PUBLICATIONS

Selected Publications

For a complete list, please refer to the nih.gov page.

  1. Narayan SM, Santori EM, Toga AW. Mapping Functional Activity In Rodent Cortex Using Optical Intrinsic Signals. Cerebral Cortex 1994a; 4(2): 194-204 and 1993; 3(6) cover article.
  2. Narayan SM, Santori EM, Blood AJ, Burton JS, Toga AW. Imaging Optical Reflectance In Rodent Barrel And Forelimb Sensory Cortex. Neuroimage 1994b; 1: 181-190.
  3. Narayan SM, Esfahani P, Blood AJ, Sikkens L, Toga AW. Functional Increases In Cerebral Blood Volume Over Somatosensory Cortex. J Cerebral Blood Flow and Metabolism 1995; 15: 754-765.
  4. Narayan SM, Cain ME, Smith, JM. Atrial Fibrillation.  Lancet 1997; 350: 943-950.
  5. Narayan SM, Smith JM. Spectral Analysis of Periodic Fluctuations in Electrocardiographic Repolarization.  IEEE Transactions in Biomedical Engineering 1999b; 46(2): 203-212.
  6. Narayan SM, Lindsay BD, Smith JM. Demonstration of the Proarrhythmic Preconditioning of Single Premature Extrastimuli by Use of the Magnitude, Phase and Distribution of Repolarization Alternans.  Circulation 1999; 100: 1887-1893.
  7. Narayan SM, Smith JM. Exploiting Rate-Related Hysteresis in Repolarization Alternans to Improve Risk Stratification for Ventricular Tachycardia.  J Am Coll Cardiol. 2000; 35(5): 1485-1492.
  8. Narayan SM, Bode F, Karasik PL, Franz MR. Alternans of Atrial Action Potentials During Atrial Flutter as a Precursor of Atrial Fibrillation. Circulation 2002; 106: 1968-1973.
  9. Sung D, Mills RW, Schettler J, Narayan SM, Omens JH, McCulloch AD. Ventricular filling slows epicardial conduction and increases action potential duration in an optical mapping study of the isolated rabbit heart.  J Cardiovasc Electrophysiol 2003; 14(7): 739-749.
  10. Narayan SM, Bhargava V. Quantifying Intracardiac Organization By Combined Spectral and Spatial Phase Analysis of the Electrocardiogram. Computers in Cardiology, IEEE Press, 2003; 30: 141-144
  11. Hoppe RL, Kahn AM, Hassankhani A, Feld GK, Narayan SM. Separating Atrial Flutter From Atrial Fibrillation with Apparent ECG Organization Using Dominant and Narrow F-Wave Spectra. J. Am. Coll Cardiol 2005; 46(12): 2079-2087
  12. Sastry A, Arnold E, Gurji H, Iwasa A, Bui HM, Hassankhani A, Patel H, Fermamisco JR, Roth DM, Lai NC, Hammond HK, Narayan, SM. Cardiac-Directed Expression of Adenylyl Cyclase VI Facilitates Atrioventricular Conduction. J. Am. Coll. Cardiol. 2006; 47: 559-565
  13. Kahn AM, Krummen DE, Feld GK, Narayan SM. Identifying the Location of Atrial Macro-Reentry Using ECG Spatial Planes of Coherent Activation. Heart Rhythm 2007; 4(4): 445-451.  Editorialized by Daoud E, Heart Rhythm 2007; 4(4):452-453.
  14. Brown JP, Krummen DE, Feld GK, Narayan SM. ECG Separation of Focal from Macro-Reentrant Atrial Tachycardias Using Relative Diastolic Intervals. J Am Coll Cardiol 2007; 49(19): 1965-1973
  15. Mills RW, Narayan SM, McCulloch AD. Mechanisms of Conduction Slowing During Myocardial Stretch by Ventricular Volume Loading.  Am J Phys Heart Circ Phys. 2008; 295(3):H1270-H1278
  16. Narayan SM, Kazi D, Krummen DE, Rappel W-J. Repolarization and Activation Restitution Near Human Pulmonary Veins and Atrial Fibrillation Initiation. A Mechanism for the initiation of Atrial Fibrillation by Premature Beats.  J Am Coll Cardiol 2008; 52(15): 1222-1230.
