Axelrod Lab
home research people publications code contact info


Reviews, Commentary, Chapters

Research (top)

  • Dobens LL, Shipman, A, Axelrod JD. (2017) FijiWingsPolarity: an open source toolkit for semi-automated detection of cell polarity. Fly Nov 30:0. doi: 10.1080/19336934.2017.1409927. online eprint

  • Kunimoto K, Bayly RD, Vladar EK, Vonderfecht T, Gallagher A-R, Axelrod JD. (2017) Disruption of Core Planar Cell Polarity Signaling Regulates Renal Tubule Morphogenesis but Is Not Cystogenic. Current Biology 27(20) 3120-3131.e4. (PDF)

  • Boscke R, Vladar EK, Konnecke M, Husing B, Linke R, Pries R, Reiling N, Axelrod JD, Nayak JV, Wollenberg B.. (2017) Wnt Signaling in Chronic Rhinosinusitis with Nasal Polyps. Am J Respir Cell Mol Biol. 2017 May;56(5):575-584 (free online PDF) doi: 10.1165/rcmb.2016-0024OC.

  • Vladar EK, Nayak JV, Milla CE, Axelrod JD. (2016) Airway epithelial homeostasis and planar cell polarity signaling depend on multiciliated cell differentiation. JCI Insight. 2016 Aug 18;1(13). pii: e88027 (online PDF) doi: 10.1172/jci.insight.88027.

  • Morgan SL, Seggio JA, Nascimento NF, Huh DD, Hicks JA, Sharp KA, Axelrod JD, Wang KC. (2016) The Phenotypic Effects of Royal Jelly on Wild-Type D. melanogaster Are Strain-Specific. PLoS One. 2016 Aug 3;11(8):e0159456 (free online PDF) doi: 10.1371/journal.pone.0159456. eCollection 2016.

  • Gibbs BC, Damerla RR, Vladar EK, Chatterjee B, Wan Y, Liu X, Cui C, Gabriel GC, Zahid M, Yagi H, Szabo-Rogers HL, Suyama KL, Axelrod JD, Lo CW. (2016) Prickle1 mutation causes planar cell polarity and directional cell migration defects associated with cardiac outflow tract anomalies and other structural birth defects. Biol Open. 2016 Feb 16;5(3):323-35. (free online PDF) doi: 10.1242/bio.015750.

  • Sharp KA, Axelrod JD. (2016) Prickle isoforms control the direction of tissue polarity by microtubule independent and dependent mechanisms. Biol Open. 2016 Feb 10;5(3):229-36. (free online PDF) doi: 10.1242/bio.016162.

  • Cho B, Pierre-Louis G, Sagner A, Eaton S, Axelrod JD. (2015) Clustering and negative feedback by endocytosis in planar cell polarity signaling is modulated by ubiquitinylation of Prickle PLoS Genetics 11(5): e1005259 (free online PDF) doi: 10.1371/journal.pgen.1005259

  • Matis M, Russler-Germain DA, Hu Q, Tomlin CJ, Axelrod JD. (2014)
    Microtubules provide directional information for core PCP function. Elife. Aug 14;3:e02893. (free online PDF) doi: 10.7554/eLife.02893.

  • Ehaideb SN, Iyengar A, Ueda A, Iacobucci GJ, Cranston C, Bassuk AG, Gubb D, Axelrod JD,Gunawardena S, Wu C-F, and Manak RJ. (2014)
    prickle modulates microtubule polarity and axonal transport to ameliorate seizures in flies. PNAS; Jul 29;111(30):11187-92. (PDF) doi:10.1073/pnas.1403357111.

  • Olofsson J, Sharp KA, Matis M, Cho B, Axelrod JD (2014) Prickle/spiny-legs isoforms control the polarity of the apical microtubule network in planar cell polarity. Development Jun 15;68(1):97-104. (PDF) doi: 10.1016/j.ymeth.2014.03.017.

  • Tan FE, Vladar EK, Ma L, Fuentealba LC, Hoh R, Espinoza FH, Axelrod JD, Alvarez-Buylla A, Stearns T, Kintner C, & Krasnow MA (2013) Myb promotes centriole amplification and later steps of the multiciliogenesis program. Development 140, 4277-4286 (PDF) doi: 10.1242/dev.094102.

