Karl Deisseroth, M.D., Ph.D.

E-mail: deissero at stanford.edu

D.H. Chen Professor of Bioengineering
and of Psychiatry and Behavioral Sciences
Stanford University
Howard Hughes Medical Institute

318 Campus Drive West
Clark Center W083
Department of Bioengineering
Stanford University
Stanford, CA 94305


1988-1992 A.B., Biochemical Sciences, summa cum laude, Harvard University
1992-2000 M.D., Stanford University Medical School (MSTP Program)
1994-1998 Ph.D. Stanford University (Neuroscience)

Postgraduate Training

2000-2001 MD internship/licensure, Stanford
2000-2004 Psychiatry Residency, Stanford

Specialty Board Certification

2006 Diplomate, American Board of Neurology and Psychiatry (renewed 2016)

Previous Academic and Administrative Appointments

2004-2005 Principal Investigator and Clinical Educator, Department of Psychiatry, Stanford University School of Medicine
2005-2008 Assistant Professor of Bioengineering and Psychiatry, Stanford
2009-2012 Associate Professor of Bioengineering and Psychiatry, Stanford
2009-2013 HHMI Early Career Investigator
2012-pres Professor of Bioengineering and Psychiatry, Stanford University
2012-pres D.H. Chen Professorship and Chair, Stanford University
2013-2019 Foreign Adjunct Professor, Karolinska Institutet
2014-pres Investigator, HHMI


National and International
2005-2007 Scientific advisor, nonprofit: Michael J Fox Foundation for Parkinson's Research
2007-2009 Member, NIH Molecular Neurogenetics chartered study section (MNG)
2007- Ad hoc member, NIH study sections
2007- Scientific advisor, nonprofit: Kinetics Foundation for Parkinson's Research
2008- Woods Hole and Cold Spring Harbor couses; yearly optogenetics teaching
2008- Stanford, optogenetics course for visiting students
2009- NARSAD Council (Brain and Behavior Research Foundation)
2010- Elected to the National Academy of Medicine
2011- Elected to the National Academy of Sciences
2019- Elected to the National Academy of Engineering
2010- Chair of Undergraduate Education in Bioengineering
2004- Inpatient and outpatient care: attending physician, inpatient and outpatient service, interventional psychiatry

Honors and Awards

1990-1992 John Harvard Scholarship: Academic Achievement of the Highest Distinction, Harvard
1992 Phi Beta Kappa, Harvard
1992 Summa cum laude, Harvard
1992 Highest Honors, Department of Biochemistry and Molecular Biology, Harvard
1997 Stanford Yanofsky Graduate Research Award
2002 NIMH Outstanding Resident Award
2004 American Psychiatric Association Resident Research Award
2004 Charles E. Culpeper Scholarship in Medical Science Award
2005 Klingenstein Fellowship Award and Robert H. Ebert Clinical Scholar Award
2005 Whitehall Foundation Award
2005 NARSAD Young Investigator Award
2005 American Psychiatric Institute for Research and Education Young Faculty Award
2005 McKnight Foundation Technological Innovations in Neuroscience Award
2005 Coulter Foundation Early Career Translational Research Award in Biomedical Engineering
2005 NIH Director's Pioneer Award
2006 Presidential Early Career Award in Science and Engineering (PECASE)
2007 McKnight Foundation Scholar Award
2007 Top 10 Technologies Award, MIT Technology Review
2008 Brilliant 10 Award, Popular Science
2008 World Economic Forum Lecturer, Davos Switzerland
2008 William M. Keck Foundation Medical Research Award
2008 Lawrence C. Katz Prize, Duke University, for optogenetics
2008 Schuetze Prize, Columbia University, for optogenetics
2009 Society for Neuroscience YIA Award, for optogenetics
2009 Society for Neuroscience Special Lecture: "Optogenetics: Development and Application"
2010 Gill YIA Award, Indiana University, for optogenetics
2010 Koetser Prize laureate, Zurich Switzerland, for optogenetics
2010 Nakasone Prize laureate, International Human Frontier Science Program/HFSP, for optogenetics
2010 National Academy of Medicine (NAM) Election
2011 Alden Spencer Prize, Columbia, for optogenetics
2012 Perl/UNC Prize, for optogenetics
2012 Record Prize, Baylor, for optogenetics
2012 National Academy of Sciences (NAS)
2012 Zuelch Prize, Max-Planck Society, for optogenetics
2013 Richard Lounsbery Prize from the National Academy of Sciences, for optogenetics
2013 BRAIN Prize, Lundbeck Research Foundation, for optogenetics
2013 Pasarow Foundation Award, for neuropsychiatry
2013 Howard Hughes Medical Institute Investigator
2013 Premio Citta' di Firenze for Molecular Sciences, for optogenetics and CLARITY
2013 Gabbay Award, Brandeis University, for optogenetics
2013 Goldman-Rakic Award, Yale/NARSAD, for optogenetics and CLARITY
2014 Dickson Prize in Science, for optogenetics
2014 Keio Medical Science Prize, for optogenetics
2014 National Academy of Sciences, Germany (Leopoldina)
2014 Wilson Prize (Harvard Chemistry)
2014 Scientist of the Year (R+D Magazine)
2015 Albany Prize in Medicine and Biomedical Research, for optogenetics
2015 Lurie Prize in Biomedical Sciences, for optogenetics and CLARITY
2015 Breakthrough Prize in Life Science, for optogenetics
2015 Dickson Prize in Medicine, for optogenetics
2015 Adolph Meyer Award, American Psychiatric Association
2016 Massry Prize, for optogenetics
2016 BBVA Award, for optogenetics
2016 American Institute for Medical and Biological Engineering
2016 McGovern Award in Science
2017 Harvey Prize in Human Health, Technion/Israel, for optogenetics
2017 Redelsheimer Award, for optogenetics
2017 Else Kröner Fresenius Prize: "for his discoveries of optogenetics and of hydrogel-tissue chemistry, and for developing circuit-level insight into depression"
2017 NOMIS Foundation Distinguished Scientist Award
2018 Eisenberg Prize, University of Michigan, for "the field of optogenetics"
2018 Rumford Prize, AAAS
2018 NAI (National Academy of Inventors)
2018 Kyoto Prize, "for the discovery of optogenetics and the development of causal systems neuroscience"
2018 Leibinger Prize, for the "development and implementation of optogenetics"
2019 National Academy of Engineering
2019 Alpert Award
2020 Heineken Prize from the Royal Netherlands Academy of Arts and Sciences, "for developing optogenetics - a method to influence the activity of nerve cells with light - as well as for developing hydrogel-tissue chemistry, which enables researchers to make biological tissue accessible to light and molecular probes"
2021 Lasker Basic Medical Research Award to Deisseroth, Hegemann, and Oesterhelt for "the discovery of light-sensitive microbial proteins that can activate or deactivate individual brain cells-leading to the development of optogenetics and revolutionizing neuroscience"
2022 Luisa Gross Horwitz Prize, for optogenetics
2023 Japan Prize, in Life Sciences, for optogenetics


  1. Zhang A, Loh KY, Kadur CS, Michalek L, Dou J, Ramakrishnan C, Bao Z & Deisseroth K Genetically targeted chemical assembly of polymers specifically localized extracellularly to surface membranes of living neurons. Science Advances. 2023. [  PDF ]