  17. Narayan SM, Bayer J, Lalani G, Trayanova NA. Action Potential Dynamics Explain Arrhythmic Vulnerability in Human Heart Failure: A Combined Clinical and Modeling Study Implicating Abnormal Calcium Handling.  J Am Coll Cardiol, 2008; 52(22): 1782-1792.
  18. Ravi KC, Krummen DE, Tran AJ, Bullinga JR, Narayan SM. Measuring Regional Atrial Cycle Lengths in Atrial Fibrillation from the Electrocardiogram. Pacing Clin Electrophysiol 2009; 32 (S1): S66-S71.
  19. Knecht S, Sacher F, Wright M, Hocini M, Nogami A, Arentz T, Petit B, Franck R, DeChillou C, Lamaison D, Farre J, Lavergne T, Verbeet T, Nault I, Matsuo S, Leroux L, Weerasooriya R, Cauchemez B, Lellouche N, Derval N, Narayan SM, Jaïs P, Clementy J, Haïssaguerre M. Long Term Follow-Up of Idiopathic Ventricular Fibrillation Ablation: A Multicenter Study. J Am Coll Cardiol. 2009; 54(6): 522-8
  20. Krummen DE, Peng KA, Bullinga JR, Narayan SM. Centrifugal Gradients in Rate and Organization in Human Atrial Fibrillation.  Pacing Clin Electrophys 2009; 32(11): 1366-1378
  21. Knecht S, Wright M, Matsuo S, Nault I, Lellouche N, Sacher F, Kim SJ, Morgan D, Afonso V, Shinzuke M, Hocini M, Clémenty J, Narayan SM, Ritter P, Jaïs P, Haïssaguerre M. Impact of Pharmacological Autonomic Blockade on Complex Fractionated Atrial Electrograms. J Cardiovasc Electrophysiol. 2010; 21(7); 766-772
  22. Bayer JD, Narayan SM, Lalani G, Trayanova NA. Rate-Dependent Action Potential Alternans in Human Heart Failure Implicate Abnormal Intracellular Calcium Handling. Heart Rhythm 2010; 7(8): 1093-1101.
  23. Krummen DE, Peng K, Ho G, Kazi D, Feld GK, Narayan SM. Accurate ECG Diagnosis of Atrial Tachyarrhythmias Using Quantitative Analysis: A Prospective Diagnostic and Cost-Benefit Study.  J Cardiovasc. Electrophysiol. 2010; 21(11):1251-9.
  24. Forclaz A, Derval N, Nault I, Narayan S, Wright M, Miyazaki S, Jadidi A, Shah A, Haïssaguerre M, Hocini M, Jaïs P. Atrial Bigeminy With Recurrent Supraventricular Tachycardia. J Cardiovasc Electrophysiol. 2010; 21(10):1181-3
  25. Narayan SM, Wright M, Derval N, Nault I, Jadidi A, Miyazaki S, Forclaz A, Sacher F, Jaïs P, Clementy J, Haïssaguerre M, Hocini M. Classifying Fractionated Electrograms in Human Atrial Fibrillation Using Monophasic Action Potentials and Activation Mapping: Evidence for Localized Drivers, Rate Acceleration and Non-Local Signal Etiologies. Heart Rhythm 2011; 8(2): 244-253 Editorialized by Chugh A.  Winner of Best Clinical Manuscript at HRS Annual Sessions 2012.
  26. Narayan SM, Franz MR, Clopton P, Pruvot E, Krummen DE. Repolarization Alternans Indicates Vulnerability to Human Atrial Fibrillation. Circulation 2011; 123: 2922-2930
  27. Forclaz A, Narayan SM, Nault I, Jadidi A, Miyazaki S, Wright M, Derval N, Sacher F, Jaïs P, Clementy J, Hocini M, Haïssaguerre M. Temporospatial Organization After Pulmonary Vein Isolation Predicts Termination of Persistent AF During Ablation. Heart Rhythm 2011; 8 (9):1374-82. Epub 2011 May 14.
