatic autoligation in direct three-color detection of RNA and DNA point mutations. Nat. Biotechnol. 2001, 19 (2), 148-52.
86. Kool, E. T.* Hydrogen bonding, base stacking, and steric effects in DNA replication. Ann. Rev. Biophys. Biomol. Struct. 2001, 30, 1-22.
85. Sun, L.; Wang, M.; Kool, E. T.; Taylor, J. S.* Pyrene nucleotide as a mechanistic probe: evidence for a transient abasic site-like intermediate in the bypass of dipyrimidine photoproducts by T7 DNA polymerase. Biochemistry 2000, 39 (47), 14603-10.
84. Morales, J. C.; Kool, E. T.* Functional Hydrogen-Bonding Map of the Minor Groove Binding Track of Six DNA Polymerases. Biochemistry 2000, 39, 12979-12988.
83. Kool, E. T.* Roles of Watson-Crick and minor groove hydrogen bonds in DNA replication. Cold Spring Harb. Symp. Quant. Biol. 2000, 65, 93-102.
82. Kool, E. T.* Synthetically modified DNAs as substrates for polymerases. Curr. Opin. Chem. Biol. 2000, 4 (6), 602-8.
81. Xu, Y.; Kool, E. T.* Rapid, selective selenium-mediated autoligation of DNA strands. J. Am. Chem. Soc. 2000, 122, 9040-9041.
80. Guckian, K. M.; Krugh, T. R.; Kool, E. T.* Solution Structure of a Nonpolar, Non-Hydrogen-Bonded Base Pair Surrogate in DNA. J. Am. Chem. Soc. 2000, 122 (29), 6841-6847.
79. Morales, J. C.; Kool, E. T.* Varied Molecular Interactions at the Active Sites of Several DNA Polymerases: Nonpolar Nucleoside Isosteres as Probes. J. Am. Chem. Soc. 2000, 122 (6), 1001-1007.
78. Morales, J. C.; Kool, E. T.* Importance of terminal base pair hydrogen-bonding in 3′-end proofreading by the Klenow fragment of DNA polymerase I. Biochemistry 2000, 39 (10), 2626-32.
77. Guckian, K. M.; Schweitzer, B. A.; Ren, R. X.; Sheils, C. J.; Tahmassebi, D. C.; Kool, E. T.* Factors Contributing to Aromatic Stacking in Water: Evaluation in the Context of DNA. J. Am. Chem. Soc. 2000, 122 (10), 2213-2222.
76. Kool, E. T.;* Morales, J. C.; Guckian, K. M. Mimicking the Structures and Functions of DNA: Insights into DNA Stability and Replication. Angew. Chem. Int. Ed. 2000, 39, 990-1009.
75. Ohmichi, T.; Kool, E. T.* The virtues of self-binding: high sequence specificity for RNA cleavage by self-processed hammerhead ribozymes. Nucleic Acids Res. 2000, 28 (3), 776-83.
74. Strässler, C.; Davis, N. E.; Kool, E. T.* Novel Nucleoside Analogues with Fluorophores Replacing the DNA Base. Helv. Chim. Acta. 1999, 82 (12), 2160-2171.
73. Rowley, P. T.;* Kosciolek, B. A.; Kool, E. T. Circular Antisense Oligonucleotides Inhibit Growth of Chronic Myeloid Leukemia Cells. Mol. Med. 1999, 5, 693-700.
72. Frieden, M.; Pedroso, E.;* Kool, E. T.* Tightening the Belt on Polymerases: Evaluating the Physical Constraints on Enzyme Substrate Size. Angew. Chem. Int. Ed. 1999, 38, 3654-3657.
71. Diegelman, A. M.; Kool, E. T.* Mimicry of the hepatitis delta virus replication cycle mediated by synthetic circular oligodeoxynucleotides. Chem. Biol. 1999, 6 (8), 569-76.
70. Hansma, H.;* Golan, R.; Hsieh, W.; Daubendiek, S. L.; Kool, E. T. Polymerase Activities and RNA Structures in the Atomic Force Microscope. J. Struct. Biol. 1999, 127, 240-247.