  • Ducuing A, Mollereau B, Axelrod JD, Vincent, S. (2013) Absolute requirement of cholesterol binding for Hedgehog gradient formation in Drosophila. Biology Open 0, 1-9 (Free Online) doi: 10.1242/bio.20134952.

  • Vladar E, Bayly RD, Sangoram A, Scott M & Axelrod JD. (2012) Microtubules enable the planar cell polarity of airway cilia. Current Biology 22, 2203-12 (PDF) Supporting Online Material: (3.4MB PDF)

  • Abate A, Vincent S, Dobbe R, Silletti A, Axelrod JD & Tomlin CJ. (2012) A mathematical model to study the dynamics of ephtielial cell networks. IEEE/ACM Transactions on Computational Biology and Bioinformatics 9, 1607-20 (PDF) doi 10.1109/TCBB.2012.126. Supplementary simulation output movies available here.

  • Peng Y, Han C, Axelrod JD. (2012) Planar polarized protrusions break the symmetry of EGFR signaling during Drosophila bract cell fate induction. Developmental Cell 23, 507-518. (PDF)
    Supporting Online Material: (2.9MB PDF)
  • Matis M, Axelrod JD, and Galic M (2012) A universal analysis tool for the detection of asymmetric signal distribution in microscopic images. Developmenatal Dynamics 241, 1301-9. Free PDF Epub date 2012/06/13. doi: 10.1002/dvdy.23818

  • Tao, H, Inouea, K, Kiyonaria, H, Bassuk, AG, Axelrod, JD, Sasaki, H, Aizawa, S, Ueno, N (2012) Nuclear localization of Prickle2 is required to establish cell polarity during early mouse embryogenesis. Dev Biol 364(2), 138-48. PDF

  • Stubbs JL, Vladar EK, Axelrod JD, & Kintner C (2012) Multicilin promotes centriole assembly and ciliogenesis during multiciliate cell differentiation. Nat Cell Biol. 14(2), 140-7. PDF doi: 10.1038/ncb2406.

  • Tao, H., Manak, J.R., Sowers, L., Mei, X., Kiyonari, H., Abe, T., Dahdaleh, N.S., Yang, T., Wu, S., Chen, S., Fox, M.H., Gurnett, C., Montine, T., Bird, T., Shaffer, L.G., Rosenfeld, J.A., McConnell, J., Madan-Khetarpal, S., Berry-Kravis, E., Griesbach, H., Saneto, R.P., Scott, M.P., Antic, D., Reed, J., Boland, R., Ehaideb, S.N., El-Shanti, H., Mahajan, V.B., Ferguson, P.J., Axelrod, J.D., Lehesjoki, A.E., Fritzsch, B., Slusarski, D.C., Wemmie, J., Ueno, N., & Bassuk, A.G. (2011) Mutations in Prickle Orthologs Cause Seizures in Flies, Mice, and Humans. American Journal of Human Genetics Feb 11;88(2):138-49. Free PDF doi:10.1016/j.ajhg.2010.12.012

  • Silletti, A., Abate, A., Axelrod, J.D., Tomlin, C.J. (2011) Versatile spectral methods for point set matching. Pattern Recognition Letters 32(5), 731-739. PDF doi:10.1016/j.patrec.2010.11.022

  • Antic D, Stubbs JL, Suyama K, Kintner C, Scott MP, & Axelrod JD (2010) Planar Cell Polarity Enables Posterior Localization of Nodal Cilia and Left-Right Axis Determination during Mouse and Xenopus Embryogenesis. PLoS ONE 5(2), e8999. Free PDF doi:10.1371/journal.pone.0008999

  • de Jesus Perez VA, Alastalo TP, Wu JC, Axelrod JD, Cooke JP, Amieva M, & Rabinovitch M (2009) Bone morphogenetic protein 2 induces pulmonary angiogenesis via Wnt-beta-catenin and Wnt-RhoA-Rac1 pathways. Journal of Cell Biology 184, 183-99. Free PDF doi:10.1083/jcb.200806049