  2. Richman EB, Ticea N, Allen WE, Deisseroth K & Luo L Neural landscape diffusion resolves conflicts between needs across time. Nature. 2023. [  PDF ]
  3. Gore F, Hernandez M, Ramakrishnan C, Crow AK, Malenka R & Deisseroth K Orbitofrontal cortex control of striatum leads economic decision-making. Nature Neuroscience. 2023. [  PDF | Commentary ]
  4. Zhang A, Jiang Y, Loh KY, Bao Z & Deisseroth K Genetically targeted chemical assembly. Nature Reviews Bioengineering. 2023. [  PDF ]
  5. Tajima S, Kim YS, Fukuda M, Jo YJ, Wang P, Paggi JM, Inoue M, Byrne EFX, Kishi KE, Nakamura S, Ramakrishnan C, Takaramoto S, Nagata T, Konno M, Sugiura M, Katayama K, Matsui TE, Yamashita K, Kim S, Ikeda H, Kim J, Kandori H, Dror RO, Inoue K, Deisseroth K & Kato HE Structural basis for ion selectivity in potassium-selective channelrhodopsins. Cell. 2023. [  PDF ]
  6. Tan L, Shi J, Moghadami S, Parasar B, Wright CP, Seo Y, Vallejo K, Cobos I, Duncan L, Chen R, Deisseroth K Lifelong restructuring of 3D genome architecture in cerebellar granule cells Science. 2023. [  PDF ]
  7. Salimando GJ, Tremblay S, Kimmey BA, Li J, Rogers SA, Wojick JA, McCall NM, Wooldridge LM, Rodrigues A, Borner T, Gardiner KL, Jayakar SS, Singeç I, Woolf CJ, Hayes MR, De Jonghe BC, Bennett FC, Bennett ML, Blendy JA, Platt ML, Creasy KT, Renthal WR, Ramakrishnan C, Deisseroth K & Corder G Human OPRM1 and murine Oprm1 promoter driven viral constructs for genetic access to μ-opioidergic cell types. Nature Communications. 2023. [  PDF ]
  8. Hsueh B, Chen R, Jo YJ, Tang D, Raffiee M, Kim YS, Inoue M, Randles S, Ramakrishnan C, Patel S, Kim DK, Liu TX, Kim SH, Tan L, Mortazavi L, Cordero A, Shi J, Zhao M, Ho TT, Crow A, Yoo A-C W, Raja C, Evans K, Bernstein D, Zeineh M, Goubran M, Deisseroth K Cardiogenic control of affective behavioural state. Nature. 2023. [  PDF | News & Views | Nature News | Science News | Stanford Medicine | The Scientist ]
  9. Fan LZ, Kim DK, Jennings JH, Tian H, Wang P, Ramakrishnan C, Randles S, Sun Y, Thadhani E, Kim YS, Quirin S, Giocomo L, Cohen AE, Deisseroth K All-optical physiology resolves a synaptic basis for behavioral timescale plasticity. Cell. 2023. [  PDF ]
  10. Tian H, Davis HC, Wong-Campos JD, Park P, Fan LZ, Gmeiner B, Begum S, Werley CA, Borja GB, Upadhyay H, Shah H, Jacques J, Qi Y, Parot V, Deisseroth K, Cohen AE Video-based pooled screening yields improved far-red genetically encoded voltage indicators. Nature Methods. 2022. [  PDF ]
  11. Machado TA, Kauvar IV, Deisseroth K. Multiregion neuronal activity: the forest and the trees. Nature Reviews Neuroscience. 2022. [  PDF ]
  12. Sylwestrak EL, Jo YJ, Vesuna S, Wang X, Holcomb B, Tien RH, Kim DK, Fenno LE, Ramakrishnan C, Allen WE, Chen R, Shenoy KV, Sussillo D, Deisseroth K. Cell-type-specific population dynamics of diverse reward computations. Cell. 2022. [  PDF ]
  13. Kishi KE, Kim YS, Fukuda M, Kusakizako T, Thadhani E, Byrne EFX, Paggi JM, Ramakrishnan C, Matsui T, Yamashita K, Nagata T, Konno M, Wang P, Inoue M, Benster T, Uemura T, Liu K, Shibata M, Nomura N, Iwata S, Nureki O, Dror RO, Inoue K, Deisseroth K, Kato HE. Structural basis for channel conduction in the pump-like channelrhodopsin ChRmine. Cell. 2022. [  PDF ]
  14. Deisseroth K. From microbial membrane proteins to the mysteries of emotion. Cell. 2021. S0092-8674(21)00992-2. [  PDF ]
  15. Kim CK, Sanchez MI, Hoerbelt P, Fenno LE, Malenka RC, Deisseroth K, Ting AY. A molecular calcium integrator reveals a striatal cell type driving aversion. Cell. 2020. [  PDF ]
  16. Vesuna S, Kauvar IV, Richman E, Gore F, Oskotsky T, Sava-Segal C, Luo L, Malenka RC, Henderson JM, Nuyujukian P, Parvizi J, Deisseroth K. Deep posteromedial cortical rhythm in dissociation. Nature. 2020. [  PDF | Supplement | News & Views | NPR | Stanford Medicine ]
  17. Chen, R, Gore F, Nguyen Q-A, Ramakrishnan C, Patel S, Kim SH, Raffiee M, Kim YS, HsuehB, Krook-Magnusson E, Soltesz I, Deisseroth K. Deep brain optogenetics without intracranial surgery. Nature Biotechnology. 2020. [  PDF | Supplement ]
  18. Fenno LE, Ramakrishnan C, Kim YS, Evans KE, Lo M, Vesuna S, Inoue M, Cheung KYM, Yuen E, Pichamoorthy N, Hong ASO, Deisseroth K. Comprehensive Dual- and Triple-Feature Intersectional Single-Vector Delivery of Diverse Functional Payloads to Cells of Behaving Mammals. Neuron. 2020. [  PDF | Supplement ]
  19. Lovett-Barron M, Chen R, Bradbury S, Andalman AS, Wagle M, Guo S, Deisseroth K. Multiple convergent hypothalamus-brainstem circuits drive defensive behavior. Nature Neuroscience. 2020. [  PDF ]
  20. Kauvar IV, Machado TA, Yuen E, Kochalka J, Choi M, Allen WE, Wetzstein G, Deisseroth K. Cortical Observation by Synchronous Multifocal Optical Sampling Reveals Widespread Population Encoding of Actions. Neuron. 2020. [  PDF | Supplement ]
  21. Liu J, Kim YS, Richardson CE, Tom A, Ramakrishnan C, Birey F, Katsumata T, Chen S, Wang C, Wang X, Joubert L-M, Jiang Y, Wang H, Fenno LE, Tok JB-H, Paşca, Shen K, Bao Z, Deisseroth K. Genetically targeted chemical assembly of functional materials in living cells, tissues, and animals. Science. 2020. [  PDF | Supplement | Perspective | Inverse coverage | Stanford News ]
  22. Marshel JH, Kim YS, Machado TA, Quirin S, Benson B, Kadmon J, Raja C, Chibukhchyan A, Ramakrishnan C, Inoue M, Shane JC, McKnight DJ, Yoshizawa S, Kato HE, Ganguli S, Deisseroth K. Cortical layer-specific critical dynamics triggering perception. Science. 2019. [  PDF | Supplement ]
  23. Andalman AS, Burns VM, Lovett-Barron M, Broxton M, Poole B, Yang SJ, Grosenick L, Lerner TN, Chen R, Benster T, Mourrain P, Levoy M, Rajan K, Deisseroth K. Neuronal dynamics regulating brain and behavioral state transitions. Cell. 2019. [  PDF ]
  24. Allen WE, Chen MZ, Pichamoorthy N, Tien RH, Pachitariu M, Luo L, Deisseroth K. Thirst regulates motivated behavior through modulation of brainwide neural population dynamics. Science. 2019. [  PDF | Supplement | Supplemental video 1 ]
  25. Jennings JH, Kim CK, Marshel JH, Raffiee M, Ye L, Quirin S, Pak S, Ramakrishnan C, Deisseroth K. Interacting neural ensembles in orbitofrontal cortex for social and feeding behavior. Nature. 2019. [  PDF | Supplemental video 1 | Supplemental video 2 | Supplemental video 3 | Supplemental video 4 | Supplemental video5 | Supplemental video 6 ]
  26. Kim YS, Kato HE, Yamashita K, Ito S, Inoue K, Ramakrishnan C, Fenno LE, Evans KE, Paggi JM, Dror RO, Kandori H, Kobilka BK, Deisseroth K. Crystal structure of the natural anion-conducting channelrhodopsin GtACR1. Nature. 2018. [  PDF ]
  27. Kato HE, Kim YS, Paggi JM, Evans KE, Allen WE, Richardson C, Inoue K, Ito S, Ramakrishnan C, Fenno LE, Yamashita K, Hilger D, Lee SY, Berndt A, Shen K, Kandori H, Dror RO, Kobilka BK, Deisseroth K. Structural mechanisms of selectivity and gating in anion channelrhodopsins. Nature. 2018. [  PDF ]