69. Matray, T. J.; Kool, E. T.* A specific partner for abasic damage in DNA. Nature 1999, 399 (6737), 704-8.
68. Barsky, D.; Colvin, M;* Kool, E. T. Interaction and Solvation Energies of Nonpolar DNA Base Analogues and Their Role in Polymerase Insertion Fidelity. J. Biomol. Struct. Dyn. 1999, 16 (6), 1119-1134.
67. Thomson, N. H.; Smith, B. L.;* Almqvist, N.; Schmitt, L.; Kashlev, M.; Kool, E. T.; Hansma, P. K. Oriented, Active Escherichia coli RNA Polymerase: An Atomic Force Microscope Study. Biophys. J. 1999, 76 (2), 1024-1033.
66. Morales, J. C.; Kool, E. T.* Minor Groove Interactions between Polymerase and DNA: More Essential to Replication than Watson−Crick Hydrogen Bonds? J. Am. Chem. Soc. 1999, 121 (10), 2723-2724.
65. Xu, Y.; Kool, E. T.* High sequence fidelity in nonenzymatic autoligation of oligodeoxynucleotides. Nucleic Acids Res.1999, 27 (3), 875-881.
64. Hecht, M. H.;* Hindsgaul, O.;* Kool, E. T.* Biopolymers: Editorial Review. Curr. Opin. Chem. Biol. 1998, 2 (6), 673-674.
63. Guckian, K. M.; Morales, J. C.; Kool, E. T.* Structure and Base Pairing Properties of a Replicable Nonpolar Isostere for Deoxyadenosine. J. Org. Chem. 1998, 63 (26), 9652-9656.
62. Guckian, K. M.; Krugh, T. R.; Kool, E. T.* Solution structure of a DNA duplex containing a replicable difluorotoluene-adenine pair. Nat. Struct. Biol. 1998, 5 (11), 954-9.
61. Guckian, K. M.; Krugh, T. R.; Kool, E. T.* Solution structure of a DNA duplex containing a replicable difluorotoluene-adenine pair. Nat. Struct. Biol. 1998, 5 (11), 954-9.
60. Kool, E. T.* Replication of non-hydrogen bonded bases by DNA polymerases: A mechanism for steric matching . Biopolymers 1998, 48 (1), 3-17.
59. Diegelman, A. M.; Daubendiek, S. L.; Kool, E. T.* Generation of RNA ladders by rolling circle transcription of small circular oligodeoxyribonucleotides. Biotechniques 1998, 25 (5), 754-8.
58. Morales, J. C.; Kool, E. T.* Efficient replication of a DNA base pair between non-hydrogen-bonded nucleoside analogues. Nat. Struct. Biol. 1998, 5 (11), 590-4.
57. Paris, P. L.; Langenhan, J. M.; Kool, E. T.* Probing DNA sequences in solution with a monomer-excimer fluorescence color change. Nucleic Acids Res. 1998, 26 (16), 3789-93.
56. Xu, Y.; Kool, E. T.* Chemical and enzymatic properties of bridging 5′-S-phosphorothioester linkages in DNA. Nucleic Acids Res. 1998, 26 (13), 3159-64.
55. Matray, T. J.; Kool, E. T.* Selective and Stable DNA Base Pairing without Hydrogen Bonds. J. Am. Chem. Soc. 1998, 120 (24), 6191-6192.
54. Diegelman, A. M.; Kool, E. T.* Generation of circular RNAs and trans-cleaving catalytic RNAs by rolling transcription of circular DNA oligonucleotides encoding hairpin ribozymes. Nucleic Acids Res. 1998, 26 (13), 3235-41.
53. Kool, E. T.* Recognition of DNA, RNA, and Proteins by Circular Oligonucleotides. Acc. Chem. Res. 1998, 31 (8), 502-510.
52. Ryan, K.; Kool, E. T.* Triplex-directed self-assembly of an artificial sliding clamp on duplex DNA. Chem. Biol. 1998, 5 (2), 59-67.
51. Guckian, K. M.; Kool, E. T.* Highly Precise Shape Mimicry by a Difluorotoluene Deoxynucleoside, a Replication-Competent Substitute for Thymidine. Angew. Chem. Int. Ed. Engl. 1997, 36 (24), 2825-2828.
