The laboratory focuses on signaling in the immune system and study of oncogenic process. Study of cancer, autoimmunity, and the manners in which single cells can be distinguished from normal human tissues, and their biology understood thereby, are prominent in our studies.

We use advanced Flow Cytometric analysis (FACS) of phosphoproteins in single cells and dominant effector genetics to achieve many of our goals. For this we have developed a range of FACS assays, cDNA and peptide expression systems using advanced signaling analysis at the single cells level, coupled to high throughput proteomics technologies and Bayesian mathematics, to study pathways of interest to us and derive signaling structures in normal and diseased cells.