  28. Hocini M, Shah AJ, Nault I, Sanders P, Wright M, Narayan SM, Takahashi Y, Jaïs P, Matsuo S, Knecht S, Sacher F, Lim KT, Clémenty J, Haïssaguerre M. Localized Re-entry within the Left Atrial Appendage: Arrhythmogenic Role in Patients Undergoing Ablation of Persistent Atrial Fibrillation. Heart Rhythm. 2011 Jul 12. [Epub ahead of print]; 8(12): 1853-1861
  29. Shivkumar K, Narayan SM. Imaging Cardiac Arrhythmias (editorial). Science Transl Med. 2011; 3(98):98fs2
  30. Verrier RL, Klingenheben T, Malik M, El-Sherif N, Exner D, Hohnloser S, Ikeda, Martinez Cortes JP, Narayan SM, Nieminen T, Rosenbaum DS. Microvolt T-Wave Alternans: Physiologic Basis, Methods of Measurement, and Clinical Utility (Consensus Statement by the International Society for Holter and Noninvasive Electrocardiology in collaboration with Japanese Circulation Society, Computers in Cardiology Working Group of European Society of Cardiology, and European Cardiac Arrhythmia Society). J Am Coll Cardiol. 2011; 58(13):1309-24.
  31. Albert CM, Chen PS, Anderson ME, Cain ME, Fishman GI, Narayan SM, Olgin JE, Spooner PM, Stevenson WG, Van Wagoner DR, Packer DL for the Heart Rhythm Society Research Task Force. Full Report from the First Annual Heart Rhythm Society Research Forum: A Vision for Our Research Future, “Dream, Discover, Develop, Deliver”. Executive Summary.  Heart Rhythm 2011; 8(12):e1-12; epub October 21, 2011
  32. Jadidi AS, Duncan E, Miyazaki S, Lellouche N, Shah AJ, Forclaz A, Nault I, Wright M, Rivard L, Liu X, Scherr D, Wilton S, Sacher F, Derval N, Knecht S, Kim SJ, Hocini M, Narayan S, Haïssaguerre M, Jaïs P. Functional Nature of Electrogram Fractionation Demonstrated by Left Atrial High Density Mapping Circulation Arrhyth Electrophysiol 2012: 5(1):32-42
  33. Lalani G, Gibson M, Schricker A, Rostamian A, Krummen DE, Narayan SM. Slowing of Atrial Conduction Prior to the Initiation of Human Atrial Fibrillation: A Bi-Atrial Contact Mapping Study of Transitions to Atrial Fibrillation. J Am Coll Cardiol 2012. 59(9): 595-606
  34. Narayan SM, Krummen DE, Rappel Clinical Mapping Approach To Diagnose Electrical Rotors and Focal Impulse Sources for Human AF. J Cardiovasc Electrophys 2012; 23(5): 447-454
  35. Narayan SM, Krummen DE, Shivkumar K, Clopton PS, Rappel WJ, Miller JM. Treatment of Atrial Fibrillation by the Ablation of Localized Sources: The CONventional Ablation For Atrial Fibrillation With and Without Focal Impulse and Rotor Modulation (CONFIRM) Trial. J Am Coll Cardiol 2012; 60(7):628-36.  Subject of an editorial.
