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Dept of Molecular Pharmacology
Dept of Microbiology & Immunology

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6. Multiple, but Possible, Steps Towards Replication Competency


Even bipartite constructs are not immune to the potential for outbreak of helper virus. Although less likely, I outline here some crossovers that can occur at the DNA or RNA level with constructs in cells that can lead to replication competent helper-virus outbreak.




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