  28. Wang Xiao, Allen WE, Wright MA, Sylwestrak EL, Samusik N, Vesuna S, Evans K, Liu C, Ramakrishnan C, Liu J, Nolan GP, Bava FA, Deisseroth K. Three-dimensional intact-tissue sequencing of single-cell transcriptional states. Science. 2018. [  PDF | Supplement | Perspective ]
  29. Walsh JJ, Christoffel DJ, Heifets BD, Ben-Dor GA, Selimbeyoglu A, Hung LW, Deisseroth K, Malenka RC. 5-HT release in nucleus accumbens rescues social deficits in mouse autism model. Nature. 2018. [  PDF ]
  30. Gradinaru V, Treweek J, Overton K, Deisseroth K. Hydrogel-tissue chemistry: principles and applications. Annu. Rev. Biophys. 2018. [  PDF ]
  31. Lovett-Barron M, Andalman AS, Allen WE, Vesuna S, Kauvar I, Burns VM, Deisseroth K. Ancestral circuits for the coordinated modulation of brain state. Cell. 2017. [  PDF | S1 (mov) | S1 (mp4) | Highlight | Stanford Medicine | NIMH News | Scope Blog ]
  32. Deisseroth K, Hegemann P. The form and function of channelrhodopsin. Science. 2017. [  PDF ]
  33. Beier KT, Kim CK, Hoerbelt P, Hung LW, Heifets BD, DeLoach KE, Mosca TJ, Neuner S, Deisseroth K, Luo L, Malenka RC. Rabies screen reveals GPe control of cocaine-triggered plasticity. Nature. 2017. [  PDF ]
  34. Allen WE, DeNardo LA, Chen MZ, Cindy, DL, Loh KM, Fenno LE, Ramakrishnan C, Deisseroth K, Luo L. Thirst-associated preoptic neurons encode an aversive motivational drive. Science. 2017. [  PDF | Perspective | Highlight ]
  35. Kim CK, Ye L, Jennings JH, Pichamoorthy N, Tang DD, Yoo A-C W, Ramakrishnan C, Deisseroth K. Molecular and circuit-dynamical identification of top-down neural mechanisms for restraint of reward seeking. Cell. 2017. [  PDF | Video S1 | Highlight | Stanford News ]
  36. Selimbeyoglu A, Kim CK, Inoue M, Lee SY, Hong ASO, Kauvar I, Ramakrishnan C, Fenno LE, Davidson TJ, Wright M, Deisseroth K. Modulation of prefrontal cortex excitation/inhibition balance rescues social behavior in CNTNAP2-deficient mice. Science Translational Medicine. 2017. [  PDF | supplement ]
  37. Hsueh B, Burns VM, Pauerstein P, Holzem K, Ye L, Engberg K, Wang A-C, Gu X, Chakravarthy H, Arda HE, Charville G, Vogel H, Efimov IR, Kim S, Deisseroth K. Pathways to clinical CLARITY: volumetric analysis of irregular, soft, and heterogeneous tissues in development and disease. Scientific Reports. 2017. [  PDF | supplement ]
  38. Deisseroth, Karl. Optical and chemical discoveries recognized for impact on biology and psychiatry. EMBO Reports. 2017. [  PDF ]
  39. Allen WE, Kauvar IV, Chen MZ, Richman EB, Yang SJ, Chan K, Gradinaru V, Deverman BE, Luo L, Deisseroth K. Global representations of goal-directed behavior in distinct cell types of mouse neocortex. Neuron. 2017. [  PDF ]
  40. Kim CK, Adhikari A, Deisseroth K. Integration of optogenetics with complementary methodologies in systems neuroscience. Nature Reviews Neuroscience. 2017. [  PDF ]
  41. Young NP, Deisseroth K. In search of lost time. Nature. 2017. [  PDF ]
  42. Carus-Cadavieco M, Gorbati M, Ye L, Bender F, van der Veldt S, Kosse C, Börgers C, Lee SY, Ramakrishnan C, Hu Y, Denisova N, Ramm F, Volitaki E, Burdakov D, Deisseroth K, Ponomarenko A, Korotkova T. Gamma oscillations organize top-down signalling to hypothalamus and enable food seeking. Nature. 2017. [  PDF ]
  43. Deisseroth K. A look inside the brain. Scientific American. 2016. [  PDF ]
  44. Ye L, Allen WE, Thompson KR, Tian Q, Hsueh B, Ramakrishnan C, Wang A-C, Jennings JH, Adhikari A, Halpern CH, Witten IB, Barth AL, Luo L, McNab, JA, Deisseroth K. Wiring and Molecular Features of Prefrontal Ensembles Representing Distinct Experiences. Cell. 2016. [  PDF | Video S1 | Automated CLARITY Analysis Software Packages | Protocols | Stanford News ]
  45. Zalocusky KA, Ramakrishnan C, Lerner TN, Davidson TJ, Knutson B, Deisseroth K. Nucleus accumbens D2R cells signal prior outcomes and control risky decision-making. Nature. 2016. [  PDF | News & Views ]
  46. Rajasethupathy P, Ferenczi E, Deisseroth K. Targeting neural circuits. Cell. 2016. [  PDF ]
  47. Ferenczi EA, Vierock J, Atsuta-Tsunoda K, Tsunoda SP, Ramakrishnan C, Gorini C, Thompson K, Lee SY, Berndt A, Perry C, Minniberger S, Vogt A, Mattis J, Prakash R, Delp S, Deisseroth K, Hegemann P. Optogenetic approaches addressing extracellular modulation of neural excitability. Scientific Reports. 2016. [  PDF | supplement ]
  48. Lerner TN, Ye L, Deisseroth K. Communication in neural circuits: tools, opportunities, and challenges. Cell. 2016. [  PDF | Table S1 tracing methods | Table S2 transparency methods | Table S3 activity readout methods ]
  49. Falkner AL, Grosenick L, Davidson TJ, Deisseroth K, Lin D. Hypothalamic control of male aggression-seeking behavior. Nature Neuroscience. 2016. [  PDF ]
  50. Sylwestrak EL, Rajasethupathy P, Wright MA, Jaffe A, Deisseroth K. Multiplexed intact-tissue transcriptional analysis at cellular resolution. Cell. 2016. [  PDF | supplement | 3D mouse cortex | 3D mouse midbrain | 3D mouse midbrain | 3D mouse tissue | 3D double in situ ]
  51. Kim CK, Yang SJ, Pichamoorthy N, Young NP, Kauvar I, Jennings JH, Lerner TN, Berndt A, Lee SY, Ramakrishnan C, Davidson TJ, Inoue M, Bito H, Deisseroth K. Simultaneous fast measurement of circuit dynamics at multiple sites across the mammalian brain. Nature Methods. 2016. [  PDF | supplement | freely-moving mouse with 7 fibers | GCaMP6f fiber emission during reward | GCaMP6f fiber emission during tail shock ]
  52. Ferenczi E, Deisseroth K. Illuminating next-generation brain therapies. Nature Neuroscience. 2016. [  PDF ]
  53. Ferenczi EA, Zalocusky KA, Liston C, Grosenick L, Warden MR, Amatya D, Katovich K, Mehta H, Patenaude B, Ramakrishnan C, Kalanithi P, Etkin A, Knutson B, Glover GH, Deisseroth K. Prefrontal cortical regulation of brainwide circuit dynamics and reward-related behavior. Science. 2016. [  PDF | supplement | perspective ]
  54. Berndt A, Lee SY, Wietek J, Ramakrishnan C, Steinberg EE, Rashid AJ, Kim H, Park S, Santoro A, Frankland PW, Iyer SM, Pak S, Ährlund-Richter S, Delp SL, Malenka RC, Josselyn SA, Carlén M, Hegemann P, Deisseroth K. Structural foundations of optogenetics: determinants of channelrhodopsin ion selectivity. PNAS. 2015. [  PDF | supplement ]
  55. Tomer R, Lovett-Barron M, Kauvar I, Andalman A, Burns VM, Sankaran S, Grosenick L, Broxton M, Yang S, Deisseroth K. SPED light sheet microscopy: fast mapping of biological system structure and function. Cell. 2015. [  PDF | supplement | code | PSFs for different objectives | Clarified mouse brain imaging with SPED | Zebrafish GCaMP imaging with SPED | Zebrafish GCaMP imaging with SPED | Entire zebrafish nervous system, 6.23 volumes/second | Zebrafish brain: 12 volumes/second | Zebrafish brain and spinal cord at 4.14 volumes/second | 3D segmentation in zebrafish ]
  56. Yang SJ, Allen WE, Kauvar I, Andalman AS, Young NP, Kim CK, Marshel JH, Wetzstein G, Deisseroth K. Extended field-of-view and increased-signal 3D holographic illumination with time-division multiplexing. Optics Express. 2015. [  PDF ]