  • Ma, D., Amonlirdviman, K., Raffard, R.L., Abate, A., Tomlin, C.J., Axelrod, J.D. (2008) Cell packing influences planar cell polarity signaling. Proc. Natl. Acad. Sci. 105, 18800-18805. Free PDF doi:10.1073/pnas.0808868105

  • Bassuk, A.G., Wallace, R.H., Buhr, A., Buller, A.R., Afawi, Z., Shimojo, M., Miyata, S., Chen, S., Gonzalez-Alegre, P., Griesbach, H.L., Wu, S., Nashelsky, M., Vladar, E.K., Antic, D., Ferguson, P.J., Cirak, S., Voit, T., Scott, M.P., Axelrod, J.D., Gurnett, C., Daoud, A.S., Kivity, S., Neufeld, M.Y., Mazarib, A. Strasssberg, R., Walid, S., Korczyn, A.D., Slusarski, D.C., Berkovic, S.F., El-Shanti, H.I. (2008) A Homozygous mutation in human PRICKLE1 causes an autosomal-recessive progressive myoclonus epilepsy-ataxia syndrome. American Journal of Human Genetics 83, 572-81. Free PDF doi:10.1016/j.ajhg.2008.10.003

  • Vincent, S., Perrimon, N. and Axelrod, J.D. (2008) Hedgehog and Wingless stabilize but do not induce cell fate during Drosophila dorsal embryonic epidermal patterning. Development 135, 2767-2775. Free PDF doi:10.1242/dev.017814

  • Chen, W.-S., Antic, D., Matis, M. Logan, C.Y., Povelones, M., Anderson, G.A., Nusse, R., Axelrod, J.D. (2008) Asymmetric homotypic interactions of the atypical cadherin Flamingo mediate intercellular polarity signaling. Cell 133, 1093-1105. Free PDF DOI 10.1016/j.cell.2008.04.048
    Supplemental Online Material: (Free PDF)

  • Raffard, R., Amonlirdviman, K., Axelrod, J.D. and Tomlin, C. (2008) An Adjoint-based Parameter Identifcation Algorithm applied to Planar Cell Polarity Signaling. Joint Issue of IEEE Transactions on Circuits and Systems and IEEE Transactions on Automatic Control January, 2008, 109-121. PDF

  • Deans, M.R., Antic, D., Suyama, K., Scott, M.P., Axelrod, J.D. and Goodrich, L.V. (2007) Asymmetric distribution of Prickle-Like 2 reveals an early underlying polarization of vestibular sensory epithelia in the inner ear. Journal of Neuroscience 27, 3139-3147. Free PDF DOI:10.1523/JNEUROSCI.5151-06.2007

  • Guan, J., Li, H., Rogulja, A., Axelrod, J.D. and Cadigan, K.M. (2007) The Drosophila casein kinase Iepsilon/delta Discs overgrown promotes cell survival via activation of DIAP1 expression. Dev Biol. 303, 16-28. Free PDF doi:10.1016/j.ydbio.2006.10.028.

  • Raffard, R., Amonlirdviman, K., Axelrod, J. D., and Tomlin, C. J. (2006) Automatic Parameter Identification via the Adjoint Method, with Application to Understanding Planar Cell Polarity. In the Proceedings of the 45th IEEE Conference on Decision and Control, San Diego

  • Kovoor, A., Seyffarth, P., Ebert, J., Barghashoon, S., Chen, C.K., Schwarz, S., Axelrod, J.D., Simon, M.I., Lester, H.A., Schwarz, J. (2005) D2-dopamine receptors colocalize RGS9-2 via the RGS9 DEP domain and RGS9 knockout mice develop dyskinesias associated with dopamine pathways. Journal of Neuroscience 25, 2157-2165. Free PDF

  • Amonlirdviman, K., Khare, N.A., Tree, D.R.P., Chen, W.-S., Axelrod, J.D. and Tomlin, C.J. (2005) Mathematical modeling of planar cell polarity to understand domineering nonautonomy. Science 307, 423-426. Free PDF
    Supporting Online Material: (19MB high resolution PDF) or (5.3MB low resolution PDF)

  • Ma, D., Yang, C.H., McNeill, H., Simon, M.A. and Axelrod, J.D. (2003) Fidelity in planar cell polarity signalling. Nature 421, 543-547. PDF