  36. Jousset F, Tenkorang J, Vesin J-M, Pascale P, Ruchat P, Rollin AG, Fromer M, Narayan SM, Pruvot, E.  Kinetics of atrial repolarization alternans in a freebehaving ovine model. J Cardiovasc Electrophys 2012; 23(9): 1003-12
  37. Narayan SM, Krummen DE, Enyeart M, Rappel WJ. Computational Identification and Ablation of Localized Sources for Human Atrial Fibrillation. Plos One 2012; 7(9):e46034
  38. Krummen DE, Bayer JD, Peng K, Trayanova N, Narayan SM. Mechanisms of human atrial fibrillation initiation: Clinical and Computational Studies of Repolarization Restitution and Activation Latency. Circulation Arrhyth Electrophysiol 2012; 5(6): 1149-1159
  39. Zhang Y, Liang X, Ma J, Jing Y, Gonzales MJ, Villongco C, Krishnamurthy A, Frank LR, Nigam V, Stark P, Narayan SM, McCulloch AD. An atlas-based geometry pipeline for cardiac Hermite model construction and diffusion tensor reorientation. Med Image Anal. 2012; 16(6):1130-41; PMID: 2284177
  40. Narayan SM, Shivkumar K, Krummen DE, Miller JM, Rappel WJ. Panoramic Electrophysiological Mapping But Not Individual Electrogram Morphology Identifies Sustaining Sites for Human Atrial Fibrillation: Stable AF Rotors and Focal Sources Relate Poorly to Fractionated Electrograms. Circulation Arrhythm Electrophysiol. 2013; 6(1): 58-67
  41. Jones A, Krummen DE, Narayan SM. Noninvasive Identification of Stable Rotors and Focal Sources for Human Atrial Fibrillation: Classification of AF from the Electrocardiogram. Europace 2013; 15(9):1249-58
  42. Gonzales MJ, Sturgeon G, Krishnamurthy A, Hake A, Jonas R, Stark PS, Rappel W-J, Narayan SM, Zhang Y, Segars P, McCulloch AD. A three-dimensional finite element model of human atrial anatomy: New methods for cubic Hermite meshes with extraordinary vertices.  Med Imag Analysis 2013; 7(5):525-37
  43. Narayan SM, Krummen DE, Clopton P, Shivkumar K, Miller JM. Direct Or Coincidental Elimination of Stable Rotors or Focal Sources May Explain Successful Atrial Fibrillation Ablation: On-Treatment Analysis of the CONFIRM Trial.  J Am Coll Cardiol 2013; 62 (2): 138-147
  44. Rappel W-J, Narayan SM. Theoretical Considerations for Mapping Activation in Human Cardiac Fibrillation. Chaos: An International Journal of Nonlinear Dynamics. 2013; 23(2): 023113.
  45. Krishnamurthy A, Villongco CT, Chuang J, Frank LR, Nigam V, Belezzuoli E, Stark P, Krummen DE, Narayan S, Omens JH, McCulloch AD, Kerckhoffs RC. Patient-Specific Models of Cardiac Biomechanics. J Comput Phys. 2013 Jul 1;244:4-21
  46. Baykaner T, Clopton P, Schricker A, Lalani G, Krummen DE, Narayan SM. Targeted Ablation at Stable Atrial Fibrillation Sources Improves Success Over Conventional Ablation In High Risk Patients A Substudy of the CONFIRM Trial. Can J Cardiol 2013; 10: 1218-1226
  47. Hayase J, Tung R, Narayan SM, Krummen DE. A Rotor in Human Ventricular Fibrillation and Its Relationship to Ablation Sites for Ventricular Tachycardia. Heart Rhythm, 2013; 10(12): 1913-1916Lalani GG, Schricker AA, Krummen DE, Narayan SM. Frequency Analysis of Atrial Action
  48. Jousset F, Tenkorang J, Vesin J-M, Pascale P, Ruchat P, Rollin AG, Fromer M, Narayan SM, Pruvot, E. Intermittent atrial tachycardia promotes repolarization alternans and conduction slowing during rapid rates, and increases susceptibility to atrial fibrillation in a free-behaving sheep model. J Cardiovasc Electrophys 2014; 25(4):418-27
  49. Wyse DG; Van Gelder IC, Rienstra M, Ellinor PT, Go AS, Kalman J, Narayan SM, Nattel S, Schotten U. Lone Atrial Fibrillation: Does It Exist? White Paper. J Am Coll Cardiol. 2014; 63(17):1715-1723; epub March 2014
  50. Narayan SM, Baykaner T, Clopton P, Schricker AA, Lalani GG, Krummen DE, Shivkumar K, Miller JM. Elimination of Stable Rotor or Focal Sustaining Substrates Prevents Late Recurrence of Atrial Fibrillation After Ablation: Extended Followup from the CONFIRM Trial. J Am Coll Cardiol, 2014; 63(17):1761-8. epub March 2014.