  57. Adhikari A, Lerner TN, Finkelstein J, Pak S, Jennings JH, Davidson TJ, Ferenczi E, Gunaydin LA, Mirzabekov JJ, Ye L, Kim S, Lei A, Deisseroth K. Basomedial amygdala mediates top-down control of anxiety and fear. Nature. 2015. [  PDF | IL-amygdala projections: CLARITY movie ]
  58. Wimmer RD, Schmitt LI, Davidson TJ, Nakajima M, Deisseroth K, Halassa MM. Thalamic control of sensory selection in divided attention. Nature. 2015. [  PDF ]
  59. Rajasethupathy P, Sankaran S, Marshel JH, Kim CK, Ferenczi E, Lee SY, Berndt A, Ramakrishnan C, Jaffe A, Lo Maisie, Liston C, Deisseroth K. Projections from neocortex mediate top-down control of memory retrieval Nature. 2015. [  PDF | Hippocampl activity imaging movie ]
  60. Deisseroth K. Optogenetics: 10 years of microbial opsins in neuroscience. Nature Neuroscience. 2015. [  PDF ]
  61. Berndt A, Deisseroth K. Expanding the optogenetics toolkit. Science, Volume 349, Issue 6248, 590-591. [  PDF ]
  62. Lerner TN, Shilyansky C, Davidson TJ, Evans KE, Beier KT, Zalocusky KA, Crow AK, Malenka RC, Luo L, Tomer R, Deisseroth K. Intact-Brain Analyses Reveal Distinct Information Carried by SNc Dopamine Subcircuits. Cell, Volume 162, Issue 3, 635-647 [  PDF | S1 (high res) | S2 (high res) | S3 (high res) | S4 (high res) | S5 (high res COLM) ]
  63. K Deisseroth, Etkin A, Malenka RC. Optogenetics and the Circuit Dynamics of Psychiatric Disease. JAMA. 2015. [  PDF ]
  64. Grosenick L, Marshel JH, Deisseroth K. Closed-Loop and Activity-Guided Optogenetic Control. Neuron, Volume 86, Issue 1, 106 - 139 [  PDF ]
  65. Jorgenson LA, Newsome WT, Anderson DJ, Bargmann CA, Brown EN, Deisseroth K, Donoghue JP, Hudson KL, Ling GSF, MacLeish PR, Marder E, Normann RA, Sanes JR, Schnitzer MJ, Sejnowski TJ, Tank DW, Tsien RY, Ugurbil K, Wingfield JC. The BRAIN Initiative: developing technology to catalyse neuroscience discovery. Phil. Trans. R. Soc. B 2015 370 20140164; DOI: 10.1098/rstb.2014.0164. Published 30 March 2015 [  PDF ]
  66. Rickgauer JP, Deisseroth K, Tank DW Simultaneous Cellular-Resolution Optical Perturbation and Imaging of Place Cell Firing Fields. Nature Neuroscience. November 2014. [  PDF ]
  67. Warden MR, Cardin JA, Deisseroth K. Optical Neural Interfaces. Annu. Rev. Biomed. Eng. 2014. 16:103-29. [  PDF ]
  68. Gunaydin LA, Grosenick L, Finkelstein JC, Kauvar IV, Fenno LE, Adhikari A, Lammel S, Mirzabekov JJ, Airan RD, Zalocusky KA, Tye KM, Anikeeva P, Malenka RC, Deisseroth K. Natural Neural Projection Dynamics Underlying Social Behavior. Cell. June 2014. [  PDF | VTA-NAc social behavior video | VTA-NAc novel objects video | VTA social behavior video | VTA novel object video | Stanford Medicine | Scope Blog | Nature ]
  69. Fenno LE, Mattis J, Ramakrishnan C, Hyun M, Lee SY, He M, Tucciarone J, Selimbeyoglu A, Berndt A, Grosenick L, Zalocusky KA, Bernstein H, Swanson H, Perry C, Diester I, Boyce FM, Bass CE, Neve R, Huang ZJ, Deisseroth K. Targeting cells with single vectors using multiple-feature Boolean logic Nature Methods. June 2014. 11, 763-772. [  PDF | Supplement ]
  70. Tomer R, Ye L, Hsueh B, Deisseroth K. Advanced CLARITY for rapid and high-resolution imaging of intact tissues. Nature Protocols. June 2014. [  PDF | COLM resources and hi-res figures/movies | Stanford News | DARPA ]
  71. Berndt A, Lee SY, Ramakrishnan C, Deisseroth K Structure-guided transformation of a channelrhodopsin into a light-activated chloride channel. Science. April 2014. 344(6182):420-4 [  PDF | Supplement | Perspective ]
  72. Deisseroth K. Circuit dynamics of adaptive and maladaptive behavior. Nature. January 2014. 505(7483):309-17 [  PDF | Fig 1 (hi-res) | Fig 2 (hi-res) ]
  73. Williams SCP and Deisseroth K. Optogenetics. PNAS. October 2013. [  PDF ]
  74. Kim SY, Chung K, and Deisseroth K. Light microscopy mapping of connections in the intact brain. Trends in Cognitive Sciences. November 2013. 17(12):596-9 [  PDF ]
  75. Stamatakis AM, Jennings JH, Ung RL, Blair GA, Weinberg RJ, NEve RL, Boyce F, Mattis J, Ramakrishnan C, Deisseroth K, Stuber GD. A unique population of ventral tegmental area neurons inhibits the lateral habenula to promote reward. Neuron. November 2013. 80(4):1039-53 [  PDF ]
  76. Deisseroth K and Schnitzer MJ. Engineering approaches to illuminating brain structure and dynamics. Neuron. October 2013. 80(3):568-77 [  PDF ]
  77. Chen AC, Oathes DJ, Chang C, Bradley T, Zhou ZW, Williams LM, Glover GH, Deisseroth K, Etkin A. Causal interactions between fronto-parietal central executive and default-mode networks in humans. 110(49):19944-9 PNAS. October 2013. [  PDF ]
  78. Hamilton LS, Sohl-Dickstein J, Huth AG, Carels VM, Deisseroth K, Bao S. Optogenetic activation of an inhibitory network enhances feedforward functional connectivity in auditory cortex. Neuron. November 2013. 80(4):1066-76 [  PDF ]
  79. Chung K, Deisseroth K. CLARITY for mapping the nervous system. Nature Methods. June 2013. 10(6):508-13. [  PDF ]
  80. Ahmari SE, Spellman T, Douglass NL, Kheirbek MA, Simpson HB, Deisseroth K, Gordon JA, Hen R. Repeated Cortico-Striatal Stimulation Generates Persistent OCD-Like Behavior. Science. June 7, 2013. 340:1234-9 [  PDF | News & Views ]
  81. Steinberg EE, Keiflin R, Boivin JR, Witten IB, Deisseroth K, Janak PH. A causal link between prediction errors, dopamine neurons and learning. Nature Neuroscience. Advance Online Pulbication 2013 May 26. 16(7):966-73 [  PDF ]
  82. Kempadoo KA, Tourino C, Cho SL, Magnani F, Leinninger G-M, Stuber GD, Zhang F, Myers MG, Deisseroth K, de Lecea L, Bonci, A. Hypothalamic Neurotensin Projections Promote Reward by Enhancing Glutamate Transmission in the VTA. J Neuroscience. May 1, 2013. 33(18):7618-26. [  PDF ]
  83. Stroh A, Adelsberger H, Groh A, Ruhlmann C, Fischer S, Schierloh A, Deisseroth K, Konnerth A. Making Waves: Initiation and Propagation of Corticothalamic Ca2+ Waves In Vivo. Neuron. March 20, 2013. 77:1136-50 [  PDF ]
  84. Chung K., Wallace J., Kim S.Y., Kalyanasundaram, S., Andalman A.S., Davidson T.J., Mirzabekov J.J., Zalocusky K.A., Mattis J., Denisin A.K., Pak S., Bernstein H., Ramakrishnan C., Grosenick L., Gradinaru V., Deisseroth K. Structural and molecular interrogation of intact biological systems. Nature. Advance Online Publication 2013 Apr 10. [  PDF | Supplementary Information | Nature Video | Stanford Video | Nature News | Stanford News | CLARITY images | SCOPE ]
  85. Kim SY, Adhikari A, Lee SY, Marshel JH, Kim CK, Mallory CS, Lo M, Pak S, Mattis J, Lim BK, Malenka RC, Warden MR, Neve R, Tye KM, Deisseroth K. Diverging neural pathways assemble a behavioural state from separable features in anxiety. Nature. Advance Online Publication 2013 Mar 20. [  PDF | Supplementary Information | News & Views ]