  • Tree, D.R., Shulman, J.M., Rousset, R., Scott, M.P., Gubb, D. and Axelrod, J.D. (2002) Prickle mediates feedback amplification to generate asymmetric planar cell polarity signaling. Cell 109, 371-381. Free PDF

  • Yang, C.H., Axelrod, J.D. and Simon, M.A. (2002) Regulation of Frizzled by Fat-like cadherins during planar polarity signaling in the Drosophila compound eye. Cell 108, 675-688. Free PDF

  • Winter, C.G., Wang, B., Ballew, A., Royou, A., Karess, R., Axelrod, J.D. and Luo, L. (2001) Drosophila Rho-associated kinase (Drok) links Frizzled-mediated planar cell polarity signaling to the actin cytoskeleton. Cell 105, 81-91. Free PDF

  • Rousset, R., Mack, J.A., Wharton, K.A., Jr., Axelrod, J.D., Cadigan, K.M., Fish, M.P., Nusse, R. and Scott, M.P. (2001) naked cuticle targets dishevelled to antagonize Wnt signal transduction. Genes Dev 15, 658-671. Free PDF

  • Axelrod, J.D. (2001) Unipolar membrane association of Dishevelled mediates Frizzled planar cell polarity signaling. Genes Dev 15, 1182-1187. Free PDF

  • Axelrod, J.D., Miller, J.R., Shulman, J.M., Moon, R.T. and Perrimon, N. (1998) Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways. Genes Dev 12, 2610-2622. Free PDF

  • Rulifson, E.J., Micchelli, C.A., Axelrod, J.D., Perrimon, N. and Blair, S.S. (1996) wingless refines its own expression domain on the Drosophila wing margin. Nature 384, 72-74. PDF

  • Park, M., Wu, X., Golden, K., Axelrod, J.D. and Bodmer, R. (1996) The wingless signaling pathway is directly involved in Drosophila heart development. Dev Biol 177, 104-116. Free PDF

  • Klingensmith, J., Yang, Y., Axelrod, J.D., Beier, D.R., Perrimon, N. and Sussman, D.J. (1996) Conservation of dishevelled structure and function between flies and mice: isolation and characterization of Dvl2. Mech Dev 58, 15-26. PDF

  • Axelrod, J.D., Matsuno, K., Artavanis-Tsakonas, S. and Perrimon, N. (1996) Interaction between Wingless and Notch signaling pathways mediated by Dishevelled. Science 271, 1826-1832. PDF

  • Benjamin, R.J., Linsley, L., Axelrod, J.D., Churchill, W.H., Sieff, C., Shulman, L.N., Elias, A., Ayash, L., Malachowski, M.E., Uhl, L. and et al. (1995) The collection and evaluation of peripheral blood progenitor cells sufficient for repetitive cycles of high-dose chemotherapy support. Transfusion 35, 837-844.

  • Axelrod, J.D., Reagan, M.S. and Majors, J. (1993) GAL4 disrupts a repressing nucleosome during activation of GAL1 transcription in vivo. Genes Dev 7, 857-869. Free PDF

  • Axelrod, J.D., Majors, J. and Brandriss, M.C. (1991) Proline-independent binding of PUT3 transcriptional activator protein detected by footprinting in vivo. Mol Cell Biol 11, 564-567. Free PDF

  • Axelrod, J.D. and Majors, J. (1989) An improved method for photofootprinting yeast genes in vivo using Taq polymerase. Nucleic Acids Res 17, 171-183. Free PDF

  • Lacey, D.L., Axelrod, J., Chappel, J.C., Kahn, A.J. and Teitelbaum, S.L. (1987) Vitamin D affects proliferation of a murine T helper cell clone. J Immunol 138, 1680-1686.

  • Axelrod, J.D. and Pilch, P.F. (1983) Unique cytochalasin B binding characteristics of the hepatic glucose carrier. Biochemistry 22, 2222-2227.

  • Pilch, P.F., Axelrod, J.D., Colello, J. and Czech, M.P. (1981) Unimpaired signal transduction by the adipocyte insulin receptor following its partial proteolytic fragmentation. J Biol Chem 256, 1570-1575. Free PDF

Reviews, Commentary, Chapters (top)

[an error occurred while processing this directive]