  51. Krummen DE, Hayase J, Morris DJ, Ho J, Smetak MR, Clopton PS, Rappel WJ, Narayan SM. Rotor Stability Separates Sustained Ventricular Fibrillation From Self-Terminating Episodes in Humans. J Am Coll Cardiol, 2014; 63(24):2712-21 (epub May 2014)
  52. Narayan SM, Jalife J. CrossTalk proposal: Rotors have been demonstrated to drive human atrial fibrillation. Journal of Physiology. 2014; 592: 3163-6
  53. Narayan SM, Jalife J. Rotors have been demonstrated to drive human atrial fibrillation: Rebuttal. Journal of Physiology. 2014; 592: 3171.
  54. Miller JM, Kowal RC, Swarup V, Daubert J, Day J, Ellenbogen K, Hummel J, Krummen DE, Mansour M, Narayan SM, Reddy VY, Shivkumar K, Steinberg JS and Wheelan K. Initial External Multicenter Prospective Study of Focal Impulse and Rotor Modulation (FIRM) For Atrial Fibrillation. J Cardiovasc Electrophysiology 2014; 25(9): 921-9
  55. Schricker AA, Lalani GG, Krummen DE, Rappel W-J, Narayan SM. Human Atrial Fibrillation Initiates Via Organized Rather Than Disorganized Mechanisms. Circulation: Arrhyth Electrophysiol. 2014; 7(5): 816-824
  56. Swarup V, Baykaner T, Rostamian A, Daubert J, Hummel J, Krummen DE, Trikha R, Miller JM, Tomassoni G, Narayan SM. Stability of Rotors and Focal Sources for Human Atrial Fibrillation: Mapping Source Dynamics By Focal Impulse and Rotor Mapping (FIRM).  J Cardiovasc Electrophysiol. 2014; 25(12): 1284-92
  57. Gonzales MJ, Vincent KP, Rappel WJ, Narayan SM, McCulloch AD. Structural Contributions to Fibrillatory Rotors in a Patient-Specific Computational Model of The Atria. Europace 2014; 16 Suppl; iv3-iv10
  58. Van Wagoner DR, Piccini JP, Albert CM, Anderson ME, Benjamin EJ, Brundel B, Califf RM, Calkins H, Chen PS, Chiamvimonvat N, Darbar D, Eckhardt L, Ellinor PT, Exner DV, Fogel RI, Gillis AM, Healey J, Hohnloser SH, Kamel H, Lathrop DA, Lip GY, Mehra R, Narayan SM, Olgin J, Packer D, Peters NS, Roden DM, Ross HM, Sheldon R, Wehrens XH. Progress towards the Prevention and Treatment of Atrial Fibrillation: A summary of the Heart Rhythm Society Research Forum on the Treatment and Prevention of Atrial Fibrillation, Washington, D.C., December 9-10, 2013. Heart Rhythm. 2015; 12(1):e5-e29
  59. Krummen DE, Hayase J, Vampola SP, Ho G, Schricker AA, Lalani GG, Baykaner T, Coe TM, Clopton P, Rappel WJ, Omens JH, Narayan SM. Modifying Ventricular Fibrillation by Targeted Rotor Substrate Ablation: Proof-of-Concept from Experimental Studies to Clinical VF. J Cardiovasc Electrophysiol. 2015; 26(10): 1117-26 Jul 14. doi: 10.1111/jce.12753
  60. Rappel, W-J, Zaman, ZAB, Narayan SM. Mechanisms For the Termination of Atrial Fibrillation by Localized Ablation: Computational and Clinical Studies, Circulation Arrhyth Electrophysiol 2015; 8(6): 1325-33
  61. Vidmar D, Narayan SM, Rappel W-J. Phase Synchrony Reveals Organization in Human Atrial Fibrillation. Am J Physiol Heart Circ Physiol. 2015;309(12):H2118-26