  86. Zalocusky K, Deisseroth K. Optogenetics in the behaving rat: integration of diverse new technologies in a vital animal model. Optogenetics. Mar. 2013 [  PDF ]
  87. Tye KM, Mirzabekov JJ, Warden MR, Ferenczi EA, Tsai HC, Finkelstein J, Kim SY, Adhikari A, Thompson KR, Andalman AS, Gunaydin LA, Witten IB, Deisseroth K. Dopamine neurons modulate neural encoding and expression of depression-related behaviour. Nature. Advance Online Publication 2012 Dec. [  PDF | Supplementary Information ]
  88. Chaudhury D, Walsh JJ, Friedman AK, Juarez B, Ku SM, Koo JW, Ferguson D, Tsai HC, Pomeranz L, Christoffel DJ, Nectow AR, Ekstrand M, Domingos A, Mazei-Robison MS, Mouzon E, Lobo MK, Neve RL, Friedman JM, Russo SJ, Deisseroth K, Nestler EJ, Han MH. Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons. Nature. Advance Online Publication 2012 Dec. [  PDF | Supplementary Information ]
  89. Warden MR, Selimbeyoglu A, Mirzabekov JJ, Lo M, Thompson KR, Kim SY, Adhikari A, The KM, Frank LM, Deisseroth K. A prefrontal cortex-brainstem neuronal projection that controls response to behavioural challenge. Nature. 2012 Dec 20;492(7429):428-32. [  PDF | Supplementary Information ]
  90. Paz JT, Davidson TJ, Frechette ES, Delord B, Parada I, Peng K, Deisseroth K, Huguenard JR. Closed-loop optogenetic control of thalamus as a tool for interrupting seizures after cortical injury. Nat Neurosci. 2013 Jan;16(1):64-70. Epub 2012 Nov 7. [  PDF ]
  91. Prakash R, Yizhar O, Grewe B, Ramakrishnan C, Wang N, Goshen I, Packer AM, Peterka DS, Yuste R, Schnitzer MJ, Deisseroth K. Two-photon optogenetic toolbox for fast inhibition, excitation and bistable modulation. Nat Methods. Advance Online Publication 2012 Nov 11. [  PDF | Supplemental Information ]
  92. Packer AM, Peterka DS, Hirtz JJ, Prakash R, Deisseroth K, Yuste R. Two-photon optogenetics of dendritic spines and neural circuits. Nat Methods. 2012 Dec 7;9(12):1202-5. Epub 2012 Nov 11. [  PDF | Supplemental Information ]
  93. Deisseroth K. Optogenetics and psychiatry: applications, challenges, and opportunities. Biol Psychiatry. 2012 Jun 15;71(12):1030-2. Epub 2012 Apr 13. [  PDF ]
  94. Ferenczi E, Deisseroth K. When the electricity (and the lights) go out: transient changes in excitability. Nat Neurosci. 2012 Jul 26;15(8):1058-60. [  PDF ]
  95. Tanaka KF, Matsui K, Sasaki T, Sano H, Sugio S, Fan K, Hen R, Nakai J, Yanagawa Y, Hasuwa H, Okabe M, Deisseroth K, Ikenaka K, Yamanaka A. Expanding the Repertoire of Optogenetically Targeted Cells with an Enhanced Gene Expression System. Cell Rep. 2012 Aug 30;2(2):397-406. Epub 2012 Jul 26. [  PDF with Supplemental Information ]
  96. Song J, Zhong C, Bonaguidi MA, Sun GJ, Hsu D, Gu Y, Meletis K, Huang ZJ, Ge S, Enikolopov G, Deisseroth K, Luscher B, Christian KM, Ming GL, Song H. Neuronal circuitry mechanism regulating adult quiescent neural stem-cell fate decision. Nature. 2012 Sep 6;489(7414):150-4. [  PDF | Supplemental Information ]
  97. Stefanik MT, Moussawi K, Kupchik YM, Smith KC, Miller RL, Huff ML, Deisseroth K, Kalivas PW, Lalumiere RT. Optogenetic inhibition of cocaine seeking in rats. Addict Biol. 2012 Jul 24. [  ePub] [PDF ]
  98. Threlfell S, Lalic T, Platt NJ, Jennings KA, Deisseroth K, Cragg SJ. Striatal dopamine release is triggered by synchronized activity in cholinergic interneurons. Neuron. 2012 Jul 12;75(1):58-64. [  PDF | Supplemental Information ]
  99. Liu X, Ramirez S, Pang PT, Puryear CB, Govindarajan A, Deisseroth K, Tonegawa S. Optogenetic stimulation of a hippocampal engram activates fear memory recall. Nature. 2012 Mar 22;484(7394):381-5. [  PDF | Supplemental Information ]
  100. Tye KM, Deisseroth K. Optogenetic investigation of neural circuits underlying brain disease in animal models. Nat Rev Neurosci. 2012 Mar 20;13(4):251-66. [  PDF ]
  101. Ledri M, Nikitidou L, Erdelyi F, Szabo G, Kirik D, Deisseroth K, Kokaia M. Altered profile of basket cell afferent synapses in hyper-excitable dentate gyrus revealed by optogenetic and two-pathway stimulations. Eur J Neurosci. 2012 Jul;36(1):1971-83. Epub 2012 Apr 18. [  PDF ]
  102. Gee S, Ellwood I, Patel T, Luongo F, Deisseroth K, Sohal VS. Synaptic activity unmasks dopamine D2 receptor modulation of a specific class of layer V pyramidal neurons in prefrontal cortex. J Neurosci. 2012 Apr 4;32(14):4959-71. [  PDF ]
  103. Tan KR, Yvon C, Turiault M, Mirzabekov JJ, Doehner J, Labouèbe G, Deisseroth K, Tye KM, Lüscher C. GABA neurons of the VTA drive conditioned place aversion. Neuron. 2012 Mar 22;73(6):1173-83. Epub 2012 Mar 21. [  PDF | Supplemental Information ]
  104. Watanabe HC, Welke K, Schneider F, Tsunoda S, Zhang F, Deisseroth K, Hegemann P, Elstner M. Structural model of channelrhodopsin. J Biol Chem. 2012 Mar 2;287(10):7456-66. Epub 2012 Jan 11. [  PDF ]
  105. Kato HE, Zhang F, Yizhar O, Ramakrishnan C, Nishizawa T, Hirata K, Ito J, Aita Y, Tsukazaki T, Hayashi S, Hegemann P, Maturana AD, Ishitani R, Deisseroth K, Nureki O. Crystal structure of the channelrhodopsin light-gated cation channel. Nature. 2012 Jan 22;482(7385):369-74. [  PDF | Supplemental Information | News & Views ]
  106. Zhang F, Vierock J, Yizhar O, Fenno LE, Tsunoda S, Kianianmomeni A, Prigge M, Berndt A, Cushman J, Polle J, Magnuson J, Hegemann P, Deisseroth K. The microbial opsin family of optogenetic tools. Cell. 2011 Dec 23;147(7):1446-57. [  PDF | Supplemental Information ]
  107. Witten IB, Steinberg EE, Lee SY, Davidson TJ, Zalocusky KA, Brodsky M, Yizhar O, Cho SL, Gong S, Ramakrishnan C, Stuber GD, Tye KM, Janak PH, Deisseroth K. Recombinase-driver rat lines: tools, techniques, and optogenetic application to dopamine-mediated reinforcement. Neuron. 2011 Dec 8;72(5):721-33. [  PDF | Supplemental Information ]
  108. Mattis J, Tye KM, Ferenczi EA, Ramakrishnan C, O'Shea DJ, Prakash R, Gunaydin LA, Hyun M, Fenno LE, Gradinaru V, Yizhar O, Deisseroth K. Principles for applying optogenetic tools derived from direct comparative analysis of microbial opsins. Nat Methods. 2011 Dec 18;9(2):159-72. [  PDF | Supplemental Information ]
  109. Anikeeva P, Andalman AS, Witten I, Warden M, Goshen I, Grosenick L, Gunaydin LA, Frank LM, Deisseroth K. Optetrode: a multichannel readout for optogenetic control in freely moving mice. Nature Neuroscience. 2011 Dec 4;15(1):163-70. [  PDF | SolidWorks File ]
  110. English DF, Ibanez-Sandoval O, Stark E, Tecuapetla F, Buzsáki G, Deisseroth K, Tepper JM, Koos T. GABAergic circuits mediate the reinforcement-related signals of striatal cholinergic interneurons. Nat Neurosci. 2011 Dec 11;15(1):123-30. [  PDF | Supplemental Information ]
  111. Domingos AI, Vaynshteyn J, Voss HU, Ren X, Gradinaru V, Zang F, Deisseroth K, de Araujo IE, Friedman J. Leptin regulates the reward value of nutrient. Nat Neurosci. 2011 Nov 13;14(12):1562-8. [  PDF | Supplemental Information ]
  112. Blumhagen F, Zhu P, Shum J, Schärer YP, Yaksi E, Deisseroth K, Friedrich RW. Neuronal filtering of multiplexed odour representations. Nature. 2011 Nov 13;479(7374):493-8. [  PDF | Supplemental Information ]
