CS279: Structure and Organization of Biomolecules and Cells

Course Information

Description: This course will focus on computational techniques used to study the structure and dynamics of biomolecules, cells, and everything in between. For example, what is the structure of proteins, DNA, and RNA? How do their motions contribute to their function? How do they bind to other molecules? How are molecules distributed and compartmentalized within a cell, and how do they move around? How might one modify the behavior of these systems using drugs or other therapeutics? How can structural information and associated computational methods contribute to the design of drugs, vaccines, proteins, or other important molecules?

Computation can contribute to addressing such questions in at least two distinct ways. First, computational analysis is required to extract useful information from experimental measurements. Second, one can use computational techniques to predict structures, dynamics, and important biochemical properties.

The course will cover (1) atomic-level molecular modeling methods for proteins and other biomolecules, including structure prediction, molecular dynamics simulation, docking, and protein design, (2) computational methods involved in solving molecular structures by x-ray crystallography and cryo-electron microscopy, and (3) computational methods for studying spatial organization of cells, including computational analysis of optical microscopy images and video, and simulations at the cellular scale. The course will cover both foundational material and cutting-edge research in each of these areas, including recent advances in machine learning for structural biology.

Coursework: Students will be expected to complete three assignments, each of which will involve a combination of theoretical questions and computer work. Additionally, students will be expected to complete a project. The project will involve about as much work as an assignment, but it will be more open-ended and will allow students to delve into a topic of their choosing in more depth. Finally, students will be expected to complete an exam at the end of the quarter. More details regarding content of the exam will be released toward the second half of the quarter.

Prerequisites: Elementary programming background (at the level of CS 106A) and introductory course in biology.

Class: Tuesdays and Thursdays, 3:00 PM - 4:20 PM in Shriram 104.

Materials: There is no required textbook. We will suggest a variety of optional reading material throughout the course.

Instructor: Ron Dror

TA: Armaun Sanayei

TA: Divya Nagaraj

TA: Grace Kim

TA: Hyun Soo Jeon

TA: Tristan Saucedo

Office Hours:

Please use Ed Discussion for questions related to lectures and assignments. If you have issues that cannot be resolved on Ed, please contact us at cs279staff@cs.stanford.edu. For instructions on how to get set up on Ed, please see the Getting Set Up handout.

All announcements will be made on Ed Discussion. For instructions on how to get set up on Ed, please see the Getting Set Up handout.



Some topics may be covered a bit earlier or later than listed, due to circumstances beyond the instructor’s control. Missing some lectures is fine. If you need to miss a lecture, we highly recommend reading through the annotated lecture slides and coming to OH for any questions you may have.


Please note that the following dates are approximate.

Submission: All assignments and the project writeup should be submitted to Gradescope.


The final exam will be on Thursday, December 15 from 12:15-3:15pm, located in 320-105.

Python Resources

In this class, the programming assignments will be in Python. If you have prior experience with Python, great! If you don't, no worries! All we expect is familiarity with basic programming. That said, if you've never worked with Python before, it may be helpful to look at some of the following resources to help you get up to speed.

Click here for last year's (Fall 2021) website and content.