50. Kool, E. T.; Topological Modification of DNA: Circles, Loops, Knots, and Branches. Chapter in Comprehensive Natural Products Chemistry, vol.VII, 1999, 341-369, Elsevier Press: Oxford, UK.
49. Liu, D.; Moran, S.; Kool, E. T.* Bi-stranded, multisite replication of a base pair between difluorotoluene and adenine: confirmation by ‘inverse’ sequencing. Chem. Biol. 1997, 4 (12), 919-926.
48. Moran, S.; Ren, R X.-F.; Kool, E. T.* A thymidine triphosphate shape mimic lacking Watson-Crick pairing ability is replicated with high specificity. Proc. Natl. Acad. Sci. U. S. A. 1997, 94 (20), 10506-10511.
47. Sun, W.; Hattman, S.;* Kool, E. T. Interaction of the bacteriophage Mu transcriptional activator protein, C, with its target site in the mom promoter. J. Mol. Biol. 1997, 273 (4), 765-774.
46. Xu, Y.; Kool, E. T.* A Novel 5′-Iodonucleoside Allows Efficient Nonenzymatic Ligation of Single-stranded and Duplex DNAs. Tetrahedron Lett. 1997, 38 (32), 5595-5598.
45. Gupta, V.; Kool, E. T.* A self-cleaving DNA nucleoside. Chem. Commun. 1997, 15, 1425-1426.
44. Daubendiek, S. L.; Kool, E. T.* Generation of catalytic RNAs by rolling transcription of synthetic DNA nanocircles. Nat. Biotechnol. 1997, 15 (3), 273-7.
43. Moran, S.; Ren, R. X.; Rumney, S.; Kool, E. T.* Difluorotoluene, a Nonpolar Isostere for Thymine, Codes Specifically and Efficiently for Adenine in DNA Replication. J. Am. Chem. Soc. 1997, 119 (8), 2056-2057.
42. Wang, S.; Xu, Y.; Kool, E. T.* Recognition of RNA by triplex formation: divergent effects of pyrimidine C-5 methylation. Bioorg. Med. Chem. 1997, 5 (6), 1043-50.
41. Kool, E. T.* Preorganization of DNA: Design Principles for Improving Nucleic Acid Recognition by Synthetic Oligonucleotides. Chem. Rev. 1997, 97 (5), 1473-1487.
40. Kasas, S.; Thomson, N. H.; Smith, B.; Hansma, H. G.; Zhu, X.; Guthold, M.; Bustamente, C.; Kool, E. T.; Kashlev, M.; Hansma, P. K.* Escherichia coli RNA Polymerase Activity Observed Using Atomic Force Microscopy. Biochemistry 1997, 36 (3), 461-468.
39. Kool, E. T.* Design of triplex-forming oligonucleotides for binding DNA and RNA: Optimizing affinity and selectivity. New J. Chem. 1997, 21 (1), 33-45.
38. Chaudhuri, N. C.; Ren, R. X.; Kool, E. T.* C-Nucleosides Derived from Simple Aromatic Hydrocarbons. Synlett 1997, 4, 341-347.
37. Guckian, K. M.; Schweitzer, B. A.; Ren, R. X.; Sheils, C. J.; Paris, P. L.; Tahmassebi, D. C.; Kool, E. T.* Experimental Measurement of Aromatic Stacking Affinities in the Context of Duplex DNA. J. Am. Chem. Soc. 1996, 118 (34), 8182-8183.
36. Ren, R. X.-F.; Chaudhuri, N. C.; Paris, P. L.; Rumney IV, S.; Kool, E. T.* Naphthalene, Phenanthrene, and Pyrene as DNA Base Analogues: Synthesis, Structure, and Fluorescence in DNA. J. Am. Chem. Soc. 1996, 118 (33), 7671-7678.
35. Moran, S.; Ren, R. X.-F. Sheils, C. J.; Rumney IV, S.; Kool, E. T.* Non-Hydrogen Bonding ‘Terminator’ Nucleosides Increase the 3′-end Homogeneity of Enzymatic RNA and DNA Synthesis. Nucleic Acids Res. 1996, 24 (11), 2044-2052.