  113. Ellender TJ, Huerta-Ocampo I, Deisseroth K, Capogna M, Bolam JP. Differential modulation of excitatory and inhibitory striatal synaptic transmission by histamine. J Neurosci. 2011 Oct 26;31(43):15340-51. [  PDF ]
  114. Zhao S, Ting JT, Atallah HE, Qiu L, Tan J, Gloss B, Augustine GJ, Deisseroth K, Luo M, Graybiel AM, Feng G. Cell type-specific channelrhodopsin-2 transgenic mice for optogenetic dissection of neural circuitry function. Nat Methods. 2011 Sep;8(9):745-52. [  PDF | Supplemental Information ]
  115. Kohl MM, Shipton OA, Deacon RM, Rawlins JN, Deisseroth K, Paulsen O. Hemisphere-specific optogenetic stimulation reveals left-right asymmetry of hippocampal plasticity. Nat Neurosci. 2011 Sep 25;14(11):1413-5. [  PDF | Supplemental Information ]
  116. Mateo C, Avermann M, Gentet LJ, Zhang F, Deisseroth K, Petersen CC. In vivo optogenetic stimulation of neocortical excitatory neurons drives brain-state-dependent inhibition. Curr Biol. 2011 Oct 11;21(19):1593-602. Epub 2011 Sep 22. [  PDF | Supplemental Information ]
  117. Paz JT, Bryant AS, Peng K, Fenno L, Yizhar O, Frankel WN, Deisseroth K, Huguenard JR. A new mode of corticothalamic transmission revealed in the Gria4(-/-) model of absence epilepsy. Nat Neurosci. 2011 Aug 21;14(9):1167-73. [  PDF | Supplemental Information ]
  118. Wang J, Wagner F, Borton DA, Zhang J, Ozden I, Burwell RD, Nurmikko AV, van Wagenen R, Diester I, Deisseroth K. Integrated device for combined optical neuromodulation and electrical recording for chronic in vivo applications. J Neural Eng. 2012 Feb;9(1):016001. Epub 2011 Dec 7. [  PDF ]
  119. Goshen I, Brodsky M, Prakash R, Wallace J, Gradinaru V, Ramakrishnan C, Deisseroth K. Dynamics of Retrieval Strategies for Remote Memories. Cell. 2011 Oct 28;147(3):678-89. Epub 2011 Oct 20. [  PDF | Comment | Nature Reviews Neuroscience | Trends in Cognitive Sciences ]
  120. Yizhar O, Fenno LE, Prigge M, Schneider F, Davidson TJ, O'Shea DJ, Sohal VS, Goshen I, Finkelstein J, Paz JT, Stehfest K, Fudim R, Ramakrishnan C, Huguenard JR, Hegemann P, Deisseroth K. Neocortical excitation/inhibition balance in information processing and social dysfunction. Nature. 2011 Jul 27;477(7363):171-8. [  PDF | Supplement | News & Views ]
  121. Yizhar O, Fenno LE, Davidson TJ, Mogri M, Deisseroth K. Optogenetics in Neural Systems. Neuron. 2011 July;72:9-34. [  PDF ]
  122. Fenno LE, Yizhar O, Deisseroth K. The development and application of optogenetics. Annual Review of Neuroscience. 2011 July;34:389-412. [  PDF ]
  123. Stuber G., Sparta D., Stamatakis A.M., van Leeuwen W.A., Hardjoprajitno J.E., Cho S., Tye K.M., A. Kempadoo K.A., Zhang F., Deisseroth D., Bonci A. Excitatory transmission from the amygdala to nucleus accumbens facilitates reward seeking. Nature. 2011 Jun 29;475(7356):377-80. [  PDF | Supplement ]
  124. Tye KM, Prakash R, Kim SY, Fenno LE, Grosenick L, Zarabi H, Thompson KR, Gradinaru V, Ramakrishnan C, Deisseroth K. Amygdala circuitry mediating reversible and bidirectional control of anxiety. Nature. Mar 17;471(7338):358-62. Epub 2011 Mar 9. [  PDF | Supplement | Supplementary Movie ]
  125. Berndt A, Schoenenberger P, Mattis J, Tye KM, Deisseroth K, Hegemann P, Oertner TG. High-efficiency channelrhodopsins for fast neuronal stimulation at low light levels. Proc Natl Acad Sci U S A. 2011 May 3;108(18):7595-600. Epub 2011 Apr 19. [  PDF ]
  126. Carlén M, Meletis K, Siegle JH, Cardin JA, Futai K, Vierling-Claassen D, Rühlmann C, Jones SR, Deisseroth K, Sheng M, Moore CI, Tsai LH. A critical role for NMDA receptors in parvalbumin interneurons for gamma rhythm induction and behavior. Mol Psychiatry. 2012 May;17(5):537-48. Epub 2011 Apr 5. [  PDF ]
  127. Pagliardini S, Janczewski WA, Tan W, Dickson CT, Deisseroth K, Feldman JL. Active expiration induced by excitation of ventral medulla in adult anesthetized rats. J Neurosci. 2011 Feb 23;31(8):2895-905. [  PDF ]
  128. Tønnesen J, Parish CL, Sørensen AT, Andersson A, Lundberg C, Deisseroth K, Arenas E, Lindvall O, Kokaia M. Functional integration of grafted neural stem cell-derived dopaminergic neurons monitored by optogenetics in an in vitro Parkinson model. PLoS One. 2011 Mar 4;6(3):e17560. [  PDF ]
  129. Diester I, Kaufman MT, Mogri M, Pashaie R, Goo W, Yizhar O, Ramakrishnan C, Deisseroth K, Shenoy KV. An optogenetic toolbox designed for primates. Nat Neuro. 2011 Mar;14(3):387-97. Epub 2011 Jan 30. [  PDF ]
  130. Deisseroth, K. Optogenetics. Nat Methods. 2011 Jan;8(1):26-9. Epub 2010 Dec 20. [  PDF | Nature Method of the Year Primer ]
  131. Brown MT, Bellone C, Mameli M, Labouèbe G, Bocklisch C, Balland B, Dahan L, Luján R, Deisseroth K, Lüscher C. Drug-driven AMPA receptor redistribution mimicked by selective dopamine neuron stimulation. PLoS One. 2010 Dec 31;5(12):e15870. [  PDF ]
  132. Witten IB, Lin SC, Brodsky M, Prakash R, Diester I, Anikeeva P, Gradinaru V, Ramakrishnan C, Deisseroth K. Cholinergic interneurons control local circuit activity and cocaine conditioning. Science. 2010 Dec 17;330(6011):1677-81. [  PDF | Supplement ]
  133. Covington HE 3rd, Lobo MK, Maze I, Vialou V, Hyman JM, Zaman S, LaPlant Q, Mouzon E, Ghose S, Tamminga CA, Neve RL, Deisseroth K, Nestler EJ. Antidepressant effect of optogenetic stimulation of the medial prefrontal cortex. J Neurosci. 2010 Dec 1;30(48):16082-90. [  PDF ]
  134. Stroh A, Tsai HC, Ping Wang L, Zhang F, Kressel J, Aravanis A, Santhanam N, Deisseroth K, Konnerth A, Schneider MB. Tracking stem cell differentiation in the setting of automated optogenetic stimulation. Stem Cells. 2010 Nov 18. [  PDF ]
  135. Ciocchi S, Herry C, Grenier F, Wolff SB, Letzkus JJ, Vlachos I, Ehrlich I, Sprengel R, Deisseroth K, Stadler MB, Müller C, Lüthi A. Encoding of conditioned fear in central amygdala inhibitory circuits. Nature. 2010 Nov 11. [  PDF ]
  136. Haubensak W, Kunwar PS, Cai H, Ciocchi S, Wall NR, Ponnusamy R, Biag J, Dong HW, Deisseroth K, Callaway EM, Fanselow MS, Lüthi A, Anderson DJ. Genetic dissection of an amygdala microcircuit that gates conditioned fear. Nature. 2010 Nov 11;468(7321):270-6. [  PDF ]
  137. Carter ME, Yizhar O, Chikahisa S, Nguyen H, Adamantidis A, Nishino S, Deisseroth K, de Lecea L. Tuning arousal with optogenetic modulation of locus coeruleus neurons. Nat Neurosci. 2010 Dec;13(12):1526-33. Epub 2010 Oct 31. [  PDF ]
  138. Deisseroth K. Controlling the brain with light. Sci Am. 2010 Nov;303(5):48-55. [  Link | PDF ]
  139. Lobo MK, Covington HE 3rd, Chaudhury D, Friedman AK, Sun H, Damez-Werno D, Dietz DM, Zaman S, Koo JW, Kennedy PJ, Mouzon E, Mogri M, Neve RL, Deisseroth K, Han MH, Nestler EJ. Cell type-specific loss of BDNF signaling mimics optogenetic control of cocaine reward. Science. 2010 Oct 15;330(6002):385-90. [  PDF ]
