Investigator: Scott A. Yerby, PhD Project Staff: Gary S. Beaupré, PhD; Adam F. Paal, MD; P.M. Young, BS; Stuart B. Goodman, MD, PhD; Reiner H. Dauskardt, PhD; and K.L. Ohashi, PhD Project Category: Arthritis - 2000 Debonding of the cement-implant interface is the initial event in loosening of total hip implants. The cement-implant interface is inherently weak in tension and shear and in many cases does not provide adequate strength throughout the life of the implant. Silane coupling agents are a chemical coating applied to the implant which provides a chemical bond between the implant and the cement. This study was undertaken to analyze the strength of this interface immediately after application and after 60 days of saline immersion. The silane provided significantly improved strength both immediately after application and after 60 days of saline immersion. This silane coupling agent should provide improved interface strength in vivo and result in a reduced rate of implant loosening. Publications: This project has resulted in a number of conference presentations and one journal article. Yerby SA, Young PM, Beaupré GS, Paal A, Goodman SB: The Effect of a Silane Coupling Agent on the Bond Strength of Bone Cement and Cobalt-Chromium Alloy. 1st Annual Rehab R&D Meeting 181, 1998. Paal AF, Yerby SA, Young PM, Beaupré GS, Goodman SB: The Effect of a Silane Bonding Agent at the Bone Cement-Implant Interface. Trans Orthop Res Soc 24:122, 1999. Yerby SA, Paal AF, Young PM, Beaupré GS, Goodman SB: The Effect of a Silane Coupling Agent on the Bond Strength of Bone Cement and Cobalt-Chrome Alloy. J Biomed Mater Res 49(1):127-133, 2000. Ohashi KL, Yerby SA, Dauskardt RH: Effects of a Silane Adhesion Promoter on the Fracture and Fatigue Debond Characteristics of Metal/PMMA Interfaces. Trans Orthop Res Soc 25:219, 2000. Young PM, Yerby SA, Beaupré GS, Ohashi KL, Goodman SB: The Effect of a Silane Coupling Agent on the Alloy/PMMA Interface. Trans Orthop Res Soc 25:251, 2000. Funding Source: Kulzer GmbH |