34. Schweitzer, B. A.; Sheils, C. J.; Ren, X.-F.; Chaudhuri, N. C.; Kool, E. T.* Hydrophobic nucleoside isosteres as biophysical probes of noncovalent interactions: Analysis of structure and electrostatics. Biological Structure and Dynamics, vol. 2, R. H. Sarma, M. H. Sarma, Eds., Adenine Press: Albany,1996, 209-216.
33. Ren, X.-F.; Schweitzer, B. A.; Sheils, C. J.; Kool, E. T.* Formation of Stable DNA Loops by Incorporation of Nonpolar, Non-Hydrogen-Bonding Nucleoside Isosteres. Angew. Chem. Int. Ed. 1996, 35 (7), 743-746.
32. Liu, D.; Daubendiek, S. L.; Zillmann, M. A.; Ryan, K.; Kool, E. T.* Rolling Circle DNA Synthesis: Small Circular Oligonucleotides as Efficient Templates for DNA Polymerases. J. Am. Chem. Soc.1996, 118 (7), 1587-1594.
31. Kool, E. T.* Topological modification of oligonucleotides for potential inhibition of gene expression. Perspect. Drug Discov. Des. 1996, 4, 61-75.
30. Kool, E. T.* Circular Oligonucleotides: New Concepts in Oligonucleotide Design. Ann. Rev. Biophys. Biomol. Struct. 1996, 25, 1-28.
29. Kool, E. T.* Topologically Modified Biopolymers: Properties of Synthetic Circular DNAs and RNAs. Trends Polym. Sci. 1995, 3 (12), 396-402.
28. Chaudhuri, N. C.; Kool, E. T.* Very High Affinity DNA Recognition by Bicyclic and Cross-Linked Oligonucleotides. J. Am. Chem. Soc. 1995, 117 (42), 10434-10442.
27. Rubin, E.; Rumney IV, S.; Wang, S.; Kool, E. T.* Convergent DNA synthesis: a non-enzymatic dimerization approach to circular oligodeoxynucleotides. Nucleic Acids Res. 1995, 23 (17), 3547-3553.
26. Kool, E. T.* Expanding the functional capabilities of nucleic acids by molecular design. Polymer Reprints 1995, 36, 589-590.
25. Vo, T.; Wang, S.; Kool, E. T.* Targeting pyrimidine single strands by triplex formation: structural optimization of binding. Nucleic Acids Res. 1995, 23 (15), 2937-44.
24. Daubendiek, S. L.; Ryan, K.; Kool, E. T.* Rolling-Circle RNA Synthesis: Circular Oligonucleotides as Efficient Substrates for T7 RNA Polymerase. J. Am. Chem. Soc. 1995, 117 (29), 7818-7819.
23. Wang, S.; Friedman, A. E.; Kool, E. T.* Origins of high sequence selectivity: a stopped-flow kinetics study of DNA/RNA hybridization by duplex- and triplex-forming oligonucleotides. Biochemistry 1995, 34 (30), 9774-84.
22. Rumney, S.; Kool, E. T.* Structural Optimization of Non-Nucleotide Loop Replacements for Duplex and Triplex DNAs. J. Am. Chem. Soc. 1995, 117 (21), 5635-5646.
21. Wang, S.; Kool, E. T.* Relative stabilities of triple helices composed of combinations of DNA, RNA and 2′-O-methyl-RNA backbones: chimeric circular oligonucleotides as probes. Nucleic. Acids. Res. 1995, 23 (7), 1157-64.
20. Chaudhuri, N. C.; Kool, E. T.* An efficient method for the synthesis of aromatic C-nucleosides. Tetrahedron Lett. 1995, 36 (11), 1795-1798.
19. Wang, S.; Kool, E. T.* Origins of the large differences in stability of DNA and RNA helices: C-5 methyl and 2′-hydroxyl effects. Biochemistry 1995, 34 (12), 4125-32.
18. Schweitzer, B. A.; Kool, E. T.* Hydrophobic, Non-Hydrogen-Bonding Bases and Base Pairs in DNA. J. Am. Chem. Soc. 1995, 117 (7), 1863-1872.