  140. Llewellyn ME, Thompson KR, Deisseroth K, Delp SL. Orderly recruitment of motor units under optical control in vivo. Nat Med. 2010 Oct;16(10):1161-5. Epub 2010 Sep 26. [  PDF ]
  141. Weick JP, Johnson MA, Skroch SP, Williams JC, Deisseroth K, Zhang SC. Functional control of transplantable human ESC-derived neurons via optogenetic targeting. Stem Cells. 2010 Nov;28(11):2008-16. [  PDF ]
  142. Gourine AV, Kasymov V, Marina N, Tang F, Figueiredo MF, Lane S, Teschemacher AG, Spyer KM, Deisseroth K, Kasparov S. Astrocytes control breathing through pH-dependent release of ATP. Science. 2010 Jul 30;329(5991):571-5. Epub 2010 Jul 15. [  PDF ]
  143. Shoham S, Deisseroth K. Special issue on optical neural engineering: advances in optical stimulation technology. J Neural Eng. 2010 Aug;7(4):040201. Epub 2010 Jul 19. [  PDF ]
  144. Johansen JP, Hamanaka H, Monfils MH, Behnia R, Deisseroth K, Blair HT, LeDoux JE. Optical activation of lateral amygdala pyramidal cells instructs associative fear learning. Proc Natl Acad Sci U S A. 2010 Jul 13;107(28):12692-7. Epub 2010 Jun 25. [  PDF ]
  145. Kravitz AV, Freeze BS, Parker PR, Kay K, Thwin MT, Deisseroth K, Kreitzer AC. Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry. Nature. 2010 Jul 29;466(7306):622-6. Epub 2010 Jul 7. [  PDF ]
  146. Busskamp V, Duebel J, Balya D, Fradot M, Viney TJ, Siegert S, Groner AC, Cabuy E, Forster V, Seeliger M, Biel M, Humphries P, Paques M, Mohand-Said S, Trono D, Deisseroth K, Sahel JA, Picaud S, Roska B. Genetic reactivation of cone photoreceptors restores visual responses in retinitis pigmentosa. Science. 2010 Jul 23;329(5990):413-7. Epub 2010 Jun 24. [  PDF ]
  147. Tecuapetla F, Patel JC, Xenias H, English D, Tadros I, Shah F, Berlin J, Deisseroth K, Rice ME, Tepper JM, Koos T. Glutamatergic signaling by mesolimbic dopamine neurons in the nucleus accumbens. J Neurosci. 2010 May 19;30(20):7105-10. [  PDF ]
  148. Jin Hyung Lee, Remy Durand, Viviana Gradinaru, Feng Zhang, Inbal Goshen, Dae-Shik Kim, Lief E. Fenno, Charu Ramakrishnan & Karl Deisseroth Global and local fMRI signals driven by neurons defined optogenetically by type and wiring. Nature. 2010 Jun 10;465(7299):788-92. [  PDF | Supplement | News & Views ]
  149. Wang Y, Dye CA, Sohal V, Long JE, Estrada RC, Roztocil T, Lufkin T, Deisseroth K, Baraban SC, Rubenstein JL. Dlx5 and Dlx6 regulate the development of parvalbumin-expressing cortical interneurons. J Neurosci. 2010 Apr 14;30(15):5334-45. [  PDF ]
  150. Gradinaru V, Zhang, F, Ramakrishnan C, Mattis J, Prakash R, Diester I, Goshen I, Thompson K, Deisseroth K. Molecular and Cellular Approaches for Diversifying and Extending Optogenetics. Cell. Apr 2;141(1):154-65. Epub 2010 Mar 18. [  PDF with Supplementary Material | Commentary ]
  151. Zhang F, Gradinaru V, Adamantidis AR, Durand R, Airan RD, de Lecea L, Deisseroth K. Optogenetic interrogation of neural circuits: technology for probing mammalian brain structures. Nat Protoc. 2010 Mar;5(3):439-56. Epub 2010 Feb 18. [  PDF ]
  152. Cardin JA, Carlén M, Meletis K, Knoblich U, Zhang F, Deisseroth K, Tsai LH, Moore CI. Targeted optogenetic stimulation and recording of neurons in vivo using cell-type-specific expression of Channelrhodopsin-2. Nat Protoc. 2010 Feb;5(2):247-54. Epub 2010 Jan 21. [  PDF ]
  153. Gunaydin LA, Yizhar O, Berndt A, Sohal VS, Deisseroth K, Hegemann P. Ultrafast optogenetic control. Nat Neurosci. 2010 Mar;13(3):387-92. Epub 2010 Jan 17. [  PDF | Supplementary Materials ]
  154. Zhu P, Narita Y, Bundschuh ST, Fajardo O, Schärer YP, Chattopadhyaya B, Bouldoires EA, Stepien AE, Deisseroth K, Arber S, Sprengel R, Rijli FM, Friedrich RW. Optogenetic Dissection of Neuronal Circuits in Zebrafish using Viral Gene Transfer and the Tet System. Front Neural Circuits. 2009 Dec 11;3:21. [  PDF ]
  155. Zhang J, Laiwalla F, Kim JA, Urabe H, Van Wagenen R, Song YK, Connors BW, Zhang F, Deisseroth K, Nurmikko AV. Integrated device for optical stimulation and spatiotemporal electrical recording of neural activity in light-sensitized brain tissue. J Neural Eng. 2009 Oct;6(5):055007. Epub 2009 Sep 1. [  PDF ]
  156. Carter ME, Adamantidis A, Ohtsu H, Deisseroth K, de Lecea L. Sleep homeostasis modulates hypocretin-mediated sleep-to-wake transitions. J Neurosci. 2009 Sep 2;29(35):10939-49. [  PDF ]
  157. Tønnesen J, Sørensen AT, Deisseroth K, Lundberg C, Kokaia M. Optogenetic control of epileptiform activity. PNAS 2009 Jul 21;106(29):12162-7. Epub 2009 Jul 6. [  PDF ]
  158. Sohal VS, Zhang F, Yizhar O, Deisseroth K. Parvalbumin neurons and gamma rhythms enhance cortical circuit performance. Nature. 2009 Jun 4;459(7247):698-702. Epub 2009 Apr 26. [  PDF | Supplementary Materials ]
  159. Cardin JA, Carlén M, Meletis K, Knoblich U, Zhang F, Deisseroth K, Tsai LH, Moore CI. Driving fast-spiking cells induces gamma rhythm and controls sensory responses. Nature. 2009 Jun 4;459(7247):663-7. Epub 2009 Apr 26. [  PDF ]
  160. Tsai HC, Zhang F, Adamantidis A, Stuber GD, Bonci A, de Lecea L, Deisseroth K. Phasic Firing in Dopaminergic Neurons Is Sufficient for Behavioral Conditioning. Science. 2009 May 22;324(5930):1080-4. Epub 2009 Apr 23. [  PDF | Supplementary Material ]
  161. Zimmermann G, Wang LP, Vaughan AG, Manoli DS, Zhang F, Deisseroth K, Baker BS, Scott MP. Manipulation of an innate escape response in Drosophila: photoexcitation of acj6 neurons induces the escape response. PLoS ONE. 2009;4(4):e5100. Epub 2009 Apr 2. [  PDF ]
  162. Gradinaru V, Mogri M, Thompson KR, Henderson JM, Deisseroth K. Optical deconstruction of parkinsonian neural circuitry. Science. 2009 Apr 17;324(5925):354-9. Epub 2009 Mar 19. [  PDF | Supplementary Material | NewsFocus ]
  163. Airan RD, Thompson KR, Fenno LE, Bernstein H, Deisseroth K. Temporally precise in vivo control of intracellular signalling. Nature. 2009 Apr 23;458(7241):1025-9. Epub 2009 Mar 18. [  PDF | Supplementary Materials | News and Views ]
  164. Li HH, Roy M, Kuscuoglu U, Spencer CM, Halm B, Harrison KC, Bayle JH, Splendore A, Ding F, Meltzer LA, Wright E, Paylor R, Deisseroth K, Francke U. Induced chromosome deletions cause hypersociability and other features of Williams-Beuren syndrome in mice. EMBO Mol Med. 2009 Apr;1(1):50-65. [  PDF ]
  165. Berndt A, Yizhar O, Gunaydin LA, Hegemann P, Deisseroth K. Bi-stable neural state switches. Nat Neurosci. 2009 Feb;12(2):229-34. Epub 2008 Dec 8. [  PDF ]
  166. Zhao S, Cunha C, Zhang F, Liu Q, Gloss B, Deisseroth K, Augustine GJ, Feng G. Improved expression of halorhodopsin for light-induced silencing of neuronal activity. Brain Cell Biol. 2008 Aug;36(1-4):141-54. Epub 2008 Oct 17. [  PDF ]
  167. Douglass AD, Kraves S, Deisseroth K, Schier AF, Engert F. Escape behavior elicited by single, channelrhodopsin-2-evoked spikes in zebrafish somatosensory neurons. Curr Biol. 2008 Aug 5;18(5):1133-7. [  PDF ]
  168. Gradinaru V, Thompson KR, Deisseroth K. eNpHR: aNatronomonashalorhodopsin enhanced for optogenetic applications. Brain Cell Biol. 2008 Aug;36(1-4):129-39. Epub 2008 Aug 2. [  PDF ]
  169. Hu ES, Airan RD, Vijaykumar R, Deisseroth K. Brain circuit dynamics. Am J Psychiatry. 2008 Jul;165(7):800. [  PDF ]
  170. Schneider MB, Gradinaru V, Zhang F, Deisseroth K. Controlling neuronal activity. Am J Psychiatry. 2008 May;165(5):562. [  PDF ]
  171. Zhang F, Prigge M, Beyriere F, Tsunoda SP, Mattis J, Yizhar O, Hegemann P, Deisseroth K. Red-shifted optogenetic excitation: a tool for fast neural control derived from Volvox carteri. Nat Neurosci. 2008 Jun;11(6):631-3. Epub 2008 Apr 23. [  PDF ]
  172. Gradinaru V, Thompson KR, Zhang F, Mogri M, Kay K, Schneider MB, Deisseroth K. Targeting and readout strategies for fast optical neural control in vitro and in vivo. J Neurosci. 2007 Dec 26;27(52):14231-8. [  PDF | Thy-1::ChR2-EYFP Mouse | Wildtype Mouse Control ]
  173. Airan RD, Hu ES, Vijaykumar R, Roy M, Meltzer LA, Deisseroth K. Integration of light-controlled neuronal firing and fast circuit imaging. Curr Opin Neurobiol. 2007 Dec 17. [  PDF ]
  174. Hwang RY, Zhong L, Xu Y, Johnson T, Zhang F, Deisseroth K, Tracey WD. Nociceptive neurons protect Drosophila larvae from parasitoid wasps. Curr Biol. 2007 Dec 18;17(24):2105-16. Epub 2007 Nov 29. [  PDF ]
  175. Adamantidis AR, Zhang F, Aravanis AM, Deisseroth K, de Lecea L. Neural substrates of awakening probed with optogenetic control of hypocretin neurons. Nature. 2007 Nov 15;450(7168):420-4. Epub 2007 Oct 17. [  PDF ]
  176. Aravanis A, Wang LP, Zhang F, Meltzer L, Mogri M, Schneider MB, Deisseroth K. An optical neural interface: in vivo control of rodent motor cortex with integrated fiberoptic and optogenetic technology. J. Neural Eng. 2007 Sep;4(3):S143-56. Epub 2007 May 31. [  PDF | Cover Image ]
  177. Airan RD, Meltzer LA, Roy M, Gong Y, Chen H, Deisseroth K. High-speed imaging reveals neurophysiological links to behavior in an animal model of depression. Science. 2007 Aug 10;317(5839):819-23. Epub 2007 Jul 5. [  PDF | NIMH Press | SciAm Coverage ]
  178. Zhang F, Aravanis AM, Adamantidis A, de Lecea L, Deisseroth K. Circuit-breakers: optical technologies for probing neural signals and systems. Nat Rev Neurosci. 2007 Aug;8(8):577-81. [  PDF | Corrigendum | Cover Image ]
  179. Arenkiel BR, Peca J, Davison IG, Feliciano C, Deisseroth K, Augustine GJ, Ehlers MD, Feng G. In vivolight-induced activation of neural circuitry in transgenic mice expressing channelrhodopsin-2. Neuron. 2007 Apr 19;54(2):205-18. [  PDF ]
  180. Wang H, Peca J, Matsuzaki M, Matsuzaki K, Noguchi J, Qiu L, Wang D, Zhang F, Boyden E, Deisseroth K, Kasai H, Hall WC, Feng G, Augustine GJ. High-speed mapping of synaptic connectivity using photostimulation in Channelrhodopsin-2 transgenic mice. Proc Natl Acad Sci U S A. 2007 May 8;104(19):8143-8. Epub 2007 May 1. [  PDF ]
  181. Zhang F, Wang LP, Brauner M, Liewald JF, Kay K, Watzke N, Wood PH, Bamberg E, Nagel G, Gottschalk A, Deisseroth K. Multimodal fast optical interrogation of neural circuitry. Nature. 2007 Apr 5;446:633-39. [  PDF | N&V; | 2007 Highlight ]
  182. Deisseroth K, Feng G, Majewska AK, Miesenbock G, Ting A, Schnitzer MJ. Next-generation optical technologies for illuminating genetically targeted brain circuits. J Neurosci. 2006 Oct 11; 26(41):10380-6. [  PDF ]
  183. Zhang F, Wang LP, Boyden ES, Deisseroth K. Channelrhodopsin-2 and optical control of excitable cells. Nat Methods. 2006 Oct; 3(10):785-92. [  PDF ]
  184. Deisseroth K, Malenka RC. GABA excitation in the adult brain: a mechanism for excitation- neurogenesis coupling. Neuron. 2005 Sep 15;47(6):775-7. [  PDF ]
  185. Meltzer LA, Yabaluri R, Deisseroth K. A role for circuit homeostasis in adult neurogenesis. Trends Neurosci. 2005 Dec;28(12):653-60. Epub 2005 Nov 3. [  PDF ]
  186. Boyden ES, Zhang F, Bamberg E, Nagel G, Deisseroth K. Millisecond-timescale, genetically targeted optical control of neural activity. Nat Neurosci. 2005 Sep;8(9):1263-8. Epub 2005 Aug 14. [  PDF ]
  187. Deisseroth K, Singla S, Toda H, Monje M, Palmer TD, Malenka RC. Excitation-neurogenesis coupling in adult neural stem/progenitor cells. Neuron. 2004 May 27;42(4):535-52. [  PDF ]
  188. Deisseroth K, Mermelstein PG, Xia H, Tsien RW. Signaling from synapse to nucleus: the logic behind the mechanisms. Curr Opin Neurobiol. 2003 Jun;13(3):354-65. [  PDF ]
  189. Deisseroth K, Tsien RW. Dynamic multiphosphorylation passwords for activity-dependent gene expression. Neuron. 2002 Apr 11;34(2):179-82. [  PDF ]
  190. Mermelstein PG, Deisseroth K, Dasgupta N, Isaksen AL, Tsien RW. Calmodulin priming: nuclear translocation of a calmodulin complex and the memory of prior neuronal activity. Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):15342-7. Epub 2001 Dec 11. [  PDF | Erratum ]
  191. Wu GY, Deisseroth K, Tsien RW. Activity-dependent CREB phosphorylation: convergence of a fast, sensitive calmodulin kinase pathway and a slow, less sensitive mitogen-activated protein kinase pathway. Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2808-13. Epub 2001 Feb 20. [  PDF ]
  192. Wu GY, Deisseroth K, Tsien RW. Spaced stimuli stabilize MAPK pathway activation and its effects on dendritic morphology. Nat Neurosci. 2001 Feb;4(2):151-8. [  PDF ]
  193. Mermelstein PG, Bito H, Deisseroth K, Tsien RW. Critical dependence of cAMP response element-binding protein phosphorylation on L-type calcium channels supports a selective response to EPSPs in preference to action potentials. J Neurosci. 2000 Jan 1;20(1):266-73. [  PDF ]
  194. Graef IA, Mermelstein PG, Stankunas K, Neilson JR, Deisseroth K, Tsien RW, Crabtree GR. L-type calcium channels and GSK-3 regulate the activity of NF-ATc4 in hippocampal neurons. Nature. 1999 Oct 14;401(6754):703-8. [  PDF ]
  195. Zuhlke RD, Pitt GS, Deisseroth K, Tsien RW, Reuter H. Calmodulin supports both inactivation and facilitation of L-type calcium channels. Nature. 1999 May 13;399(6732):159-62. [  PDF | News and Views ]
  196. Deisseroth K, Heist EK, Tsien RW. Translocation of calmodulin to the nucleus supports CREB phosphorylation in hippocampal neurons. Nature. 1998 Mar 12;392(6672):198-202. [  PDF ]
  197. Bito H, Deisseroth K, Tsien RW. Ca2+-dependent regulation in neuronal gene expression. Curr Opin Neurobiol. 1997 Jun;7(3):419-29. [  PDF ]
  198. Bito H, Deisseroth K, Tsien RW. CREB phosphorylation and dephosphorylation: a Ca(2+)- and stimulus duration-dependent switch for hippocampal gene expression. Cell. 1996 Dec 27;87(7):1203-14. [  PDF ]
  199. Deisseroth K, Bito H, Tsien RW. Signaling from synapse to nucleus: postsynaptic CREB phosphorylation during multiple forms of hippocampal synaptic plasticity. Neuron. 1996 Jan;16(1):89-101. [  PDF ]
  200. Deisseroth K, Bito H, Schulman H, Tsien RW. Synaptic plasticity: A molecular mechanism for metaplasticity. Curr Biol. 1995 Dec 1;5(12):1334-8. [  PDF ]