17. Kool, E. T.* Circular Oligonucleotides as Potential Modulators of Gene Expression. Chapter in Delivery Systems for Antisense Oligonucleotide Therapeutics, S. Akhtar, ed., CRC Press: Boca Raton, 1995, pp. 123-149.
16. Schweitzer, B. A.; Kool, E. T.* Aromatic Nonpolar Nucleosides as Hydrophobic Isosteres of Pyrimidine and Purine Nucleosides. J. Org. Chem. 1994, 59 (24), 7238-7242.
15. Wang, S.; Kool, E. T.* Recognition of Single-Stranded Nucleic Acids by Triplex Formation: The Binding of Pyrimidine-Rich Sequences. J. Am. Chem. Soc. 1994, 116 (19), 8857-8858.
14. Wang, S.; Kool, E. T.* Circular RNA oligonucleotides. Synthesis, nucleic acid binding properties, and a comparison with circular DNAs. Nucleic Acids Res. 1994, 22 (12), 2326-2333.
13. Wang, S.; Booher, M. A.; Kool, E. T.* Stabilities of nucleotide loops bridging the pyrimidine strands in DNA pyrimidine·purine·pyrimidine triplexes: special stability of the CTTTG loop. Biochemistry 1994, 33 (15), 4639-44.
12. Booher, M. A.; Wang, S.; Kool, E. T.* Base Pairing and Steric Interactions Between Pyrimidine Strand Bridging Loops and the Purine Strand in DNA Pyrimidine·Purine·Pyrimidine Triple Helices. Biochemistry 1994, 33 (15), 4645-4651.
11. Rubin, E.; Kool, E. T.* Strong Selective Binding of Six Different DNA Sequences by a Single Conformation-Switching DNA Macrocycle. Angew. Chem. Int. Ed. 1994, 33 (9), 1004-1007.
10. D’Souza, D. J.; Kool, E. T.* Solvent, pH, and Ionic Effects on the Binding of Single-Stranded DNA by Circular Oligodeoxynucleotides. Bioorg. Med. Chem. Lett. 1994, 4 (8), 965-970.
9. Rubin, E.; McKee, T. L.; Kool, E. T.* Binding of Two Different DNA Sequences by Conformational Switching. J. Am. Chem. Soc. 1993, 115 (1), 360-361.
8. Perkins, T. A.; Goodman, J. L.;* Kool, E. T.* Accelerated displacement of duplex DNA strands by a synthetic circular oligodeoxynucleotide. J. Chem. Soc., Chem. Commun. 1993, 3, 215-217.
7. Rumney, S.; Kool, E. T.* DNA Recognition by Hybrid Oligoether-Oligodeoxynucleotide Macrocycles. Angew. Chem. Int. Ed. 1992, 31 (12), 1617-1619.
6. D’Souza, D. J.; Kool, E. T.* Strong binding of single-stranded DNA by stem-loop oligonucleotides. J. Biomol. Struct. Dyn. 1992, 10 (1), 141-52.
5. Prakash, G.; Kool, E. T.* Structural Effects in the Recognition of DNA by Circular Oligonucleotides. J. Am. Chem. Soc. 1992, 114 (9), 3523-3527.
4. Kool, E. T.* Molecular recognition by circular oligonucleotides: increasing the selectivity of DNA binding, J. Am. Chem. Soc. 1991, 113 (16), 6265-6266.
3. Prakash, G.; Kool, E. T.* Molecular Recognition by Circular Oligonucleotides. Strong Binding of Single-stranded DNA and RNA. J. Chem. Soc. Chem. Commun. 1991, 1991 (17), 1161-1163.
2. Kool, E. T.; Breslow, R.* Dichotomous salt effects in the hydrophobic acceleration of the benzoin condensation, J. Am. Chem. Soc. 1988, 110 (5), 1596-1597.
1. Breslow, R.*; Kool, E. T. A γ-cyclodextrin thiazolium salt holoenzyme mimic for the benzoin condensation. Tet. Lett. Soc. Chem. Commun. 1988, 29 (14), 1635-1638.